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Development of a quantitative semi‐mechanistic model of Alzheimer's disease based on the amyloid/tau/neurodegeneration framework (the Q‐ATN model).
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 6, p. 2287, doi. 10.1002/alz.12877
By:
- Mazer, Norman A.;
- Hofmann, Carsten;
- Lott, Dominik;
- Gieschke, Ronald;
- Klein, Gregory;
- Boess, Frank;
- Grimm, Hans Peter;
- Kerchner, Geoffrey A.;
- Baudler‐Klein, Monika;
- Smith, Janice;
- Doody, Rachelle S.
Publication type:
Article
Baseline participant characteristics of GRADUATION: a study to evaluate once‐weekly subcutaneous administration of gantenerumab.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.061781
By:
- Boess, Frank;
- Lane, Christopher;
- Scelsi, Marzia A.;
- Delmar, Paul;
- Hofmann, Carsten;
- Tonietto, Matteo;
- Klein, Gregory;
- Kerchner, Geoffrey A.;
- Baudler, Monika;
- Doody, Rachelle S.
Publication type:
Article
Linking amyloid to clinical outcome: A quantitative semi‐mechanistic model based on the A/T/N biomarker framework to simulate the natural history of Alzheimer's disease and the effects of anti‐amyloid treatment.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 3, p. 1, doi. 10.1002/alz.067069
By:
- Mazer, Norman A;
- Hofmann, Carsten;
- Lott, Dominik;
- Gieschke, Ronald;
- Klein, Gregory;
- Boess, Frank;
- Grimm, Hans Peter;
- Kerchner, Geoffrey A.;
- Baudler, Monika;
- Smith, Janice;
- Schobel, Scott;
- Doody, Rachelle S.
Publication type:
Article
Graduation study design: Evaluation of once‐weekly subcutaneous administration of gantenerumab on brain amyloid load.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.052060
By:
- Boess, Frank;
- Sakaoka, Shunsuke;
- Abi‐Saab, Danielle;
- Scelsi, Marzia Antonella;
- Delmar, Paul;
- Hofmann, Carsten;
- Klein, Gregory;
- Baudler, Monika;
- Doody, Rachelle;
- Kerchner, Geoffrey A
Publication type:
Article
Characterization of amyloid‐related imaging abnormality in the DIAN‐TU‐001 trial.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.056393
By:
- Joseph‐Mathurin, Nelly;
- Llibre‐Guerra, Jorge J;
- McCullough, Austin A.;
- Li, Yan;
- Hofmann, Carsten;
- Wojtowicz, Jakub;
- Wang, Qing;
- Wang, Guoqiao;
- Gordon, Brian A.;
- Chen, Charles D.;
- Brooks, William S.;
- Gauthier, Serge;
- Holdridge, Karen C.;
- Hsiung, Ging‐Yuek Robin;
- Jack, Clifford R.;
- Klein, Gregory;
- Masellis, Mario;
- Mummery, Catherine J.;
- Preboske, Gregory M.;
- Santacruz, Anna
Publication type:
Article
Why does ARIA‐E appear bright? A quantitative model linking brain tissue composition and T<sub>2</sub> FLAIR hyperintensities: Neuroimaging / evaluating treatments.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.046115
By:
- Aldea, Roxana;
- Grimm, Hans Peter;
- Gieschke, Ronald;
- Hofmann, Carsten;
- Klein, Gregory;
- Kunnecke, Basil;
- Piazza, Fabrizio;
- Carare, Roxana O;
- Mazer, Norman A
Publication type:
Article
DT‐01‐02: CONTINUED LARGE AMYLOID PET REDUCTIONS AT 36 MONTHS IN THE GANTENERUMAB OPEN‐LABEL EXTENSION STUDIES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P1484, doi. 10.1016/j.jalz.2019.08.005
By:
- Klein, Gregory;
- Delmar, Paul;
- Kerchner, Geoffrey A.;
- Hofmann, Carsten;
- Abi-Saab, Danielle;
- Ristic, Smiljana;
- Rehal, Sunita;
- Voyle, Nicola;
- Baudler, Monika;
- Fontoura, Paulo;
- Doody, Rachelle
Publication type:
Article
O1‐09‐02: THE EFFECT OF LOW DOSES OF GANTENERUMAB ON AMYLOID AND TAU BIOMARKERS IN CEREBROSPINAL FLUID (CSF) IN THE MARGUERITE ROAD STUDY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P240, doi. 10.1016/j.jalz.2018.06.2379
By:
- Voyle, Nicola;
- Abi-Saab, Danielle;
- Klein, Gregory;
- Hofmann, Carsten;
- Delmar, Paul;
- Pross, Nathalie;
- Andjelkovic, Mirjana;
- Milosavljevic-Ristic, Smiljana;
- Martenyi, Ferenc;
- Fontoura, Paulo;
- Doody, Rachelle
Publication type:
Article
O1‐09‐03: 24‐MONTH AMYLOID PET RESULTS OF THE GANTENERUMAB HIGH‐DOSE OPEN LABEL EXTENSION STUDIES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P240, doi. 10.1016/j.jalz.2018.06.2380
By:
- Klein, Gregory;
- Delmar, Paul;
- Hofmann, Carsten;
- Abi-Saab, Danielle;
- Andjelkovic, Mirjana;
- Ristic, Smiljana;
- Voyle, Nicola;
- Seibyl, John;
- Marek, Ken;
- Martenyi, Ferenc;
- Baudler, Monika;
- Fontoura, Paulo;
- Doody, Rachelle
Publication type:
Article
Gantenerumab reduces amyloid-β plaques in patients with prodromal to moderate Alzheimer's disease: a PET substudy interim analysis.
Published in:
Alzheimer's Research & Therapy, 2019, v. 11, n. 1, p. 1, doi. 10.1186/s13195-019-0559-z
By:
- Klein, Gregory;
- Delmar, Paul;
- Voyle, Nicola;
- Rehal, Sunita;
- Hofmann, Carsten;
- Abi-Saab, Danielle;
- Andjelkovic, Mirjana;
- Ristic, Smiljana;
- Wang, Guoqiao;
- Bateman, Randall;
- Kerchner, Geoffrey A.;
- Baudler, Monika;
- Fontoura, Paulo;
- Doody, Rachelle
Publication type:
Article
Correction to: A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease.
Published in:
2018
By:
- Ostrowitzki, Susanne;
- Lasser, Robert A.;
- Dorflinger, Ernest;
- Scheltens, Philip;
- Barkhof, Frederik;
- Nikolcheva, Tania;
- Ashford, Elizabeth;
- Retout, Sylvie;
- Hofmann, Carsten;
- Delmar, Paul;
- Klein, Gregory;
- Andjelkovic, Mirjana;
- Dubois, Bruno;
- Boada, Mercè;
- Blennow, Kaj;
- Santarelli, Luca;
- Fontoura, Paulo
Publication type:
Correction Notice
A phase III randomized trial of gantenerumab in prodromal Alzheimer's disease.
Published in:
Alzheimer's Research & Therapy, 2017, v. 9, p. 1, doi. 10.1186/s13195-017-0318-y
By:
- Ostrowitzki, Susanne;
- Lasser, Robert A.;
- Dorflinger, Ernest;
- Scheltens, Philip;
- Barkhof, Frederik;
- Nikolcheva, Tania;
- Ashford, Elizabeth;
- Retout, Sylvie;
- Hofmann, Carsten;
- Delmar, Paul;
- Klein, Gregory;
- Andjelkovic, Mirjana;
- Dubois, Bruno;
- Boada, Mercè;
- Blennow, Kaj;
- Santarelli, Luca;
- Fontoura, Paulo
Publication type:
Article
[<sup>11</sup>C]-RO5013853: a New PET Radioligand for the Glycine Transporter TYPE 1.
Published in:
Neuropsychopharmacology, 2014, v. 39, n. 9, p. 2272, doi. 10.1038/npp.2014.52
By:
- Wong, Dean;
- Ostrowitzki, Susanne;
- Zhou, Yun;
- Alberati, Daniela;
- Pinard, Emmanuel;
- Raymont, Vanessa;
- Martin-Facklam, Meret;
- Hofmann, Carsten;
- Parkar, Nikhat;
- Brasic, James;
- Hilton, John;
- Dannals, Robert;
- Borroni, Edilio
Publication type:
Article
Amyloid‐Related Imaging Abnormalities in the DIAN‐TU‐001 Trial of Gantenerumab and Solanezumab: Lessons from a Trial in Dominantly Inherited Alzheimer Disease.
Published in:
Annals of Neurology, 2022, v. 92, n. 5, p. 729, doi. 10.1002/ana.26511
By:
- Joseph‐Mathurin, Nelly;
- Llibre‐Guerra, Jorge J.;
- Li, Yan;
- McCullough, Austin A.;
- Hofmann, Carsten;
- Wojtowicz, Jakub;
- Park, Ethan;
- Wang, Guoqiao;
- Preboske, Gregory M.;
- Wang, Qing;
- Gordon, Brian A.;
- Chen, Charles D.;
- Flores, Shaney;
- Aggarwal, Neelum T.;
- Berman, Sarah B.;
- Bird, Thomas D.;
- Black, Sandra E.;
- Borowski, Bret;
- Brooks, William S.;
- Chhatwal, Jasmeer P.
Publication type:
Article
Disease Modeling and Model‐Based Meta‐Analyses to Define a New Direction for a Phase III Program of Gantenerumab in Alzheimer's Disease.
Published in:
Clinical Pharmacology & Therapeutics, 2022, v. 111, n. 4, p. 857, doi. 10.1002/cpt.2535
By:
- Retout, Sylvie;
- Gieschke, Ronald;
- Serafin, Daniel;
- Weber, Cornelia;
- Frey, Nicolas;
- Hofmann, Carsten
Publication type:
Article
Quantitative systems pharmacology model of the amyloid pathway in Alzheimer's disease: Insights into the therapeutic mechanisms of clinical candidates.
Published in:
CPT: Pharmacometrics & Systems Pharmacology, 2023, v. 12, n. 1, p. 62, doi. 10.1002/psp4.12876
By:
- Ramakrishnan, Vidya;
- Friedrich, Christina;
- Witt, Colleen;
- Sheehan, Robert;
- Pryor, Meghan;
- Atwal, Jasvinder K.;
- Wildsmith, Kristin;
- Kudrycki, Katherine;
- Lee, Seung‐Hye;
- Mazer, Norman;
- Hofmann, Carsten;
- Fuji, Reina N.;
- Jin, Jin Y.;
- Ramanujan, Saroja;
- Dolton, Michael;
- Quartino, Angelica
Publication type:
Article
Effects of Cytochrome P450 3A4 Inhibitors-Ketoconazole and Erythromycin-on Bitopertin Pharmacokinetics and Comparison with Physiologically Based Modelling Predictions.
Published in:
2016
By:
- Boetsch, Christophe;
- Parrott, Neil;
- Fowler, Stephen;
- Poirier, Agnes;
- Hainzl, Dominik;
- Banken, Ludger;
- Martin-Facklam, Meret;
- Hofmann, Carsten
Publication type:
journal article
Physiologically Based Pharmacokinetic Modelling to Predict Single- and Multiple-Dose Human Pharmacokinetics of Bitopertin.
Published in:
Clinical Pharmacokinetics, 2013, v. 52, n. 8, p. 673, doi. 10.1007/s40262-013-0061-x
By:
- Parrott, Neil;
- Hainzl, Dominik;
- Alberati, Daniela;
- Hofmann, Carsten;
- Robson, Richard;
- Boutouyrie, Bruno;
- Martin-Facklam, Meret
Publication type:
Article
Effect of Saquinavir-Ritonavir on Cytochrome P450 3A4 Activity in Healthy Volunteers Using Midazolam as a Probe.
Published in:
Pharmacotherapy, 2009, v. 29, n. 10, p. 1175, doi. 10.1592/phco.29.10.1175
By:
- Schmitt, Christophe;
- Hofmann, Carsten;
- Rick, Myriam;
- Patel, Arpna;
- Zwanziger, Elke
Publication type:
Article
Impact of model misspecification on model-based tests in PK studies with parallel design: real case and simulation studies.
Published in:
Journal of Pharmacokinetics & Pharmacodynamics, 2022, v. 49, n. 5, p. 557, doi. 10.1007/s10928-022-09821-z
By:
- Guhl, Mélanie;
- Mercier, François;
- Hofmann, Carsten;
- Sharan, Satish;
- Donnelly, Mark;
- Feng, Kairui;
- Sun, Wanjie;
- Sun, Guoying;
- Grosser, Stella;
- Zhao, Liang;
- Fang, Lanyan;
- Mentré, France;
- Comets, Emmanuelle;
- Bertrand, Julie
Publication type:
Article
In silico exploration of amyloid-related imaging abnormalities in the gantenerumab open-label extension trials using a semi-mechanistic model.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2022, v. 8, n. 1, p. 1, doi. 10.1002/trc2.12306
By:
- Aldea, Roxana;
- Grimm, Hans Peter;
- Gieschke, Ronald;
- Hofmann, Carsten;
- Lott, Dominik;
- Bullain, Szofia;
- Delmar, Paul;
- Klein, Gregory;
- Lyons, Marco;
- Piazza, Fabrizio;
- Carare, Roxana O.;
- Mazer, Norman A.
Publication type:
Article
Assessment of Drug-Drug Interactions between Taspoglutide, a Glucagon-Like Peptide-1 Agonist, and Drugs Commonly Used in Type 2 Diabetes Mellitus: Results of Five Phase I Trials.
Published in:
2019
By:
- Bogman, Katrijn;
- Brumm, Jochen;
- Hofmann, Carsten;
- Giraudon, Mylène;
- Niggli, Markus;
- Sturm-Pellanda, Carolina;
- Sauter, Annette;
- Sturm, Stefan;
- Mangold, Bernhard;
- Schmitt, Christophe
Publication type:
journal article
Effects of the glycine reuptake inhibitors bitopertin and RG7118 on glycine in cerebrospinal fluid: results of two proofs of mechanism studies in healthy volunteers.
Published in:
Psychopharmacology, 2016, v. 233, n. 13, p. 2429, doi. 10.1007/s00213-016-4317-7
By:
- Hofmann, Carsten;
- Pizzagalli, Flavia;
- Boetsch, Christophe;
- Alberati, Daniela;
- Ereshefsky, Larry;
- Jhee, Stanford;
- Patat, Alain;
- Boutouyrie-Dumont, Bruno;
- Martin-Facklam, Meret
Publication type:
Article
LanV, a Bifunctional Enzyme: Aromatase and Ketoreductase during Landomycin A Biosynthesis.
Published in:
ChemBioChem, 2005, v. 6, n. 12, p. 2312, doi. 10.1002/cbic.200500205
By:
- Almuth Mayer;
- Takaaki Taguchi;
- Anton Linnenbrink;
- Carsten Hofmann;
- Andriy Luzhetskyy;
- Andreas Bechthold
Publication type:
Article
Generation of Novel Landomycins M and O through Targeted Gene Disruption.
Published in:
ChemBioChem, 2005, v. 6, n. 4, p. 675, doi. 10.1002/cbic.200400316
By:
- Andriy Luzhetskyy;
- Lili Zhu;
- Miranda Gibson;
- Marta Fedoryshyn;
- Clemens Dürr;
- Carsten Hofmann;
- Dirk Hoffmeister;
- Bohdan Ostash;
- Cynthia Mattingly;
- Val Adams;
- Victor Fedorenko;
- Jürgen Rohr;
- Andreas Bechthold
Publication type:
Article

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