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Zebrafish Patient-Derived Xenograft Model as a Preclinical Platform for Uveal Melanoma Drug Discovery.
Published in:
Pharmaceuticals (14248247), 2023, v. 16, n. 4, p. 598, doi. 10.3390/ph16040598
By:
- Yin, Jie;
- Zhao, Gangyin;
- Kalirai, Helen;
- Coupland, Sarah E.;
- Jochemsen, Aart G.;
- Forn-Cuní, Gabriel;
- Wierenga, Annemijn P. A.;
- Jager, Martine J.;
- Snaar-Jagalska, B. Ewa;
- Groenewoud, Arwin
Publication type:
Article
Overexpression of EZH2 in conjunctival melanoma offers a new therapeutic target.
Published in:
Journal of Pathology, 2018, v. 245, n. 4, p. 433, doi. 10.1002/path.5094
By:
- Cao, Jinfeng;
- Pontes, Kelly C. S.;
- Heijkants, Renier C.;
- Brouwer, Niels J.;
- Groenewoud, Arwin;
- Jordanova, Ekaterina S.;
- Marinkovic, Marina;
- van Duinen, Sjoerd;
- Teunisse, Amina F. A. S.;
- Verdijk, Robert M.;
- Snaar‐Jagalska, Ewa;
- Jochemsen, Aart G.;
- Jager, Martine J.
Publication type:
Article
MDM4 is a rational target for treating breast cancers with mutant p53.
Published in:
Journal of Pathology, 2017, v. 241, n. 5, p. 661, doi. 10.1002/path.4877
By:
- Miranda, Panimaya Jeffreena;
- Buckley, Daniel;
- Raghu, Dinesh;
- Pang, Jia‐Min B;
- Takano, Elena A;
- Vijayakumaran, Reshma;
- Teunisse, Amina FAS;
- Posner, Atara;
- Procter, Tahlia;
- Herold, Marco J;
- Gamell, Cristina;
- Marine, Jean‐Christophe;
- Fox, Stephen B;
- Jochemsen, Aart;
- Haupt, Sue;
- Haupt, Ygal
Publication type:
Article
Fluorescent CXCR4 targeting peptide as alternative for antibody staining in Ewing sarcoma.
Published in:
2017
By:
- Sand, Laurens G. L.;
- Buckle, Tessa;
- van Leeuwen, Fijs W. B.;
- Corver, Willem E.;
- Kruisselbrink, Alwine B.;
- Jochemsen, Aart G.;
- Hogendoorn, Pancras C. W.;
- Szuhai, Károly
Publication type:
journal article
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms.
Published in:
EMBO Reports, 2001, v. 2, n. 11, p. 1029, doi. 10.1093/embo-reports/kve227
By:
- Stad, Robert;
- Little, Natalie A.;
- Xirodimas, Dimitris P.;
- Frenk, Ruth;
- van der Eb, Alex J.;
- Lane, David P.;
- Saville, Mark K.;
- Jochemsen, Aart G.
Publication type:
Article
Distinct p53-independent apoptotic cell death signalling pathways in testicular germ cell tumour cell lines.
Published in:
International Journal of Cancer, 1999, v. 81, n. 4, p. 620, doi. 10.1002/(SICI)1097-0215(19990517)81:4<620::AID-IJC19>3.0.CO;2-S
By:
- Burger, Herman;
- Nooter, Kees;
- Boersma, Antonius W.M.;
- van Wingerden, Kyra E.;
- Looijenga, Leendert H.J.;
- Jochemsen, Aart G.;
- Stoter, Gerrit
Publication type:
Article
MDM4 is a key therapeutic target in cutaneous melanoma.
Published in:
Nature Medicine, 2012, v. 18, n. 8, p. 1239, doi. 10.1038/nm.2863
By:
- Gembarska, Agnieszka;
- Luciani, Flavie;
- Fedele, Clare;
- Russell, Elisabeth A;
- Dewaele, Michael;
- Villar, Stéphanie;
- Zwolinska, Aleksandra;
- Haupt, Sue;
- de Lange, Job;
- Yip, Dana;
- Goydos, James;
- Haigh, Jody J;
- Haupt, Ygal;
- Larue, Lionel;
- Jochemsen, Aart;
- Shi, Hubing;
- Moriceau, Gatien;
- Lo, Roger S;
- Ghanem, Ghanem;
- Shackleton, Mark
Publication type:
Article
Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53.
Published in:
Journal of Pathology, 2014, v. 233, n. 4, p. 415, doi. 10.1002/path.4378
By:
- van der Ent, Wietske;
- Jochemsen, Aart G;
- Teunisse, Amina FAS;
- Krens, SF Gabriel;
- Szuhai, Karoly;
- Spaink, Herman P;
- Hogendoorn, Pancras CW;
- Snaar ‐ Jagalska, B Ewa
Publication type:
Article
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53.
Published in:
Nature Genetics, 2001, v. 29, n. 1, p. 92, doi. 10.1038/ng714
By:
- Parant, John;
- Chavez-Reyes, Arturo;
- Little, Natalie A.;
- Yan, Wen;
- Reinke, Valerie;
- Jochemsen, Aart G.;
- Lozano, Guillermina
Publication type:
Article
Patient-derived zebrafish xenografts of uveal melanoma reveal ferroptosis as a drug target.
Published in:
Cell Death Discovery, 2023, v. 9, n. 1, p. 1, doi. 10.1038/s41420-023-01446-6
By:
- Groenewoud, Arwin;
- Yin, Jie;
- Gelmi, Maria Chiara;
- Alsafadi, Samar;
- Nemati, Fariba;
- Decaudin, Didier;
- Roman-Roman, Sergio;
- Kalirai, Helen;
- Coupland, Sarah E.;
- Jochemsen, Aart G.;
- Jager, Martine J.;
- Engel, Felix B.;
- Snaar-Jagalska, B. E.
Publication type:
Article
MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts.
Published in:
Oncogene, 2002, v. 21, n. 6, p. 867, doi. 10.1038/sj.onc.1205137
By:
- Gentiletti, Francesca;
- Mancini, Francesca;
- D'Angelo, Marco;
- Saachi, Ada;
- Pontecorvi, Alfredo;
- Jochemsen, Aart G.;
- Moretti, Fabiola
Publication type:
Article
Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.
Published in:
Oncogene, 2001, v. 20, n. 33, p. 4576, doi. 10.1038/sj.onc.1204615
By:
- Little, Natalie A;
- Jochemsen, Aart G
Publication type:
Article
FAK Inhibitor-Based Combinations with MEK or PKC Inhibitors Trigger Synergistic Antitumor Effects in Uveal Melanoma.
Published in:
Cancers, 2023, v. 15, n. 8, p. 2280, doi. 10.3390/cancers15082280
By:
- Tarin, Malcy;
- Némati, Fariba;
- Decaudin, Didier;
- Canbezdi, Christine;
- Marande, Benjamin;
- Silva, Lisseth;
- Derrien, Héloïse;
- Jochemsen, Aart G.;
- Gardrat, Sophie;
- Piperno-Neumann, Sophie;
- Rodrigues, Manuel;
- Mariani, Pascale;
- Cassoux, Nathalie;
- Stern, Marc-Henri;
- Roman-Roman, Sergio;
- Alsafadi, Samar
Publication type:
Article
MDMX Regulates Transcriptional Activity of p53 and FOXO Proteins to Stimulate Proliferation of Melanoma Cells.
Published in:
Cancers, 2022, v. 14, n. 18, p. N.PAG, doi. 10.3390/cancers14184482
By:
- Heijkants, Renier C.;
- Teunisse, Amina F. A. S.;
- de Jong, Danielle;
- Glinkina, Kseniya;
- Mei, Hailiang;
- Kielbasa, Szymon M.;
- Szuhai, Karoly;
- Jochemsen, Aart G.
Publication type:
Article
Targeting MDM4 as a Novel Therapeutic Approach in Prostate Cancer Independent of p53 Status.
Published in:
Cancers, 2022, v. 14, n. 16, p. 3947, doi. 10.3390/cancers14163947
By:
- Mejía-Hernández, Javier Octavio;
- Raghu, Dinesh;
- Caramia, Franco;
- Clemons, Nicholas;
- Fujihara, Kenji;
- Riseborough, Thomas;
- Teunisse, Amina;
- Jochemsen, Aart G.;
- Abrahmsén, Lars;
- Blandino, Giovanni;
- Russo, Andrea;
- Gamell, Cristina;
- Fox, Stephen B.;
- Mitchell, Catherine;
- Takano, Elena A.;
- Byrne, David;
- Miranda, Panimaya Jeffreena;
- Saleh, Reem;
- Thorne, Heather;
- Sandhu, Shahneen
Publication type:
Article
Novel Treatments of Uveal Melanoma Identified with a Synthetic Lethal CRISPR/Cas9 Screen.
Published in:
Cancers, 2022, v. 14, n. 13, p. N.PAG, doi. 10.3390/cancers14133186
By:
- Glinkina, Kseniya;
- Groenewoud, Arwin;
- Teunisse, Amina F. A. S.;
- Snaar-Jagalska, B. Ewa;
- Jochemsen, Aart G.
Publication type:
Article
Expression of HDACs 1, 3 and 8 Is Upregulated in the Presence of Infiltrating Lymphocytes in Uveal Melanoma.
Published in:
Cancers, 2021, v. 13, n. 16, p. 4146, doi. 10.3390/cancers13164146
By:
- Souri, Zahra;
- Jochemsen, Aart G.;
- Wierenga, Annemijn P. A.;
- Kroes, Wilma G. M.;
- Verdijk, Rob M.;
- van der Velden, Pieter A.;
- Luyten, Gregorius P. M.;
- Jager, Martine J.
Publication type:
Article
HDAC Inhibition Increases HLA Class I Expression in Uveal Melanoma.
Published in:
Cancers, 2020, v. 12, n. 12, p. 3690, doi. 10.3390/cancers12123690
By:
- Souri, Zahra;
- Jochemsen, Aart G.;
- Versluis, Mieke;
- Wierenga, Annemijn P.A.;
- Nemati, Fariba;
- van der Velden, Pieter A.;
- Kroes, Wilma G.M.;
- Verdijk, Robert M.;
- Luyten, Gregorius P.M.;
- Jager, Martine J.
Publication type:
Article
HLA Expression in Uveal Melanoma: An Indicator of Malignancy and a Modifiable Immunological Target.
Published in:
Cancers, 2019, v. 11, n. 8, p. 1132, doi. 10.3390/cancers11081132
By:
- Souri, Zahra;
- Wierenga, Annemijn P.A.;
- Mulder, Arend;
- Jochemsen, Aart G.;
- Jager, Martine J.
Publication type:
Article
Differential Expression of DNA Repair Genes in Prognostically-Favorable versus Unfavorable Uveal Melanoma.
Published in:
Cancers, 2019, v. 11, n. 8, p. 1104, doi. 10.3390/cancers11081104
By:
- Dogrusöz, Mehmet;
- Ruschel Trasel, Andrea;
- Cao, Jinfeng;
- Ҫolak, Selҫuk;
- van Pelt, Sake I.;
- Kroes, Wilma G. M.;
- Teunisse, Amina F. A. S.;
- Alsafadi, Samar;
- van Duinen, Sjoerd G.;
- Luyten, Gregorius P. M.;
- van der Velden, Pieter A.;
- Amaro, Adriana;
- Pfeffer, Ulrich;
- Jochemsen, Aart G.;
- Jager, Martine J.
Publication type:
Article
Loss of BAP1 Is Associated with Upregulation of the NFkB Pathway and Increased HLA Class I Expression in Uveal Melanoma.
Published in:
Cancers, 2019, v. 11, n. 8, p. 1102, doi. 10.3390/cancers11081102
By:
- Souri, Zahra;
- Wierenga, Annemijn P. A.;
- van Weeghel, Christiaan;
- van der Velden, Pieter A.;
- Kroes, Wilma G. M.;
- Luyten, Gregorius P. M.;
- van der Burg, Sjoerd H.;
- Jochemsen, Aart G.;
- Jager, Martine J.
Publication type:
Article
So Close, yet so Far: Discrepancies between Uveal and Other Melanomas. A Position Paper from UM Cure 2020.
Published in:
Cancers, 2019, v. 11, n. 7, p. 1032, doi. 10.3390/cancers11071032
By:
- Rodrigues, Manuel;
- de Koning, Leanne;
- Coupland, Sarah E.;
- Jochemsen, Aart G.;
- Marais, Richard;
- Stern, Marc-Henri;
- Valente, André;
- Barnhill, Raymond;
- Cassoux, Nathalie;
- Evans, Andrew;
- Galloway, Iain;
- Jager, Martine J.;
- Kapiteijn, Ellen;
- Romanowska-Dixon, Bozena;
- Ryll, Bettina;
- Roman-Roman, Sergio;
- Piperno-Neumann, Sophie
Publication type:
Article
Wild-type p53 inhibits pro-invasive properties of TGF-β3 in breast cancer, in part through regulation of EPHB2, a new TGF-β target gene.
Published in:
Breast Cancer Research & Treatment, 2014, v. 148, n. 1, p. 7, doi. 10.1007/s10549-014-3147-8
By:
- Lam, Suzanne;
- Wiercinska, Eliza;
- Teunisse, Amina;
- Lodder, Kirsten;
- ten Dijke, Peter;
- Jochemsen, Aart
Publication type:
Article
Inactivation of the p53 pathway in retinoblastoma.
Published in:
Nature, 2006, v. 444, n. 7115, p. 61, doi. 10.1038/nature05194
By:
- Laurie, Nikia A.;
- Donovan, Stacy L.;
- Shih, Chie-Schin;
- Zhang, Jiakun;
- Mills, Nicholas;
- Fuller, Christine;
- Teunisse, Amina;
- Lam, Suzanne;
- Ramos, Yolande;
- Mohan, Adithi;
- Johnson, Dianna;
- Wilson, Matthew;
- Rodriguez-Galindo, Carlos;
- Quarto, Micaela;
- Francoz, Sarah;
- Mendrysa, Susan M.;
- Kiplin Guy, R.;
- Marine, Jean-Christophe;
- Jochemsen, Aart G.;
- Dyer, Michael A.
Publication type:
Article
Synthetic lethality between Rb, p53 and Dicer or miR-17-92 in retinal progenitors suppresses retinoblastoma formation.
Published in:
Nature Cell Biology, 2012, v. 14, n. 9, p. 958, doi. 10.1038/ncb2556
By:
- Nittner, David;
- Lambertz, Irina;
- Clermont, Frederic;
- Mestdagh, Pieter;
- Köhler, Corinna;
- Nielsen, Søren Jensby;
- Jochemsen, Aart;
- Speleman, Frank;
- Vandesompele, Jo;
- Dyer, Michael A.;
- Schramm, Alexander;
- Schulte, Johannes H.;
- Marine, Jean-Christophe
Publication type:
Article
EGR-1 enhances tumor growth and modulates the effect of the Wilms' tumor 1 gene products on tumorigenicity.
Published in:
Oncogene, 2000, v. 19, n. 6, p. 791, doi. 10.1038/sj.onc.1203390
By:
- Scharnhorst, Volkher;
- Menke, Aswin L;
- Attema, Joline;
- Haneveld, Johan Klein;
- Riteco, Nicole;
- van Steenbrugge, Gert J;
- van der Eb, Alex J;
- Jochemsen, Aart G
Publication type:
Article
Comparative study of the p53-mdm2 and p53-MDMX interfaces.
Published in:
Oncogene, 1999, v. 18, n. 1, p. 189, doi. 10.1038/sj.onc.1202281
By:
- Böttger, Volker;
- Böttger, Angelika;
- Garcia-Echeverria, Carlos;
- Ramos, Yolande FM;
- van der Eb, Alex J;
- Jochemsen, Aart G;
- Lane, David P
Publication type:
Article
Central chondrosarcoma progression is associated with pRb pathway alterations: CDK4 down-regulation and p16 overexpression inhibit cell growth in vitro.
Published in:
Journal of Cellular & Molecular Medicine, 2009, v. 13, n. 9a, p. 2843, doi. 10.1111/j.1582-4934.2008.00406.x
By:
- Schrage, Yvonne M.;
- Lam, Suzanne;
- Jochemsen, Aart G.;
- Cleton-Jansen, Anne-Marie;
- Taminiau, Antonie H. M.;
- Hogendoorn, Pancras C. W.;
- Bovée, Judith V. M. G.
Publication type:
Article
Inflammation‐related MiRNAs are associated with Monosomy 3 in Uveal Melanoma.
Published in:
Acta Ophthalmologica (1755375X), 2021, v. 99, p. N.PAG, doi. 10.1111/j.1755-3768.2020.0271
By:
- Souri, Zahra;
- Jochemsen, Aart G.;
- Verdijk, Robert;
- van der Velden, Pieter A.;
- Luyten, Gregorius;
- Jager, Martine
Publication type:
Article
Analysis of CRISPR‐Cas9 screens identifies genetic dependencies in melanoma.
Published in:
Pigment Cell & Melanoma Research, 2021, v. 34, n. 1, p. 122, doi. 10.1111/pcmr.12919
By:
- Christodoulou, Eirini;
- Rashid, Mamunur;
- Pacini, Clare;
- Droop, Alastair;
- Robertson, Holly;
- Groningen, Tim van;
- Teunisse, Amina F. A. S.;
- Iorio, Francesco;
- Jochemsen, Aart G.;
- Adams, David J.;
- Doorn, Remco van
Publication type:
Article
Cytoplasmic tethering is involved in synergistic inhibition of p53 by Mdmx and Mdm2.
Published in:
Cancer Science, 2009, v. 100, n. 7, p. 1291, doi. 10.1111/j.1349-7006.2009.01180.x
By:
- Ohtsubo, Chihiro;
- Shiokawa, Daisuke;
- Kodama, Masami;
- Gaiddon, Christian;
- Nakagama, Hitoshi;
- Jochemsen, Aart G.;
- Taya, Yoichi;
- Okamoto, Koji
Publication type:
Article
Functions of MDMX in the Modulation of the p53-Response.
Published in:
Journal of Biomedicine & Biotechnology, 2011, p. 1, doi. 10.1155/2011/876173
By:
- Lenos, Kristiaan;
- Jochemsen, Aart G.
Publication type:
Article

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