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Corallopyronin A for short-course anti-wolbachial, macrofilaricidal treatment of filarial infections.
Published in:
PLoS Neglected Tropical Diseases, 2020, v. 14, n. 12, p. 1, doi. 10.1371/journal.pntd.0008930
By:
- Schiefer, Andrea;
- Hübner, Marc P.;
- Krome, Anna;
- Lämmer, Christine;
- Ehrens, Alexandra;
- Aden, Tilman;
- Koschel, Marianne;
- Neufeld, Helene;
- Chaverra-Muñoz, Lillibeth;
- Jansen, Rolf;
- Kehraus, Stefan;
- König, Gabriele M.;
- Pogorevc, Domen;
- Müller, Rolf;
- Stadler, Marc;
- Hüttel, Stephan;
- Hesterkamp, Thomas;
- Wagner, Karl;
- Pfarr, Kenneth;
- Hoerauf, Achim
Publication type:
Article
A qPCR to quantify Wolbachia from few Onchocerca volvulus microfilariae as a surrogate for adult worm histology in clinical trials of antiwolbachial drugs.
Published in:
Parasitology Research, 2022, v. 121, n. 4, p. 1199, doi. 10.1007/s00436-021-07411-5
By:
- Schlabe, Stefan;
- Korir, Patricia;
- Lämmer, Christine;
- Landmann, Frederic;
- Dubben, Bettina;
- Koschel, Marianne;
- Albers, Anna;
- Debrah, Linda Batsa;
- Debrah, Alexander Yaw;
- Hübner, Marc P.;
- Pfarr, Kenneth;
- Klarmann-Schulz, Ute;
- Hoerauf, Achim
Publication type:
Article
Potential of Nucleic Acid Receptor Ligands to Improve Vaccination Efficacy against the Filarial Nematode Litomosoides sigmodontis.
Published in:
Vaccines, 2023, v. 11, n. 5, p. 966, doi. 10.3390/vaccines11050966
By:
- Scheunemann, Johanna F.;
- Risch, Frederic;
- Reichwald, Julia J.;
- Lenz, Benjamin;
- Neumann, Anna-Lena;
- Garbe, Stephan;
- Frohberger, Stefan J.;
- Koschel, Marianne;
- Ajendra, Jesuthas;
- Rothe, Maximilian;
- Latz, Eicke;
- Coch, Christoph;
- Hartmann, Gunther;
- Schumak, Beatrix;
- Hoerauf, Achim;
- Hübner, Marc P.
Publication type:
Article
Macrophages Mediate Increased CD8 T Cell Inflammation During Weight Loss in Formerly Obese Mice.
Published in:
Frontiers in Endocrinology, 2020, v. 11, p. 1, doi. 10.3389/fendo.2020.00257
By:
- Surendar, Jayagopi;
- Karunakaran, Indulekha;
- Frohberger, Stefan J.;
- Koschel, Marianne;
- Hoerauf, Achim;
- Hübner, Marc P.
Publication type:
Article
The efficacy of the benzimidazoles oxfendazole and flubendazole against Litomosoides sigmodontis is dependent on the adaptive and innate immune system.
Published in:
Frontiers in Microbiology, 2023, p. 1, doi. 10.3389/fmicb.2023.1213143
By:
- Risch, Frederic;
- Scheunemann, Johanna F.;
- Reichwald, Julia J.;
- Lenz, Benjamin;
- Ehrens, Alexandra;
- Gal, Joséphine;
- Fercoq, Frédéric;
- Koschel, Marianne;
- Fendler, Martina;
- Hoerauf, Achim;
- Martin, Coralie;
- Hübner, Marc P.
Publication type:
Article
Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
Published in:
PLoS Neglected Tropical Diseases, 2019, v. 13, n. 2, p. 1, doi. 10.1371/journal.pntd.0007159
By:
- von Geldern, Thomas W.;
- Morton, Howard E.;
- Clark, Rick F.;
- Brown, Brian S.;
- Johnston, Kelly L.;
- Ford, Louise;
- Specht, Sabine;
- Carr, Robert A.;
- Stolarik, Deanne F.;
- Ma, Junli;
- Rieser, Matthew J.;
- Struever, Dominique;
- Frohberger, Stefan J.;
- Koschel, Marianne;
- Ehrens, Alexandra;
- Turner, Joseph D.;
- Hübner, Marc P.;
- Hoerauf, Achim;
- Taylor, Mark J.;
- Ward, Stephen A.
Publication type:
Article
Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds.
Published in:
PLoS Neglected Tropical Diseases, 2019, v. 13, n. 1, p. 1, doi. 10.1371/journal.pntd.0006320
By:
- Hübner, Marc P.;
- Ehrens, Alexandra;
- Koschel, Marianne;
- Dubben, Bettina;
- Lenz, Franziska;
- Frohberger, Stefan J.;
- Specht, Sabine;
- Hoerauf, Achim;
- Quirynen, Ludo;
- Lachau-Durand, Sophie;
- Tekle, Fetene;
- Baeten, Benny;
- Engelen, Marc;
- Mackenzie, Charles D.
Publication type:
Article
Combinations of registered drugs reduce treatment times required to deplete Wolbachia in the Litomosoides sigmodontis mouse model.
Published in:
PLoS Neglected Tropical Diseases, 2018, v. 12, n. 1, p. 1, doi. 10.1371/journal.pntd.0006116
By:
- Specht, Sabine;
- Pfarr, Kenneth M.;
- Arriens, Sandra;
- Hübner, Marc P.;
- Klarmann-Schulz, Ute;
- Koschel, Marianne;
- Sternberg, Sonja;
- Martin, Coralie;
- Ford, Louise;
- Taylor, Mark J.;
- Hoerauf, Achim
Publication type:
Article
Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
Published in:
PLoS Neglected Tropical Diseases, 2020, v. 14, n. 7, p. 1, doi. 10.1371/journal.pntd.0008427
By:
- Hübner, Marc P.;
- Martin, Coralie;
- Specht, Sabine;
- Koschel, Marianne;
- Dubben, Bettina;
- Frohberger, Stefan J.;
- Ehrens, Alexandra;
- Fendler, Martina;
- Struever, Dominique;
- Mitre, Edward;
- Vallarino-Lhermitte, Nathaly;
- Gokool, Suzanne;
- Lustigman, Sara;
- Schneider, Manfred;
- Townson, Simon;
- Hoerauf, Achim;
- Scandale, Ivan
Publication type:
Article
In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.
Published in:
PLoS Neglected Tropical Diseases, 2020, v. 14, n. 1, p. 1, doi. 10.1371/journal.pntd.0007957
By:
- Ehrens, Alexandra;
- Lunde, Christopher S.;
- Jacobs, Robert T.;
- Struever, Dominique;
- Koschel, Marianne;
- Frohberger, Stefan J.;
- Lenz, Franziska;
- Fendler, Martina;
- Turner, Joseph D.;
- Ward, Stephen A.;
- Taylor, Mark J.;
- Freund, Yvonne R.;
- Stefanakis, Rianna;
- Easom, Eric;
- Li, Xianfeng;
- Plattner, Jacob J.;
- Hoerauf, Achim;
- Hübner, Marc P.
Publication type:
Article
In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.
Published in:
PLoS Neglected Tropical Diseases, 2019, v. 13, n. 8, p. 1, doi. 10.1371/journal.pntd.0007636
By:
- Hübner, Marc P.;
- Koschel, Marianne;
- Struever, Dominique;
- Nikolov, Venelin;
- Frohberger, Stefan J.;
- Ehrens, Alexandra;
- Fendler, Martina;
- Johannes, Iliana;
- von Geldern, Thomas W.;
- Marsh, Kennan;
- Turner, Joseph D.;
- Taylor, Mark J.;
- Ward, Stephen A.;
- Pfarr, Kenneth;
- Kempf, Dale J.;
- Hoerauf, Achim
Publication type:
Article
Eosinophils Are an Endogenous Source of Interleukin-4 during Filarial Infections and Contribute to the Development of an Optimal T Helper 2 Response.
Published in:
Journal of Innate Immunity, 2024, v. 16, n. 1, p. 159, doi. 10.1159/000536357
By:
- Guth, Cécile;
- Schumacher, Pia Philippa;
- Vijayakumar, Archena;
- Borgmann, Hannah;
- Balles, Helene;
- Koschel, Marianne;
- Risch, Frederic;
- Lenz, Benjamin;
- Hoerauf, Achim;
- Hübner, Marc P.;
- Ajendra, Jesuthas
Publication type:
Article

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