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Inhibition of epigenetic reader proteins by apabetalone counters inflammation in activated innate immune cells from Fabry disease patients receiving enzyme replacement therapy.
Published in:
Pharmacology Research & Perspectives, 2022, v. 10, n. 3, p. 1, doi. 10.1002/prp2.949
By:
- Li Fu;
- Wasiak, Sylwia;
- Tsujikawa, Laura M.;
- Rakai, Brooke D.;
- Stotz, Stephanie C.;
- Wong, Norman C. W.;
- Johansson, Jan O.;
- Sweeney, Michael;
- Mohan, Connie M.;
- Khan, Aneal;
- Kulikowski, Ewelina
Publication type:
Article
UPREGULATING ABCA1‐MEDIATED CHOLESTEROL TRANSPORTATION BY CS6253 – OPPORTUNITY FOR CONVENIENT SC ROUTE OF ADMINISTRATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 21, p. 1, doi. 10.1002/alz.076868
By:
- Johansson, Jan O.;
- Winblad, Bengt;
- Michaelson, Daniel M;
- Zetterberg, Henrik;
- Cummings, Jeffrey L.;
- Yassine, Hussein N.
Publication type:
Article
Strong effects of the ABCA1 agonist CS6253 on Amyloidβ42/40 ratio and lipoproteins in cynomolgus monkeys.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.068189
By:
- Kerman, Bilal E.;
- Noveir, Sassan D;
- Xian, Haotian;
- Meuret, Cristiana;
- Smadi, Sabrina;
- Martinez, Ashley E.;
- Johansson, Johannes;
- Zetterberg, Henrik;
- Parks, Bryan A;
- Kuklenyik, Zsuzsanna;
- Johansson, Jan O.;
- Yassine, Hussein N.
Publication type:
Article
Favorable cognitive effects of the BET protein inhibitor apabetalone in patients 70 and older.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.057846
By:
- Johansson, Jan O;
- Cummings, Jeffrey L.;
- Zetterberg, Henrik;
- Winblad, Bengt;
- Sweeney, Mike;
- Kulikowski, Ewelina;
- Lebioda, Kenneth;
- Khan, Aziz;
- Toth, Peter P.;
- Kalantar‐Zadeh, Kam;
- Ginsburg, Henry N.;
- Nicholls, Stephen J.;
- Ray, Kausik K;
- Schwartz, Greg G
Publication type:
Article
P4‐033: ABCA1 ACTIVATION BY CS6253 AS A THERAPEUTIC FOR APOE4‐ASSOCIATED ALZHEIMER'S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1287, doi. 10.1016/j.jalz.2019.06.3692
By:
- Johansson, Jan O.;
- Yassine, Hussein N.;
- Liraz, Ori;
- Zetterberg, Henrik;
- Valencia - Olvera, Ana;
- Ladu, Mary Jo;
- Michaelson, Daniel M.
Publication type:
Article
P1‐188: APOE4 TRAPS ABCA1 IN ENDOSOMES AND IMPAIRS ITS CHOLESTEROL EFFLUX FUNCTION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P309, doi. 10.1016/j.jalz.2019.06.743
By:
- Sima, Jian;
- Rawat, Varun;
- Liraz, Ori;
- Gundimeda, Usha;
- Parekh, Trusha;
- Wang, Shaowei;
- Johansson, Jan O.;
- Chui, Helena C.;
- Harrington, Michael G.;
- Michaelson, Daniel M.;
- Yassine, Hussein N.
Publication type:
Article
P1‐058: EFFECTS OF THE EPIGENETIC BET‐INHIBITOR SMALL MOLECULE APABETALONE ON COGNITION IN PATIENTS WITH DIABETES AND CARDIOVASCULAR DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P255, doi. 10.1016/j.jalz.2019.06.083
By:
- Cummings, Jeffrey L.;
- Johansson, Jan O.;
- Sweeney, Mike;
- Kulikowski, Ewelina;
- Wong, Norman C.W.;
- Halliday, Christopher;
- Lebioda, Kenneth;
- Winblad, Bengt;
- Zetterberg, Henrik;
- Kalantar-Zadeh, Kam;
- Nicholls, Stephen J.;
- Schwartz, Greg G.;
- Ray, Kausik K.
Publication type:
Article
O5‐06‐03: NEW PARADIGMS IN TREATING APOE4‐DRIVEN DEMENTIA DISEASES: PROOF OF CONCEPT AND TRANSLATIONAL FINDINGS FROM STUDIES WITH THE ABCA1 AGONIST THERAPEUTIC CS6253.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1658, doi. 10.1016/j.jalz.2018.06.3027
By:
- Johansson, Jan O.;
- Yassine, Hussein N.;
- Boehm-Cagan, Anat;
- Zetterberg, Henrik;
- Winblad, Bengt;
- Bielicki, John K.;
- LaDu, Mary Jo;
- Michaelson, Daniel M.
Publication type:
Article
P4‐242: APOE4 AGGREGATION AND HYPOLIPIDATION IS IMPLICATED IN ALZHEIMER'S DISEASE PATHOLOGY IN CELLULAR, ANIMAL AND HUMAN STUDIES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1537, doi. 10.1016/j.jalz.2018.07.063
By:
- Yassine, Hussein N.;
- Rawat, Varun;
- Liraz, Ori;
- Johansson, Jan O.;
- Chui, Helena C.;
- Harrington, Michael;
- Michaelson, Daniel M.
Publication type:
Article
P2‐037: APABETALONE (AN EPIGENETIC BET‐INHIBITOR SMALL MOLECULE) AND EFFECTS ON COGNITION IN DIABETES PATIENTS WITH CARDIOVASCULAR DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P680, doi. 10.1016/j.jalz.2018.06.721
By:
- Cummings, Jeffrey L.;
- Johansson, Jan O.;
- Kulikowski, Ewelina;
- Wong, Norman C.W.;
- Halliday, Christopher;
- Lebioda, Ken;
- Winblad, Bengt;
- Zetterberg, Henrik;
- Kalantar-Zadeh, Kam;
- Nicholls, Stephen J.;
- Schwartz, Greg G.;
- Ray, Kausik K.;
- Sweeney, Mike
Publication type:
Article
FO080 APABETALONE, AN INHIBITOR OF BET PROTEINS, IMPROVES CARDIOVASCULAR RISK AND REDUCES ALKALINE PHOSPHATASE IN BOTH CVD PATIENTS AND PRIMARY HUMAN CELL CULTURE SYSTEMS.
Published in:
Nephrology Dialysis Transplantation, 2019, v. 34, p. N.PAG, doi. 10.1093/ndt/gfz096.FO080
By:
- Gilham, Dean;
- Tsujikawa, Laura;
- Wasiak, Sylwia;
- Halliday, Christopher;
- Lebioda, Ken;
- Kalantar-Zadeh, Kamyar;
- Beddhu, Srinivasan;
- Brandenburg, Vincent;
- Tonelli, Marcello;
- Jahagirdar, Ravi;
- Wong, Norman C W;
- Zoccali, Carmine;
- Johansson, Jan O;
- Sweeney, Michael;
- Haarhaus, Mathias;
- Kulikowski, Ewelina
Publication type:
Article
Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease.
Published in:
Cardiovascular Therapeutics, 2020, p. 1, doi. 10.1155/2020/9397109
By:
- Wasiak, Sylwia;
- Gilham, Dean;
- Daze, Emily;
- Tsujikawa, Laura M.;
- Halliday, Christopher;
- Stotz, Stephanie C.;
- Rakai, Brooke D.;
- Fu, Li;
- Jahagirdar, Ravi;
- Sweeney, Michael;
- Johansson, Jan O.;
- Wong, Norman C. W.;
- Kulikowski, Ewelina
Publication type:
Article
THE ABCA1 AGONIST CS6253 REVERSES APOE4-DRIVEN ALZHEIMER’S DISEASE IN APOE4 TR MICE AND SHOWS CONCOMITANT PLASMA AND BRAIN APOE AND APOJ CHANGES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P267, doi. 10.1016/j.jalz.2017.06.143
By:
- Johansson, Jan O.;
- Boehm-Cagan, Anat;
- Bielicki, John K.;
- Michaelson, Daniel M.
Publication type:
Article
THE ABCA-1 AGONIST (CS-6253) REVERSES APOE4 HYPOLIPIDATION IN ALZHEIMER’S DISEASE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P1257, doi. 10.1016/j.jalz.2017.06.1874
By:
- Rawat, Varun;
- Feng, Qingru;
- Michaelson, Daniel M.;
- Chui, Helena C.;
- Fonteh, Alfred;
- Johansson, Jan O.;
- Bielicki, John K.;
- Harrington, Michael;
- Yassine, Hussein N.
Publication type:
Article
THE NOVEL APOE4 THERAPEUTIC CS6253 PENETRATES THE BLOOD BRAIN BARRIER, UPREGULATES THE ABCA1 TRANSPORTER AND PREVENTS ALZHEIMER’S DISEASE PATHOGENESIS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P181, doi. 10.1016/j.jalz.2016.06.313
By:
- Johansson, Jan O.;
- Boehm-Cagan, Anat;
- Bielicki, John K.;
- Michaelson, Daniel M.
Publication type:
Article
Correction of ApoE4 dysfunction and reversal of Alzheimer’s disease phenotype and cognition in ApoE4 target replacement mice by cogpepb, an abca1 agonist peptide derived from the lipid binding segment of ApoE.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P611, doi. 10.1016/j.jalz.2015.06.851
By:
- Boehm-Cagan, Anat;
- Johansson, Jan O.;
- Bielicki, John K.;
- Michaelson, Daniel M.
Publication type:
Article
Novel Apo E-Derived ABCA1 Agonist Peptide (CS-6253) Promotes Reverse Cholesterol Transport and Induces Formation of preβ-1 HDL In Vitro.
Published in:
PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0131997
By:
- Hafiane, Anouar;
- Bielicki, John K.;
- Johansson, Jan O.;
- Genest, Jacques
Publication type:
Article
Relation of insulin treatment for type 2 diabetes to the risk of major adverse cardiovascular events after acute coronary syndrome: an analysis of the BETonMACE randomized clinical trial.
Published in:
Cardiovascular Diabetology, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12933-021-01311-9
By:
- Schwartz, Gregory G.;
- Nicholls, Stephen J.;
- Toth, Peter P.;
- Sweeney, Michael;
- Halliday, Christopher;
- Johansson, Jan O.;
- Wong, Norman C. W.;
- Kulikowski, Ewelina;
- Kalantar-Zadeh, Kamyar;
- Ginsberg, Henry N.;
- Ray, Kausik K.
Publication type:
Article
Apabetalone and hospitalization for heart failure in patients following an acute coronary syndrome: a prespecified analysis of the BETonMACE study.
Published in:
Cardiovascular Diabetology, 2021, v. 20, n. 1, p. 1, doi. 10.1186/s12933-020-01199-x
By:
- Nicholls, Stephen J.;
- Schwartz, Gregory G.;
- Buhr, Kevin A.;
- Ginsberg, Henry N.;
- Johansson, Jan O.;
- Kalantar-Zadeh, Kamyar;
- Kulikowski, Ewelina;
- Toth, Peter P.;
- Wong, Norman;
- Sweeney, Michael;
- Ray, Kausik K.
Publication type:
Article
Selective BET Protein Inhibition with Apabetalone and Cardiovascular Events: A Pooled Analysis of Trials in Patients with Coronary Artery Disease.
Published in:
American Journal of Cardiovascular Drugs, 2018, v. 18, n. 2, p. 109, doi. 10.1007/s40256-017-0250-3
By:
- Nicholls, Stephen J.;
- Ray, Kausik K.;
- Johansson, Jan O.;
- Gordon, Alan;
- Sweeney, Michael;
- Halliday, Chris;
- Kulikowski, Ewelina;
- Wong, Norman;
- Kim, Susan W.;
- Schwartz, Gregory G.
Publication type:
Article
BET protein inhibitor apabetalone (RVX-208) suppresses pro-inflammatory hyper-activation of monocytes from patients with cardiovascular disease and type 2 diabetes.
Published in:
Clinical Epigenetics, 2020, v. 12, n. 1, p. N.PAG, doi. 10.1186/s13148-020-00943-0
By:
- Wasiak, Sylwia;
- Dzobo, Kim E.;
- Rakai, Brooke D.;
- Kaiser, Yannick;
- Versloot, Miranda;
- Bahjat, Mahnoush;
- Stotz, Stephanie C.;
- Fu, Li;
- Sweeney, Michael;
- Johansson, Jan O.;
- Wong, Norman C. W.;
- Stroes, Erik S. G.;
- Kroon, Jeffrey;
- Kulikowski, Ewelina
Publication type:
Article
Apabetalone (RVX-208) reduces vascular inflammation in vitro and in CVD patients by a BET-dependent epigenetic mechanism.
Published in:
Clinical Epigenetics, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13148-019-0696-z
By:
- Tsujikawa, Laura M.;
- Fu, Li;
- Das, Shovon;
- Halliday, Christopher;
- Rakai, Brooke D.;
- Stotz, Stephanie C.;
- Sarsons, Christopher D.;
- Gilham, Dean;
- Daze, Emily;
- Wasiak, Sylwia;
- Studer, Deborah;
- Rinker, Kristina D.;
- Sweeney, Michael;
- Johansson, Jan O.;
- Wong, Norman C. W.;
- Kulikowski, Ewelina
Publication type:
Article
Effect of Apabetalone Added to Standard Therapy on Major Adverse Cardiovascular Events in Patients With Recent Acute Coronary Syndrome and Type 2 Diabetes: A Randomized Clinical Trial.
Published in:
2020
By:
- Ray, Kausik K.;
- Nicholls, Stephen J.;
- Buhr, Kevin A.;
- Ginsberg, Henry N.;
- Johansson, Jan O.;
- Kalantar-Zadeh, Kamyar;
- Kulikowski, Ewelina;
- Toth, Peter P.;
- Wong, Norman;
- Sweeney, Michael;
- Schwartz, Gregory G.;
- BETonMACE Investigators and Committees
Publication type:
journal article
Differential Effects of apoE4 and Activation of ABCA1 on Brain and Plasma Lipoproteins.
Published in:
PLoS ONE, 2016, v. 11, n. 11, p. 1, doi. 10.1371/journal.pone.0166195
By:
- Boehm-Cagan, Anat;
- Bar, Roni;
- Harats, Dror;
- Shaish, Aviv;
- Levkovitz, Hana;
- Bielicki, John K.;
- Johansson, Jan O.;
- Michaelson, Daniel M.
Publication type:
Article
Apabetalone Downregulates Fibrotic, Inflammatory and Calcific Processes in Renal Mesangial Cells and Patients with Renal Impairment.
Published in:
Biomedicines, 2023, v. 11, n. 6, p. 1663, doi. 10.3390/biomedicines11061663
By:
- Gilham, Dean;
- Wasiak, Sylwia;
- Rakai, Brooke D.;
- Fu, Li;
- Tsujikawa, Laura M.;
- Sarsons, Christopher D.;
- Carestia, Agostina;
- Lebioda, Kenneth;
- Johansson, Jan O.;
- Sweeney, Michael;
- Kalantar-Zadeh, Kamyar;
- Kulikowski, Ewelina
Publication type:
Article
Bromodomain and Extraterminal Protein Inhibitor, Apabetalone (RVX-208), Reduces ACE2 Expression and Attenuates SARS-Cov-2 Infection In Vitro.
Published in:
Biomedicines, 2021, v. 9, n. 4, p. 437, doi. 10.3390/biomedicines9040437
By:
- Gilham, Dean;
- Smith, Audrey L.;
- Fu, Li;
- Moore, Dalia Y.;
- Muralidharan, Abenaya;
- Reid, St. Patrick M.;
- Stotz, Stephanie C.;
- Johansson, Jan O.;
- Sweeney, Michael;
- Wong, Norman C. W.;
- Kulikowski, Ewelina;
- El-Gamal, Dalia
Publication type:
Article
ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes.
Published in:
Journal of Neuroscience, 2019, v. 39, n. 48, p. 9611, doi. 10.1523/JNEUROSCI.1400-19.2019
By:
- Rawat, Varun;
- Shaowei Wang;
- Jian Sima;
- Bar, Roni;
- Liraz, Ori;
- Gundimeda, Usha;
- Parekh, Trusha;
- Chan, Jamie;
- Johansson, Jan O.;
- Chongren Tang;
- Chui, Helena C.;
- Harrington, Michael G.;
- Michaelson, Daniel M.;
- Yassine, Hussein N.
Publication type:
Article
Effect of the ABCA1 agonist CS-6253 on amyloid-β and lipoprotein metabolism in cynomolgus monkeys.
Published in:
Alzheimer's Research & Therapy, 2022, v. 14, n. 1, p. 1, doi. 10.1186/s13195-022-01028-1
By:
- Noveir, Sasan D.;
- Kerman, Bilal E.;
- Xian, Haotian;
- Meuret, Cristiana;
- Smadi, Sabrina;
- Martinez, Ashley E.;
- Johansson, Johannes;
- Zetterberg, Henrik;
- Parks, Bryan A.;
- Kuklenyik, Zsuzsanna;
- Mack, Wendy J.;
- Johansson, Jan O.;
- Yassine, Hussein N.
Publication type:
Article
474-P: Apabetalone (RVX-208) Attenuates an Inflammatory Milieu that Enhances Adhesion of Monocytes to Endothelial Cells in Type 2 Diabetes Mellitus with Cardiovascular Disease Patients.
Published in:
Diabetes, 2019, v. 68, p. N.PAG, doi. 10.2337/db19-474-P
By:
- TSUJIKAWA, LAURA;
- KULIKOWSKI, EWELINA;
- CALOSING, CYRUS;
- WASIAK, SYLWIA;
- GILHAM, DEAN;
- HALLIDAY, CHRISTOPHER;
- JOHANSSON, JAN O.;
- SWEENEY, MICHAEL;
- WONG, NORMAN C.
Publication type:
Article

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