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The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca 2+ Homeostasis by Targeting a Unique Ion Channel.
Published in:
Pharmaceutics, 2022, v. 14, n. 7, p. N.PAG, doi. 10.3390/pharmaceutics14071371
By:
- Gupta, Yash;
- Sharma, Neha;
- Singh, Snigdha;
- Romero, Jesus G.;
- Rajendran, Vinoth;
- Mogire, Reagan M.;
- Kashif, Mohammad;
- Beach, Jordan;
- Jeske, Walter;
- Poonam;
- Ogutu, Bernhards R.;
- Kanzok, Stefan M.;
- Akala, Hoseah M.;
- Legac, Jennifer;
- Rosenthal, Philip J.;
- Rademacher, David J.;
- Durvasula, Ravi;
- Singh, Agam P.;
- Rathi, Brijesh;
- Kempaiah, Prakasha
Publication type:
Article
Comparative genomic and phenotypic characterization of invasive non-typhoidal Salmonella isolates from Siaya, Kenya.
Published in:
PLoS Neglected Tropical Diseases, 2021, v. 15, n. 2, p. 1, doi. 10.1371/journal.pntd.0008991
By:
- Kubicek-Sutherland, Jessica Z.;
- Xie, Gary;
- Shakya, Migun;
- Dighe, Priya K.;
- Jacobs, Lindsey L.;
- Daligault, Hajnalka;
- Davenport, Karen;
- Stromberg, Loreen R.;
- Stromberg, Zachary R.;
- Cheng, Qiuying;
- Kempaiah, Prakasha;
- Ong'echa, John Michael;
- Otieno, Vincent;
- Raballah, Evans;
- Anyona, Samuel;
- Ouma, Collins;
- Chain, Patrick S. G.;
- Perkins, Douglas J.;
- Mukundan, Harshini;
- McMahon, Benjamin H.
Publication type:
Article
Mycolactone: A Broad Spectrum Multitarget Antiviral Active in the Picomolar Range for COVID-19 Prevention and Cure.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 8, p. 7151, doi. 10.3390/ijms24087151
By:
- Asiedu, Seth Osei;
- Gupta, Yash;
- Nicolaescu, Vlad;
- Gula, Haley;
- Caulfield, Thomas R.;
- Durvasula, Ravi;
- Kempaiah, Prakasha;
- Kwofie, Samuel K.;
- Wilson, Michael D.
Publication type:
Article
Carborane-Containing Hydroxamate MMP Ligands for the Treatment of Tumors Using Boron Neutron Capture Therapy (BNCT): Efficacy without Tumor Cell Entry.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 8, p. 6973, doi. 10.3390/ijms24086973
By:
- Flieger, Sebastian;
- Takagaki, Mao;
- Kondo, Natsuko;
- Lutz Jr., Marlon R.;
- Gupta, Yash;
- Ueda, Hiroki;
- Sakurai, Yoshinori;
- Moran, Graham;
- Kempaiah, Prakasha;
- Hosmane, Narayan;
- Suzuki, Minoru;
- Becker, Daniel P.
Publication type:
Article
In Silico Binding of 2-Aminocyclobutanones to SARS-CoV-2 Nsp13 Helicase and Demonstration of Antiviral Activity.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 6, p. 5120, doi. 10.3390/ijms24065120
By:
- Mohammad, Thahani S. Habeeb;
- Gupta, Yash;
- Reidl, Cory T.;
- Nicolaescu, Vlad;
- Gula, Haley;
- Durvasula, Ravi;
- Kempaiah, Prakasha;
- Becker, Daniel P.
Publication type:
Article
Multi-Cellular Immunological Interactions Associated With COVID-19 Infections.
Published in:
Frontiers in Immunology, 2022, v. 13, p. 1, doi. 10.3389/fimmu.2022.794006
By:
- Verma, Jitender S.;
- Libertin, Claudia R.;
- Gupta, Yash;
- Khanna, Geetika;
- Kumar, Rohit;
- Arora, Balvinder S.;
- Krishna, Loveneesh;
- Fasina, Folorunso O.;
- Hittner, James B.;
- Antoniades, Athos;
- van Regenmortel, Marc H. V.;
- Durvasula, Ravi;
- Kempaiah, Prakasha;
- Rivas, Ariel L.
Publication type:
Article
Reduced Parasite Burden in Children with Falciparum Malaria and Bacteremia Coinfections: Role of Mediators of Inflammation.
Published in:
Mediators of Inflammation, 2016, p. 1, doi. 10.1155/2016/4286576
By:
- Davenport, Gregory C.;
- Hittner, James B.;
- Otieno, Vincent;
- Karim, Zachary;
- Mukundan, Harshini;
- Fenimore, Paul W.;
- Hengartner, Nicolas W.;
- McMahon, Benjamin H.;
- Kempaiah, Prakasha;
- Ong’echa, John M.;
- Perkins, Douglas J.
Publication type:
Article
Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model.
Published in:
Scientific Reports, 2017, v. 7, n. 1, p. 1, doi. 10.1038/s41598-017-06097-z
By:
- Kumar, Prashant;
- Achieng, Angela O.;
- Rajendran, Vinoth;
- Ghosh, Prahlad C.;
- Singh, Brajendra K.;
- Rawat, Manmeet;
- Perkins, Douglas J.;
- Kempaiah, Prakasha;
- Rathi, Brijesh
Publication type:
Article
Mycobacterium abscessus Glycopeptidolipid Prevents Respiratory Epithelial TLR2 Signaling as Measured by HβD2 Gene Expression and IL-8 Release.
Published in:
PLoS ONE, 2011, v. 6, n. 12, p. 1, doi. 10.1371/journal.pone.0029148
By:
- Davidson, Lisa B.;
- Nessar, Rachid;
- Kempaiah, Prakasha;
- Perkins, Douglas J.;
- Byrd, Thomas F.
Publication type:
Article
Reduced interferon (IFN)-α conditioned by IFNA2 (−173) and IFNA8 (−884) haplotypes is associated with enhanced susceptibility to severe malarial anemia and longitudinal all-cause mortality.
Published in:
Human Genetics, 2012, v. 131, n. 8, p. 1375, doi. 10.1007/s00439-012-1175-1
By:
- Kempaiah, Prakasha;
- Anyona, Samuel;
- Raballah, Evans;
- Davenport, Gregory;
- Were, Tom;
- Hittner, James;
- Ong'echa, John;
- Perkins, Douglas
Publication type:
Article
Functional haplotypes of Fc gamma (Fcγ) receptor (FcγRIIA and FcγRIIIB) predict risk to repeated episodes of severe malarial anemia and mortality in Kenyan children.
Published in:
Human Genetics, 2012, v. 131, n. 2, p. 289, doi. 10.1007/s00439-011-1076-8
By:
- Ouma, Collins;
- Davenport, Gregory;
- Garcia, Steven;
- Kempaiah, Prakasha;
- Chaudhary, Ateefa;
- Were, Tom;
- Anyona, Samuel;
- Raballah, Evans;
- Konah, Stephen;
- Hittner, James;
- Vulule, John;
- Ong'echa, John;
- Perkins, Douglas
Publication type:
Article
Genetic variation in interleukin-7 is associated with a reduced erythropoietic response in Kenyan children infected with Plasmodium falciparum.
Published in:
BMC Medical Genetics, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s12881-019-0866-z
By:
- Kisia, Lily E.;
- Kempaiah, Prakasha;
- Anyona, Samuel B.;
- Munde, Elly O.;
- Achieng, Angela O.;
- Ong'echa, John M.;
- Lambert, Christophe G.;
- Chelimo, Kiprotich;
- Ouma, Collins;
- Perkins, Douglas J.;
- Raballah, Evans
Publication type:
Article
Structure-Based Identification of Natural-Product-Derived Compounds with Potential to Inhibit HIV-1 Entry.
Published in:
Molecules, 2023, v. 28, n. 2, p. 474, doi. 10.3390/molecules28020474
By:
- Ugwu-Korie, Nneka;
- Quaye, Osbourne;
- Wright, Edward;
- Languon, Sylvester;
- Agyapong, Odame;
- Broni, Emmanuel;
- Gupta, Yash;
- Kempaiah, Prakasha;
- Kwofie, Samuel K.
Publication type:
Article
Iron dysregulation in COVID‐19 and reciprocal evolution of SARS‐CoV‐2: Natura nihil frustra facit.
Published in:
Journal of Cellular Biochemistry, 2022, v. 123, n. 3, p. 601, doi. 10.1002/jcb.30207
By:
- Gupta, Yash;
- Maciorowski, Dawid;
- Medernach, Brian;
- Becker, Daniel P.;
- Durvasula, Ravi;
- Libertin, Claudia R.;
- Kempaiah, Prakasha
Publication type:
Article
The emerging paradigm of calcium homeostasis as a new therapeutic target for protozoan parasites.
Published in:
Medicinal Research Reviews, 2022, v. 42, n. 1, p. 56, doi. 10.1002/med.21804
By:
- Gupta, Yash;
- Goicoechea, Steven;
- Pearce, Catherine M.;
- Mathur, Raman;
- Romero, Jesus G.;
- Kwofie, Samuel K.;
- Weyenberg, Matthew C.;
- Daravath, Bharathi;
- Sharma, Neha;
- Poonam;
- Akala, Hoseah M.;
- Kanzok, Stefan M.;
- Durvasula, Ravi;
- Rathi, Brijesh;
- Kempaiah, Prakasha
Publication type:
Article
Review of Atypical Organometallic Compounds as Antimalarial Drugs.
Published in:
Journal of Chemistry, 2020, p. 1, doi. 10.1155/2020/9414093
By:
- Kwofie, Samuel K.;
- Broni, Emmanuel;
- Dankwa, Bismark;
- Enninful, Kweku S.;
- Teye, Joshua;
- Davidson, Cedar R.;
- Nimely, Josephine B.;
- Chioma Orizu, J.;
- Kempaiah, Prakasha;
- Rathi, Brijesh;
- Miller III, Whelton A.
Publication type:
Article
Repurposing Lansoprazole and Posaconazole to treat leishmaniasis: Integration of in vitro testing, pharmacological corroboration, and mechanisms of action.
Published in:
Journal of Food & Drug Analysis, 2022, v. 30, n. 1, p. 128, doi. 10.38212/2224-6614.3394
By:
- Gupta, Yash;
- Goicoechea, Steven;
- Romero, Jesus G.;
- Mathur, Raman;
- Caulfield, Thomas R.;
- Becker, Daniel P.;
- Durvasula, Ravi;
- Kempaiah, Prakasha
Publication type:
Article
Author Correction: Synergistic blending of high-valued heterocycles inhibits growth of Plasmodium falciparum in culture and P. berghei infection in mouse model.
Published in:
2020
By:
- Kumar, Prashant;
- Achieng, Angela O.;
- Rajendran, Vinoth;
- Ghosh, Prahlad C.;
- Singh, Brajendra K.;
- Rawat, Manmeet;
- Perkins, Douglas J.;
- Kempaiah, Prakasha;
- Rathi, Brijesh
Publication type:
Correction Notice
Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of hemozoin in Suppressing Hsp70 and NF-κB Activation.
Published in:
Molecular Medicine, 2016, v. 22, n. 1, p. 570, doi. 10.2119/molmed.2016.00130
By:
- Kempaiah, Prakasha;
- Dokladny, Karol;
- Karim, Zachary;
- Raballah, Evans;
- Ong'echa, John M;
- Moseley, Pope L;
- Perkins, Douglas J
Publication type:
Article
Reduced Hsp70 and Glutamine in Pediatric Severe Malaria Anemia: Role of Hemozoin in Suppressing Hsp70 and NF-κB Activation.
Published in:
Molecular Medicine, 2016, v. 22, p. 570, doi. 10.2119/molmed.2016.00130
By:
- Kempaiah, Prakasha;
- Dokladny, Karol;
- Karim, Zachary;
- Raballah, Evans;
- Ong'echa, John M.;
- Moseley, Pope L.;
- Perkins, Douglas J.
Publication type:
Article
Reduced systemic bicyclo-prostaglandin-E<sub>2</sub> and cyclooxygenase-2 gene expression are associated with inefficient erythropoiesis and enhanced uptake of monocytic hemozoin in children with severe malarial anemia.
Published in:
American Journal of Hematology, 2012, v. 87, n. 8, p. 782, doi. 10.1002/ajh.23253
By:
- Anyona, Samuel B.;
- Kempaiah, Prakasha;
- Raballah, Evans;
- Davenport, Gregory C.;
- Were, Tom;
- Konah, Stephen N.;
- Vulule, John M.;
- Hittner, James B.;
- Gichuki, Charity W.;
- Ong'echa, John M.;
- Perkins, Douglas J.
Publication type:
Article
Mechanisms of erythropoiesis inhibition by malarial pigment and malaria-induced proinflammatory mediators in an in vitro model.
Published in:
American Journal of Hematology, 2011, v. 86, n. 2, p. 155, doi. 10.1002/ajh.21933
By:
- Awandare, Gordon A.;
- Kempaiah, Prakasha;
- Ochiel, Daniel O.;
- Piazza, Paolo;
- Keller, Christopher C.;
- Perkins, Douglas J.
Publication type:
Article
Decoding Immuno-Competence: A Novel Analysis of Complete Blood Cell Count Data in COVID-19 Outcomes.
Published in:
Biomedicines, 2024, v. 12, n. 4, p. 871, doi. 10.3390/biomedicines12040871
By:
- Kempaiah, Prakasha;
- Libertin, Claudia R.;
- Chitale, Rohit A.;
- Naeyma, Islam;
- Pleqi, Vasili;
- Sheele, Johnathan M.;
- Iandiorio, Michelle J.;
- Hoogesteijn, Almira L.;
- Caulfield, Thomas R.;
- Rivas, Ariel L.
Publication type:
Article
Human tissue factor pathway inhibitor-2 induces caspase-mediated apoptosis in a human fibrosarcoma cell line.
Published in:
Apoptosis, 2008, v. 13, n. 5, p. 702, doi. 10.1007/s10495-008-0207-8
By:
- Kempaiah, Prakasha;
- Kisiel, Walter
Publication type:
Article
Genetic variation in CSF2 (5q31.1) is associated with longitudinal susceptibility to pediatric malaria, severe malarial anemia, and all-cause mortality in a high-burden malaria and HIV region of Kenya.
Published in:
Tropical Medicine & Health, 2022, v. 50, n. 1, p. 1, doi. 10.1186/s41182-022-00432-5
By:
- Kisia, Lily E.;
- Cheng, Qiuying;
- Raballah, Evans;
- Munde, Elly O.;
- McMahon, Benjamin H.;
- Hengartner, Nick W.;
- Ong'echa, John M.;
- Chelimo, Kiprotich;
- Lambert, Christophe G.;
- Ouma, Collins;
- Kempaiah, Prakasha;
- Perkins, Douglas J.;
- Schneider, Kristan A.;
- Anyona, Samuel B.
Publication type:
Article
CD4 T-cell expression of IFN-γ and IL-17 in pediatric malarial anemia.
Published in:
PLoS ONE, 2017, v. 12, n. 4, p. 1, doi. 10.1371/journal.pone.0175864
By:
- Raballah, Evans;
- Kempaiah, Prakasha;
- Karim, Zachary;
- Orinda, George O.;
- Otieno, Michael F.;
- Perkins, Douglas J.;
- Ong’echa, John Michael
Publication type:
Article

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