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Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities
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- Chemical Biology & Drug Design, 2019, v. 93, n. 4, p. 511, doi. 10.1111/cbdd.13442
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- Article
In the search for a lead structure among series of potent and selective hydantoin 5- HT<sub>7</sub>R agents: The drug-likeness in vitro study.
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- Chemical Biology & Drug Design, 2017, v. 90, n. 6, p. 1295, doi. 10.1111/cbdd.13106
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- Article
Are the Hydantoin-1,3,5-triazine 5-HT6R Ligands a Hope to a Find New Procognitive and Anti-Obesity Drug? Considerations Based on Primary In Vivo Assays and ADME-Tox Profile In Vitro.
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- Molecules, 2019, v. 24, n. 24, p. 4472, doi. 10.3390/molecules24244472
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- Article
Computer-Aided Studies for Novel Arylhydantoin 1,3,5-Triazine Derivatives as 5-HT6 Serotonin Receptor Ligands with Antidepressive-Like, Anxiolytic and Antiobesity Action In Vivo.
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- Molecules, 2018, v. 23, n. 10, p. 2529, doi. 10.3390/molecules23102529
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- Article
Monitorowanie stężenia takrolimusu po przeszczepie nerki lub serca – znaczenie parametrów zmienności wewnątrzosobniczej.
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- Farmacja Polska, 2022, v. 78, n. 8, p. 415, doi. 10.32383/farmpol/155157
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- Article
The Subtype Selectivity in Search of Potent Hypotensive Agents among 5,5-Dimethylhydantoin Derived α 1 -Adrenoceptors Antagonists.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 23, p. 16609, doi. 10.3390/ijms242316609
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- Article
Anti-Inflammatory Activities of 8-Benzylaminoxanthines Showing High Adenosine A 2A and Dual A 1 /A 2A Receptor Affinity.
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- International Journal of Molecular Sciences, 2023, v. 24, n. 18, p. 13707, doi. 10.3390/ijms241813707
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- Article
The Antidepressant-like Activity, Effects on Recognition Memory Deficits, Bioavailability, and Safety after Chronic Administration of New Dual-Acting Small Compounds Targeting Neuropsychiatric Symptoms in Dementia.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 19, p. 11452, doi. 10.3390/ijms231911452
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- Article
The Phenoxyalkyltriazine Antagonists for 5-HT 6 Receptor with Promising Procognitive and Pharmacokinetic Properties In Vivo in Search for a Novel Therapeutic Approach to Dementia Diseases.
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- International Journal of Molecular Sciences, 2021, v. 22, n. 19, p. 10773, doi. 10.3390/ijms221910773
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- Article
The 1,3,5-Triazine Derivatives as Innovative Chemical Family of 5-HT6 Serotonin Receptor Agents with Therapeutic Perspectives for Cognitive Impairment.
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- International Journal of Molecular Sciences, 2019, v. 20, n. 14, p. 3420, doi. 10.3390/ijms20143420
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- Article
Synthesis and Pharmacological Evaluation of Novel Tricyclic[2,1- f]theophylline Derivatives.
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- Archiv der Pharmazie, 2013, v. 346, n. 11, p. 832, doi. 10.1002/ardp.201300257
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- Article
Metabolic and Cardiovascular Benefits and Risks of EMD386088--A 5-HT<sub>6 </sub>Receptor Partial Agonist and Dopamine Transporter Inhibitor.
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- Frontiers in Neuroscience, 2017, v. 11, p. 1, doi. 10.3389/fnins.2017.00050
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- Article
The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling.
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- Journal of Psychopharmacology, 2020, v. 34, n. 12, p. 1431, doi. 10.1177/0269881120959605
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- Article
Effect of 5-HT<sub>6</sub> Receptor Ligands Combined with Haloperidol or Risperidone on Antidepressant-/Anxiolytic-Like Behavior and BDNF Regulation in Hippocampus and Prefrontal Cortex of Rats.
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- Neuropsychiatric Disease & Treatment, 2021, v. 17, p. 2105, doi. 10.2147/NDT.S309818
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- Article
HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats.
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- Neurochemical Research, 2023, v. 48, n. 3, p. 839, doi. 10.1007/s11064-022-03802-x
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Novel tricyclic[2,1- f]theophylline derivatives of LCAP with activity in mouse models of affective disorders.
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- Journal of Pharmacy & Pharmacology, 2014, v. 66, n. 12, p. 1755, doi. 10.1111/jphp.12305
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- Article
Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT<sub>1A</sub> receptor partial agonists.
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- PLoS ONE, 2020, v. 15, n. 8, p. 1, doi. 10.1371/journal.pone.0237196
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- Article
Study on the effect of EMD386088, a 5-HT receptor partial agonist, in enhancing the anti-immobility action of some antidepressants in rats.
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- Naunyn-Schmiedeberg's Archives of Pharmacology, 2018, v. 391, n. 1, p. 37, doi. 10.1007/s00210-017-1431-y
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- Article
Study of a mechanism responsible for potential antidepressant activity of EMD 386088, a 5-HT partial agonist in rats.
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- Naunyn-Schmiedeberg's Archives of Pharmacology, 2016, v. 389, n. 8, p. 839, doi. 10.1007/s00210-016-1245-3
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- Article
ADN-1184, a monoaminergic ligand with 5-HT receptor antagonist action, exhibits activity in animal models of anxiety.
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- Naunyn-Schmiedeberg's Archives of Pharmacology, 2016, v. 389, n. 6, p. 593, doi. 10.1007/s00210-016-1229-3
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- Article
Antidepressant-like activity of EMD 386088, a 5-HT receptor partial agonist, following systemic acute and chronic administration to rats.
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- Naunyn-Schmiedeberg's Archives of Pharmacology, 2015, v. 388, n. 10, p. 1079, doi. 10.1007/s00210-015-1141-2
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- Article
Selective 5-HT 6 Receptor Ligands (Agonist and Antagonist) Show Different Effects on Antipsychotic Drug-Induced Metabolic Dysfunctions in Rats.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 2, p. 154, doi. 10.3390/ph16020154
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- Article
Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT<sub>1A</sub> and 5-HT<sub>7</sub> Antagonists in Animal Models.
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- PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0142499
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- Article