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Bcl-2/Bcl-xL inhibition predominantly synergistically enhances the anti-neoplastic activity of a low-dose CUSP9 repurposed drug regime against glioblastoma.
- Published in:
- 2019
- By:
- Publication type:
- journal article
In Vitro and Clinical Compassionate Use Experiences with the Drug-Repurposing Approach CUSP9v3 in Glioblastoma.
- Published in:
- Pharmaceuticals (14248247), 2021, v. 14, n. 12, p. 1241, doi. 10.3390/ph14121241
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- Publication type:
- Article
Heat Shock Protein Inhibitor 17-Allyamino-17-Demethoxygeldanamycin, a Potent Inductor of Apoptosis in Human Glioma Tumor Cell Lines, Is a Weak Substrate for ABCB1 and ABCG2 Transporters.
- Published in:
- Pharmaceuticals (14248247), 2021, v. 14, n. 2, p. 107, doi. 10.3390/ph14020107
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- Publication type:
- Article
Reuse of Molecules for Glioblastoma Therapy.
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- Pharmaceuticals (14248247), 2021, v. 14, n. 2, p. 99, doi. 10.3390/ph14020099
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- Publication type:
- Article
Activation of LXRβ inhibits tumor respiration and is synthetically lethal with Bcl‐xL inhibition.
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- EMBO Molecular Medicine, 2019, v. 11, n. 10, p. N.PAG, doi. 10.15252/emmm.201910769
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- Publication type:
- Article
Killing Me Softly--Future Challenges in Apoptosis Research.
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- International Journal of Molecular Sciences, 2014, v. 15, n. 3, p. 3746, doi. 10.3390/ijms15033746
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- Publication type:
- Article
Compare and contrast: pediatric cancer versus adult malignancies.
- Published in:
- Cancer & Metastasis Reviews, 2019, v. 38, n. 4, p. 673, doi. 10.1007/s10555-019-09836-y
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- Publication type:
- Article
Aurora kinase A inhibition reverses the Warburg effect and elicits unique metabolic vulnerabilities in glioblastoma.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25501-x
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- Publication type:
- Article
The Benefit of Intraoperative Magnetic Resonance Imaging in Endoscopic and Microscopic Transsphenoidal Resection of Recurrent Pituitary Adenomas.
- Published in:
- Current Oncology, 2022, v. 29, n. 1, p. 392, doi. 10.3390/curroncol29010035
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- Publication type:
- Article
Block of Voltage-Gated Sodium Channels as a Potential Novel Anti-cancer Mechanism of TIC10.
- Published in:
- Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.737637
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- Publication type:
- Article
PARP Inhibition Restores Extrinsic Apoptotic Sensitivity in Glioblastoma.
- Published in:
- PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0114583
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- Publication type:
- Article
Ten years' experience with intraoperative MRI-assisted transsphenoidal pituitary surgery.
- Published in:
- Neurosurgical Focus, 2020, v. 48, n. 6, p. 1, doi. 10.3171/2020.3.FOCUS2072
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- Publication type:
- Article
A New Treatment Opportunity for DIPG and Diffuse Midline Gliomas: 5-ALA Augmented Irradiation, the 5aai Regimen.
- Published in:
- Brain Sciences (2076-3425), 2020, v. 10, n. 1, p. 51, doi. 10.3390/brainsci10010051
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- Publication type:
- Article
Augmentation of 5-Aminolevulinic Acid Treatment of Glioblastoma by Adding Ciprofloxacin, Deferiprone, 5-Fluorouracil and Febuxostat: The CAALA Regimen.
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- Brain Sciences (2076-3425), 2018, v. 8, n. 12, p. 203, doi. 10.3390/brainsci8120203
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- Publication type:
- Article
Novel IDH1-Targeted Glioma Therapies.
- Published in:
- 2019
- By:
- Publication type:
- journal article
MDACT: A New Principle of Adjunctive Cancer Treatment Using Combinations of Multiple Repurposed Drugs, with an Example Regimen.
- Published in:
- Cancers, 2022, v. 14, n. 10, p. 2563, doi. 10.3390/cancers14102563
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- Publication type:
- Article
Photodynamic Therapy Combined with Bcl-2/Bcl-xL Inhibition Increases the Noxa/Mcl-1 Ratio Independent of Usp9X and Synergistically Enhances Apoptosis in Glioblastoma.
- Published in:
- Cancers, 2021, v. 13, n. 16, p. 4123, doi. 10.3390/cancers13164123
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- Publication type:
- Article
Epigenetic Targeting of Mcl-1 Is Synthetically Lethal with Bcl-xL/Bcl-2 Inhibition in Model Systems of Glioblastoma.
- Published in:
- Cancers, 2020, v. 12, n. 8, p. 2137, doi. 10.3390/cancers12082137
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- Publication type:
- Article
Activation of LXR Receptors and Inhibition of TRAP1 Causes Synthetic Lethality in Solid Tumors.
- Published in:
- Cancers, 2019, v. 11, n. 6, p. 788, doi. 10.3390/cancers11060788
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- Publication type:
- Article
Epidermal to Mesenchymal Transition and Failure of EGFR-Targeted Therapy in Glioblastoma.
- Published in:
- Cancers, 2012, v. 4, n. 2, p. 523, doi. 10.3390/cancers4020523
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- Publication type:
- Article
The limitations of targeting MEK signalling in Glioblastoma therapy.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-64289-6
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- Publication type:
- Article
CBMT-37. FDA-APPROVED HDAC INHIBITORS ANTAGONIZE THE WARBURG EFFECT AND CAUSE UNIQUE METABOLIC VULNERABILITIES.
- Published in:
- Neuro-Oncology, 2018, v. 20, p. vi40, doi. 10.1093/neuonc/noy148.156
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- Publication type:
- Article
EXTH-55. CONCOMITANT INHIBITION OF RAC1 AND Bcl-2/Bcl-xL INTERFERES WITH THE Mcl-1/Usp9X AXIS AND YIELDS SYNERGISTIC ANTI-GLIOMA ACTIVITY.
- Published in:
- Neuro-Oncology, 2018, v. 20, p. vi96, doi. 10.1093/neuonc/noy148.403
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- Publication type:
- Article
EXTH-54. Bcl-2/Bcl-xL INHIBITION SYNERGISTICALLY ENHANCES THE ANTI-NEOPLASTIC ACTIVITY OF CUSP9 AGAINST GLIOBLASTOMA CELLS IN VITRO.
- Published in:
- Neuro-Oncology, 2018, v. 20, p. vi96, doi. 10.1093/neuonc/noy148.402
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- Publication type:
- Article
EXTH-45. THE REPURPOSED CUSP9 REGIMEN EXERTS POTENT ANTI-NEOPLASTIC ACTIVITY AGAINST GLIOBLASTOMA CELLS IN VITRO.
- Published in:
- Neuro-Oncology, 2018, v. 20, p. vi94, doi. 10.1093/neuonc/noy148.393
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- Publication type:
- Article
The ABC7 regimen: a new approach to metastatic breast cancer using seven common drugs to inhibit epithelial-to-mesenchymal transition and augment capecitabine efficacy.
- Published in:
- Breast Cancer: Targets & Therapy, 2017, v. 9, p. 495, doi. 10.2147/BCTT.S139963
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- Publication type:
- Article
HDAC inhibitors elicit metabolic reprogramming by targeting super-enhancers in glioblastoma models.
- Published in:
- 2020
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- Publication type:
- journal article
Anti-glioma Activity of Dapsone and Its Enhancement by Synthetic Chemical Modification.
- Published in:
- Neurochemical Research, 2017, v. 42, n. 12, p. 3382, doi. 10.1007/s11064-017-2378-6
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- Publication type:
- Article
Dual metabolic reprogramming by ONC201/TIC10 and 2-Deoxyglucose induces energy depletion and synergistic anti-cancer activity in glioblastoma.
- Published in:
- 2020
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- Publication type:
- journal article
Inhibition of PI3K signalling increases the efficiency of radiotherapy in glioblastoma cells.
- Published in:
- International Journal of Oncology, 2018, v. 53, n. 5, p. 1881, doi. 10.3892/ijo.2018.4528
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- Publication type:
- Article
A paired comparison between glioblastoma 'stem cells' and differentiated cells.
- Published in:
- International Journal of Cancer, 2016, v. 138, n. 7, p. 1709, doi. 10.1002/ijc.29908
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- Publication type:
- Article
RIST: A potent new combination therapy for glioblastoma.
- Published in:
- International Journal of Cancer, 2015, v. 136, n. 4, p. E173, doi. 10.1002/ijc.29138
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- Publication type:
- Article
Cell death-based treatment of childhood cancer.
- Published in:
- Cell Death & Disease, 2018, v. 9, n. 2, p. 1, doi. 10.1038/s41419-017-0062-z
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- Publication type:
- Article
Tumor Treating Fields (TTFields) combined with the drug repurposing approach CUSP9v3 induce metabolic reprogramming and synergistic anti-glioblastoma activity in vitro.
- Published in:
- British Journal of Cancer, 2024, v. 130, n. 8, p. 1365, doi. 10.1038/s41416-024-02608-8
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- Publication type:
- Article
Considering the Experimental Use of Temozolomide in Glioblastoma Research.
- Published in:
- Biomedicines, 2020, v. 8, n. 6, p. 151, doi. 10.3390/biomedicines8060151
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- Publication type:
- Article
Comment in Response to "Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy etc. by B. Kaina".
- Published in:
- Biomedicines, 2020, v. 8, n. 4, p. 93, doi. 10.3390/biomedicines8040093
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- Publication type:
- Article
Temozolomide and Other Alkylating Agents in Glioblastoma Therapy.
- Published in:
- Biomedicines, 2019, v. 7, n. 3, p. 69, doi. 10.3390/biomedicines7030069
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- Publication type:
- Article
Suppressing PD-L1 Expression via AURKA Kinase Inhibition Enhances Natural Killer Cell-Mediated Cytotoxicity against Glioblastoma.
- Published in:
- Cells (2073-4409), 2024, v. 13, n. 13, p. 1155, doi. 10.3390/cells13131155
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- Publication type:
- Article
Therapeutic Drug-Induced Metabolic Reprogramming in Glioblastoma.
- Published in:
- Cells (2073-4409), 2022, v. 11, n. 19, p. 2956, doi. 10.3390/cells11192956
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- Publication type:
- Article
Inhibition of HDAC1/2 Along with TRAP1 Causes Synthetic Lethality in Glioblastoma Model Systems.
- Published in:
- Cells (2073-4409), 2020, v. 9, n. 7, p. 1661, doi. 10.3390/cells9071661
- By:
- Publication type:
- Article
Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL.
- Published in:
- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00984-9
- By:
- Publication type:
- Article
Combined inhibition of RAC1 and Bcl-2/Bcl-xL synergistically induces glioblastoma cell death through down-regulation of the Usp9X/Mcl-1 axis.
- Published in:
- Cellular Oncology (2211-3428), 2019, v. 42, n. 3, p. 287, doi. 10.1007/s13402-019-00425-3
- By:
- Publication type:
- Article
Characterization of tumor remnants in intraoperative MRI-assisted microscopic and endoscopic transsphenoidal resection of less invasive pituitary adenomas.
- Published in:
- Neurosurgical Review, 2022, v. 45, n. 2, p. 1701, doi. 10.1007/s10143-021-01705-z
- By:
- Publication type:
- Article
Olanzapine inhibits proliferation, migration and anchorage-independent growth in human glioblastoma cell lines and enhances temozolomide's antiproliferative effect.
- Published in:
- Journal of Neuro-Oncology, 2015, v. 122, n. 1, p. 21, doi. 10.1007/s11060-014-1688-7
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- Publication type:
- Article
Ribozyme-Mediated Inhibition of 801-bp Deletion-Mutant Epidermal Growth Factor Receptor mRNA Expression in Glioblastoma Multiforme.
- Published in:
- Molecules, 2010, v. 15, n. 7, p. 4670, doi. 10.3390/molecules15074670
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- Publication type:
- Article
Dual Inhibition of Bcl-2/Bcl-xL and XPO1 is synthetically lethal in glioblastoma model systems.
- Published in:
- Scientific Reports, 2018, v. 8, n. 1, p. 1, doi. 10.1038/s41598-018-33784-2
- By:
- Publication type:
- Article
What Animal Cancers teach us about Human Biology.
- Published in:
- Theranostics, 2021, v. 11, n. 14, p. 6682, doi. 10.7150/thno.56623
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- Publication type:
- Article
Toward a noncytotoxic glioblastoma therapy: blocking MCP-1 with the MTZ Regimen.
- Published in:
- OncoTargets & Therapy, 2016, v. 9, p. 2535, doi. 10.2147/ott.s100407
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- Publication type:
- Article
The effects of PI3K-mediated signalling on glioblastoma cell behaviour.
- Published in:
- Oncogenesis, 2017, v. 6, n. 11, p. 1, doi. 10.1038/s41389-017-0004-8
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- Publication type:
- Article