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Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform.
- Published in:
- Frontiers in Pharmacology, 2024, p. 1, doi. 10.3389/fphar.2024.1448744
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- Publication type:
- Article
Use of Tox21 Screening Data to Evaluate the COVID-19 Drug Candidates for Their Potential Toxic Effects and Related Pathways.
- Published in:
- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.935399
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- Publication type:
- Article
Identification of Selective CYP3A7 and CYP3A4 Substrates and Inhibitors Using a High-Throughput Screening Platform.
- Published in:
- Frontiers in Pharmacology, 2022, v. 13, p. 1, doi. 10.3389/fphar.2022.899536
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- Publication type:
- Article
Identification of hit compounds with anti-schistosomal activity on in vitro generated juvenile worms in cell-free medium.
- Published in:
- PLoS Neglected Tropical Diseases, 2021, v. 15, n. 5, p. 1, doi. 10.1371/journal.pntd.0009432
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- Publication type:
- Article
Three-Dimensional Structural Insights Have Revealed the Distinct Binding Interactions of Agonists, Partial Agonists, and Antagonists with the µ Opioid Receptor.
- Published in:
- International Journal of Molecular Sciences, 2023, v. 24, n. 8, p. 7042, doi. 10.3390/ijms24087042
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- Publication type:
- Article
Application of dynamic topic models to toxicogenomics data.
- Published in:
- BMC Bioinformatics, 2016, v. 17, p. 153, doi. 10.1186/s12859-016-1225-0
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- Publication type:
- Article
Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation.
- Published in:
- Archives of Toxicology, 2022, v. 96, n. 7, p. 1975, doi. 10.1007/s00204-022-03291-5
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- Publication type:
- Article
Exploring NCATS in-house biomedical data for evidence-based drug repurposing.
- Published in:
- PLoS ONE, 2024, v. 19, n. 1, p. 1, doi. 10.1371/journal.pone.0289518
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- Publication type:
- Article
Biological activity-based modeling identifies antiviral leads against SARS-CoV-2.
- Published in:
- Nature Biotechnology, 2021, v. 39, n. 6, p. 747, doi. 10.1038/s41587-021-00839-1
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- Publication type:
- Article
Erratum: Prediction of human population responses to toxic compounds by a collaborative competition.
- Published in:
- Nature Biotechnology, 2015, v. 33, n. 10, p. 1109, doi. 10.1038/nbt1015-1109a
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- Publication type:
- Article
Prediction of human population responses to toxic compounds by a collaborative competition.
- Published in:
- Nature Biotechnology, 2015, v. 33, n. 9, p. 933, doi. 10.1038/nbt.3299
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- Publication type:
- Article
Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.
- Published in:
- Nature Biotechnology, 2009, v. 27, n. 11, p. 1050, doi. 10.1038/nbt.1581
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- Publication type:
- Article
Observation on the Efficacy of Acupuncture Plus Medication in Treating Anovulatory Dysfunctional Uterine Bleeding due to Spleen-Kidney Deficiency.
- Published in:
- International Journal of Clinical Acupuncture, 2020, v. 29, n. 2, p. 90, doi. 10.3103/S104719792002009X
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- Publication type:
- Article
Observation on the Efficacy of Acupuncture plus Herbs Medicine in Treating Anovulatory Dysfunctional Uterine Bleeding due to Spleen-Kidney Deficiency.
- Published in:
- International Journal of Clinical Acupuncture, 2019, v. 28, n. 3, p. 165, doi. 10.3103/S104719791903013X
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- Publication type:
- Article
Identification of known drugs targeting the endoplasmic reticulum stress response.
- Published in:
- Analytical & Bioanalytical Chemistry, 2015, v. 407, n. 18, p. 5343, doi. 10.1007/s00216-015-8694-2
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- Publication type:
- Article
PfCRT and PfMDR1 modulate interactions of artemisinin derivatives and ion channel blockers.
- Published in:
- Scientific Reports, 2016, p. 25379, doi. 10.1038/srep25379
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- Publication type:
- Article
Unraveling Gene Fusions for Drug Repositioning in High-Risk Neuroblastoma.
- Published in:
- Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2021.608778
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- Publication type:
- Article
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.
- Published in:
- Frontiers in Pharmacology, 2021, v. 11, p. N.PAG, doi. 10.3389/fphar.2020.592737
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- Publication type:
- Article
Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40537-x
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- Publication type:
- Article
Paradigm Shift in Toxicity Testing and Modeling.
- Published in:
- AAPS Journal, 2012, v. 14, n. 3, p. 473, doi. 10.1208/s12248-012-9358-1
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- Publication type:
- Article
DYNAMICAL BEHAVIOR OF AN SIR EPIDEMIC MODEL WITH RATIO-DEPENDENT IMPULSIVE CONTROL AND BEDDINGTON–DEANGELIS INCIDENCE.
- Published in:
- Journal of Biological Systems, 2024, v. 32, n. 3, p. 1093, doi. 10.1142/S0218339024500360
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- Publication type:
- Article
Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of Assays.
- Published in:
- PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0130796
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- Publication type:
- Article
A Novel Chordoma Xenograft Allows <i>In Vivo</i> Drug Testing and Reveals the Importance of NF-κB Signaling in Chordoma Biology.
- Published in:
- PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0079950
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- Publication type:
- Article
Linking tumor cell cytotoxicity to mechanism of drug action: An integrated analysis of gene expression, small-molecule screening and structural databases.
- Published in:
- Proteins, 2005, v. 59, n. 3, p. 403, doi. 10.1002/prot.20392
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- Publication type:
- Article
Assessment of the DNA damaging potential of environmental chemicals using a quantitative high-throughput screening approach to measure p53 activation.
- Published in:
- Environmental & Molecular Mutagenesis, 2017, v. 58, n. 7, p. 494, doi. 10.1002/em.22112
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- Publication type:
- Article
Fingerprinting Interactions between Proteins and Ligands for Facilitating Machine Learning in Drug Discovery.
- Published in:
- Biomolecules (2218-273X), 2024, v. 14, n. 1, p. 72, doi. 10.3390/biom14010072
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- Publication type:
- Article
Drug Repositioning for Noonan and LEOPARD Syndromes by Integrating Transcriptomics With a Structure-Based Approach.
- Published in:
- Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.00927
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- Publication type:
- Article
Prediction of hERG Liability - Using SVM Classification, Bootstrapping and Jackknifing.
- Published in:
- Molecular Informatics, 2017, v. 36, n. 4, p. n/a, doi. 10.1002/minf.201600126
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- Publication type:
- Article
Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-Like Molecules.
- Published in:
- Molecular Informatics, 2012, v. 31, n. 11/12, p. 783, doi. 10.1002/minf.201200065
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- Publication type:
- Article
Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition.
- Published in:
- Environmental Health Perspectives, 2021, v. 129, n. 4, p. 047008-1, doi. 10.1289/EHP6993
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- Publication type:
- Article
Limited Chemical Structural Diversity Found to Modulate Thyroid Hormone Receptor in the Tox21 Chemical Library.
- Published in:
- Environmental Health Perspectives, 2019, v. 127, n. 9, p. 1, doi. 10.1289/EHP5314
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- Publication type:
- Article
Comprehensive Analyses and Prioritization of Tox21 10K Chemicals Affecting Mitochondrial Function by in-Depth Mechanistic Studies.
- Published in:
- Environmental Health Perspectives, 2018, v. 126, n. 7, p. 077010-1, doi. 10.1289/EHP2589
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- Publication type:
- Article
Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data.
- Published in:
- Environmental Health Perspectives, 2016, v. 124, n. 5, p. 634, doi. 10.1289/ehp.1509763
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- Publication type:
- Article
Population-Based in Vitro Hazard and Concentration--Response Assessment of Chemicals: The 1000 Genomes High-Throughput Screening Study.
- Published in:
- Environmental Health Perspectives, 2015, v. 123, n. 5, p. 458, doi. 10.1289/ehp.1408775
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- Publication type:
- Article
Profiling of the Tox21 Chemical Collection for Mitochondrial Function to Identify Compounds that Acutely Decrease Mitochondrial Membrane Potential.
- Published in:
- Environmental Health Perspectives, 2015, v. 123, n. 1, p. 49, doi. 10.1289/ehp.1408642
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- Publication type:
- Article
Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals.
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- 2013
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- Publication type:
- Journal Article
Supplemental Material. Using in Vitro High-Throughput Screening Assays to Identify Potential Endocrine Disrupting Chemicals.
- Published in:
- Environmental Health Perspectives, 2013, v. 121, n. 1, p. 1, doi. 10.1289/ehp.1205065
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- Publication type:
- Article
Profiling Environmental Chemicals for Activity in the Antioxidant Response Element Signaling Pathway Using a High Throughput Screening Approach.
- Published in:
- Environmental Health Perspectives, 2012, v. 120, n. 8, p. 1150, doi. 10.1289/ehp.1104709
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- Publication type:
- Article
Chemical Genomics Profiling of Environmental Chemical Modulation of Human Nuclear Receptors.
- Published in:
- Environmental Health Perspectives, 2011, v. 119, n. 8, p. 1142, doi. 10.1289/ehp.1002952
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- Publication type:
- Article
Compound Cytotoxicity Profiling Using Quantitative High-Throughput Screening.
- Published in:
- Environmental Health Perspectives, 2008, v. 116, n. 3, p. 284, doi. 10.1289/ehp.10727
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- Publication type:
- Article
Identification of Environmental Compounds That May Trigger Early Female Puberty by Activating Human GnRHR and KISS1R.
- Published in:
- Endocrinology, 2024, v. 165, n. 10, p. 1, doi. 10.1210/endocr/bqae103
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- Publication type:
- Article
XIST lost induces ovarian cancer stem cells to acquire taxol resistance via a KMT2C-dependent way.
- Published in:
- Cancer Cell International, 2020, v. 20, n. 1, p. N.PAG, doi. 10.1186/s12935-020-01500-8
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- Publication type:
- Article
Decoding the κ Opioid Receptor (KOR): Advancements in Structural Understanding and Implications for Opioid Analgesic Development.
- Published in:
- Molecules, 2024, v. 29, n. 11, p. 2635, doi. 10.3390/molecules29112635
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- Publication type:
- Article
Discovery and characterization of potent And-1 inhibitors for cancer treatment.
- Published in:
- Clinical & Translational Medicine, 2021, v. 11, n. 12, p. 1, doi. 10.1002/ctm2.627
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- Publication type:
- Article
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.
- Published in:
- Breast Cancer Research, 2014, v. 16, n. 3, p. 1, doi. 10.1186/bcr3682
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- Publication type:
- Article
Drug repurposing screen identifies lestaurtinib amplifies the ability of the poly (ADP-ribose) polymerase 1 inhibitor AG14361 to kill breast cancer associated gene-1 mutant and wild type breast cancer cells.
- Published in:
- 2014
- By:
- Publication type:
- journal article
Characterization of environmental chemicals with potential for DNA damage using isogenic DNA repair-deficient chicken DT40 cell lines.
- Published in:
- Environmental & Molecular Mutagenesis, 2011, v. 52, n. 7, p. 547, doi. 10.1002/em.20656
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- Publication type:
- Article
Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.
- Published in:
- Nature Communications, 2016, v. 7, n. 1, p. 10425, doi. 10.1038/ncomms10425
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- Publication type:
- Article
Effect of ratio threshold control on epidemic dynamics: analysis of an SIR model with non-monotonic incidence.
- Published in:
- Nonlinear Dynamics, 2024, v. 112, n. 14, p. 12677, doi. 10.1007/s11071-024-09699-1
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- Publication type:
- Article
Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-86110-8
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- Publication type:
- Article