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Der zytotoxische Naturstoff Vioprolid A interagiert mit dem für die Ribosomen‐Biogenese essentiellen nukleolären Protein 14.
Published in:
Angewandte Chemie, 2020, v. 132, n. 4, p. 1611, doi. 10.1002/ange.201911158
By:
- Kirsch, Volker C.;
- Orgler, Christina;
- Braig, Simone;
- Jeremias, Irmela;
- Auerbach, David;
- Müller, Rolf;
- Vollmar, Angelika M.;
- Sieber, Stephan A.
Publication type:
Article
Lessons learned: the first consecutive 1000 patients of the CCCMunich<sup>LMU</sup> Molecular Tumor Board.
Published in:
Journal of Cancer Research & Clinical Oncology, 2023, v. 149, n. 5, p. 1905, doi. 10.1007/s00432-022-04165-0
By:
- Heinrich, Kathrin;
- Miller-Phillips, Lisa;
- Ziemann, Frank;
- Hasselmann, Korbinian;
- Rühlmann, Katharina;
- Flach, Madeleine;
- Biro, Dorottya;
- von Bergwelt-Baildon, Michael;
- Holch, Julian;
- Herold, Tobias;
- von Baumgarten, Louisa;
- Greif, Philipp A.;
- Jeremias, Irmela;
- Wuerstlein, Rachel;
- Casuscelli, Jozefina;
- Spitzweg, Christine;
- Seidensticker, Max;
- Renz, Bernhard;
- Corradini, Stefanie;
- Baumeister, Philipp
Publication type:
Article
X‐linked inhibitor of apoptosis protein represents a promising therapeutic target for relapsed/refractory ALL.
Published in:
EMBO Molecular Medicine, 2023, v. 15, n. 1, p. 1, doi. 10.15252/emmm.202114557
By:
- Carlet, Michela;
- Schmelz, Karin;
- Vergalli, Jenny;
- Herold, Tobias;
- Senft, Daniela;
- Jurinovic, Vindi;
- Hoffmann, Thomas;
- Proba, Jutta;
- Weichert, Nina;
- Junghanß, Christian;
- Roth, Mareike;
- Eschenburg, Georg;
- Barz, Malwine;
- Henze, Günter;
- Eckert, Cornelia;
- Eggert, Angelika;
- Zuber, Johannes;
- Hundsdoerfer, Patrick;
- Jeremias, Irmela
Publication type:
Article
The ubiquitin ligase RNF5 determines acute myeloid leukemia growth and susceptibility to histone deacetylase inhibitors.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25664-7
By:
- Khateb, Ali;
- Deshpande, Anagha;
- Feng, Yongmei;
- Finlay, Darren;
- Lee, Joo Sang;
- Lazar, Ikrame;
- Fabre, Bertrand;
- Li, Yan;
- Fujita, Yu;
- Zhang, Tongwu;
- Yin, Jun;
- Pass, Ian;
- Livneh, Ido;
- Jeremias, Irmela;
- Burian, Carol;
- Mason, James R.;
- Almog, Ronit;
- Horesh, Nurit;
- Ofran, Yishai;
- Brown, Kevin
Publication type:
Article
Disruption of the PRKCD-FBXO25-HAX-1 axis attenuates the apoptotic response and drives lymphomagenesis.
Published in:
Nature Medicine, 2014, v. 20, n. 12, p. 1401, doi. 10.1038/nm.3740
By:
- Baumann, Ursula;
- Fernández-Sáiz, Vanesa;
- Rudelius, Martina;
- Lemeer, Simone;
- Rad, Roland;
- Knorn, Anna-Maria;
- Slawska, Jolanta;
- Engel, Katharina;
- Jeremias, Irmela;
- Li, Zhoulei;
- Tomiatti, Viktoriya;
- Illert, Anna-Lena;
- Targosz, Bianca-Sabrina;
- Braun, Martin;
- Perner, Sven;
- Leitges, Michael;
- Klapper, Wolfram;
- Dreyling, Martin;
- Miething, Cornelius;
- Lenz, Georg
Publication type:
Article
Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL.
Published in:
Biomarker Research, 2020, v. 8, n. 1, p. N.PAG, doi. 10.1186/s40364-020-00226-z
By:
- Liu, Wen-Hsin;
- Mrozek-Gorska, Paulina;
- Wirth, Anna-Katharina;
- Herold, Tobias;
- Schwarzkopf, Larissa;
- Pich, Dagmar;
- Völse, Kerstin;
- Melo-Narváez, M. Camila;
- Carlet, Michela;
- Hammerschmidt, Wolfgang;
- Jeremias, Irmela
Publication type:
Article
Inducible transgene expression in PDX models in vivo identifies KLF4 as a therapeutic target for B-ALL.
Published in:
Biomarker Research, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40364-020-00226-z
By:
- Liu, Wen-Hsin;
- Mrozek-Gorska, Paulina;
- Wirth, Anna-Katharina;
- Herold, Tobias;
- Schwarzkopf, Larissa;
- Pich, Dagmar;
- Völse, Kerstin;
- Melo-Narváez, M. Camila;
- Carlet, Michela;
- Hammerschmidt, Wolfgang;
- Jeremias, Irmela
Publication type:
Article
Prime-seq, efficient and powerful bulk RNA sequencing.
Published in:
Genome Biology, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s13059-022-02660-8
By:
- Janjic, Aleksandar;
- Wange, Lucas E.;
- Bagnoli, Johannes W.;
- Geuder, Johanna;
- Nguyen, Phong;
- Richter, Daniel;
- Vieth, Beate;
- Vick, Binje;
- Jeremias, Irmela;
- Ziegenhain, Christoph;
- Hellmann, Ines;
- Enard, Wolfgang
Publication type:
Article
An Advanced Preclinical Mouse Model for Acute Myeloid Leukemia Using Patients' Cells of Various Genetic Subgroups and In Vivo Bioluminescence Imaging.
Published in:
PLoS ONE, 2015, v. 10, n. 3, p. 1, doi. 10.1371/journal.pone.0120925
By:
- Vick, Binje;
- Rothenberg, Maja;
- Sandhöfer, Nadine;
- Carlet, Michela;
- Finkenzeller, Cornelia;
- Krupka, Christina;
- Grunert, Michaela;
- Trumpp, Andreas;
- Corbacioglu, Selim;
- Ebinger, Martin;
- André, Maya C.;
- Hiddemann, Wolfgang;
- Schneider, Stephanie;
- Subklewe, Marion;
- Metzeler, Klaus H.;
- Spiekermann, Karsten;
- Jeremias, Irmela
Publication type:
Article
In Vivo Imaging Enables High Resolution Preclinical Trials on Patients' Leukemia Cells Growing in Mice.
Published in:
PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0052798
By:
- Terziyska, Nadia;
- Alves, Catarina Castro;
- Groiss, Volker;
- Schneider, Katja;
- Farkasova, Katarina;
- Ogris, Manfred;
- Wagner, Ernst;
- Ehrhardt, Harald;
- Brentjens, Renier J.;
- Stadt, Udo zur;
- Horstmann, Martin;
- Quintanilla-Martinez, Leticia;
- Jeremias, Irmela
Publication type:
Article
CD95/Apo-1/Fas: independent cell death induced by doxorubicin in normal cultured cardiomyocytes.
Published in:
Cancer Immunology, Immunotherapy, 2005, v. 54, n. 7, p. 655, doi. 10.1007/s00262-004-0604-y
By:
- Jeremias, Irmela;
- Stahnke, Karsten;
- Debatin, Klaus
Publication type:
Article
Cooperation of betulinic acid and TRAIL to induce apoptosis in tumor cells.
Published in:
Oncogene, 2004, v. 23, n. 46, p. 7611, doi. 10.1038/sj.onc.1207970
By:
- Fulda, Simone;
- Jeremias, Irmela;
- Debatin, Klaus-Michael
Publication type:
Article
TRAIL induced survival and proliferation in cancer cells resistant towards TRAIL-induced apoptosis mediated by NF-?B.
Published in:
Oncogene, 2003, v. 22, n. 25, p. 3842, doi. 10.1038/sj.onc.1206520
By:
- Ehrhardt, Harald;
- Fulda, Simone;
- Schmid, Irene;
- Hiscott, John;
- Debatin, Klaus-Michael;
- Jeremias, Irmela
Publication type:
Article
The Multi-Kinase Inhibitor EC-70124 Is a Promising Candidate for the Treatment of FLT3-ITD-Positive Acute Myeloid Leukemia.
Published in:
Cancers, 2022, v. 14, n. 6, p. 1593, doi. 10.3390/cancers14061593
By:
- Lopez-Millan, Belen;
- Costales, Paula;
- Gutiérrez-Agüera, Francisco;
- Díaz de la Guardia, Rafael;
- Roca-Ho, Heleia;
- Vinyoles, Meritxell;
- Rubio-Gayarre, Alba;
- Safi, Rémi;
- Castaño, Julio;
- Romecín, Paola Alejandra;
- Ramírez-Orellana, Manuel;
- Anguita, Eduardo;
- Jeremias, Irmela;
- Zamora, Lurdes;
- Rodríguez-Manzaneque, Juan Carlos;
- Bueno, Clara;
- Morís, Francisco;
- Menendez, Pablo
Publication type:
Article
CD79a promotes CNS-infiltration and leukemia engraftment in pediatric B-cell precursor acute lymphoblastic leukemia.
Published in:
Communications Biology, 2021, v. 4, n. 1, p. 1, doi. 10.1038/s42003-020-01591-z
By:
- Lenk, Lennart;
- Carlet, Michela;
- Vogiatzi, Fotini;
- Spory, Lea;
- Winterberg, Dorothee;
- Cousins, Antony;
- Vossen-Gajcy, Michaela;
- Ibruli, Olta;
- Vokuhl, Christian;
- Cario, Gunnar;
- El Ayoubi, Omar;
- Kramer, Lisa;
- Ritgen, Matthias;
- Brüggemann, Monika;
- Häsler, Robert;
- Schrappe, Martin;
- Fuhrmann, Stephan;
- Halsey, Christina;
- Jeremias, Irmela;
- Hobeika, Elias
Publication type:
Article
Gold Nanoparticles with Selective Antileukemic Activity In Vitro and In Vivo Target Mitochondrial Respiration.
Published in:
Advanced Therapeutics, 2019, v. 2, n. 6, p. N.PAG, doi. 10.1002/adtp.201800149
By:
- Gaiser, Ann‐Kathrin;
- Hafner, Susanne;
- Schmiech, Michael;
- Büchele, Berthold;
- Schäfer, Patrick;
- Arnim, Christine A.;
- Calzia, Enrico;
- Feuring‐Buske, Michaela;
- Buske, Christian;
- Vick, Binje;
- Jeremias, Irmela;
- Syrovets, Tatiana;
- Simmet, Thomas
Publication type:
Article
MycN and IFNγ cooperate in apoptosis of human neuroblastoma cells.
Published in:
Oncogene, 1998, v. 17, n. 3, p. 339, doi. 10.1038/sj.onc.1200201
By:
- Lutz, Werner;
- Fulda, Simone;
- Jeremias, Irmela;
- Debatin, Klaus-Michael;
- Schwab, Manfred
Publication type:
Article
Betulinic acid: A new cytotoxic agent against malignant brain-tumor cells.
Published in:
International Journal of Cancer, 1999, v. 82, n. 3, p. 435, doi. 10.1002/(SICI)1097-0215(19990730)82:3<435::AID-IJC18>3.0.CO;2-1
By:
- Fulda, Simone;
- Jeremias, Irmela;
- Steiner, Hans H.;
- Pietsch, Torsten;
- Debatin, Klaus-Michael
Publication type:
Article
In vivo monitoring of leukemia-niche interactions in a zebrafish xenograft model.
Published in:
PLoS ONE, 2024, v. 19, n. 8, p. 1, doi. 10.1371/journal.pone.0309415
By:
- Arner, Anja;
- Ettinger, Andreas;
- Blaser, Bradley Wayne;
- Schmid, Bettina;
- Jeremias, Irmela;
- Rostam, Nadia;
- Binder-Blaser, Vera
Publication type:
Article
The Cytotoxic Natural Product Vioprolide A Targets Nucleolar Protein 14, Which Is Essential for Ribosome Biogenesis.
Published in:
Angewandte Chemie International Edition, 2020, v. 59, n. 4, p. 1595, doi. 10.1002/anie.201911158
By:
- Kirsch, Volker C.;
- Orgler, Christina;
- Braig, Simone;
- Jeremias, Irmela;
- Auerbach, David;
- Müller, Rolf;
- Vollmar, Angelika M.;
- Sieber, Stephan A.
Publication type:
Article
Significance of molecular diagnostics for therapeutic decision-making in recurrent glioma.
Published in:
Neuro-Oncology Advances, 2023, v. 5, n. 1, p. 1, doi. 10.1093/noajnl/vdad060
By:
- Blobner, Jens;
- Dengler, Laura;
- Blobner, Sven;
- Eberle, Constantin;
- Weller, Jonathan;
- Teske, Nico;
- Karschnia, Philipp;
- Rühlmann, Katharina;
- Heinrich, Kathrin;
- Ziemann, Frank;
- Greif, Philipp A;
- Jeremias, Irmela;
- Wuerstlein, Rachel;
- Hasselmann, Korbinian;
- Dorostkar, Mario;
- Harter, Patrick N;
- Quach, Stefanie;
- Stoecklein, Veit;
- Albert, Nathalie L;
- Niyazi, Maximilian
Publication type:
Article
A reporter system for enriching CRISPR/Cas9 knockout cells in technically challenging settings like patient models.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-91760-9
By:
- Liu, Wen-Hsin;
- Völse, Kerstin;
- Senft, Daniela;
- Jeremias, Irmela
Publication type:
Article
Small molecule inhibitors of the mitochondrial ClpXP protease possess cytostatic potential and re-sensitize chemo-resistant cancers.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-90801-7
By:
- Meßner, Martina;
- Mandl, Melanie M.;
- Hackl, Mathias W.;
- Reinhardt, Till;
- Ardelt, Maximilian A.;
- Szczepanowska, Karolina;
- Frädrich, Julian E.;
- Waschke, Jens;
- Jeremias, Irmela;
- Fux, Anja;
- Stahl, Matthias;
- Vollmar, Angelika M.;
- Sieber, Stephan A.;
- Pachmayr, Johanna
Publication type:
Article
Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-84708-6
By:
- Kempf, Julia M.;
- Weser, Sabrina;
- Bartoschek, Michael D.;
- Metzeler, Klaus H.;
- Vick, Binje;
- Herold, Tobias;
- Völse, Kerstin;
- Mattes, Raphael;
- Scholz, Manuela;
- Wange, Lucas E.;
- Festini, Moreno;
- Ugur, Enes;
- Roas, Maike;
- Weigert, Oliver;
- Bultmann, Sebastian;
- Leonhardt, Heinrich;
- Schotta, Gunnar;
- Hiddemann, Wolfgang;
- Jeremias, Irmela;
- Spiekermann, Karsten
Publication type:
Article
JNK/SAPK activity contributes to TRAIL-induced apoptosis.
Published in:
Cell Death & Differentiation, 1999, v. 6, n. 2, p. 130, doi. 10.1038/sj.cdd.4400467
By:
- Herr, Ingrid;
- Wilhelm, Dagmar;
- Meyer, Eric;
- Jeremias, Irmela;
- Angel, Peter;
- Debatin, Klaus-Michael
Publication type:
Article
Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis.
Published in:
International Journal of Cancer, 2010, v. 126, n. 9, p. 2216, doi. 10.1002/ijc.24816
By:
- Loeder, Sandra;
- Drensek, Annekathrin;
- Jeremias, Irmela;
- Debatin, Klaus-Michael;
- Fulda, Simone
Publication type:
Article
A Novel Anti-CD73 Antibody That Selectively Inhibits Membrane CD73 Shows Antitumor Activity and Induces Tumor Immune Escape.
Published in:
Biomedicines, 2022, v. 10, n. 4, p. 825, doi. 10.3390/biomedicines10040825
By:
- Kellner, Markus;
- von Neubeck, Bettina;
- Czogalla, Bastian;
- Feederle, Regina;
- Vick, Binje;
- Jeremias, Irmela;
- Zeidler, Reinhard
Publication type:
Article
The Molecular Subtype of Adult Acute Lymphoblastic Leukemia Samples Determines the Engraftment Site and Proliferation Kinetics in Patient-Derived Xenograft Models.
Published in:
Cells (2073-4409), 2022, v. 11, n. 1, p. 150, doi. 10.3390/cells11010150
By:
- Richter, Anna;
- Roolf, Catrin;
- Sekora, Anett;
- Knuebel, Gudrun;
- Krohn, Saskia;
- Lange, Sandra;
- Krebs, Vivien;
- Schneider, Bjoern;
- Lakner, Johannes;
- Wittke, Christoph;
- Kiefel, Christoph;
- Jeremias, Irmela;
- Murua Escobar, Hugo;
- Vollmar, Brigitte;
- Junghanss, Christian
Publication type:
Article
CLUE: a bioinformatic and wet-lab pipeline for multiplexed cloning of custom sgRNA libraries.
Published in:
Nucleic Acids Research, 2020, v. 48, n. 13, p. e78, doi. 10.1093/nar/gkaa459
By:
- Becker, Martin;
- Noll-Puchta, Heidi;
- Amend, Diana;
- Nolte, Florian;
- Fuchs, Christiane;
- Jeremias, Irmela;
- Braun, Christian J
Publication type:
Article
Adverse stem cell clones within a single patient's tumor predict clinical outcome in AML patients.
Published in:
Journal of Hematology & Oncology, 2022, v. 15, n. 1, p. 1, doi. 10.1186/s13045-022-01232-4
By:
- Zeller, Christina;
- Richter, Daniel;
- Jurinovic, Vindi;
- Valtierra-Gutiérrez, Ilse A.;
- Jayavelu, Ashok Kumar;
- Mann, Matthias;
- Bagnoli, Johannes W.;
- Hellmann, Ines;
- Herold, Tobias;
- Enard, Wolfgang;
- Vick, Binje;
- Jeremias, Irmela
Publication type:
Article
SIRPα-αCD123 fusion antibodies targeting CD123 in conjunction with CD47 blockade enhance the clearance of AML-initiating cells.
Published in:
Journal of Hematology & Oncology, 2021, v. 14, n. 1, p. 1, doi. 10.1186/s13045-021-01163-6
By:
- Tahk, Siret;
- Vick, Binje;
- Hiller, Björn;
- Schmitt, Saskia;
- Marcinek, Anetta;
- Perini, Enrico D.;
- Leutbecher, Alexandra;
- Augsberger, Christian;
- Reischer, Anna;
- Tast, Benjamin;
- Humpe, Andreas;
- Jeremias, Irmela;
- Subklewe, Marion;
- Fenn, Nadja C.;
- Hopfner, Karl-Peter
Publication type:
Article
Impact of the p53 status of tumor cells on extrinsic and intrinsic apoptosis signaling.
Published in:
Cell Communication & Signaling, 2013, v. 11, n. 1, p. 1, doi. 10.1186/1478-811X-11-27
By:
- Wachter, Franziska;
- Grunert, Michaela;
- Blaj, Cristina;
- Weinstock, David M.;
- Jeremias, Irmela;
- Ehrhardt, Harald
Publication type:
Article
TRAIL/Apo-2-ligand-induced apoptosis in human T cells.
Published in:
European Journal of Immunology, 1998, v. 28, n. 1, p. 143, doi. 10.1002/(SICI)1521-4141(199801)28:01<143::AID-IMMU143>3.0.CO;2-3
By:
- Jeremias, Irmela;
- Herr, Ingrid;
- Boehler, Thomas;
- Debatin, Klaus-Michael
Publication type:
Article

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