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CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline.
Published in:
EMBO Molecular Medicine, 2018, v. 10, n. 12, p. N.PAG, doi. 10.15252/emmm.201809712
By:
- Suárez‐Calvet, Marc;
- Capell, Anja;
- Araque Caballero, Miguel Ángel;
- Morenas‐Rodríguez, Estrella;
- Fellerer, Katrin;
- Franzmeier, Nicolai;
- Kleinberger, Gernot;
- Eren, Erden;
- Deming, Yuetiva;
- Piccio, Laura;
- Karch, Celeste M;
- Cruchaga, Carlos;
- Paumier, Katrina;
- Bateman, Randall J;
- Fagan, Anne M;
- Morris, John C;
- Levin, Johannes;
- Danek, Adrian;
- Jucker, Mathias;
- Masters, Colin L
Publication type:
Article
Brain network decoupling with increased serum neurofilament and reduced cognitive function in Alzheimer's disease.
Published in:
Brain: A Journal of Neurology, 2023, v. 146, n. 7, p. 2928, doi. 10.1093/brain/awac498
By:
- Wheelock, Muriah D;
- Strain, Jeremy F;
- Mansfield, Patricia;
- Tu, Jiaxin Cindy;
- Tanenbaum, Aaron;
- Preische, Oliver;
- Chhatwal, Jasmeer P;
- Cash, David M;
- Cruchaga, Carlos;
- Fagan, Anne M;
- Fox, Nick C;
- Graff-Radford, Neill R;
- Hassenstab, Jason;
- Jack, Clifford R;
- Karch, Celeste M;
- Levin, Johannes;
- McDade, Eric M;
- Perrin, Richard J;
- Schofield, Peter R;
- Xiong, Chengjie
Publication type:
Article
Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease.
Published in:
2021
By:
- Ewers, Michael;
- Luan, Ying;
- Frontzkowski, Lukas;
- Neitzel, Julia;
- Rubinski, Anna;
- Dichgans, Martin;
- Hassenstab, Jason;
- Gordon, Brian A;
- Chhatwal, Jasmeer P;
- Levin, Johannes;
- Schofield, Peter;
- Benzinger, Tammie L S;
- Morris, John C;
- Goate, Alison;
- Karch, Celeste M;
- Fagan, Anne M;
- McDade, Eric;
- Allegri, Ricardo;
- Berman, Sarah;
- Chui, Helena
Publication type:
journal article
Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease.
Published in:
2019
By:
- Vöglein, Jonathan;
- Paumier, Katrina;
- Jucker, Mathias;
- Preische, Oliver;
- McDade, Eric;
- Hassenstab, Jason;
- Benzinger, Tammie L;
- Noble, James M;
- Berman, Sarah B;
- Graff-Radford, Neill R;
- Ghetti, Bernardino;
- Farlow, Martin R;
- Chhatwal, Jasmeer;
- Salloway, Stephen;
- Xiong, Chengjie;
- Karch, Celeste M.;
- Cairns, Nigel;
- Mori, Hiroshi;
- Schofield, Peter R;
- Masters, Colin L
Publication type:
journal article
Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models.
Published in:
Journal of Neuroscience, 2024, v. 44, n. 24, p. 1, doi. 10.1523/JNEUROSCI.1709-23.2024
By:
- Rei Murakami;
- Hirotaka Watanabe;
- Hideko Hashimoto;
- Mayu Kashiwagi-Hakozaki;
- Tadafumi Hashimoto;
- Karch, Celeste M.;
- Takeshi Iwatsubo;
- Hideyuki Okano
Publication type:
Article
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 9, p. 6590, doi. 10.1002/alz.13877
By:
- Kloske, Courtney M.;
- Belloy, Michael E.;
- Blue, Elizabeth E.;
- Bowman, Gregory R.;
- Carrillo, Maria C.;
- Chen, Xiaoying;
- Chiba‐Falek, Ornit;
- Davis, Albert A.;
- Paolo, Gilbert Di;
- Garretti, Francesca;
- Gate, David;
- Golden, Lesley R.;
- Heinecke, Jay W.;
- Herz, Joachim;
- Huang, Yadong;
- Iadecola, Costantino;
- Johnson, Lance A.;
- Kanekiyo, Takahisa;
- Karch, Celeste M.;
- Khvorova, Anastasia
Publication type:
Article
Novel avenues of tau research.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2024, v. 20, n. 3, p. 2240, doi. 10.1002/alz.13533
By:
- Sexton, Claire E.;
- Bitan, Gal;
- Bowles, Kathryn R.;
- Brys, Miroslaw;
- Buée, Luc;
- Maina, Mahmoud Bukar;
- Clelland, Claire D.;
- Cohen, Ann D.;
- Crary, John F.;
- Dage, Jeffrey L.;
- Diaz, Kristophe;
- Frost, Bess;
- Gan, Li;
- Goate, Alison M;
- Golbe, Lawrence I.;
- Hansson, Oskar;
- Karch, Celeste M.;
- Kolb, Hartmuth C.;
- La Joie, Renaud;
- Lee, Suzee E.
Publication type:
Article
Functional variations in gamma‐secretase processing of APP are critical determinants of the clinical, biomarker, and cognitive progression of autosomal dominant Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.082318
By:
- Schultz, Stephanie A.;
- Liu, Lei;
- Schultz, Aaron P.;
- Fitzpatrick, Colleen D;
- Levin, Raina;
- Bellier, Jean‐Pierre;
- Shirzadi, Zahra;
- Joseph‐Mathurin, Nelly;
- Chen, Charles D.;
- Benzinger, Tammie L.S.;
- Day, Gregory S.;
- Farlow, Martin R.;
- Hassenstab, Jason J.;
- Jack, Clifford R.;
- Jucker, Mathias;
- Lee, Jae‐Hong;
- Levin, Johannes;
- Perrin, Richard J.;
- Schofield, Peter W.;
- Karch, Celeste M.
Publication type:
Article
Investigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.071752
By:
- Wagemann, Olivia;
- Li, Yan;
- Hassenstab, Jason J.;
- Aschenbrenner, Andrew J.;
- Benzinger, Tammie L.S.;
- Gordon, Brian A.;
- Wang, Guoqiao;
- Karch, Celeste M.;
- Renton, Alan E.;
- Cruchaga, Carlos;
- Morris, John C;
- Xiong, Chengjie;
- Perrin, Richard J.;
- Levin, Johannes;
- Daniels, Alisha;
- Bateman, Randall J.;
- McDade, Eric;
- Llibre‐Guerra, Jorge J
Publication type:
Article
Plasma tau phosphorylation at T217 predicts amyloid deposition in dominantly inherited and late onset Alzheimer disease participants without clinical symptoms.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.079220
By:
- Barthélemy, Nicolas R.;
- Li, Yan;
- Janelidze, Shorena;
- He, Yingxin;
- Xiong, Chengjie;
- Stomrud, Erik;
- Fagan, Anne M.;
- Karch, Celeste M.;
- Benzinger, Tammie L.S.;
- McDade, Eric;
- Hansson, Oskar;
- Gordon, Brian A.;
- Bateman, Randall J.
Publication type:
Article
Exploring Predictable CSF derived biomarkers between mutation carriers and noncarriers in autosomal dominant Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076919
By:
- Shen, Yuanyuan;
- Morris, John C;
- Llibre‐Guerra, Jorge J;
- Karch, Celeste M.;
- Xiong, Chengjie;
- Perrin, Richard J.;
- Renton, Alan E.;
- McDade, Eric;
- Bateman, Randall J.;
- Cruchaga, Carlos
Publication type:
Article
Ubiquitin‐Proteasome System in Different Staging of Dominantly Inherited Alzheimer's Disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.071786
By:
- Liu, Haiyan;
- Li, Yan;
- Hassenstab, Jason J.;
- Gordon, Brian A.;
- Benzinger, Tammie L.S.;
- Timsina, Jigyasha;
- Wang, Lihua;
- Sung, Yun Ju;
- Bui, Quoc;
- Karch, Celeste M.;
- Renton, Alan E.;
- Cruchaga, Carlos;
- Daniels, Alisha;
- Morris, John C;
- Xiong, Chengjie;
- Perrin, Richard J.;
- Bateman, Randall J.;
- Llibre‐Guerra, Jorge J;
- McDade, Eric
Publication type:
Article
Cross‐omics integration analysis revels synaptic dysregulation across brain regions at later stages of Alzheimer disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077100
By:
- Eteleeb, Abdallah M;
- Novotny, Brenna C;
- Soriano‐Tarraga, Carolina;
- Sohn, Christopher;
- Dhungel, Eliza;
- Brase, Logan;
- Nallapu, Aasritha;
- Buss, Jared;
- Farias, Fabiana H.G.;
- Bergmann, Kristy;
- Norton, Joanne;
- Gentsch, Jen;
- Wang, Fengxian;
- Davis, Albert A;
- Morris, John C;
- Karch, Celeste M.;
- Perrin, Richard J.;
- Benitez, Bruno A.;
- Harari, Oscar
Publication type:
Article
Community‐based recruitment in Nigeria and cell biobanking to understand the impact of the apolipoprotein E variants on Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074864
By:
- Maina, Mahmoud Bukar;
- Goni, Baba Waru;
- Marsh, Jacob;
- Wray, Selina;
- Serpell, Louise;
- Karch, Celeste M.
Publication type:
Article
Modeling neuropathology of Alzheimer's disease in aged patient‐derived neurons through 3D direct neuronal reprogramming.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074488
By:
- Sun, Zhao;
- Chen, Shawei;
- Cates, Kitra;
- Kwon, Ji‐Sun;
- Sviben, Sanja;
- Ren, Yudong;
- Lv, Xinguo;
- Karahan, Hande;
- Sato, Chihiro;
- Houlden, Henry;
- Karch, Celeste M.;
- Bateman, Randall J.;
- Mennerick, Steven;
- Kim, Jungsu;
- Diamond, Marc;
- Tanzi, Rudolph E.;
- Holtzman, David M.;
- Yoo, Andrew S
Publication type:
Article
Ambient RNA from CSF to capture brain cell‐type signatures in AD and other neurodegenerative diseases.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077297
By:
- Kaczaral, Jacqueline;
- Buss, Jared;
- Eteleeb, Abdallah;
- Novotny, Brenna C;
- D'Oliveira Albanus, Ricardo;
- Brase, Logan;
- Benitez, Bruno A.;
- Karch, Celeste M.;
- Piccio, Laura;
- Ter‐Ovanesyan, Dima;
- Harari, Oscar
Publication type:
Article
Leveraging systems biology approaches and single‐nucleus RNA‐seq to study sex differences in AD.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076877
By:
- Brase, Logan;
- Dunn, Amy R;
- Morris, John C;
- Perrin, Richard J.;
- Dumitrescu, Logan;
- Kaczorowski, Catherine C.;
- Hohman, Timothy J.;
- Karch, Celeste M.;
- Harari, Oscar;
- Benitez, Bruno A.
Publication type:
Article
Microglia transcriptional heterogeneity across human and experimental models.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076619
By:
- Garg, Anjali;
- Novotny, Brenna C;
- D'Oliveira Albanus, Ricardo;
- Brase, Logan;
- Karch, Celeste M.;
- Morris, John C;
- Perrin, Richard J.;
- Sutherland, Greg T;
- Benitez, Bruno A.;
- Harari, Oscar
Publication type:
Article
Ambient RNA from CSF to capture brain cell‐type signatures in AD and other neurodegenerative diseases.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077297
By:
- Kaczaral, Jacqueline;
- Buss, Jared;
- Eteleeb, Abdallah;
- Novotny, Brenna C;
- D'Oliveira Albanus, Ricardo;
- Brase, Logan;
- Benitez, Bruno A.;
- Karch, Celeste M.;
- Piccio, Laura;
- Ter‐Ovanesyan, Dima;
- Harari, Oscar
Publication type:
Article
Leveraging systems biology approaches and single‐nucleus RNA‐seq to study sex differences in AD.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076877
By:
- Brase, Logan;
- Dunn, Amy R;
- Morris, John C;
- Perrin, Richard J.;
- Dumitrescu, Logan;
- Kaczorowski, Catherine C.;
- Hohman, Timothy J.;
- Karch, Celeste M.;
- Harari, Oscar;
- Benitez, Bruno A.
Publication type:
Article
Microglia transcriptional heterogeneity across human and experimental models.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076619
By:
- Garg, Anjali;
- Novotny, Brenna C;
- D'Oliveira Albanus, Ricardo;
- Brase, Logan;
- Karch, Celeste M.;
- Morris, John C;
- Perrin, Richard J.;
- Sutherland, Greg T;
- Benitez, Bruno A.;
- Harari, Oscar
Publication type:
Article
Using amyloid PET as a biomarker to detect progression of early Alzheimer disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.066189
By:
- Ali, Muhammad;
- Mafimoghaddam, Samira;
- Sung, Yun Ju;
- Wang, Fengxian;
- Fernandez, Maria Victoria;
- Archer, Derek B;
- Hohman, Timothy J.;
- Satizabal, Claudia L.;
- Yang, Qiong;
- Beiser, Alexa S.;
- Wang, Ruiqi;
- Gordon, Brian A.;
- Benzinger, Tammie L.S.;
- Xiong, Chengjie;
- Morris, John C;
- Bateman, Randall J.;
- Karch, Celeste M.;
- McDade, Eric;
- Goate, Alison;
- Seshadri, Sudha
Publication type:
Article
Pattern and implications of neurological examination findings in autosomal dominant Alzheimer disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 2, p. 632, doi. 10.1002/alz.12684
By:
- Vöglein, Jonathan;
- Franzmeier, Nicolai;
- Morris, John C.;
- Dieterich, Marianne;
- McDade, Eric;
- Simons, Mikael;
- Preische, Oliver;
- Hofmann, Anna;
- Hassenstab, Jason;
- Benzinger, Tammie L.;
- Fagan, Anne;
- Noble, James M.;
- Berman, Sarah B.;
- Graff‐Radford, Neill R.;
- Ghetti, Bernardino;
- Farlow, Martin R.;
- Chhatwal, Jasmeer P.;
- Salloway, Stephen;
- Xiong, Chengjie;
- Karch, Celeste M
Publication type:
Article
Identification of the Aβ37/42 peptide ratio in CSF as an improved Aβ biomarker for Alzheimer's disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 1, p. 79, doi. 10.1002/alz.12646
By:
- Liu, Lei;
- Lauro, Bianca M.;
- He, Amy;
- Lee, Hyo;
- Bhattarai, Sanjay;
- Wolfe, Michael S.;
- Bennett, David A.;
- Karch, Celeste M.;
- Young‐Pearse, Tracy;
- Selkoe, Dennis J.
Publication type:
Article
Plasma levels of an N‐terminal tau fragment predict core AD and neurodegenerative biomarkers in autosomal dominant Alzheimer's disease: Findings from DIAN.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.069285
By:
- Schultz, Stephanie A.;
- Liu, Lei;
- Ostaszewski, Beth;
- Fitzpatrick, Colleen D;
- Xiong, Chengjie;
- Fagan, Anne M.;
- Noble, James M;
- Rosa‐Neto, Pedro;
- Farlow, Martin R.;
- Schofield, Peter W.;
- Morris, John C.;
- Perrin, Richard J.;
- Jucker, Mathias;
- Jack, Clifford R.;
- Karch, Celeste M.;
- Gordon, Brian A.;
- Johnson, Keith A.;
- McDade, Eric;
- Sperling, Reisa A.;
- Bateman, Randall J.
Publication type:
Article
Progressive white matter injury in autosomal dominant Alzheimer's disease is strongly associated with cerebral microbleeds and neurodegeneration.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 6, p. 1, doi. 10.1002/alz.066715
By:
- Shirzadi, Zahra;
- Schultz, Stephanie A.;
- Yau, Wai‐Ying Wendy;
- Joseph‐Mathurin, Nelly;
- Kantarci, Kejal;
- Preboske, Gregory M.;
- Jack, Clifford R.;
- Farlow, Martin R.;
- Fagan, Anne M.;
- Hassenstab, Jason J.;
- Jucker, Mathias;
- Morris, John C.;
- Xiong, Chengjie;
- Karch, Celeste M.;
- Fitzpatrick, Colleen D;
- Levey, Allan I.;
- Gordon, Brian A.;
- Schofield, Peter W.;
- Salloway, Stephen P.;
- Perrin, Richard J.
Publication type:
Article
CSF tau phosphorylation at sites 217 and 205 mediate the relationship between PET amyloid and downstream AD markers.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 1, doi. 10.1002/alz.065718
By:
- Meeker, Karin L.;
- Barthélemy, Nicolas R.;
- Gordon, Brian A.;
- McDade, Eric;
- Karch, Celeste M.;
- Fagan, Anne M.;
- Strain, Jeremy F.;
- Luckett, Patrick H;
- Benzinger, Tammie L.S.;
- Bateman, Randall J.;
- Holtzman, David M.;
- Ances, Beau M
Publication type:
Article
AD‐causing variants that affect PSEN1 transmembrane domains are associated with faster neurodegeneration and cognitive decline compared to those affecting cytoplasmic domains.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.067186
By:
- Schultz, Stephanie A.;
- Allegri, Ricardo Francisco;
- Schultz, Aaron P;
- Goate, Alison;
- Levey, Allan I.;
- Fagan, Anne M.;
- Hanseeuw, Bernard J;
- Koeppe, Robert A.;
- Gordon, Brian A.;
- Cruchaga, Carlos;
- Karch, Celeste M.;
- Chen, Charles D.;
- Xiong, Chengjie;
- Jack, Clifford R.;
- Fitzpatrick, Colleen D;
- McDade, Eric;
- Chui, Helena C;
- Mori, Hiroshi;
- Lee, Jae‐Hong;
- Noble, James M
Publication type:
Article
Characterizing Disrupted Cellular Crosstalk Signaling Networks in Alzheimer's Disease Using Single‐Nuclei Transcriptomics.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.062304
By:
- Albanus, Ricardo D'Oliveira;
- Brase, Logan;
- You, Shih‐Feng;
- Soriano‐Tarraga, Carolina;
- Benitez, Bruno A.;
- Cruchaga, Carlos;
- Karch, Celeste M.;
- Harari, Oscar
Publication type:
Article
Genetic and glial heterogeneity in Alzheimer disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.061185
By:
- Brase, Logan;
- You, Shih‐Feng;
- Novotny, Brenna C;
- Soriano‐Tarraga, Carolina;
- Morris, John C.;
- Bateman, Randall J.;
- Perrin, Richard J.;
- McDade, Eric;
- Goate, Alison;
- Karch, Celeste M.;
- Benitez, Bruno A.;
- Cruchaga, Carlos;
- Harari, Oscar
Publication type:
Article
KDM6A expression is associated with a sex‐disease interaction in activated microglia.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.065829
By:
- Brase, Logan;
- Dunn, Amy R;
- Dumitrescu, Logan;
- Kaczorowski, Catherine C.;
- Hohman, Timothy J.;
- Karch, Celeste M.;
- Harari, Oscar;
- Benitez, Bruno A.
Publication type:
Article
AD‐causing variants that affect PSEN1 transmembrane domains are associated with faster neurodegeneration and cognitive decline compared to those affecting cytoplasmic domains.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, p. 1, doi. 10.1002/alz.068221
By:
- Schultz, Stephanie A.;
- Allegri, Ricardo Francisco;
- Schultz, Aaron P.;
- Goate, Alison;
- Levey, Allan I.;
- Fagan, Anne M.;
- Hanseeuw, Bernard J;
- Koeppe, Robert A.;
- Gordon, Brian A.;
- Cruchaga, Carlos;
- Karch, Celeste M.;
- Chen, Charles D.;
- Xiong, Chengjie;
- Jack, Clifford R.;
- Fitzpatrick, Colleen D;
- McDade, Eric;
- Chui, Helena C;
- Mori, Hiroshi;
- Lee, Jae‐Hong;
- Noble, James M
Publication type:
Article
CSF tau phosphorylation at sites 217 and 181 are associated with preclinical and biphasic alterations in resting‐state functional connectivity in Autosomal Dominant AD.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, p. 1, doi. 10.1002/alz.065641
By:
- Meeker, Karin L.;
- Barthélemy, Nicolas R.;
- Gordon, Brian A.;
- McDade, Eric;
- Karch, Celeste M.;
- Fagan, Anne M.;
- Strain, Jeremy F.;
- Luckett, Patrick H;
- Benzinger, Tammie L.S.;
- Bateman, Randall J.;
- Holtzman, David M.;
- Ances, Beau M
Publication type:
Article
Current directions in tau research: Highlights from Tau 2020.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 988, doi. 10.1002/alz.12452
By:
- Sexton, Claire;
- Snyder, Heather;
- Beher, Dirk;
- Boxer, Adam L.;
- Brannelly, Pat;
- Brion, Jean‐Pierre;
- Buée, Luc;
- Cacace, Angela M.;
- Chételat, Gaël;
- Citron, Martin;
- DeVos, Sarah L.;
- Diaz, Kristophe;
- Feldman, Howard H.;
- Frost, Bess;
- Goate, Alison M.;
- Gold, Michael;
- Hyman, Bradley;
- Johnson, Keith;
- Karch, Celeste M.;
- Kerwin, Diana R.
Publication type:
Article
Targeted Atp1a2 knockdown by antisense oligonucleotides leads to reduced SOD1 aggregation and accelerated disease progression in the SOD1*G93A mouse model of ALS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058737
By:
- Iyer, Abhirami Kannan;
- Schoch, Kathleen M.;
- Oldenborg, Anna;
- Chen, Hao;
- Smith, Sarah E;
- Miller, Timothy M;
- Karch, Celeste M.;
- Bonni, Azad
Publication type:
Article
Systematic validation of variants of unknown significance in PSEN1.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058686
By:
- Burgute, Bhagyashri;
- Renton, Alan E.;
- Ziegemeier, Ellen;
- Cruchaga, Carlos;
- Goate, Alison M.;
- McDade, Eric;
- Llibre‐Guerra, Jorge J;
- Karch, Celeste M.
Publication type:
Article
Defining the role of PLD3 in Alzheimer disease pathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.054611
By:
- Rosene, Matthew J;
- Hsu, Simon;
- Martinez, Rita;
- Norton, Joanne;
- Yan, Ping;
- Cirrito, John R;
- Lee, Jin‐Moo;
- Cuervo, Ana Maria;
- Goate, Alison M.;
- Cruchaga, Carlos;
- Karch, Celeste M.
Publication type:
Article
Impact of MAPT mutations on transcriptomic signatures of FTLD brains and patient‐derived pluripotent cell models.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.054570
By:
- Minaya, Miguel;
- Martinez, Rita;
- Seeley, William W.;
- Eteleeb, Abdallah M;
- Cruchaga, Carlos;
- Harari, Oscar;
- Karch, Celeste M.
Publication type:
Article
Stem cell models of primary tauopathies reveal defects in synaptic function.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.054566
By:
- Martinez, Rita;
- Jiang, Shan;
- Marsh, Jacob;
- Harari, Oscar;
- Cruchaga, Carlos;
- Goate, Alison M.;
- Temple, Sally;
- Karch, Celeste M.
Publication type:
Article
Multi‐omics approaches reveal a link between the MS4A gene loci, TREM2, and microglia function.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.054553
By:
- You, Shih‐Feng;
- Brase, Logan;
- Filipello, Fabia;
- Del‐Aguila, Jorge L.;
- Mihindukulasuriya, Kathie A.;
- Benitez, Bruno A.;
- Cruchaga, Carlos;
- Harari, Oscar;
- Karch, Celeste M.
Publication type:
Article
Defective proteostasis in patient‐derived iPSC astrocytes and neurons carrying a MAPT IVS10+16 mutation.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.054448
By:
- Mahali, Sidhartha;
- Martinez, Rita;
- Hu, Miwei;
- Marsh, Jacob;
- Temple, Sally;
- Karch, Celeste M.
Publication type:
Article
Single nuclei RNA‐sequencing of GWAS loci variant carriers elucidates cell‐types and transcriptional profile alterations associated with Alzheimer disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.054402
By:
- Brase, Logan;
- Del‐Aguila, Jorge L.;
- You, Shih‐Feng;
- Soriano‐Tarraga, Carolina;
- Farias, Fabiana H.G.;
- Benitez, Bruno A.;
- Karch, Celeste M.;
- Cruchaga, Carlos;
- Harari, Oscar
Publication type:
Article
LMNA‐mediated nucleoskeleton dysregulation in Alzheimer disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.054396
By:
- Rosene, Matthew J;
- Wen, Natalie;
- Li, Zeran;
- Brase, Logan;
- Hsu, Simon;
- Cruchaga, Carlos;
- Temple, Sally;
- Harari, Oscar;
- Karch, Celeste M.
Publication type:
Article
Functional exploration of AGFG2, a novel player in the pathology of Alzheimer disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.054240
By:
- Fernandez, Maria Victoria;
- Budde, John P.;
- Eteleeb, Abdallah;
- Wang, Fengxian;
- Martinez, Rita;
- Norton, Joanne;
- Gentsch, Jen;
- Morris, John C.;
- Bateman, Randall J.;
- McDade, Eric;
- Perrin, Richard J.;
- Harari, Oscar;
- Benitez, Bruno A.;
- Karch, Celeste M.;
- Cruchaga, Carlos
Publication type:
Article
Multi‐omics data integration reveals clinically meaningful molecular profiles of Alzheimer disease.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.052942
By:
- Eteleeb, Abdallah M;
- Novotny, Brenna C;
- Morris, John C.;
- Bateman, Randall J.;
- Perrin, Richard J.;
- Karch, Celeste M.;
- Cruchaga, Carlos;
- Benitez, Bruno A.;
- Harari, Oscar
Publication type:
Article
Caspase inhibition mitigates tau cleavage and neurotoxicity in iPSC‐induced neurons with the V337M MAPT mutation.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.051471
By:
- Theofilas, Panos;
- Ambrose, Andrew J.;
- Butler, David;
- Wang, Chao;
- Morales, Dulce O.;
- Petersen, Cathrine;
- Chin, Brian;
- Yang, Teddy;
- Khan, Shireen;
- Ng, Raymond;
- Kayed, Rakez;
- Karch, Celeste M.;
- Miller, Bruce L.;
- Gestwicki, Jason E.;
- Gan, Li;
- Temple, Sally;
- Arkin, Michelle R.;
- Grinberg, Lea T.
Publication type:
Article
Profiling the metabolic landscape of AD.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, n. 3, p. 1, doi. 10.1002/alz.050086
By:
- Novotny, Brenna C;
- Fernandez, Victoria;
- Budde, John P.;
- Bergmann, Kristy;
- Morris, John C.;
- Bateman, Randall J.;
- Karch, Celeste M.;
- Benitez, Bruno A.;
- Cruchaga, Carlos;
- Harari, Oscar
Publication type:
Article
Defining the role of PLD3 in Alzheimer's disease pathology.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058730
By:
- Rosene, Matthew J;
- Hsu, Simon;
- Martinez, Rita;
- Norton, Joanne;
- Yan, Ping;
- Cirrito, John R;
- Lee, Jin‐Moo;
- Cuervo, Ana Maria;
- Goate, Alison M.;
- Cruchaga, Carlos;
- Karch, Celeste M.
Publication type:
Article
Functional characterization of hiPSCs‐derived glial cells and neurons from patients harboring a TREM2 loss of function mutation.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058712
By:
- Filipello, Fabia;
- You, Shih‐Feng;
- Martinez, Rita;
- Korvatska, Olena;
- Raskind, Wendy H;
- Mahali, Sidhartha;
- Ghezzi, Laura;
- Wandy, Beatty;
- Cella, Marina;
- Piccio, Laura;
- Karch, Celeste M.
Publication type:
Article
Impact of MAPT mutations on transcriptomic signatures of FTLD brains and patient‐derived pluripotent cell models.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.058313
By:
- Minaya, Miguel;
- Martinez, Rita;
- Eteleeb, Abdallah;
- Cruchaga, Carlos;
- Harari, Oscar;
- Karch, Celeste M.
Publication type:
Article

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