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A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity.
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- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40170-8
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- Article
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.
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- Cell Death & Disease, 2021, v. 12, n. 3, p. 1, doi. 10.1038/s41419-020-03269-0
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- Article
Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis.
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- Nature Communications, 2015, v. 6, n. 2, p. 6253, doi. 10.1038/ncomms7253
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- Article
Regulation of Janus kinases by SOCS proteins.
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- Biochemical Society Transactions, 2013, v. 41, n. 4, p. 1042, doi. 10.1042/BST20130077
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- Article
Proteomic analyses reveal that immune integrins are major targets for regulation by Membrane‐Associated Ring‐CH (MARCH) proteins MARCH2, 3, 4 and 9.
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- Proteomics, 2021, v. 21, n. 11/12, p. 1, doi. 10.1002/pmic.202000244
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- Article
The molecular details of cytokine signaling via the JAK/STAT pathway.
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- Protein Science: A Publication of the Protein Society, 2018, v. 27, n. 12, p. 1984, doi. 10.1002/pro.3519
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- Article
SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition.
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- Nature Structural & Molecular Biology, 2013, v. 20, n. 4, p. 469, doi. 10.1038/nsmb.2519
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- Article
Identification of a second binding site on the TRIM25 B30.2 domain.
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- Biochemical Journal, 2018, v. 475, n. 2, p. 429, doi. 10.1042/BCJ20170427
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- Article
Notch ligand delta-like1: X-ray crystal structure and binding affinity.
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- Biochemical Journal, 2015, v. 468, n. 1, p. 159, doi. 10.1042/BJ20150010
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- Article
Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling.
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- Biochemical Journal, 2013, v. 456, n. 2, p. 231, doi. 10.1042/BJ20121425
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- Article
The molecular basis of JAK/STAT inhibition by SOCS1.
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- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04013-1
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- Article
SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine.
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- Bioscience Reports, 2022, v. 42, n. 12, p. 1, doi. 10.1042/BSR20221683
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- Article
Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26394-6
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- Article
Independent Interactions of Phosphorylated β-Catenin with E-Cadherin at Cell-Cell Contacts and APC at Cell Protrusions.
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- PLoS ONE, 2010, v. 5, n. 11, p. 1, doi. 10.1371/journal.pone.0014127
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- Article
Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
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- Nature, 2014, v. 510, n. 7505, p. 422, doi. 10.1038/nature13263
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- Article
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
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- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26983-5
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- Article
Crystallographic and mass spectrometric analyses of a tandem GNAT protein from the clavulanic acid biosynthesis pathway.
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- Proteins, 2010, v. 78, n. 6, p. 1398, doi. 10.1002/prot.22653
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- Article
RIPLET, and not TRIM25, is required for endogenous RIG‐I‐dependent antiviral responses.
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- Immunology & Cell Biology, 2019, v. 97, n. 9, p. 840, doi. 10.1111/imcb.12284
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- Article
Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin.
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- Nature Communications, 2024, p. 1, doi. 10.1038/s41467-024-45356-2
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- Article
Diversity in the intrinsic apoptosis pathway of nematodes.
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- Communications Biology, 2020, v. 3, n. 1, p. N.PAG, doi. 10.1038/s42003-020-01208-5
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- Article
Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern.
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- Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-12711-7
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- Article
Enzymatic Characterization of Wild-Type and Mutant Janus Kinase 1.
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- Cancers, 2019, v. 11, n. 11, p. 1701, doi. 10.3390/cancers11111701
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Structure guided studies of the interaction between PTP1B and JAK.
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- Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05020-9
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- Article
Structure–function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum’s disease.
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- Human Molecular Genetics, 2001, v. 10, n. 18, p. 1971, doi. 10.1093/hmg/10.18.1971
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- Article
The Role of LNK (SH2B3) in the Regulation of JAK-STAT Signalling in Haematopoiesis.
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- Pharmaceuticals (14248247), 2022, v. 15, n. 1, p. 24, doi. 10.3390/ph15010024
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- Article