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Deep learning from multiple experts improves identification of amyloid neuropathologies.
Published in:
Acta Neuropathologica Communications, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40478-022-01365-0
By:
- Wong, Daniel R.;
- Tang, Ziqi;
- Mew, Nicholas C.;
- Das, Sakshi;
- Athey, Justin;
- McAleese, Kirsty E.;
- Kofler, Julia K.;
- Flanagan, Margaret E.;
- Borys, Ewa;
- White III, Charles L.;
- Butte, Atul J.;
- Dugger, Brittany N.;
- Keiser, Michael J.
Publication type:
Article
Validation of machine learning models to detect amyloid pathologies across institutions.
Published in:
Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40478-020-00927-4
By:
- Vizcarra, Juan C.;
- Gearing, Marla;
- Keiser, Michael J.;
- Glass, Jonathan D.;
- Dugger, Brittany N.;
- Gutman, David A.
Publication type:
Article
Relating protein pharmacology by ligand chemistry.
Published in:
Nature Biotechnology, 2007, v. 25, n. 2, p. 197, doi. 10.1038/nbt1284
By:
- Keiser, Michael J.;
- Roth, Bryan L.;
- Armbruster, Blaine N.;
- Ernsberger, Paul;
- Irwin, John J.;
- Shoichet, Brian K.
Publication type:
Article
A Pilot Study of the Pharmacodynamic Impact of SSRI Drug Selection and Beta-1 Receptor Genotype (ADRB1) on Cardiac Vital Signs in Depressed Patients: A Novel Pharmacogenetic Approach.
Published in:
Psychopharmacology Bulletin, 2010, v. 43, n. 1, p. 1
By:
- Thomas, Kelan L. H.;
- Ellingrod, Vicki L.;
- Bishop, Jeffrey R.;
- Keiser, Michael J.
Publication type:
Article
Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-11936-w
By:
- McCarroll, Matthew N.;
- Gendelev, Leo;
- Kinser, Reid;
- Taylor, Jack;
- Bruni, Giancarlo;
- Myers-Turnbull, Douglas;
- Helsell, Cole;
- Carbajal, Amanda;
- Rinaldi, Capria;
- Kang, Hye Jin;
- Gong, Jung Ho;
- Sello, Jason K.;
- Tomita, Susumu;
- Peterson, Randall T.;
- Keiser, Michael J.;
- Kokel, David
Publication type:
Article
Interpretable classification of Alzheimer's disease pathologies with a convolutional neural network pipeline.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-10212-1
By:
- Tang, Ziqi;
- Chuang, Kangway V.;
- DeCarli, Charles;
- Jin, Lee-Way;
- Beckett, Laurel;
- Keiser, Michael J.;
- Dugger, Brittany N.
Publication type:
Article
Predicting new molecular targets for known drugs.
Published in:
Nature, 2009, v. 462, n. 7270, p. 175, doi. 10.1038/nature08506
By:
- Keiser, Michael J.;
- Setola, Vincent;
- Irwin, John J.;
- Laggner, Christian;
- Abbas, Atheir I.;
- Hufeisen, Sandra J.;
- Jensen, Niels H.;
- Kuijer, Michael B.;
- Matos, Roberto C.;
- Tran, Thuy B.;
- Whaley, Ryan;
- Glennon, Richard A.;
- Hert, J&;#x00E9;rôme;
- Thomas, Kelan L. H.;
- Edwards, Douglas D.;
- Shoichet, Brian K.;
- Roth, Bryan L.
Publication type:
Article
The Presynaptic Component of the Serotonergic System is Required for Clozapine's Efficacy.
Published in:
Neuropsychopharmacology, 2011, v. 36, n. 3, p. 638, doi. 10.1038/npp.2010.195
By:
- Yadav, Prem N.;
- Abbas, Atheir I.;
- Farrell, Martilias S.;
- Setola, Vincent;
- Sciaky, Noah;
- Huang, Xi-Ping;
- Kroeze, Wesley K.;
- Crawford, LaTasha K.;
- Piel, David A.;
- Keiser, Michael J.;
- Irwin, John J.;
- Shoichet, Brian K.;
- Deneris, Evan S.;
- Gingrich, Jay;
- Beck, Sheryl G.;
- Roth, Bryan L.
Publication type:
Article
A Mapping of Drug Space from the Viewpoint of Small Molecule Metabolism.
Published in:
PLoS Computational Biology, 2009, v. 5, n. 8, p. 1, doi. 10.1371/journal.pcbi.1000474
By:
- Adams, James Corey;
- Keiser, Michael J.;
- Basuino, Li;
- Chambers, Henry F.;
- Lee, Deok-Sun;
- Wiest, Olaf G.;
- Babbitt, Patricia C.
Publication type:
Article
Stress testing reveals gaps in clinic readiness of image-based diagnostic artificial intelligence models.
Published in:
NPJ Digital Medicine, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s41746-020-00380-6
By:
- Young, Albert T.;
- Fernandez, Kristen;
- Pfau, Jacob;
- Reddy, Rasika;
- Cao, Nhat Anh;
- von Franque, Max Y.;
- Johal, Arjun;
- Wu, Benjamin V.;
- Wu, Rachel R.;
- Chen, Jennifer Y.;
- Fadadu, Raj P.;
- Vasquez, Juan A.;
- Tam, Andrew;
- Keiser, Michael J.;
- Wei, Maria L.
Publication type:
Article
<i>In Silico</i> Molecular Comparisons of <i>C. elegans</i> and Mammalian Pharmacology Identify Distinct Targets That Regulate Feeding.
Published in:
PLoS Biology, 2013, v. 11, n. 11, p. 1, doi. 10.1371/journal.pbio.1001712
By:
- Lemieux, George A.;
- Keiser, Michael J.;
- Sassano, Maria F.;
- Laggner, Christian;
- Mayer, Fahima;
- Bainton, Roland J.;
- Werb, Zena;
- Roth, Bryan L.;
- Shoichet, Brian K.;
- Ashrafi, Kaveh
Publication type:
Article
Large-scale prediction and testing of drug activity on side-effect targets.
Published in:
Nature, 2012, v. 486, n. 7403, p. 361, doi. 10.1038/nature11159
By:
- Lounkine, Eugen;
- Keiser, Michael J.;
- Whitebread, Steven;
- Mikhailov, Dmitri;
- Hamon, Jacques;
- Jenkins, Jeremy L.;
- Lavan, Paul;
- Weber, Eckhard;
- Doak, Allison K.;
- Côté, Serge;
- Shoichet, Brian K.;
- Urban, Laszlo
Publication type:
Article
Learning fast and fine-grained detection of amyloid neuropathologies from coarse-grained expert labels.
Published in:
Communications Biology, 2023, v. 6, n. 1, p. 1, doi. 10.1038/s42003-023-05031-6
By:
- Wong, Daniel R.;
- Magaki, Shino D.;
- Vinters, Harry V.;
- Yong, William H.;
- Monuki, Edwin S.;
- Williams, Christopher K.;
- Martini, Alessandra C.;
- DeCarli, Charles;
- Khacherian, Chris;
- Graff, John P.;
- Dugger, Brittany N.;
- Keiser, Michael J.
Publication type:
Article
Chemical informatics and target identification in a zebrafish phenotypic screen.
Published in:
Nature Chemical Biology, 2012, v. 8, n. 2, p. 144, doi. 10.1038/nchembio.732
By:
- Laggner, Christian;
- Kokel, David;
- Setola, Vincent;
- Tolia, Alexandra;
- Lin, Henry;
- Irwin, John J;
- Keiser, Michael J;
- Cheung, Chung Yan J;
- Minor, Daniel L;
- Roth, Bryan L;
- Peterson, Randall T;
- Shoichet, Brian K
Publication type:
Article
Quantifying biogenic bias in screening libraries.
Published in:
Nature Chemical Biology, 2009, v. 5, n. 7, p. 479, doi. 10.1038/nchembio.180
By:
- Hert, Jérôme;
- Irwin, John J.;
- Laggner, Christian;
- Keiser, Michael J.;
- Shoichet, Brian K.
Publication type:
Article

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