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Electropharmacological Characterization of Licorice Using the Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Sheets and the Chronic Atrioventricular Block Dogs.
- Published in:
- Cardiovascular Toxicology, 2023, v. 23, n. 5/6, p. 207, doi. 10.1007/s12012-023-09795-5
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- Publication type:
- Article
Cardiohemodynamic and Arrhythmogenic Effects of the Anti-Atrial Fibrillatory Compound Vanoxerine in Halothane-Anesthetized Dogs.
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- Cardiovascular Toxicology, 2021, v. 21, n. 3, p. 206, doi. 10.1007/s12012-020-09612-3
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- Publication type:
- Article
Electropharmacological Characterization of Aciclovir in the Halothane-Anesthetized Dogs: A Proposal of Evaluation Method for Cardiovascular Safety Pharmacology of Anti-virus Drugs.
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- Cardiovascular Toxicology, 2020, v. 20, n. 4, p. 419, doi. 10.1007/s12012-020-09568-4
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- Publication type:
- Article
How the Deuteration of Dronedarone Can Modify Its Cardiovascular Profile: In Vivo Characterization of Electropharmacological Effects of Poyendarone, a Deuterated Analogue of Dronedarone.
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- Cardiovascular Toxicology, 2020, v. 20, n. 4, p. 339, doi. 10.1007/s12012-019-09559-0
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- Publication type:
- Article
Dasatinib can Impair Left Ventricular Mechanical Function But May Lack Proarrhythmic Effect: A Proposal of Non-clinical Guidance for Predicting Clinical Cardiovascular Adverse Events of Tyrosine Kinase Inhibitors.
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- Cardiovascular Toxicology, 2020, v. 20, n. 1, p. 58, doi. 10.1007/s12012-019-09538-5
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- Publication type:
- Article
Characterization of microminipig as a laboratory animal for safety pharmacology study by analyzing fluvoxamine-induced cardiovascular and dermatological adverse reactions.
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- Cardiovascular Toxicology, 2019, v. 19, n. 5, p. 412, doi. 10.1007/s12012-019-09509-w
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- Publication type:
- Article
Measurement of J–T<sub>peak</sub>c along with QT-Interval Prolongation May Increase the Assay Sensitivity and Specificity for Predicting the Onset of Drug-Induced Torsade de Pointes: Experimental Evidences Based on Proarrhythmia Model Animals.
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- Cardiovascular Toxicology, 2019, v. 19, n. 4, p. 357, doi. 10.1007/s12012-019-09506-z
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- Publication type:
- Article
Analysis of Safety Margin of Lithium Carbonate Against Cardiovascular Adverse Events Assessed in the Halothane-Anesthetized Dogs.
- Published in:
- Cardiovascular Toxicology, 2018, v. 18, n. 6, p. 530, doi. 10.1007/s12012-018-9464-0
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- Publication type:
- Article
In vivo Analysis of the Anti-atrial Fibrillatory, Proarrhythmic and Cardiodepressive Profiles of Dronedarone as a Guide for Safety Pharmacological Evaluation of Antiarrhythmic Drugs.
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- Cardiovascular Toxicology, 2018, v. 18, n. 3, p. 242, doi. 10.1007/s12012-017-9434-y
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- Publication type:
- Article
Amitriptyline May Have Possibility to Induce Brugada Syndrome Rather than Long QT Syndrome.
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- Cardiovascular Toxicology, 2018, v. 18, n. 1, p. 91, doi. 10.1007/s12012-017-9417-z
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- Publication type:
- Article
Assessment of Safety Margin of an Antipsychotic Drug Haloperidol for Torsade de Pointes Using the Chronic Atrioventricular Block Dogs.
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- Cardiovascular Toxicology, 2017, v. 17, n. 3, p. 319, doi. 10.1007/s12012-016-9388-5
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- Publication type:
- Article
Anti-atrial Fibrillatory Versus Proarrhythmic Potentials of Amiodarone: A New Protocol for Safety Evaluation In Vivo.
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- Cardiovascular Toxicology, 2017, v. 17, n. 2, p. 157, doi. 10.1007/s12012-016-9369-8
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- Publication type:
- Article
Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model.
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- Cardiovascular Toxicology, 2016, v. 16, n. 2, p. 138, doi. 10.1007/s12012-015-9322-2
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- Publication type:
- Article
Azithromycin Can Prolong QT Interval and Suppress Ventricular Contraction, but Will Not Induce Torsade de Pointes.
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- Cardiovascular Toxicology, 2015, v. 15, n. 3, p. 232, doi. 10.1007/s12012-014-9289-4
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- Publication type:
- Article
Impact of head-up tilt on expiratory negative airway pressure ventilation-induced cardiovascular hemodynamics in the halothane-anesthetized intact microminipigs.
- Published in:
- Heart & Vessels, 2022, v. 37, n. 10, p. 1808, doi. 10.1007/s00380-022-02068-1
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- Publication type:
- Article
In vivo characterization of anti-atrial fibrillatory potential and pharmacological safety profile of INa,L plus IKr inhibitor ranolazine using the halothane-anesthetized dogs.
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- Heart & Vessels, 2021, v. 36, n. 7, p. 1088, doi. 10.1007/s00380-021-01830-1
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- Publication type:
- Article
Reverse translational analysis of clinically reported, lamotrigine-induced cardiovascular adverse events using the halothane-anesthetized dogs.
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- Heart & Vessels, 2021, v. 36, n. 3, p. 424, doi. 10.1007/s00380-020-01716-8
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- Publication type:
- Article
Analysis of electropharmacological effects of AVE0118 on the atria of chronic atrioventricular block dogs: characterization of anti-atrial fibrillatory action by atrial repolarization-delaying agent.
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- Heart & Vessels, 2020, v. 35, n. 9, p. 1316, doi. 10.1007/s00380-020-01612-1
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- Publication type:
- Article
Experimental analysis of the onset mechanism of TdP reported in an LQT3 patient during pharmacological treatment with serotonin–dopamine antagonists against insomnia and nocturnal delirium.
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- Heart & Vessels, 2020, v. 35, n. 4, p. 593, doi. 10.1007/s00380-019-01521-y
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- Publication type:
- Article
Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart.
- Published in:
- Frontiers in Pharmacology, 2023, v. 14, p. 1, doi. 10.3389/fphar.2023.1055031
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- Publication type:
- Article
Effects of mechanical ventilation with expiratory negative airway pressure on porcine pulmonary and systemic circulation: mechano‑physiology and potential application.
- Published in:
- Journal of Physiological Sciences, 2021, v. 71, n. 1, p. 1, doi. 10.1186/s12576-021-00801-5
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- Publication type:
- Article
Analysis of cardiohemodynamic and electrophysiological effects of morphine along with its toxicokinetic profile using the halothane-anesthetized dogs.
- Published in:
- Journal of Toxicological Sciences, 2024, v. 49, n. 6, p. 269, doi. 10.2131/jts.49.269
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- Publication type:
- Article
Cardiovascular safety pharmacology of ivermectin assessed using the isoflurane-anesthetized beagle dogs: ICH S7B follow-up study.
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- Journal of Toxicological Sciences, 2023, v. 48, n. 12, p. 645, doi. 10.2131/jts.48.645
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- Publication type:
- Article
In vivo analysis of acute eletropharmacological effects of proton pump inhibitors using halothane-anesthetized dogs: a translational study of cardiovascular adverse events.
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- Journal of Toxicological Sciences, 2023, v. 48, n. 7, p. 375, doi. 10.2131/jts.48.375
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- Publication type:
- Article
Both osmolality-dependent and independent mechanisms are associated with acute hyperglycemia-induced cardiovascular adverse reactions: Analysis of the mutual interactions leading to cardiovascular phenotypes in dogs.
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- Journal of Toxicological Sciences, 2023, v. 48, n. 3, p. 169, doi. 10.2131/jts.48.169
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- Publication type:
- Article
Electropharmacological characterization of microminipigs as a laboratory animal using anti-influenza virus drug oseltamivir.
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- Journal of Toxicological Sciences, 2018, v. 43, n. 8, p. 507, doi. 10.2131/jts.43.507
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- Publication type:
- Article
Comparison of electropharmacological effects between terfenadine and its active derivative fexofenadine using a cross-over study in halothane-anesthetized dogs to analyze variability of pharmacodynamic and pharmacokinetic profiles of terfenadine and torsadogenic risk of fexofenadine
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- Journal of Toxicological Sciences, 2018, v. 43, n. 3, p. 183, doi. 10.2131/jts.43.183
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- Publication type:
- Article
Characterization of human iPS cell-derived cardiomyocyte sheets as a model to detect drug-induced conduction disturbance.
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- Journal of Toxicological Sciences, 2017, v. 42, n. 2, p. 183, doi. 10.2131/jts.42.183
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- Publication type:
- Article
Pharmacological characterization of microminipig as a model to assess the drug-induced cardiovascular responses for non-clinical toxicity and/or safety pharmacology studies.
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- Journal of Toxicological Sciences, 2017, v. 42, n. 1, p. 93, doi. 10.2131/jts.42.93
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- Publication type:
- Article
Cardiac safety profile of sildenafil: chronotropic, inotropic and coronary vasodilator effects in the canine isolated, blood-perfused heart preparations.
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- Journal of Toxicological Sciences, 2016, v. 41, n. 6, p. 739, doi. 10.2131/jts.41.739
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- Publication type:
- Article
Electropharmacological effects of amantadine on cardiovascular system assessed with J-T<sub>peak</sub> and T<sub>peak</sub>-T<sub>end</sub> analysis in the halothane-anesthetized beagle dogs.
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- Journal of Toxicological Sciences, 2016, v. 41, n. 3, p. 439, doi. 10.2131/jts.41.439
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- Publication type:
- Article
Antiviral drug vidarabine possessing cardiac type 5 adenylyl cyclase inhibitory property did not affect cardiohemodynamic or electrophysiological variables in the halothane-anesthetized dogs.
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- Journal of Toxicological Sciences, 2016, v. 41, n. 1, p. 115, doi. 10.2131/jts.41.115
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- Publication type:
- Article
Fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations.
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- Journal of Toxicological Sciences, 2015, v. 40, n. 1, p. 33, doi. 10.2131/jts.40.33
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- Publication type:
- Article
Translational Studies on Anti-Atrial Fibrillatory Action of Oseltamivir by its in vivo and in vitro Electropharmacological Analyses.
- Published in:
- Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.593021
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- Publication type:
- Article
Involvement of NMDAR2A tyrosine phosphorylation in depression-related behaviour.
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- EMBO Journal, 2009, v. 28, n. 23, p. 3717, doi. 10.1038/emboj.2009.300
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- Publication type:
- Article
The Ascidian Dihydropyridine-Resistant Calcium Channel as the Prototype of Chordate L-Type Calcium Channel.
- Published in:
- NeuroSignals (Karger AG), 2003, v. 12, n. 3, p. 142, doi. 10.1159/000072161
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- Publication type:
- Article
Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory.
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- GeroScience, 2022, v. 44, n. 4, p. 2305, doi. 10.1007/s11357-022-00579-3
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- Publication type:
- Article
Common parameters of acupuncture for the treatment of hypertension used in animal models.
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- Journal of Traditional Chinese Medicine, 2015, v. 35, n. 3, p. 343, doi. 10.1016/s0254-6272(15)30108-4
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- Publication type:
- Article
An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation.
- Published in:
- Naunyn-Schmiedeberg's Archives of Pharmacology, 2021, v. 394, n. 6, p. 1103, doi. 10.1007/s00210-020-02047-1
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- Publication type:
- Article
Analysis of electropharmacological and proarrhythmic effects of donepezil using the halothane-anesthetized intact dogs and the conscious chronic atrioventricular block ones.
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- Naunyn-Schmiedeberg's Archives of Pharmacology, 2021, v. 394, n. 4, p. 581, doi. 10.1007/s00210-020-01997-w
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- Publication type:
- Article
Sunitinib does not acutely alter left ventricular systolic function, but induces diastolic dysfunction.
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- 2018
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- Publication type:
- journal article
Intravenous Administration of Apomorphine Does NOT Induce Long QT Syndrome: Experimental Evidence from In Vivo Canine Models.
- Published in:
- Basic & Clinical Pharmacology & Toxicology, 2015, v. 116, n. 6, p. 468, doi. 10.1111/bcpt.12343
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- Publication type:
- Article
Beneficial and Adverse Effects of Electro-acupuncture Assessed in the Canine Chronic Atrio-ventricular Block Model Having Severe Hypertension and Chronic Heart Failure.
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- Acupuncture & Electro-Therapeutics Research, 2015, v. 40, n. 2, p. 87, doi. 10.3727/036012915X14381285982886
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- Publication type:
- Article
Comparison of anti-anginal effect of cilnidipine with those of nicardipine and nifedipine in the vasopressin-induced angina model of rats.
- Published in:
- Heart & Vessels, 2016, v. 31, n. 12, p. 2045, doi. 10.1007/s00380-016-0848-4
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- Publication type:
- Article
L/N-type Ca channels blocker cilnidipine ameliorated the repolarization abnormality in a chronic hemodialysis patient.
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- Heart & Vessels, 2017, v. 32, n. 1, p. 105, doi. 10.1007/s00380-016-0865-3
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- Publication type:
- Article
Comparison of direct effects of clinically available vasodilators; nitroglycerin, nifedipine, cilnidipine and diltiazem, on human skeletonized internal mammary harvested with ultrasonic scalpel.
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- Heart & Vessels, 2016, v. 31, n. 10, p. 1681, doi. 10.1007/s00380-016-0797-y
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- Publication type:
- Article
DHP-insensitive L-type-like Ca channel of ascidian acquires sensitivity to DHP with single amino acid change in domain III P-region
- Published in:
- FEBS Letters, 2003, v. 549, n. 1-3, p. 67, doi. 10.1016/S0014-5793(03)00772-5
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- Publication type:
- Article
Coexpression of a Ca<sub>v</sub>1.2 protein lacking an N-terminus and the first domain specifically suppresses L-type calcium channel activity
- Published in:
- FEBS Letters, 2002, v. 529, n. 2/3, p. 203, doi. 10.1016/S0014-5793(02)03340-9
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- Publication type:
- Article
Validation of Risk-Stratification Method for the Chronic Atrioventricular Block Cynomolgus Monkey Model and Its Mechanistic Interpretation Using 6 Drugs With Pharmacologically Distinct Profile.
- Published in:
- Toxicological Sciences, 2022, v. 190, n. 1, p. 99, doi. 10.1093/toxsci/kfac088
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- Publication type:
- Article
Corrigendum to: Torsadogenic Action of Cisapride, dl-Sotalol, Bepridil, and Verapamil Analyzed by the Chronic Atrioventricular Block Cynomolgus Monkeys: Comparison With That Reported in the CiPA In Silico Mechanistic Model.
- Published in:
- Toxicological Sciences, 2021, v. 182, n. 2, p. 357, doi. 10.1093/toxsci/kfab058
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- Publication type:
- Article