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Pridopidine, a clinic-ready compound, reduces 3,4-dihydroxyphenylalanine-induced dyskinesia in Parkinsonian macaques.
- Published in:
- 2019
- By:
- Publication type:
- journal article
A longitudinal study of magnetic resonance spectroscopy Huntington's disease biomarkers.
- Published in:
- Movement Disorders, 2015, v. 30, n. 3, p. 393, doi. 10.1002/mds.26118
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- Publication type:
- Article
Multisource ascertainment of Huntington disease in Canada: Prevalence and population at risk.
- Published in:
- Movement Disorders, 2014, v. 29, n. 1, p. 105, doi. 10.1002/mds.25717
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- Publication type:
- Article
A systematic review and meta-analysis of clinical variables used in Huntington disease research.
- Published in:
- Movement Disorders, 2013, v. 28, n. 14, p. 1987, doi. 10.1002/mds.25663
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- Publication type:
- Article
Re: Autopsy-proven Huntington's disease with 29 trinucleotide repeats.
- Published in:
- Movement Disorders, 2008, v. 23, n. 12, p. 1794, doi. 10.1002/mds.21820
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- Publication type:
- Article
Small Changes, Big Impact: Posttranslational Modifications and Function of Huntingtin in Huntington Disease.
- Published in:
- Neuroscientist, 2011, v. 17, n. 5, p. 475, doi. 10.1177/1073858410390378
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- Publication type:
- Article
Ultrasensitive measurement of huntingtin protein in cerebrospinal fluid demonstrates increase with Huntington disease stage and decrease following brain huntingtin suppression.
- Published in:
- Scientific Reports, 2015, p. 12166, doi. 10.1038/srep12166
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- Publication type:
- Article
Gene expression studies of a human monocyte cell line identify dissimilarities between differently manufactured glatiramoids.
- Published in:
- Scientific Reports, 2015, p. 10191, doi. 10.1038/srep10191
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- Publication type:
- Article
pS421 huntingtin modulates mitochondrial phenotypes and confers neuroprotection in an HD hiPSC model.
- Published in:
- Cell Death & Disease, 2020, v. 11, n. 9, p. 1, doi. 10.1038/s41419-020-02983-z
- By:
- Publication type:
- Article
ABCA1 Gene Mutations, HDL Cholesterol Levels, and Risk of Ischemic Heart Disease.
- Published in:
- 2008
- By:
- Publication type:
- Letter
Transgenic Mouse Model Expressing the Caspase 6 Fragment of Mutant Huntingtin.
- Published in:
- Journal of Neuroscience, 2012, v. 32, n. 1, p. 183, doi. 10.1523/JNEUROSCI.1305-11.2012
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- Publication type:
- Article
Cleavage at the 586 Amino Acid Caspase-6 Site in Mutant huntingtin Influences Caspase-6 Activation In Vivo.
- Published in:
- Journal of Neuroscience, 2010, v. 30, n. 45, p. 15019, doi. 10.1523/JNEUROSCI.2071-10.2010
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- Publication type:
- Article
BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice.
- Published in:
- Journal of Neuroscience, 2010, v. 30, n. 44, p. 14708, doi. 10.1523/JNEUROSCI.1637-10.2010
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- Publication type:
- Article
Phosphorylation of Huntingtin at Ser<sup>421</sup> in YAC128 Neurons Is Associated with Protection of YAC 128 Neurons from NMDA-Mediated Excitotoxicity and Is Modulated by PP1 and PP2A.
- Published in:
- Journal of Neuroscience, 2010, v. 30, n. 43, p. 14318, doi. 10.1523/JNEUROSCI.1589-10.2010
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- Publication type:
- Article
Interaction of Postsynaptic Density Protein-95 with NMDA Receptors Influences Excitotoxicity in the Yeast Artificial Chromosome Mouse Model of Huntington's Disease.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 35, p. 10928, doi. 10.1523/JNEUROSCI.2491-09.2009
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- Publication type:
- Article
Presynaptic Defects Underlying Impaired Learning and Memory Function in Lipoprotein Lipase-Deficient Mice.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 14, p. 4681, doi. 10.1523/JNEUROSCI.0297-09.2009
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- Publication type:
- Article
Specific Loss of Brain ABCA1 Increases Brain Cholesterol Uptake and Influences Neuronal Structure and Function.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 11, p. 3579, doi. 10.1523/JNEUROSCI.4741-08.2009
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- Publication type:
- Article
Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 8, p. 2414, doi. 10.1523/JNEUROSCI.5687-08.2009
- By:
- Publication type:
- Article
Differential Susceptibility to Excitotoxic Stress in YAC128 Mouse Models of Huntington Disease between Initiation and Progression of Disease.
- Published in:
- Journal of Neuroscience, 2009, v. 29, n. 7, p. 2193, doi. 10.1523/JNEUROSCI.5473-08.2009
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- Publication type:
- Article
Polyglutamine-Modulated Striatal Calpain Activity in YAC Transgenic Huntington Disease Mouse Model: Impact on NMDA Receptor Function and Toxicity.
- Published in:
- Journal of Neuroscience, 2008, v. 28, n. 48, p. 12725, doi. 10.1523/JNEUROSCI.4619-08.2008
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- Publication type:
- Article
Age-Dependent Alterations of Corticostriatal Activity in the YAC128 Mouse Model of Huntington Disease.
- Published in:
- Journal of Neuroscience, 2008, p. 2414, doi. 10.1523/JNEUROSCI.5687-08.2009
- By:
- Publication type:
- Article
Mitochondrial Sensitivity and Altered Calcium Handling Underlie Enhanced NMDA-Induced Apoptosis in YAC128 Model of Huntington's Disease.
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 50, p. 13614, doi. 10.1523/JNEUROSCI.3455-07.2007
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- Publication type:
- Article
Huntingtin-Interacting Protein 1 Influences Worm and Mouse Presynaptic Function and Protects Caenorhabditis elegans Neurons against Mutant Polyglutamine Toxicity.
- Published in:
- Journal of Neuroscience, 2007, v. 27, n. 41, p. 11056, doi. 10.1523/JNEUROSCI.1941-07.2007
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- Publication type:
- Article
Identification of a novel caspase cleavage site in huntingtin that regulates mutant huntingtin clearance.
- Published in:
- FASEB Journal, 2019, v. 33, n. 3, p. 3190, doi. 10.1096/fj.201701510RRR
- By:
- Publication type:
- Article
Therapeutic modulation of the bile acid pool by Cyp8b1 knockdown protects against nonalcoholic fatty liver disease in mice.
- Published in:
- FASEB Journal, 2018, v. 32, n. 7, p. 3792, doi. 10.1096/fj.201701084RR
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- Publication type:
- Article
Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity.
- Published in:
- FASEB Journal, 2009, v. 23, n. 8, p. 2605, doi. 10.1096/fj.08-127399
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- Publication type:
- Article
Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors.
- Published in:
- Journal of Neurochemistry, 2008, v. 104, n. 3, p. 790, doi. 10.1111/j.1471-4159.2007.05016.x
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- Publication type:
- Article
Wild-type huntingtin protects neurons from excitotoxicity.
- Published in:
- Journal of Neurochemistry, 2006, v. 96, n. 4, p. 1121, doi. 10.1111/j.1471-4159.2005.03605.x
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- Publication type:
- Article
Cystamine treatment is neuroprotective in the YAC128 mouse model of Huntington disease.
- Published in:
- Journal of Neurochemistry, 2005, v. 95, n. 1, p. 210, doi. 10.1111/j.1471-4159.2005.03357.x
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- Publication type:
- Article
Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease.
- Published in:
- Journal of Neurochemistry, 2005, v. 94, n. 4, p. 1087, doi. 10.1111/j.1471-4159.2005.03255.x
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- Publication type:
- Article
Genotypic Approaches to Therapy in Children.
- Published in:
- Annals of the New York Academy of Sciences, 2007, v. 1110, p. 177, doi. 10.1196/annals.1423.020
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- Publication type:
- Article
When good drugs go bad.
- Published in:
- 2007
- By:
- Publication type:
- Editorial
Differential modulation of endotoxin responsiveness by human caspase-12 polymorphisms.
- Published in:
- Nature, 2004, v. 429, n. 6987, p. 75, doi. 10.1038/nature02451
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- Publication type:
- Article
In Vivo Evaluation of Candidate Allele-specific Mutant Huntingtin Gene Silencing Antisense Oligonucleotides.
- Published in:
- Molecular Therapy, 2014, v. 22, n. 12, p. 2093, doi. 10.1038/mt.2014.153
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- Publication type:
- Article
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
- Published in:
- Journal of Cell Biology, 2009, v. 187, n. 7, p. 1083, doi. 10.1083/jcb.200909067
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- Publication type:
- Article
A Huntingtin-based peptide inhibitor of caspase-6 provides protection from mutant Huntingtin-induced motor and behavioral deficits.
- Published in:
- Human Molecular Genetics, 2015, v. 24, n. 9, p. 2604, doi. 10.1093/hmg/ddv023
- By:
- Publication type:
- Article
The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.
- Published in:
- Human Molecular Genetics, 2014, v. 23, n. 15, p. 4142, doi. 10.1093/hmg/ddu137
- By:
- Publication type:
- Article
Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of Huntingtin.
- Published in:
- Human Molecular Genetics, 2014, v. 23, n. 12, p. 3166, doi. 10.1093/hmg/ddu027
- By:
- Publication type:
- Article
p53 increases caspase-6 expression and activation in muscle tissue expressing mutant huntingtin.
- Published in:
- Human Molecular Genetics, 2014, v. 23, n. 3, p. 717, doi. 10.1093/hmg/ddt458
- By:
- Publication type:
- Article
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
- Published in:
- Human Molecular Genetics, 2013, v. 22, n. 3, p. 452, doi. 10.1093/hmg/dds441
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- Publication type:
- Article
A fully humanized transgenic mouse model of Huntington disease.
- Published in:
- Human Molecular Genetics, 2013, v. 22, n. 1, p. 18, doi. 10.1093/hmg/dds397
- By:
- Publication type:
- Article
Marked differences in neurochemistry and aggregates despite similar behavioural and neuropathological features of Huntington disease in the full-length BACHD and YAC128 mice.
- Published in:
- Human Molecular Genetics, 2012, v. 21, n. 10, p. 2219, doi. 10.1093/hmg/dds037
- By:
- Publication type:
- Article
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
- Published in:
- Human Molecular Genetics, 2011, v. 20, n. 20, p. 3899, doi. 10.1093/hmg/ddr308
- By:
- Publication type:
- Article
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
- Published in:
- Human Molecular Genetics, 2011, v. 20, n. 17, p. 3356, doi. 10.1093/hmg/ddr242
- By:
- Publication type:
- Article
Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression.
- Published in:
- Human Molecular Genetics, 2010, v. 19, n. 8, p. 1528, doi. 10.1093/hmg/ddq026
- By:
- Publication type:
- Article
Transcriptional changes in Huntington disease identified using genome-wide expression profiling and cross-platform analysis.
- Published in:
- Human Molecular Genetics, 2010, v. 19, n. 8, p. 1438, doi. 10.1093/hmg/ddq018
- By:
- Publication type:
- Article
Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease.
- Published in:
- Human Molecular Genetics, 2008, v. 17, n. 17, p. 2738, doi. 10.1093/hmg/ddn175
- By:
- Publication type:
- Article
Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.
- Published in:
- Human Molecular Genetics, 2008, v. 17, n. 15, p. 2390, doi. 10.1093/hmg/ddn139
- By:
- Publication type:
- Article
Cholesterol biosynthesis pathway is disturbed in YAC128 mice and is modulated by huntingtin mutation.
- Published in:
- Human Molecular Genetics, 2007, v. 16, n. 18, p. 2187, doi. 10.1093/hmg/ddm170
- By:
- Publication type:
- Article
Mutant huntingtin's effects on striatal gene expression in mice recapitulate changes observed in human Huntington's disease brain and do not differ with mutant huntingtin length or wild-type huntingtin dosage.
- Published in:
- Human Molecular Genetics, 2007, v. 16, n. 15, p. 1845, doi. 10.1093/hmg/ddm133
- By:
- Publication type:
- Article