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Radiation treatment inhibits monocyte entry into the optic nerve head and prevents neuronal damage in a mouse model of glaucoma.
Published in:
Journal of Clinical Investigation, 2012, v. 122, n. 4, p. 1246, doi. 10.1172/JCI61135
By:
- Howell, Gareth R.;
- Soto, Ileana;
- Xianjun Zhu;
- Ryan, Margaret;
- Macalinao, Danilo G.;
- Sousa, Gregory L.;
- Caddle, Lura B.;
- MacNicoll, Katharine H.;
- Barbay, Jessica M.;
- Porciatti, Vittorio;
- Anderson, Michael G.;
- Smith, Richard S.;
- Clark, Abbot F.;
- Libby, Richard T.;
- John, Simon W. M.
Publication type:
Article
Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.
Published in:
2011
By:
- Howell, Gareth R.;
- Macalinao, Danilo G.;
- Sousa, Gregory L.;
- Walden, Michael;
- Soto, Ileana;
- Kneeland, Stephen C.;
- Barbay, Jessica M.;
- King, Benjamin L.;
- Marchant, Jeffrey K.;
- Hibbs, Matthew;
- Stevens, Beth;
- Barres, Ben A.;
- Clark, Abbot F.;
- Libby, Richard T.;
- John, Simon W. M.
Publication type:
journal article
GLIS1 regulates trabecular meshwork function and intraocular pressure and is associated with glaucoma in humans.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25181-7
By:
- Nair, K. Saidas;
- Srivastava, Chitrangda;
- Brown, Robert V.;
- Koli, Swanand;
- Choquet, Hélène;
- Kang, Hong Soon;
- Kuo, Yien-Ming;
- Grimm, Sara A.;
- Sutherland, Caleb;
- Badea, Alexandra;
- Johnson, G. Allan;
- Zhao, Yin;
- Yin, Jie;
- Okamoto, Kyoko;
- Clark, Graham;
- Borrás, Terete;
- Zode, Gulab;
- Kizhatil, Krishnakumar;
- Chakrabarti, Subhabrata;
- John, Simon W. M.
Publication type:
Article
Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma.
Published in:
Frontiers in Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fnins.2017.00232
By:
- Williams, Pete A.;
- Harder, Jeffrey M.;
- Foxworth, Nicole E.;
- Cardozo, Brynn H.;
- Cochran, Kelly E.;
- John, Simon W. M.
Publication type:
Article
Alteration of the serine protease PRSS56 causes angle-closure glaucoma in mice and posterior microphthalmia in humans and mice.
Published in:
Nature Genetics, 2011, v. 43, n. 6, p. 579, doi. 10.1038/ng.813
By:
- Nair, K. Saidas;
- Hmani-Aifa, Mounira;
- Ali, Zain;
- Kearney, Alison L.;
- Salem, Salma Ben;
- Macalinao, Danilo G.;
- Cosma, Ioan M.;
- Bouassida, Walid;
- Hakim, Bochra;
- Benzina, Zeineb;
- Soto, Ileana;
- Söderkvist, Peter;
- Howell, Gareth R.;
- Smith, Richard S.;
- Ayadi, Hammadi;
- John, Simon W. M.
Publication type:
Article
Complement peptide C3a receptor 1 promotes optic nerve degeneration in DBA/2J mice.
Published in:
2020
By:
- Harder, Jeffrey M.;
- Williams, Pete A.;
- Braine, Catherine E.;
- Yang, Hongtian S.;
- Thomas, Jocelyn M.;
- Foxworth, Nicole E.;
- John, Simon W. M.;
- Howell, Gareth R.
Publication type:
journal article
Retinal ganglion cell degeneration is topological but not cell type specific in DBA/2J mice.
Published in:
Journal of Cell Biology, 2005, v. 171, n. 2, p. 313, doi. 10.1083/jcb.200506099
By:
- Jakobs, Tatjana C.;
- Libby, Richard T.;
- Ben, Yixin;
- John, Simon W. M.;
- Masland, Richard H.
Publication type:
Article
Chronic consumption of a western diet induces robust glial activation in aging mice and in a mouse model of Alzheimer's disease.
Published in:
Scientific Reports, 2016, p. 21568, doi. 10.1038/srep21568
By:
- Graham, Leah C.;
- Harder, Jeffrey M.;
- Soto, Ileana;
- de Vries, Wilhelmine N.;
- John, Simon W. M.;
- Howell, Gareth R.
Publication type:
Article
Synapse Loss and Dendrite Remodeling in a Mouse Model of Glaucoma.
Published in:
PLoS ONE, 2015, v. 10, n. 12, p. 1, doi. 10.1371/journal.pone.0144341
By:
- Berry, Ryan H.;
- Qu, Juan;
- John, Simon W. M.;
- Howell, Gareth R.;
- Jakobs, Tatjana C.
Publication type:
Article
DBA/2J Mice Are Susceptible to Diabetic Nephropathy and Diabetic Exacerbation of IOP Elevation.
Published in:
PLoS ONE, 2014, v. 9, n. 9, p. 1, doi. 10.1371/journal.pone.0107291
By:
- Soto, Ileana;
- Howell, Gareth R.;
- John, Cai W.;
- Kief, Joseph L.;
- Libby, Richard T.;
- John, Simon W. M.
Publication type:
Article
Retinal Ganglion Cell Dendritic Atrophy in DBA/2J Glaucoma.
Published in:
PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0072282
By:
- Williams, Pete A.;
- Howell, Gareth R.;
- Barbay, Jessica M.;
- Braine, Catherine E.;
- Sousa, Gregory L.;
- John, Simon W. M.;
- Morgan, James E.
Publication type:
Article
Generating Embryonic Stem Cells from the Inbred Mouse Strain DBA/2J, a Model of Glaucoma and Other Complex Diseases.
Published in:
PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0050081
By:
- Reinholdt, Laura G.;
- Howell, Gareth R.;
- Czechanski, Anne M.;
- Macalinao, Danilo G.;
- MacNicoll, Katharine H.;
- Chyuan-Sheng Lin;
- Donahue, Leah Rae;
- John, Simon W. M.
Publication type:
Article
Opposing Roles for Membrane Bound and Soluble Fas Ligand in Glaucoma-Associated Retinal Ganglion Cell Death.
Published in:
PLoS ONE, 2011, v. 6, n. 3, p. 1, doi. 10.1371/journal.pone.0017659
By:
- Gregory, Meredith S.;
- Hackett, Caroline G.;
- Abernathy, Emma F.;
- Lee, Karen S.;
- Saff, Rebecca R.;
- Hohlbaum, Andreas M.;
- Moody, Krishna-sulayman L.;
- Hobson, Maura W.;
- Jones, Alexander;
- Kolovou, Paraskevi;
- Karray, Saoussen;
- Giani, Andrea;
- John, Simon W. M.;
- Chen, Dong Feng;
- Marshak-Rothstein, Ann;
- Ksander, Bruce R.
Publication type:
Article
Ultrasmall Integrated 3D Micro-Supercapacitors Solve Energy Storage for Miniature Devices.
Published in:
Advanced Energy Materials, 2014, v. 4, n. 7, p. n/a, doi. 10.1002/aenm.201301269
By:
- Meng, Chuizhou;
- Maeng, Jimin;
- John, Simon W. M.;
- Irazoqui, Pedro P.
Publication type:
Article
Ocular hypertension suppresses homeostatic gene expression in optic nerve head microglia of DBA/2 J mice.
Published in:
Molecular Brain, 2020, v. 13, n. 1, p. 1, doi. 10.1186/s13041-020-00603-7
By:
- Tribble, James R.;
- Harder, Jeffrey M.;
- Williams, Pete A.;
- John, Simon W. M.
Publication type:
Article
Transcriptomic profiling of Schlemm's canal cells reveals a lymphatic-biased identity and three major cell states.
Published in:
eLife, 2024, p. 1, doi. 10.7554/eLife.96459
By:
- Balasubramanian, Revathi;
- Kizhatil, Krishnakumar;
- Taibo Li;
- Tolman, Nicholas;
- Bhandari, Aakriti;
- Clark, Graham;
- Bupp-Chickering, Violet;
- Kelly, Ruth A.;
- Zhou, Sally;
- Peregrin, John;
- Simón, Marina;
- Montgomery, Christa;
- Stamer, W. Daniel;
- Jiang Qian;
- John, Simon W. M.
Publication type:
Article
Nicotinamide and Pyruvate for Neuroenhancement in Open-Angle Glaucoma: A Phase 2 Randomized Clinical Trial.
Published in:
2022
By:
- De Moraes, Carlos Gustavo;
- John, Simon W. M.;
- Williams, Pete A.;
- Blumberg, Dana M.;
- Cioffi, George A.;
- Liebmann, Jeffrey M.
Publication type:
journal article
GpnmbR150X allele must be present in bone marrow derived cells to mediate DBA/2J glaucoma.
Published in:
BMC Genetics, 2008, v. 9, p. 1, doi. 10.1186/1471-2156-9-30
By:
- Anderson, Michael G.;
- Nair, K. Saidas;
- Amonoo, Leslie A.;
- Mehalow, Adrienne;
- Trantow, Colleen M.;
- Masli, Sharmila;
- John, Simon W. M.
Publication type:
Article
Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure.
Published in:
BMC Genetics, 2001, v. 2, p. 1
By:
- Bo Chang;
- Smith, Richard S.;
- Peters, Maureen;
- Savinova, Olga V.;
- Hawes, Norman L.;
- Zabaleta, Adriana;
- Nusinowitz, Steven;
- Martin, Janice E.;
- Davisson, Muriel L.;
- Cepko, Constance L.;
- Hogan, Brigid L. M.;
- John, Simon W. M.
Publication type:
Article
Intraocular pressure in genetically distinct mice: an update and strain survey: Correction.
Published in:
2001
By:
- Savinova, Olga V.;
- Sugiyama, Fumihiro;
- Martin, Janice E.;
- Tomarev, Stanislav I.;
- Paigen, Beverly J.;
- Smith, Richard S.;
- John, Simon W. M.
Publication type:
Correction Notice
Intraocular pressure in genetically distinct mice: an update and strain survey.
Published in:
BMC Genetics, 2001, v. 2, p. 12, doi. 10.1186/1471-2156-2-12
By:
- Savinova, Olga V.;
- Sugiyama, Fumihiro;
- Martin, Janice E.;
- Tomarev, Stanislav I.;
- Paigen, Beverly J.;
- Smith, Richard S.;
- John, Simon W. M.
Publication type:
Article
Genetic modification of glaucoma associated phenotypes between AKXD-28/Ty and DBA/2J mice.
Published in:
BMC Genetics, 2001, v. 2, p. 1, doi. 10.1186/1471-2156-2-1
By:
- Anderson, Michael G.;
- Smith, Richard S.;
- Savinova, Olga V.;
- Hawes, Norman L.;
- Zabaleta, Adriana;
- Wilpan, Robert;
- Heckenlively, John R.;
- Davisson, Muriel;
- John, Simon W. M.
Publication type:
Article
Angiopoietin-1 is required for Schlemm's canal development in mice and humans.
Published in:
2017
By:
- Thomson, Benjamin R.;
- Tomokazu Souma;
- Onay, Tuncer;
- Tanna, Christine E.;
- Jing Jin;
- Quaggin, Susan E.;
- Finzi, Simone;
- Hewitt, Alex W.;
- Mackey, David A.;
- Wiggs, Janey L.;
- Pasutto, Francesca;
- Tompson, Stuart W.;
- Whisenhunt, Kristina N.;
- Bradfield, Yasmin S.;
- Young, Terri L.;
- Kizhatil, Krishnakumar;
- John, Simon W. M.;
- Siggs, Owen M.;
- Souzeau, Emmanuelle;
- Javadiyan, Shari
Publication type:
journal article
Axons of retinal ganglion cells are insulted in the optic nerve early in DBA/2J glaucoma.
Published in:
Journal of Cell Biology, 2007, v. 179, n. 7, p. 1523, doi. 10.1083/jcb.200706181
By:
- Howell, Gareth R.;
- Libby, Richard T.;
- Jakobs, Tatjana C.;
- Smith, Richard S.;
- Phalan, F. Campbell;
- Barter, Joseph W.;
- Barbay, Jessica M.;
- Marchant, Jeffrey K.;
- Mahesh, Nagaraju;
- Porciatti, Vittorio;
- Whitmore, Alan V.;
- Masland, Richard H.;
- John, Simon W. M.
Publication type:
Article
Jnk2 deficiency increases the rate of glaucomatous neurodegeneration in ocular hypertensive DBA/2J mice.
Published in:
Cell Death & Disease, 2018, v. 9, n. 6, p. 1, doi. 10.1038/s41419-018-0705-8
By:
- Harder, Jeffrey M.;
- Williams, Pete A.;
- Soto, Ileana;
- Foxworth, Nicole E.;
- Fernandes, Kimberly A.;
- Freeburg, Nelson F.;
- Libby, Richard T.;
- John, Simon. W. M.
Publication type:
Article
Schlemm's Canal Is a Unique Vessel with a Combination of Blood Vascular and Lymphatic Phenotypes that Forms by a Novel Developmental Process.
Published in:
PLoS Biology, 2014, v. 12, n. 7, p. 1, doi. 10.1371/journal.pbio.1001912
By:
- Kizhatil, Krishnakumar;
- Ryan, Margaret;
- Marchant, Jeffrey K.;
- Henrich, Stephen;
- John, Simon W. M.
Publication type:
Article
A novel ENU-induced mutation, peewee, causes dwarfism in the mouse.
Published in:
Mammalian Genome, 2009, v. 20, n. 7, p. 404, doi. 10.1007/s00335-009-9197-2
By:
- Bokryeon, Lee;
- Kano, Kiyoshi;
- Young, Jay;
- John, Simon W. M.;
- Nishina, Patsy M.;
- Naggert, Jurgen K.;
- Naito, Kunihiko
Publication type:
Article
Genetic analysis of Pycr1 and Pycr2 in mice.
Published in:
Genetics, 2021, v. 218, n. 1, p. 1, doi. 10.1093/genetics/iyab048
By:
- Stum, Morgane G.;
- Tadenev, Abigail L. D.;
- Seburn, Kevin L.;
- Miers, Kathy E.;
- Poon, Pak P.;
- McMaster, Christopher R.;
- Robinson, Carolyn;
- Kane, Coleen;
- Silva, Kathleen A.;
- Cliften, Paul F.;
- Sundberg, John P.;
- Reinholdt, Laura G.;
- John, Simon W. M.;
- Burgess, Robert W.
Publication type:
Article
A multiethnic genome-wide association study of primary open-angle glaucoma identifies novel risk loci.
Published in:
Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-04555-4
By:
- Choquet, Hélène;
- Paylakhi, Seyyedhassan;
- Kneeland, Stephen C.;
- Thai, Khanh K.;
- Hoffmann, Thomas J.;
- Jie Yin;
- Kvale, Mark N.;
- Banda, Yambazi;
- Tolman, Nicholas G.;
- Williams, Pete A.;
- Schaefer, Catherine;
- Melles, Ronald B.;
- Risch, Neil;
- John, Simon W. M.;
- Nair, K. Saidas;
- Jorgenson, Eric
Publication type:
Article
Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma.
Published in:
Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0091-6
By:
- Williams, Pete A.;
- Tribble, James R.;
- Pepper, Keating W.;
- Cross, Stephen D.;
- Morgan, B. Paul;
- Morgan, James E.;
- John, Simon W. M.;
- Howell, Gareth R.
Publication type:
Article
C1q propagates microglial activation and neurodegeneration in the visual axis following retinal ischemia/reperfusion injury.
Published in:
Molecular Neurodegeneration, 2016, v. 11, p. 1, doi. 10.1186/s13024-016-0089-0
By:
- Silverman, Sean M.;
- Byung-Jin Kim;
- Howell, Garreth R.;
- Miller, Joselyn;
- John, Simon W. M.;
- Wordinger, Robert J.;
- Clark, Abbot F.
Publication type:
Article
GlyCAM1 negatively regulates monocyte entry into the optic nerve head and contributes to radiation-based protection in glaucoma.
Published in:
2017
By:
- Williams, Pete A.;
- Braine, Catherine E.;
- Foxworth, Nicole E.;
- Cochran, Kelly E.;
- John, Simon W. M.
Publication type:
journal article
Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.
Published in:
Journal of Neuroinflammation, 2013, v. 10, n. 1, p. 1, doi. 10.1186/1742-2094-10-76
By:
- Howell, Gareth R.;
- Soto, Ileana;
- Ryan, Margaret;
- Graham, Leah C.;
- Smith, Richard S.;
- John, Simon W. M.
Publication type:
Article
Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.
Published in:
2013
By:
- Howell, Gareth R;
- Soto, Ileana;
- Ryan, Margaret;
- Graham, Leah C;
- Smith, Richard S;
- John, Simon Wm;
- John, Simon W M
Publication type:
journal article
A Dominant-Negative Mutation of Mouse Lmx1b Causes Glaucoma and Is Semi-lethal via LBD1-Mediated Dimerisation.
Published in:
PLoS Genetics, 2014, v. 10, n. 5, p. 1, doi. 10.1371/journal.pgen.1004359
By:
- Cross, Sally H.;
- Macalinao, Danilo G.;
- McKie, Lisa;
- Rose, Lorraine;
- Kearney, Alison L.;
- Rainger, Joe;
- Thaung, Caroline;
- Keighren, Margaret;
- Jadeja, Shalini;
- West, Katrine;
- Kneeland, Stephen C.;
- Smith, Richard S.;
- Howell, Gareth R.;
- Young, Fiona;
- Robertson, Morag;
- van t' Hof, Rob;
- John, Simon W. M.;
- Jackson, Ian J.
Publication type:
Article
Mutations in a P-Type ATPase Gene Cause Axonal Degeneration.
Published in:
PLoS Genetics, 2012, v. 8, n. 8, p. 1, doi. 10.1371/journal.pgen.1002853
By:
- Zhu, Xianjun;
- Libby, Richard T.;
- De Vries, Wilhelmine N.;
- Smith, Richard S.;
- Wright, Dana L.;
- Bronson, Roderick T.;
- Seburn, Kevin L.;
- John, Simon W. M.
Publication type:
Article
Mutations in Zebrafish lrp2 Result in Adult-Onset Ocular Pathogenesis That Models Myopia and Other Risk Factors for Glaucoma.
Published in:
PLoS Genetics, 2011, v. 7, n. 2, p. 1, doi. 10.1371/journal.pgen.1001310
By:
- Veth, Kerry N.;
- Willer, Jason R.;
- Collery, Ross F.;
- Gray, Matthew P.;
- Willer, Gregory B.;
- Wagner, Daniel S.;
- Mullins, Mary C.;
- Udvadia, Ava J.;
- Smith, Richard S.;
- John, Simon W. M.;
- Gregg, Ronald G.;
- Link, Brian A.
Publication type:
Article
Susceptibility to Neurodegeneration in a Glaucoma Is Modified by Bax Gene Dosage.
Published in:
PLoS Genetics, 2005, v. 1, n. 1, p. 17, doi. 10.1371/journal.pgen.0010004
By:
- Libby, Richard T.;
- Yan Li;
- Savinova, Olga V.;
- Barter, Joseph;
- Smith, Richard S.;
- Nickells, Robert W.;
- John, Simon W. M.;
- Valle, David
Publication type:
Article
Anterior segment dysgenesis and the developmental glaucomas are complex traits.
Published in:
Human Molecular Genetics, 2002, v. 11, n. 10, p. 1185, doi. 10.1093/hmg/11.10.1185
By:
- Gould, Douglas B.;
- John, Simon W. M.
Publication type:
Article
Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development.
Published in:
Human Molecular Genetics, 2000, v. 9, n. 7, p. 1021, doi. 10.1093/hmg/9.7.1021
By:
- Smith, Richard S.;
- Zabaleta, Adriana;
- Kume, Tsutomu;
- Savinova, Olga V.;
- Kidson, Susan H.;
- Martin, Janice E.;
- Nishimura, Darryl Y.;
- Alward, Wallace L. M.;
- Hogan, Brigid L. M.;
- John, Simon W. M.
Publication type:
Article
Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice.
Published in:
Nature Genetics, 1999, v. 21, n. 4, p. 405, doi. 10.1038/7741
By:
- Chang, Bo;
- Smith, Richard S;
- Hawes, Norman L;
- Anderson, Michael G;
- Zabaleta, Adriana;
- Savinova, Olga;
- Roderick, Thomas H;
- Heckenlively, John R.;
- Davisson, Muriel T;
- John, Simon W M
Publication type:
Article
In vitro and in vivo correlations for I65T and M1V mutations at the phenylalanine hydroxylase locus.
Published in:
Human Mutation, 1992, v. 1, n. 2, p. 147, doi. 10.1002/humu.1380010210
By:
- John, Simon W. M.;
- Scriver, Charles R.;
- Laframboise, Rachel;
- Rozen, Rima
Publication type:
Article
Male-female differences in fertility and blood pressure in ACE-deficient mice.
Published in:
Nature, 1995, v. 375, n. 6527, p. 146, doi. 10.1038/375146a0
By:
- Krege, John H.;
- John, Simon W. M.
Publication type:
Article
Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma.
Published in:
Molecular Neurodegeneration, 2019, v. 14, n. 1, p. N.PAG, doi. 10.1186/s13024-018-0303-3
By:
- Braine, Catherine E.;
- Kizhatil, Krishnakumar;
- Foxworth, Nicole E.;
- Tolman, Nicholas G.;
- Harder, Jeffrey M.;
- Sousa, Gregory L.;
- Williams, Pete A.;
- Howell, Gareth R.;
- John, Simon W. M.;
- Scott, Rebecca A.;
- Panitch, Alyssa
Publication type:
Article
A Batteryless Energy Harvesting Storage System for Implantable Medical Devices Demonstrated In Situ.
Published in:
Circuits, Systems & Signal Processing, 2019, v. 38, n. 3, p. 1360, doi. 10.1007/s00034-018-0915-4
By:
- Gall, Oren Z.;
- Meng, Chuizhou;
- Bhamra, Hansraj;
- Mei, Henry;
- John, Simon W. M.;
- Irazoqui, Pedro P.
Publication type:
Article

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