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Mice with a deficiency in Peroxisomal Membrane Protein 4 (PXMP4) display mild changes in hepatic lipid metabolism.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-06479-y
By:
- Blankestijn, Maaike;
- Bloks, Vincent W.;
- Struik, Dicky;
- Huijkman, Nicolette;
- Kloosterhuis, Niels;
- Wolters, Justina C.;
- Wanders, Ronald J. A.;
- Vaz, Frédéric M.;
- Islinger, Markus;
- Kuipers, Folkert;
- van de Sluis, Bart;
- Groen, Albert K.;
- Verkade, Henkjan J.;
- Jonker, Johan W.
Publication type:
Article
Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases.
Published in:
International Journal of Molecular Sciences, 2023, v. 24, n. 2, p. 1290, doi. 10.3390/ijms24021290
By:
- Zhan, Na;
- Wang, Boyang;
- Martens, Nikita;
- Liu, Yankai;
- Zhao, Shangge;
- Voortman, Gardi;
- van Rooij, Jeroen;
- Leijten, Frank;
- Vanmierlo, Tim;
- Kuipers, Folkert;
- Jonker, Johan W.;
- Bloks, Vincent W.;
- Lütjohann, Dieter;
- Palumbo, Marcella;
- Zimetti, Francesca;
- Adorni, Maria Pia;
- Liu, Hongbing;
- Mulder, Monique T.
Publication type:
Article
Inhibition of mTOR improves malnutrition induced hepatic metabolic dysfunction.
Published in:
Scientific Reports, 2022, v. 12, n. 1, p. 1, doi. 10.1038/s41598-022-24428-7
By:
- Arvidsson Kvissberg, Matilda E.;
- Hu, Guanlan;
- Chi, Lijun;
- Bourdon, Celine;
- Ling, Cino;
- ChenMi, YueYing;
- Germain, Kyla;
- van Peppel, Ivo P.;
- Weise, Linnea;
- Zhang, Ling;
- Di Giovanni, Valeria;
- Swain, Nathan;
- Jonker, Johan W.;
- Kim, Peter;
- Bandsma, Robert
Publication type:
Article
The breast cancer resistance protein BCRP (ABCG2) concentrates drugs and carcinogenic xenotoxins into milk.
Published in:
Nature Medicine, 2005, v. 11, n. 2, p. 127, doi. 10.1038/nm1186
By:
- Jonker, Johan W.;
- Merino, Gracia;
- Musters, Sandra;
- van Herwaarden, Antonius E.;
- Bolscher, Ellen;
- Wagenaar, Els;
- Mesman, Elly;
- Dale, Trevor C.;
- Schinkel, Alfred H.
Publication type:
Article
Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload.
Published in:
BMC Biology, 2021, v. 19, n. 1, p. 1, doi. 10.1186/s12915-021-01082-5
By:
- Vieira-Lara, Marcel A.;
- Dommerholt, Marleen B.;
- Zhang, Wenxuan;
- Blankestijn, Maaike;
- Wolters, Justina C.;
- Abegaz, Fentaw;
- Gerding, Albert;
- van der Veen, Ydwine T.;
- Thomas, Rachel;
- van Os, Ronald P.;
- Reijngoud, Dirk-Jan;
- Jonker, Johan W.;
- Kruit, Janine K.;
- Bakker, Barbara M.
Publication type:
Article
Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload.
Published in:
BMC Biology, 2021, v. 19, n. 1, p. 1, doi. 10.1186/s12915-021-01082-5
By:
- Vieira-Lara, Marcel A.;
- Dommerholt, Marleen B.;
- Wenxuan Zhang;
- Blankestijn, Maaike;
- Wolters, Justina C.;
- Abegaz, Fentaw;
- Gerding, Albert;
- van der Veen, Ydwine T.;
- Thomas, Rachel;
- van Os, Ronald P.;
- Reijngoud, Dirk-Jan;
- Jonker, Johan W.;
- Kruit, Janine K.;
- Bakker, Barbara M.
Publication type:
Article
Hepatic Farnesoid X-Receptor Isoforms α2 and α4 Differentially Modulate Bile Salt and Lipoprotein Metabolism in Mice.
Published in:
PLoS ONE, 2014, v. 9, n. 12, p. 1, doi. 10.1371/journal.pone.0115028
By:
- Boesjes, Marije;
- Bloks, Vincent W.;
- Hageman, Jurre;
- Bos, Trijnie;
- van Dijk, Theo H.;
- Havinga, Rick;
- Wolters, Henk;
- Jonker, Johan W.;
- Kuipers, Folkert;
- Groen, Albert K.
Publication type:
Article
Transport of Topoisomerase I Inhibitors by the Breast Cancer Resistance Protein: Potential Clinical Implications.
Published in:
Annals of the New York Academy of Sciences, 2000, v. 922, n. 1, p. 188, doi. 10.1111/j.1749-6632.2000.tb07037.x
By:
- SCHELLENS, JAN H.M.;
- MALIEPAARD, MARC;
- SCHEPER, RIK J.;
- SCHEFFER, GEORGE L.;
- JONKER, JOHAN W.;
- SMIT, JOHAN W.;
- BEIJNEN, JOS H.;
- SCHINKEL, ALFRED H.
Publication type:
Article
Role of breast cancer resistance protein in the bioavailability and fetal penetration of topotecan.
Published in:
2000
By:
- Jonker, Johan W.;
- Smit, Johan W.;
- Jonker, J W;
- Smit, J W;
- Brinkhuis, R F;
- Maliepaard, M;
- Beijnen, J H;
- Schellens, J H;
- Schinkel, A H
Publication type:
journal article
Biological and pharmacological functions of the FGF19- and FGF21-coreceptor beta klotho.
Published in:
Frontiers in Endocrinology, 2023, p. 1, doi. 10.3389/fendo.2023.1150222
By:
- Aaldijk, Alexandra S.;
- Verzij, Cristy R. C.;
- Jonker, Johan W.;
- Struik, Dicky
Publication type:
Article
24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer's Disease.
Published in:
Marine Drugs, 2021, v. 19, n. 4, p. 190, doi. 10.3390/md19040190
By:
- Martens, Nikita;
- Schepers, Melissa;
- Zhan, Na;
- Leijten, Frank;
- Voortman, Gardi;
- Tiane, Assia;
- Rombaut, Ben;
- Poisquet, Janne;
- Sande, Nienke van de;
- Kerksiek, Anja;
- Kuipers, Folkert;
- Jonker, Johan W.;
- Liu, Hongbing;
- Lütjohann, Dieter;
- Vanmierlo, Tim;
- Mulder, Monique T.
Publication type:
Article
Short‐term protein restriction at advanced age stimulates FGF21 signalling, energy expenditure and browning of white adipose tissue.
Published in:
FEBS Journal, 2021, v. 288, n. 7, p. 2257, doi. 10.1111/febs.15604
By:
- Dommerholt, Marleen B.;
- Blankestijn, Maaike;
- Vieira‐Lara, Marcel A.;
- van Dijk, Theo H.;
- Wolters, Henk;
- Koster, Mirjam H.;
- Gerding, Albert;
- van Os, Ronald P.;
- Bloks, Vincent W.;
- Bakker, Barbara M.;
- Kruit, Janine K.;
- Jonker, Johan W.
Publication type:
Article
Identification of the fructose transporter GLUT5 (SLC2A5) as a novel target of nuclear receptor LXR.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-45803-x
By:
- Zwarts, Irene;
- van Zutphen, Tim;
- Kruit, Janine K.;
- Liu, Weilin;
- Oosterveer, Maaike H.;
- Verkade, Henkjan J.;
- Uhlenhaut, N. Henriette;
- Jonker, Johan W.
Publication type:
Article
The Role of Lipophagy in the Development and Treatment of Non-Alcoholic Fatty Liver Disease.
Published in:
Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2020.601627
By:
- Grefhorst, Aldo;
- van de Peppel, Ivo P.;
- Larsen, Lars E.;
- Jonker, Johan W.;
- Holleboom, Adriaan G.
Publication type:
Article
Potential of therapeutic bile acids in the treatment of neonatal Hyperbilirubinemia.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-90687-5
By:
- van der Schoor, Lori W. E.;
- Verkade, Henkjan J.;
- Bertolini, Anna;
- de Wit, Sanne;
- Mennillo, Elvira;
- Rettenmeier, Eva;
- Weber, André A.;
- Havinga, Rick;
- Valášková, Petra;
- Jašprová, Jana;
- Struik, Dicky;
- Bloks, Vincent W.;
- Chen, Shujuan;
- Schreuder, Andrea B.;
- Vítek, Libor;
- Tukey, Robert H.;
- Jonker, Johan W.
Publication type:
Article
Corrigendum: Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.
Published in:
Nature, 2015, v. 520, n. 7547, p. 388, doi. 10.1038/nature14304
By:
- Suh, Jae Myoung;
- Jonker, Johan W.;
- Ahmadian, Maryam;
- Goetz, Regina;
- Lackey, Denise;
- Osborn, Olivia;
- Huang, Zhifeng;
- Liu, Weilin;
- Yoshihara, Eiji;
- van Dijk, Theo H.;
- Havinga, Rick;
- Fan, Weiwei;
- Yin, Yun-Qiang;
- Yu, Ruth T.;
- Liddle, Christopher;
- Atkins, Annette R.;
- Olefsky, Jerrold M.;
- Mohammadi, Moosa;
- Downes, Michael;
- Evans, Ronald M.
Publication type:
Article
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer.
Published in:
Nature, 2014, v. 513, n. 7518, p. 436, doi. 10.1038/nature13540
By:
- Suh, Jae Myoung;
- Jonker, Johan W.;
- Ahmadian, Maryam;
- Yoshihara, Eiji;
- Fan, Weiwei;
- Yin, Yun-Qiang;
- Yu, Ruth T.;
- Atkins, Annette R.;
- Downes, Michael;
- Goetz, Regina;
- Mohammadi, Moosa;
- Lackey, Denise;
- Osborn, Olivia;
- Olefsky, Jerrold M.;
- Huang, Zhifeng;
- Liu, Weilin;
- van Dijk, Theo H.;
- Havinga, Rick;
- Liddle, Christopher;
- Evans, Ronald M.
Publication type:
Article
A PPAR?-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.
Published in:
Nature, 2012, v. 485, n. 7398, p. 391, doi. 10.1038/nature10998
By:
- Jonker, Johan W.;
- Suh, Jae Myoung;
- Atkins, Annette R.;
- Ahmadian, Maryam;
- Li, Pingping;
- Whyte, Jamie;
- He, Mingxiao;
- Juguilon, Henry;
- Yin, Yun-Qiang;
- Phillips, Colin T.;
- Yu, Ruth T.;
- Olefsky, Jerrold M.;
- Henry, Robert R.;
- Downes, Michael;
- Evans, Ronald M.
Publication type:
Article
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor.
Published in:
Nature, 2011, v. 480, n. 7378, p. 552, doi. 10.1038/nature10700
By:
- Lamia, Katja A.;
- Papp, Stephanie J.;
- Yu, Ruth T.;
- Barish, Grant D.;
- Uhlenhaut, N. Henriette;
- Jonker, Johan W.;
- Downes, Michael;
- Evans, Ronald M.
Publication type:
Article
Cystic Fibrosis-related Liver Disease: Research Challenges and Future Perspectives.
Published in:
2017
By:
- Debray, Dominique;
- Narkewicz, Michael R.;
- Bodewes, Frank A. J. A.;
- Colombo, Carla;
- Housset, Chantal;
- de Jonge, Hugo R.;
- Jonker, Johan W.;
- Kelly, Deirdre A.;
- Ling, Simon C.;
- Poynard, Thierry;
- Sogni, Philippe;
- Trauner, Michael;
- Witters, Peter;
- Baumann, Ulrich;
- Wilschanski, Michael;
- Verkade, Henkjan J.
Publication type:
journal article
GD1a Overcomes Inhibition of Myelination by Fibronectin via Activation of Protein Kinase A: Implications for Multiple Sclerosis.
Published in:
Journal of Neuroscience, 2017, v. 37, n. 41, p. 9925, doi. 10.1523/JNEUROSCI.0103-17.2017
By:
- Jing Qin;
- Sikkema, Arend H.;
- van der Bij, Kristine;
- de Jonge, Jenny C.;
- Klappe, Karin;
- Nies, Vera;
- Jonker, Johan W.;
- Kok, Jan Willem;
- Hoekstra, Dick;
- Baron, Wia
Publication type:
Article
Dietary Sargassum fusiforme improves memory and reduces amyloid plaque load in an Alzheimer's disease mouse model.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. 1, doi. 10.1038/s41598-019-41399-4
By:
- Bogie, Jeroen;
- Hoeks, Cindy;
- Schepers, Melissa;
- Tiane, Assia;
- Cuypers, Ann;
- Leijten, Frank;
- Chintapakorn, Yupyn;
- Suttiyut, Thiti;
- Pornpakakul, Surachai;
- Struik, Dicky;
- Kerksiek, Anja;
- Liu, Hong-Bing;
- Hellings, Niels;
- Martinez-Martinez, Pilar;
- Jonker, Johan W.;
- Dewachter, Ilse;
- Sijbrands, Eric;
- Walter, Jochen;
- Hendriks, Jerome;
- Groen, Albert
Publication type:
Article
Fibroblast Growth Factor Signaling in Metabolic Regulation.
Published in:
Frontiers in Endocrinology, 2016, p. 1, doi. 10.3389/fendo.2015.00193
By:
- Nies, Vera J. M.;
- Sancar, Gencer;
- Liu, Weilin;
- van Zutphen, Tim;
- Struik, Dicky;
- Yu, Ruth T.;
- Atkins, Annette R.;
- Evans, Ronald M.;
- Jonker, Johan W.;
- Downes, Michael Robert
Publication type:
Article
The Beneficial Effects of Apical Sodium‐Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition.
Published in:
Molecular Nutrition & Food Research, 2020, v. 64, n. 24, p. 1, doi. 10.1002/mnfr.202000750
By:
- Peppel, Ivo P.;
- Rao, Anuradha;
- Dommerholt, Marleen B.;
- Bongiovanni, Laura;
- Thomas, Rachel;
- Bruin, Alain;
- Karpen, Saul J.;
- Dawson, Paul A.;
- Verkade, Henkjan J.;
- Jonker, Johan W.
Publication type:
Article
Back Cover: The Beneficial Effects of Apical Sodium‐Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition.
Published in:
Molecular Nutrition & Food Research, 2020, v. 64, n. 24, p. 1, doi. 10.1002/mnfr.202070055
By:
- Peppel, Ivo P.;
- Rao, Anuradha;
- Dommerholt, Marleen B.;
- Bongiovanni, Laura;
- Thomas, Rachel;
- Bruin, Alain;
- Karpen, Saul J.;
- Dawson, Paul A.;
- Verkade, Henkjan J.;
- Jonker, Johan W.
Publication type:
Article
Supplementation of Seaweed Extracts to the Diet Reduces Symptoms of Alzheimer's Disease in the APPswePS1ΔE9 Mouse Model.
Published in:
Nutrients, 2024, v. 16, n. 11, p. 1614, doi. 10.3390/nu16111614
By:
- Martens, Nikita;
- Zhan, Na;
- Yam, Sammie C.;
- Leijten, Frank P. J.;
- Palumbo, Marcella;
- Caspers, Martien;
- Tiane, Assia;
- Friedrichs, Silvia;
- Li, Yanlin;
- van Vark-van der Zee, Leonie;
- Voortman, Gardi;
- Zimetti, Francesca;
- Jaarsma, Dick;
- Verschuren, Lars;
- Jonker, Johan W.;
- Kuipers, Folkert;
- Lütjohann, Dieter;
- Vanmierlo, Tim;
- Mulder, Monique T.
Publication type:
Article
Activation of Liver X Receptors and Peroxisome Proliferator-Activated Receptors by Lipid Extracts of Brown Seaweeds: A Potential Application in Alzheimer's Disease?
Published in:
Nutrients, 2023, v. 15, n. 13, p. 3004, doi. 10.3390/nu15133004
By:
- Martens, Nikita;
- Zhan, Na;
- Voortman, Gardi;
- Leijten, Frank P. J.;
- van Rheenen, Connor;
- van Leerdam, Suzanne;
- Geng, Xicheng;
- Huybrechts, Michiel;
- Liu, Hongbing;
- Jonker, Johan W.;
- Kuipers, Folkert;
- Lütjohann, Dieter;
- Vanmierlo, Tim;
- Mulder, Monique T.
Publication type:
Article
Short-Chain Fatty Acids Protect Against High-Fat Diet-Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation.
Published in:
2015
By:
- den Besten, Gijs;
- Bleeker, Aycha;
- Gerding, Albert;
- van Eunen, Karen;
- Havinga, Rick;
- van Dijk, Theo H;
- Oosterveer, Maaike H;
- Jonker, Johan W;
- Groen, Albert K;
- Reijngoud, Dirk-Jan;
- Bakker, Barbara M
Publication type:
journal article
Short-Chain Fatty Acids Protect Against High-Fat Diet--Induced Obesity via a PPARγ-Dependent Switch From Lipogenesis to Fat Oxidation.
Published in:
Diabetes, 2015, v. 64, n. 7, p. 2398, doi. 10.2337/db14-1213
By:
- den Besten, Gijs;
- Bleeker, Aycha;
- Gerding, Albert;
- van Eunen, Karen;
- Havinga, Rick;
- van Dijk, Theo H.;
- Oosterveer, Maaike H.;
- Jonker, Johan W.;
- Groen, Albert K.;
- Reijngoud, Dirk-Jan;
- Bakker, Barbara M.
Publication type:
Article

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