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Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ.
Published in:
2007
By:
- Iredale, John P.
Publication type:
journal article
Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair.
Published in:
Journal of Clinical Investigation, 2005, v. 115, n. 1, p. 56, doi. 10.1172/JCI200522675
By:
- Duffield, Jeremy S.;
- Forbes, Stuart J.;
- Constandinou, Christothea M.;
- Clay, Spike;
- Partolina, Marina;
- Vuthoori, Srilatha;
- Shengji Wu;
- Lang, Richard;
- Iredale, John P.
Publication type:
Article
Persistence of functional hepatocyte-like cells in immune-compromised mice.
Published in:
Liver International, 2011, v. 31, n. 2, p. 254, doi. 10.1111/j.1478-3231.2010.02414.x
By:
- Payne, Catherine M.;
- Samuel, Kay;
- Pryde, Anne;
- King, Jason;
- Brownstein, David;
- Schrader, Joerg;
- Medine, Claire N.;
- Forbes, Stuart J.;
- Iredale, John P.;
- Newsome, Philip N.;
- Hay, David C.
Publication type:
Article
Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin.
Published in:
Liver International, 2009, v. 29, n. 7, p. 966, doi. 10.1111/j.1478-3231.2009.02070.x
By:
- Hartland, Stephen N.;
- Murphy, Frank;
- Aucott, Rebecca L.;
- Abergel, Armand;
- Xiaoying Zhou;
- Waung, Julian;
- Patel, Nishit;
- Bradshaw, Catherine;
- Collins, Jane;
- Mann, Derek;
- Benyon, R. Christopher;
- Iredale, John P.
Publication type:
Article
Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis.
Published in:
Liver International, 2004, v. 24, n. 5, p. 492, doi. 10.1111/j.1478-3231.2004.0946.x
By:
- Zhou, Xiaoying;
- Hovell, Christopher J.;
- Pawley, Susannah;
- Hutchings, Matthew I.;
- Arthur, Michael J. P.;
- Iredale, John P.;
- Benyon, R.Christopher
Publication type:
Article
Unexpectedly high incidence of indigenous acute hepatitis E within South Hampshire: Time for routine testing?
Published in:
Journal of Medical Virology, 2008, v. 80, n. 2, p. 283, doi. 10.1002/jmv.21062
By:
- De Silva, Aminda N.;
- Muddu, Ajay K.;
- Iredale, John P.;
- Sheron, Nick;
- Khakoo, Salim I.;
- Pelosi, Emanuela
Publication type:
Article
Targeting of α<sub>v</sub> integrin identifies a core molecular pathway that regulates fibrosis in several organs.
Published in:
Nature Medicine, 2013, v. 19, n. 12, p. 1617, doi. 10.1038/nm.3282
By:
- Henderson, Neil C;
- Arnold, Thomas D;
- Katamura, Yoshio;
- Giacomini, Marilyn M;
- Rodriguez, Juan D;
- McCarty, Joseph H;
- Pellicoro, Antonella;
- Raschperger, Elisabeth;
- Betsholtz, Christer;
- Ruminski, Peter G;
- Griggs, David W;
- Prinsen, Michael J;
- Maher, Jacquelyn J;
- Iredale, John P;
- Lacy-Hulbert, Adam;
- Adams, Ralf H;
- Sheppard, Dean
Publication type:
Article
Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease.
Published in:
Nature Medicine, 2012, v. 18, n. 4, p. 572, doi. 10.1038/nm.2667
By:
- Boulter, Luke;
- Govaere, Olivier;
- Bird, Tom G;
- Radulescu, Sorina;
- Ramachandran, Prakash;
- Pellicoro, Antonella;
- Ridgway, Rachel A;
- Seo, Sang Soo;
- Spee, Bart;
- Van Rooijen, Nico;
- Sansom, Owen J;
- Iredale, John P;
- Lowell, Sally;
- Roskams, Tania;
- Forbes, Stuart J
Publication type:
Article
Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner.
Published in:
2015
By:
- Filis, Panagiotis;
- Nagrath, Nalin;
- Fraser, Margaret;
- Hay, David C;
- Iredale, John P;
- O'Shaughnessy, Peter;
- Fowler, Paul A
Publication type:
journal article
Liver Fibrosis: Understanding the Dynamics of Bidirectional Wound Repair to Inform the Design of Markers and Therapies.
Published in:
Digestive Diseases, 2017, v. 35, n. 4, p. 310, doi. 10.1159/000456581
By:
- Iredale, John P.;
- Pellicoro, antonella;
- Fallowfield, Jonathan a.
Publication type:
Article
Emerging Therapies for Liver Fibrosis.
Published in:
Digestive Diseases, 2006, v. 24, n. 1/2, p. 174, doi. 10.1159/000090320
By:
- Fowell, Andrew J.;
- Iredale, John P.
Publication type:
Article
Increased levels of 3-hydroxykynurenine parallel disease severity in human acute pancreatitis.
Published in:
Scientific Reports, 2016, p. 33951, doi. 10.1038/srep33951
By:
- Skouras, Christos;
- Zheng, Xiaozhong;
- Binnie, Margaret;
- Homer, Natalie Z. M.;
- Murray, Toby B. J.;
- Robertson, Darren;
- Briody, Lesley;
- Paterson, Finny;
- Spence, Heather;
- Derr, Lisa;
- Hayes, Alastair J.;
- Tsoumanis, Andreas;
- Lyster, Dawn;
- Parks, Rowan W.;
- Garden, O. James;
- Iredale, John P.;
- Uings, Iain J.;
- Liddle, John;
- Wright, Wayne L.;
- Dukes, George
Publication type:
Article
Proteinase Activated Receptor 1 Mediated Fibrosis in a Mouse Model of Liver Injury: A Role for Bone Marrow Derived Macrophages.
Published in:
PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0086241
By:
- Kallis, Yiannis N.;
- Scotton, Christopher J.;
- MacKinnon, Alison C.;
- Goldin, Robert D.;
- Wright, Nicholas A.;
- Iredale, John P.;
- Chambers, Rachel C.;
- Forbes, Stuart J.
Publication type:
Article
Respiratory compromise relieved by laparotomy.
Published in:
Postgraduate Medical Journal, 2000, p. 436, doi. 10.1136/pmj.76.897.436
By:
- Bali, Anu;
- Walker, David A.;
- Iredale, John P.;
- Johnson, Colin D.
Publication type:
Article
Accurate Prediction of Drug-Induced Liver Injury Using Stem Cell-Derived Populations.
Published in:
Stem Cells Translational Medicine, 2014, v. 3, n. 2, p. 141, doi. 10.5966/sctm.2013-0146
By:
- SZKOLNICKA, DAGMARA;
- FARNWORTH, SARAH L.;
- LUCENDO-VILLARIN, BALTASAR;
- STORCK, CHRISTOPHER;
- WENLI ZHOU;
- IREDALE, JOHN P.;
- FLINT, OLIVER;
- HAY, DAVID C.
Publication type:
Article
Reversibility of liver fibrosis.
Published in:
Fibrogenesis & Tissue Repair, 2012, v. 5, n. Suppl 1, p. 1, doi. 10.1186/1755-1536-5-S1-S26
By:
- Pellicoro, Antonella;
- Ramachandran, Prakash;
- Iredale, John P.
Publication type:
Article
BREXIT and science, where do we go from here.
Published in:
QJM: An International Journal of Medicine, 2016, v. 109, n. 10, p. 643, doi. 10.1093/qjmed/hcw131
By:
- Iredale, John P.
Publication type:
Article
Liver fibrosis and repair: immune regulation of wound healing in a solid organ.
Published in:
Nature Reviews Immunology, 2014, v. 14, n. 3, p. 181, doi. 10.1038/nri3623
By:
- Pellicoro, Antonella;
- Ramachandran, Prakash;
- Iredale, John P.;
- Fallowfield, Jonathan A.
Publication type:
Article
Hepatic progenitor cells of biliary origin with liver repopulation capacity.
Published in:
Nature Cell Biology, 2015, v. 17, n. 8, p. 971, doi. 10.1038/ncb3203
By:
- Lu, Wei-Yu;
- Bird, Thomas G.;
- Boulter, Luke;
- Tsuchiya, Atsunori;
- Cole, Alicia M.;
- Hay, Trevor;
- Guest, Rachel V.;
- Wojtacha, Davina;
- Man, Tak Yung;
- Mackinnon, Alison;
- Ridgway, Rachel A.;
- Kendall, Timothy;
- Williams, Michael J.;
- Jamieson, Thomas;
- Raven, Alex;
- Hay, David C.;
- Iredale, John P.;
- Clarke, Alan R.;
- Sansom, Owen J.;
- Forbes, Stuart J.
Publication type:
Article
Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance.
Published in:
Advanced Healthcare Materials, 2015, v. 4, n. 12, p. 1820, doi. 10.1002/adhm.201500391
By:
- Villarin, Baltasar Lucendo;
- Cameron, Kate;
- Szkolnicka, Dagmara;
- Rashidi, Hassan;
- Bates, Nicola;
- Kimber, Susan J.;
- Flint, Oliver;
- Forbes, Stuart J.;
- Iredale, John P.;
- Bradley, Mark;
- Hay, David C.
Publication type:
Article
Polyurethane: Stable Cell Phenotype Requires Plasticity: Polymer Supported Directed Differentiation Reveals a Unique Gene Signature Predicting Stable Hepatocyte Performance (Adv. Healthcare Mater. 12/2015).
Published in:
Advanced Healthcare Materials, 2015, v. 4, n. 12, p. 1819, doi. 10.1002/adhm.201570072
By:
- Villarin, Baltasar Lucendo;
- Cameron, Kate;
- Szkolnicka, Dagmara;
- Rashidi, Hassan;
- Bates, Nicola;
- Kimber, Susan J.;
- Flint, Oliver;
- Forbes, Stuart J.;
- Iredale, John P.;
- Bradley, Mark;
- Hay, David C.
Publication type:
Article
CINC‐1 is identified as an acute‐phase protein induced by focal brain injury causing leukocyte mobilization and liver injury.
Published in:
FASEB Journal, 2003, v. 17, n. 9, p. 1168, doi. 10.1096/fj.02-0757fje
By:
- Campbell, Sandra J.;
- Hughes, Paula M.;
- Iredale, John P.;
- Wilcockson, David C.;
- Waters, Sara;
- Docagne, Fabian;
- Hugh Perry, V.;
- Anthony, Daniel C.
Publication type:
Article
Ly6C<sup>hi</sup> Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2011, v. 184, n. 5, p. 569, doi. 10.1164/rccm.201010-1719OC
By:
- Gibbons, Michael A.;
- MacKinnon, Alison C.;
- Ramachandran, Prakash;
- Dhaliwal, Kevin;
- Duffin, Rodger;
- Phythian-Adams, Alexander T.;
- van Rooijen, Nico;
- Haslett, Christopher;
- Howie, Sarah E.;
- Simpson, A. John;
- Hirani, Nikhil;
- Gauldie, Jack;
- Iredale, John P.;
- Sethi, Tariq;
- Forbes, Stuart J.
Publication type:
Article
Integration of geoscience frameworks into digital pathology analysis permits quantification of microarchitectural relationships in histological landscapes.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-74691-9
By:
- Kendall, Timothy J.;
- Duff, Catherine M.;
- Thomson, Andrew M.;
- Iredale, John P.
Publication type:
Article
An efficient method to isolate Kupffer cells eliminating endothelial cell contamination and selective bias.
Published in:
Journal of Leukocyte Biology, 2018, v. 104, n. 3, p. 579, doi. 10.1002/JLB.1TA0517-169R
By:
- Lynch, Ruairi W.;
- Hawley, Catherine A.;
- Pellicoro, Antonella;
- Bain, Calum C.;
- Iredale, John P.;
- Jenkins, Stephen J.
Publication type:
Article
Tissue inhibitors of metalloproteinases, hepatic stellate cells and liver fibrosis.
Published in:
Journal of Gastroenterology & Hepatology, 1998, v. 13, p. S33, doi. 10.1111/jgh.1998.13.s1.33
By:
- ARTHUR, MICHAEL JP;
- MANN, DEREK A;
- IREDALE, JOHN P
Publication type:
Article
N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1.
Published in:
Comparative Hepatology, 2004, v. 3, p. S8, doi. 10.1186/1476-5926-2-S1-S8
By:
- Murphy, Frank;
- Waung, Julian;
- Collins, Jane;
- Arthur, Michael J. P.;
- Nagase, Hideaki;
- Mann, Derek;
- Benyon, R. Christopher;
- Iredale, John P.
Publication type:
Article
Sites of erythropoietin production.
Published in:
Kidney International, 1997, v. 51, n. 2, p. 393, doi. 10.1038/ki.1997.52
By:
- Maxwell, Patrick H.;
- Ferguson, David J. P.;
- Nicholis, Lynn G.;
- Iredale, John P.;
- Pugh, Christopher W.;
- Johnson, Martin H.;
- Ratcliffe, Peter J.
Publication type:
Article
ECAT-V: where clinical and research training meet.
Published in:
Veterinary Record: Journal of the British Veterinary Association, 2013, v. 173, n. 15, p. 364, doi. 10.1136/vr.f6185
By:
- Argyle, David J.;
- Iredale, John P.;
- Jackson, Andrew P.;
- Walker, Brian R.
Publication type:
Article

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