Found: 6

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  • A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.

    Published in:
    Nature, 2012, v. 488, n. 7409, p. 96, doi. 10.1038/nature11283
    By:
    • Jonsson, Thorlakur;
    • Atwal, Jasvinder K.;
    • Steinberg, Stacy;
    • Snaedal, Jon;
    • Jonsson, Palmi V.;
    • Bjornsson, Sigurbjorn;
    • Stefansson, Hreinn;
    • Sulem, Patrick;
    • Gudbjartsson, Daniel;
    • Maloney, Janice;
    • Hoyte, Kwame;
    • Gustafson, Amy;
    • Liu, Yichin;
    • Lu, Yanmei;
    • Bhangale, Tushar;
    • Graham, Robert R.;
    • Huttenlocher, Johanna;
    • Bjornsdottir, Gyda;
    • Andreassen, Ole A.;
    • Jönsson, Erik G.
    Publication type:
    Article

  • Role of BACE1 and BACE2 in the production of endogenous mouse Aß

    Published in:
    2012
    By:
    • Meilandt, William;
    • Atwal, Jasvinder;
    • Solanoy, Hilda;
    • Hoyte, Kwame;
    • Luk, Wil;
    • Lu, Yanmei;
    • Watts, Ryan;
    • Scearce-Levie, Kimberly
    Publication type:
    Abstract

  • Therapeutic bispecific antibodies cross the blood-brain barrier in nonhuman primates.

    Published in:
    Science Translational Medicine, 2014, v. 6, n. 261, p. 1, doi. 10.1126/scitranslmed.3009835
    By:
    • Yu, Y. Joy;
    • Atwal, Jasvinder K.;
    • Yin Zhang;
    • Tong, Raymond K.;
    • Wildsmith, Kristin R.;
    • Tan, Christine;
    • Bien-Ly, Nga;
    • Hersom, Maria;
    • Maloney, Janice A.;
    • Meilandt, William J.;
    • Bumbaca, Daniela;
    • Gadkar, Kapil;
    • Hoyte, Kwame;
    • Luk, Wilman;
    • Yanmei Lu;
    • Ernst, James A.;
    • Scearce-Levie, Kimberly;
    • Couch, Jessica A.;
    • Dennis, Mark S.;
    • Watts, Ryan J.
    Publication type:
    Article

  • Addressing Safety Liabilities of TfR Bispecific Antibodies That Cross the Blood-Brain Barrier.

    Published in:
    Science Translational Medicine, 2013, v. 5, n. 183, p. 1, doi. 10.1126/scitranslmed.3005338
    By:
    • Couch, Jessica A.;
    • Yu, Y. Joy;
    • Yin Zhang;
    • Tarrant, Jacqueline M.;
    • Fuji, Reina N.;
    • Meilandt, William J.;
    • Solanoy, Hilda;
    • Tong, Raymond K.;
    • Kwame Hoyte;
    • Luk, Wilman;
    • Yanmei Lu;
    • Gadkar, Kapil;
    • Prabhu, Saileta;
    • Ordonia, Benjamin A.;
    • Nguyen, Quyen;
    • Yuwen Lin;
    • Zhonghua Lin;
    • Balazs, Mercedesz;
    • Scearce-Levie, Kimberly;
    • Ernst, James A.
    Publication type:
    Article

  • Boosting Brain Uptake of a Therapeutic Antibody by Reducing Its Affinity for a Transcytosis Target.

    Published in:
    Science Translational Medicine, 2011, v. 3, n. 84, p. 1, doi. 10.1126/scitranslmed.3002230
    By:
    • Y. Joy Yu;
    • Yin Zhang;
    • Kenrick, Margaret;
    • Kwame Hoyte;
    • Wilman Luk;
    • Yanmei Lu;
    • Atwal, Jasvinder;
    • Elliott, J. Michael;
    • Prabhu, Saileta;
    • Watts, Ryan J.;
    • Dennis, Mark S.
    Publication type:
    Article

  • A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-β Production in Vivo.

    Published in:
    Science Translational Medicine, 2011, v. 3, n. 84, p. 1, doi. 10.1126/scitranslmed.3002254
    By:
    • Yongmei Chen;
    • Cecilia Chiu;
    • Mortensen, Deborah L.;
    • Meilandt, William J.;
    • Yichin Liu;
    • Heise, Christopher E.;
    • Kwame Hoyte;
    • Wilman Luk;
    • Yanmei Lu;
    • Kun Peng;
    • Ping Wu;
    • Lionel Rouge;
    • Yingnan Zhang;
    • Lazarus, Robert A.;
    • Scearce-Levie, Kimberly;
    • Weiru Wang;
    • Yan Wu;
    • Tessier-Lavigne, Marc;
    • Watts, Ryan J.
    Publication type:
    Article