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A new [<sup>2</sup>H]-labelled α-trichloroimidate glucuronic ester for the synthesis of deuterated drug conjugates.
- Published in:
- Journal of Labelled Compounds & Radiopharmaceuticals, 2014, v. 57, n. 12, p. 699, doi. 10.1002/jlcr.3243
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- Publication type:
- Article
Syntheses of <sup>2</sup>H-labelled dihydropyrimidinediones and their metabolites.
- Published in:
- Journal of Labelled Compounds & Radiopharmaceuticals, 2001, v. 44, n. 1, p. 7, doi. 10.1002/jlcr.426
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- Publication type:
- Article
Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans.
- Published in:
- Frontiers in Genetics, 2020, v. 11, p. N.PAG, doi. 10.3389/fgene.2020.00944
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- Publication type:
- Article
External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 9, p. 1368, doi. 10.3390/pharmaceutics13091368
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- Publication type:
- Article
Interaction of Remdesivir with Clinically Relevant Hepatic Drug Uptake Transporters.
- Published in:
- Pharmaceutics, 2021, v. 13, n. 3, p. 369, doi. 10.3390/pharmaceutics13030369
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- Publication type:
- Article
Dynamics and Control of the Central Carbon Metabolism in Hepatoma Cells.
- Published in:
- BMC Systems Biology, 2010, v. 4, p. 54, doi. 10.1186/1752-0509-4-54
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- Publication type:
- Article
Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death.
- Published in:
- 2017
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- Publication type:
- journal article
Hepatobiliary Thyroid Hormone Deficiency Impacts Bile Acid Hydrophilicity and Aquaporins in Cholestatic C57BL/6J Mice.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 20, p. 12355, doi. 10.3390/ijms232012355
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- Publication type:
- Article
Hepatic Expression of the Na + -Taurocholate Cotransporting Polypeptide Is Independent from Genetic Variation.
- Published in:
- International Journal of Molecular Sciences, 2022, v. 23, n. 13, p. 7468, doi. 10.3390/ijms23137468
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- Publication type:
- Article
Polycyclic Aromatic Hydrocarbons Activate the Aryl Hydrocarbon Receptor and the Constitutive Androstane Receptor to Regulate Xenobiotic Metabolism in Human Liver Cells.
- Published in:
- International Journal of Molecular Sciences, 2021, v. 22, n. 1, p. 372, doi. 10.3390/ijms22010372
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- Publication type:
- Article
Gene Suppression of Transketolase-Like Protein 1 (TKTL1) Sensitizes Glioma Cells to Hypoxia and Ionizing Radiation.
- Published in:
- International Journal of Molecular Sciences, 2018, v. 19, n. 8, p. 2168, doi. 10.3390/ijms19082168
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- Publication type:
- Article
The BCL-2 inhibitor ABT-199/venetoclax synergizes with proteasome inhibition via transactivation of the MCL-1 antagonist NOXA.
- Published in:
- Cell Death Discovery, 2022, v. 8, n. 1, p. 1, doi. 10.1038/s41420-022-01009-1
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- Publication type:
- Article
Metabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS.
- Published in:
- Metabolites (2218-1989), 2020, v. 10, n. 12, p. 494, doi. 10.3390/metabo10120494
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- Publication type:
- Article
Correction to: Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.
- Published in:
- 2018
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- Publication type:
- Correction Notice
Liver cancer cell lines distinctly mimic the metabolic gene expression pattern of the corresponding human tumours.
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2018, v. 37, n. 1, p. N.PAG, doi. 10.1186/s13046-018-0872-6
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- Publication type:
- Article
Quantitative bile acid profiling by liquid chromatography quadrupole time-of-flight mass spectrometry: monitoring hepatitis B therapy by a novel Na-taurocholate cotransporting polypeptide inhibitor.
- Published in:
- Analytical & Bioanalytical Chemistry, 2015, v. 407, n. 22, p. 6815, doi. 10.1007/s00216-015-8853-5
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- Publication type:
- Article
LC-MS/MS method for the simultaneous quantification of artesunate and its metabolites dihydroartemisinin and dihydroartemisinin glucuronide in human plasma.
- Published in:
- Analytical & Bioanalytical Chemistry, 2014, v. 406, n. 17, p. 4299, doi. 10.1007/s00216-014-7820-x
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- Publication type:
- Article
Methylomes of renal cell lines and tumors or metastases differ significantly with impact on pharmacogenes.
- Published in:
- Scientific Reports, 2016, p. 29930, doi. 10.1038/srep29930
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- Publication type:
- Article
Effects of Diminished NADPH:cytochrome P450 Reductase in Human Hepatocytes on Lipid and Bile Acid Homeostasis.
- Published in:
- Frontiers in Pharmacology, 2021, v. 12, p. 1, doi. 10.3389/fphar.2021.769703
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- Publication type:
- Article
Correction to: Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression.
- Published in:
- 2021
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- Publication type:
- corrected article
Progesterone receptor membrane component 1 regulates lipid homeostasis and drives oncogenic signaling resulting in breast cancer progression.
- Published in:
- 2020
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- Publication type:
- journal article
Oncogenic Stress Induced by Acute Hyper-Activation of Bcr-Abl Leads to Cell Death upon Induction of Excessive Aerobic Glycolysis.
- Published in:
- PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0025139
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- Publication type:
- Article
Proton Pump Inhibitors Inhibit Metformin Uptake by Organic Cation Transporters (OCTs).
- Published in:
- PLoS ONE, 2011, v. 6, n. 7, p. 1, doi. 10.1371/journal.pone.0022163
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- Publication type:
- Article
Impact of the SLCO1B1 polymorphism on the pharmacokinetics and lipid-lowering efficacy of multiple-dose pravastatin<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 5, p. 419, doi. 10.1016/j.clpt.2006.01.010
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- Publication type:
- Article
Effects of ursodeoxycholic acid on P-glycoprotein and cytochrome P450 3A4–dependent pharmacokinetics in humans<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 5, p. 449, doi. 10.1016/j.clpt.2006.01.005
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- Publication type:
- Article
Evidence for morphine-independent central nervous opioid effects after administration of codeine: Contribution of other codeine metabolites<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2006, v. 79, n. 1, p. 35, doi. 10.1016/j.clpt.2005.09.005
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- Publication type:
- Article
Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: Evidence from clinical and pharmacokinetic data
- Published in:
- Clinical Pharmacology & Therapeutics, 2005, v. 78, n. 6, p. 627, doi. 10.1016/j.clpt.2005.08.017
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- Publication type:
- Article
Impact of concentration and rate of intraluminal drug delivery on absorption and gut wall metabolism of verapamil in humans<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2004, v. 76, n. 3, p. 230, doi. 10.1016/j.clpt.2004.04.013
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- Publication type:
- Article
Enzyme induction in the elderly: Effect of rifampin on the pharmacokinetics and pharmacodynamics of propafenone<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 2000, v. 67, n. 5, p. 512, doi. 10.1067/mcp.2000.106872
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- Publication type:
- Article
Effect of codeine on gastrointestinal motility in relation to CYP2D6 phenotype<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 1997, v. 61, n. 4, p. 459, doi. 10.1016/S0009-9236(97)90196-X
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- Publication type:
- Article
Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 6, p. 613, doi. 10.1016/S0009-9236(96)90001-6
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- Publication type:
- Article
Disposition and first-pass metabolism of ethanol in humans: Is it gastric or hepatic and does it depend on gender?<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 5, p. 503, doi. 10.1016/S0009-9236(96)90178-2
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- Publication type:
- Article
Assessment of individual CYP2D6 activity in extensive metabolizers with renal failure: Comparison of sparteine and dextromethorphan<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 5, p. 583, doi. 10.1016/S0009-9236(96)90187-3
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- Publication type:
- Article
Dihydrocodeine: A new opioid substrate for the polymorphic CYP2D6 in humans<sup>*</sup>.
- Published in:
- Clinical Pharmacology & Therapeutics, 1995, v. 58, n. 4, p. 374, doi. 10.1016/0009-9236(95)90049-7
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- Publication type:
- Article
Syntheses of Metabolites of S-Carboxymethyl- L-cysteine and S-Methyl- L-cysteine and of Some Isotopically Labelled (<sup>2</sup>H, <sup>13</sup>C) Analogues.
- Published in:
- Archiv der Pharmazie, 1990, v. 323, n. 12, p. 957, doi. 10.1002/ardp.19903231205
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- Publication type:
- Article
Identification of metabolic fluxes in hepatic cells from transient <sup>13</sup>C-labeling experiments: Part II. Flux estimation.
- Published in:
- Biotechnology & Bioengineering, 2008, v. 100, n. 2, p. 355, doi. 10.1002/bit.21746
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- Publication type:
- Article
Identification of metabolic fluxes in hepatic cells from transient <sup>13</sup>C-labeling experiments: Part I. Experimental observations.
- Published in:
- Biotechnology & Bioengineering, 2008, v. 100, n. 2, p. 344, doi. 10.1002/bit.21747
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- Publication type:
- Article
Hypothyroidism Increases Cholesterol Gallstone Prevalence in Mice by Elevated Hydrophobicity of Primary Bile Acids.
- Published in:
- Thyroid, 2021, v. 31, n. 6, p. 973, doi. 10.1089/thy.2020.0636
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- Publication type:
- Article
Activation of Epidermal Growth Factor Receptor Sensitizes Glioblastoma Cells to Hypoxia-Induced Cell Death.
- Published in:
- Cancers, 2020, v. 12, n. 8, p. 2144, doi. 10.3390/cancers12082144
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- Publication type:
- Article
Diclofenac does not interact with codeine metabolism in vivo: A study in healthy volunteers.
- Published in:
- BMC Clinical Pharmacology, 2002, v. 2, p. 2, doi. 10.1186/1472-6904-2-2
- By:
- Publication type:
- Article
Differential effects of metformin on breast cancer proliferation according to markers of insulin resistance and tumor subtype in a randomized presurgical trial.
- Published in:
- Breast Cancer Research & Treatment, 2014, v. 148, n. 1, p. 81, doi. 10.1007/s10549-014-3141-1
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- Publication type:
- Article
Characterisation of (R/S)-propafenone and its metabolites as substrates and inhibitors of P-glycoprotein.
- Published in:
- Naunyn-Schmiedeberg's Archives of Pharmacology, 2005, v. 371, n. 3, p. 195, doi. 10.1007/s00210-005-1025-y
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- Publication type:
- Article
Characterisation of cerivastatin as a P-glycoprotein substrate: studies in P-glycoprotein-expressing cell monolayers and mdr1a/b knock-out mice.
- Published in:
- Naunyn-Schmiedeberg's Archives of Pharmacology, 2004, v. 370, n. 2, p. 124
- By:
- Publication type:
- Article
Nicotinamide‐N‐methyltransferase is a promising metabolic drug target for primary and metastatic clear cell renal cell carcinoma.
- Published in:
- Clinical & Translational Medicine, 2022, v. 12, n. 6, p. 1, doi. 10.1002/ctm2.883
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- Publication type:
- Article
A Sensitive Sensor Cell Line for the Detection of Oxidative Stress Responses in Cultured Human Keratinocytes.
- Published in:
- Sensors (14248220), 2014, v. 14, n. 7, p. 11293, doi. 10.3390/s140711293
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- Publication type:
- Article
Translational learning from clinical studies predicts drug pharmacokinetics across patient populations.
- Published in:
- NPJ Systems Biology & Applications, 2017, v. 3, n. 1, p. N.PAG, doi. 10.1038/s41540-017-0012-5
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- Publication type:
- Article
Converting Aspartase into a β-Amino Acid Lyase by Cluster Screening.
- Published in:
- ChemCatChem, 2014, v. 6, n. 4, p. 965, doi. 10.1002/cctc.201300986
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- Publication type:
- Article
Molybdenum Cofactor Catabolism Unravels the Physiological Role of the Drug Metabolizing Enzyme Thiopurine S‐Methyltransferase.
- Published in:
- Clinical Pharmacology & Therapeutics, 2022, v. 112, n. 4, p. 808, doi. 10.1002/cpt.2637
- By:
- Publication type:
- Article
Tri‐Allelic Haplotypes Determine and Differentiate Functionally Normal Allele CYP2D6*2 and Impaired Allele CYP2D6*41.
- Published in:
- Clinical Pharmacology & Therapeutics, 2021, v. 109, n. 5, p. 1256, doi. 10.1002/cpt.2078
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- Publication type:
- Article
Cardiovascular effects of (R)- and (S)-verapamil and racemic verapamil in humans: a placebo-controlled study.
- Published in:
- European Journal of Clinical Pharmacology, 2006, v. 62, n. 8, p. 613, doi. 10.1007/s00228-006-0154-7
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- Publication type:
- Article