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In patients with primary Sjögren's syndrome innate-like MAIT cells display upregulated IL-7R, IFN-γ, and IL-21 expression and have increased proportions of CCR9 and CXCR5-expressing cells.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.1017157
By:
- Hinrichs, Anneline C.;
- Kruize, Aike A.;
- Leavis, Helen L.;
- van Roon, Joel A. G.
Publication type:
Article
CCL5 Release by CCR9+ CD8 T Cells: A Potential Contributor to Immunopathology of Primary Sjögren's Syndrome.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.887972
By:
- Hinrichs, Anneline C.;
- Blokland, Sofie L. M.;
- Kruize, Aike A.;
- Lafeber, Floris P. J.;
- Leavis, Helen L.;
- van Roon, Joel A. G.
Publication type:
Article
Short term effectiveness and experiences of a peer guided web-based self-management intervention for young adults with juvenile idiopathic arthritis.
Published in:
Pediatric Rheumatology, 2017, v. 15, p. 1, doi. 10.1186/s12969-017-0201-1
By:
- Ammerlaan, Judy;
- van Os-Medendorp, Harmieke;
- de Boer-Nijhof, Nienke;
- Scholtus, Lieske;
- Kruize, Aike A.;
- van Pelt, Philomine;
- Prakken, Berent;
- Bijlsma, Hans
Publication type:
Article
Interleukin-7 and Toll-Like Receptor 7 Induce Synergistic B Cell and T Cell Activation.
Published in:
PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0094756
By:
- Bikker, Angela;
- Kruize, Aike A.;
- van der Wurff-Jacobs, Kim M. G.;
- Peters, Rogier P.;
- Kleinjan, Marije;
- Redegeld, Frank;
- de Jager, Wilco;
- Lafeber, Floris P. J. G.;
- van Roon, Joël A. G.
Publication type:
Article
Plasmacytoid DCs From Patients With Sjögren's Syndrome Are Transcriptionally Primed for Enhanced Pro-inflammatory Cytokine Production.
Published in:
Frontiers in Immunology, 2019, p. 1, doi. 10.3389/fimmu.2019.02096
By:
- Hillen, Maarten R.;
- Pandit, Aridaman;
- Blokland, Sofie L. M.;
- Hartgring, Sarita A. Y.;
- Bekker, Cornelis P. J.;
- van der Heijden, Eefje H. M.;
- Servaas, Nila H.;
- Rossato, Marzia;
- Kruize, Aike A.;
- van Roon, Joel A. G.;
- Radstake, Timothy R. D. J.
Publication type:
Article
MicroRNA-130a Contributes to Type-2 Classical DC-activation in Sjögren's Syndrome by Targeting Mitogen- and Stress-Activated Protein Kinase-1.
Published in:
Frontiers in Immunology, 2019, p. N.PAG, doi. 10.3389/fimmu.2019.01335
By:
- Lopes, Ana P.;
- van Roon, Joel A. G.;
- Blokland, Sofie L. M.;
- Wang, Maojie;
- Chouri, Eleni;
- Hartgring, Sarita A. Y.;
- van der Wurff-Jacobs, Kim M. G.;
- Kruize, Aike A.;
- Burgering, Boudewijn M. T.;
- Rossato, Marzia;
- Radstake, Timothy R. D. J.;
- Hillen, Maarten R.
Publication type:
Article
The Transcriptomic Profile of Monocytes from Patients With Sjögren's Syndrome Is Associated With Inflammatory Parameters and Is Mimicked by Circulating Mediators.
Published in:
Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.701656
By:
- Lopes, Ana P.;
- Bekker, Cornelis P. J.;
- Hillen, Maarten R.;
- Blokland, Sofie L. M.;
- Hinrichs, Anneline C.;
- Pandit, Aridaman;
- Kruize, Aike A.;
- Radstake, Timothy R. D. J.;
- van Roon, Joel A. G.
Publication type:
Article
Transcriptome Analysis of CCR9+ T Helper Cells From Primary Sjögren's Syndrome Patients Identifies CCL5 as a Novel Effector Molecule.
Published in:
Frontiers in Immunology, 2021, v. 12, p. 1, doi. 10.3389/fimmu.2021.702733
By:
- Hinrichs, Anneline C.;
- Blokland, Sofie L. M.;
- Lopes, Ana P.;
- Wichers, Catharina G. K.;
- Kruize, Aike A.;
- Pandit, Aridaman;
- Radstake, Timothy R. D. J.;
- van Roon, Joel A. G.
Publication type:
Article
Childhood-onset of primary Sjögren's syndrome: phenotypic characterization at diagnosis of 158 children.
Published in:
Rheumatology, 2021, v. 60, n. 10, p. 4558, doi. 10.1093/rheumatology/keab032
By:
- Ramos-Casals, Manuel;
- Acar-Denizli, Nihan;
- Vissink, Arjan;
- Brito-Zerón, Pilar;
- Li, Xiaomei;
- Carubbi, Francesco;
- Priori, Roberta;
- Toplak, Nataša;
- Baldini, Chiara;
- Faugier-Fuentes, Enrique;
- Kruize, Aike A;
- Mandl, Thomas;
- Tomiita, Minako;
- Gandolfo, Saviana;
- Hashimoto, Kunio;
- Hernandez-Molina, Gabriela;
- Hofauer, Benedikt;
- Mendieta-Zerón, Samara;
- Rasmussen, Astrid;
- Sandhya, Pulukool
Publication type:
Article
Epidemiological profile and north–south gradient driving baseline systemic involvement of primary Sjögren's syndrome.
Published in:
Rheumatology, 2020, v. 59, n. 9, p. 2350, doi. 10.1093/rheumatology/kez578
By:
- Brito-Zerón, Pilar;
- Acar-Denizli, Nihan;
- Ng, Wan-Fai;
- Horváth, Ildiko Fanny;
- Rasmussen, Astrid;
- Seror, Raphaele;
- Li, Xiaomei;
- Baldini, Chiara;
- Gottenberg, Jacques-Eric;
- Danda, Debashish;
- Quartuccio, Luca;
- Priori, Roberta;
- Hernandez-Molina, Gabriela;
- Armagan, Berkan;
- Kruize, Aike A;
- Kwok, Seung-Ki;
- Kvarnstrom, Marika;
- Praprotnik, Sonja;
- Sene, Damien;
- Gerli, Roberto
Publication type:
Article
Epigenetically quantified immune cells in salivary glands of Sjögren's syndrome patients: a novel tool that detects robust correlations of T follicular helper cells with immunopathology.
Published in:
Rheumatology, 2020, v. 59, n. 2, p. 335, doi. 10.1093/rheumatology/kez268
By:
- Blokland, Sofie L M;
- Vliet-Moret, Fréderique M van;
- Hillen, Maarten R;
- Pandit, Aridaman;
- Goldschmeding, Roel;
- Kruize, Aike A;
- Bouma, Gerben;
- Maurik, André van;
- Olek, Sven;
- Hoffmueller, Ulrich;
- Roon, Joel A G van;
- Radstake, Timothy R D J
Publication type:
Article
Dysregulated miRNome of plasmacytoid dendritic cells from patients with Sjögren's syndrome is associated with processes at the centre of their function.
Published in:
Rheumatology, 2019, v. 58, n. 12, p. 2305, doi. 10.1093/rheumatology/kez195
By:
- Hillen, Maarten R;
- Chouri, Eleni;
- Wang, Maojie;
- Blokland, Sofie L M;
- Hartgring, Sarita A Y;
- Concepcion, Arno N;
- Kruize, Aike A;
- Burgering, Boudewijn M T;
- Rossato, Marzia;
- Roon, Joel A G van;
- Radstake, Timothy R D J
Publication type:
Article
Increased expression of Fas on group 2 and 3 innate lymphoid cells is associated with an interferon signature in systemic lupus erythematosus and Sjögren's syndrome.
Published in:
Rheumatology, 2019, v. 58, n. 10, p. 1740, doi. 10.1093/rheumatology/kez116
By:
- Blokland, Sofie L M;
- Hoogen, Lucas L van den;
- Leijten, Emmerik F A;
- Hartgring, Sarita A Y;
- Fritsch, Ruth;
- Kruize, Aike A;
- Roon, Joel A G van;
- Radstake, Timothy R D J
Publication type:
Article
Characterization of systemic disease in primary Sjögren's syndrome: EULAR-SS Task Force recommendations for articular, cutaneous, pulmonary and renal involvements.
Published in:
Rheumatology, 2015, v. 54, n. 12, p. 2230, doi. 10.1093/rheumatology/kev200
By:
- Ramos-Casals, Manuel;
- Brito-Zerón, Pilar;
- Seror, Raphaèle;
- Bootsma, Hendrika;
- Bowman, Simon J.;
- Dörner, Thomas;
- Gottenberg, Jacques-Eric;
- Mariette, Xavier;
- Theander, Elke;
- Bombardieri, Stefano;
- De Vita, Salvatore;
- Mandl, Thomas;
- Wan-Fai Ng;
- Kruize, Aike;
- Tzioufas, Athanasios;
- Vitali, Claudio
Publication type:
Article
Use and perceived relevance of health-related Internet sites and online contact with peers among young people with juvenile idiopathic arthritis.
Published in:
Rheumatology, 2015, v. 54, n. 10, p. 1833, doi. 10.1093/rheumatology/kev193
By:
- van Pelt, Philomine A.;
- Drossaert, Constance H. C.;
- Kruize, Aike A.;
- Huisman, Jaap;
- Dolhain, Radboud J. E. M.;
- Wulffraat, Nico M.
Publication type:
Article
Psychological profiles in patients with Sjögren's syndrome related to fatigue: a cluster analysis.
Published in:
Rheumatology, 2015, v. 54, n. 5, p. 776, doi. 10.1093/rheumatology/keu387
By:
- van Leeuwen, Ninke;
- Bossema, Ercolie R.;
- Knoop, Hans;
- Kruize, Aike A.;
- Bootsma, Hendrika;
- Bijlsma, Johannes W. J.;
- Geenen, Rinie
Publication type:
Article
IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Rα.
Published in:
2012
By:
- Bikker, Angela;
- Moret, Fréderique M.;
- Kruize, Aike A.;
- Bijlsma, Johannes W. J.;
- Lafeber, Floris P. J. G.;
- van Roon, Joël A. G.
Publication type:
Journal Article
IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Rα.
Published in:
Rheumatology, 2012, v. 51, n. 6, p. 996, doi. 10.1093/rheumatology/ker448
By:
- Bikker, Angela;
- Moret, Fréderique M.;
- Kruize, Aike A.;
- Bijlsma, Johannes W. J.;
- Lafeber, Floris P. J. G.;
- van Roon, Joël A. G.
Publication type:
Article
Decreased expression of TSLP in labial salivary glands of patients with primary Sjögren's syndrome is associated with local- and systemic disease parameters.
Published in:
2012
By:
- Hillen, Maarten R.;
- Bikker, Angela;
- Kruize, Aike A.;
- Wenting-van Wijk, Marion;
- Lafeber, Floris P. J. G.;
- Hack, C. Erik;
- Radstake, Timothy R. D. J.;
- van Roon, Joel A. G.
Publication type:
Abstract
Increased CCL25 and T Helper Cells Expressing CCR9 in the Salivary Glands of Patients With Primary Sjögren's Syndrome: Potential New Axis in Lymphoid Neogenesis.
Published in:
Arthritis & Rheumatology, 2017, v. 69, n. 10, p. 2038, doi. 10.1002/art.40182
By:
- Blokland, Sofie L. M.;
- Hillen, Maarten R.;
- Kruize, Aike A.;
- Meller, Stephan;
- Homey, Bernhard;
- Smithson, Glennda M.;
- Radstake, Timothy R. D. J.;
- van Roon, Joel A. G.
Publication type:
Article
Aerobic capacity and disease activity in children, adolescents and young adults with juvenile idiopathic arthritis (JIA).
Published in:
Pediatric Rheumatology, 2012, v. 10, n. 1, p. 27, doi. 10.1186/1546-0096-10-27
By:
- van Pelt, Philomien A.;
- Takken, Tim;
- van Brussel, Marco;
- de Witte, Inge;
- Kruize, Aike A.;
- Wulffraat, Nico M.
Publication type:
Article
Aerobic capacity and disease activity in children, adolescents and young adults with juvenile idiopathic arthritis (JIA).
Published in:
Pediatric Rheumatology, 2012, v. 10, n. 1, p. 25, doi. 10.1186/1546-0096-10-25
By:
- van Pelt, Philomine A;
- Takken, Tim;
- van Brussel, Marco;
- de Witte, Mirjam;
- Kruize, Aike A;
- Wulffraat, Nico M
Publication type:
Article
Decreased circulating CXCR3 + CCR9+T helper cells are associated with elevated levels of their ligands CXCL10 and CCL25 in the salivary gland of patients with Sjögren's syndrome to facilitate their concerted migration.
Published in:
Scandinavian Journal of Immunology, 2020, v. 91, n. 3, p. 1, doi. 10.1111/sji.12852
By:
- Blokland, Sofie L. M.;
- Kislat, Andreas;
- Homey, Bernhard;
- Smithson, Glennda M.;
- Kruize, Aike A.;
- Radstake, Timothy R. D. J.;
- van Roon, Joel A. G.
Publication type:
Article
A dry mouth and oedematous ankle.
Published in:
Nephrology Dialysis Transplantation, 2006, v. 21, n. 2, p. 535, doi. 10.1093/ndt/gfi115
By:
- Petra Vos;
- Tri Nguyen;
- Roel Goldschmeding;
- Eefke Petersen;
- Aike Kruize;
- Ronald Hené
Publication type:
Article
Decreased expression of thymic stromal lymphopoietin in salivary glands of patients with primary Sjögren's syndrome is associated with increased disease activity.
Published in:
Modern Rheumatology, 2016, v. 26, n. 1, p. 105, doi. 10.3109/14397595.2015.1054089
By:
- Hillen, Maarten R.;
- Kruize, Aike A.;
- Bikker, Angela;
- Wijk, Marion Wenting-van;
- Radstake, Timothy R. D. J.;
- Hack, Cornelis E.;
- Lafeber, Floris P. J. G.;
- van Roon, Joel A. G.
Publication type:
Article
Therapeutic Recommendations for the Management of Older Adult Patients with Sjögren's Syndrome.
Published in:
Drugs & Aging, 2021, v. 38, n. 4, p. 265, doi. 10.1007/s40266-021-00838-6
By:
- Retamozo, Soledad;
- Baldini, Chiara;
- Bootsma, Hendrika;
- De Vita, Salvatore;
- Dörner, Thomas;
- Fisher, Benjamin A.;
- Gottenberg, Jacques-Eric;
- Hernández-Molina, Gabriela;
- Kocher, Agnes;
- Kostov, Belchin;
- Kruize, Aike A.;
- Mandl, Thomas;
- Ng, Wan-Fai;
- Seror, Raphaèle;
- Shoenfeld, Yehuda;
- Sisó-Almirall, Antoni;
- Tzioufas, Athanasios G.;
- Vissink, Arjan;
- Vitali, Claudio;
- Bowman, Simon J.
Publication type:
Article
CCR9/CXCR5 Co-Expressing CD4 T Cells Are Increased in Primary Sjögren's Syndrome and Are Enriched in PD-1/ICOS-Expressing Effector T Cells.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 15, p. 11952, doi. 10.3390/ijms241511952
By:
- Hinrichs, Anneline C.;
- Kruize, Aike A.;
- Lafeber, Floris P. J. G.;
- Leavis, Helen L.;
- van Roon, Joel A. G.
Publication type:
Article
Circulating small non-coding RNAs reflect IFN status and B cell hyperactivity in patients with primary Sjögren’s syndrome.
Published in:
PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0193157
By:
- Lopes, Ana P.;
- Hillen, Maarten R.;
- Chouri, Eleni;
- Blokland, Sofie L. M.;
- Bekker, Cornelis P. J.;
- Kruize, Aike A.;
- Rossato, Marzia;
- van Roon, Joel A. G.;
- Radstake, Timothy R. D. J.
Publication type:
Article

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