OpenURL Connection Search

Select item for more details and to access through your institution.

Targeted Genetic Screen in Amyotrophic Lateral Sclerosis Reveals Novel Genetic Variants with Synergistic Effect on Clinical Phenotype.
Published in:
Frontiers in Molecular Neuroscience, 2017, p. 1, doi. 10.3389/fnmol.2017.00370
By:
- Cooper-Knock, Johnathan;
- Robins, Henry;
- Niedermoser, Isabell;
- Wyles, Matthew;
- Heath, Paul R.;
- Higginbottom, Adrian;
- Walsh, Theresa;
- Kazoka, Mbombe;
- Ince, Paul G.;
- Hautbergue, Guillaume M.;
- McDermott, Christopher J.;
- Kirby, Janine;
- Shaw, Pamela J.
Publication type:
Article
Structural and functional analysis of RNA and TAP binding to SF2/ASF.
Published in:
EMBO Reports, 2007, v. 8, n. 8, p. 756, doi. 10.1038/sj.embor.7401031
By:
- Tintaru, Aura M;
- Hautbergue, Guillaume M;
- Hounslow, Andrea M;
- Hung, Ming-Lung;
- Lian, Lu-Yun;
- Craven, C Jeremy;
- Wilson, Stuart A
Publication type:
Article
The structure and selectivity of the SR protein SRSF2 RRM domain with RNA.
Published in:
Nucleic Acids Research, 2012, v. 40, n. 7, p. 3232, doi. 10.1093/nar/gkr1164
By:
- Phelan, Marie M.;
- Goult, Benjamin T.;
- Clayton, Jonathan C.;
- Hautbergue, Guillaume M.;
- Wilson, Stuart A.;
- Lian, Lu-Yun
Publication type:
Article
Arginine methylation of REF/ALY promotes efficient handover of mRNA to TAP/NXF1.
Published in:
Nucleic Acids Research, 2010, v. 38, n. 10, p. 3351, doi. 10.1093/nar/gkq033
By:
- Hung, Ming-Lung;
- Hautbergue, Guillaume M.;
- Snijders, Ambrosius P. L.;
- Dickman, Mark J.;
- Wilson, Stuart A.
Publication type:
Article
The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41304-8
By:
- Mihaylov, Simeon R.;
- Castelli, Lydia M.;
- Lin, Ya-Hui;
- Gül, Aytac;
- Soni, Nikita;
- Hastings, Christopher;
- Flynn, Helen R.;
- Păun, Oana;
- Dickman, Mark J.;
- Snijders, Ambrosius P.;
- Goldstone, Robert;
- Bandmann, Oliver;
- Shelkovnikova, Tatyana A.;
- Mortiboys, Heather;
- Ultanir, Sila K.;
- Hautbergue, Guillaume M.
Publication type:
Article
Loss of TMEM106B exacerbates C9ALS/FTD DPR pathology by disrupting autophagosome maturation.
Published in:
Frontiers in Cellular Neuroscience, 2022, v. 16, p. 01, doi. 10.3389/fncel.2022.1061559
By:
- Bauer, Claudia S.;
- Webster, Christopher P.;
- Shaw, Allan C.;
- Kok, Jannigje R.;
- Castelli, Lydia M.;
- Ya-Hui Lin;
- Smith, Emma F.;
- Illanes-Álvarez, Francisco;
- Higginbottom, Adrian;
- Shaw, Pamela J.;
- Azzouz, Mimoun;
- Ferraiuolo, Laura;
- Hautbergue, Guillaume M.;
- Grierson, Andrew J.;
- De Vos, Kurt J.
Publication type:
Article
Stable transgenic C9orf72 zebrafish model key aspects of the ALS/FTD phenotype and reveal novel pathological features.
Published in:
Acta Neuropathologica Communications, 2018, v. 6, n. 1, p. N.PAG, doi. 10.1186/s40478-018-0629-7
By:
- Shaw, Matthew P.;
- Higginbottom, Adrian;
- McGown, Alexander;
- Castelli, Lydia M.;
- James, Evlyn;
- Hautbergue, Guillaume M.;
- Shaw, Pamela J.;
- Ramesh, Tennore M.
Publication type:
Article
In C andida albicans hyphae, Sec2p is physically associated with SEC2 mRNA on secretory vesicles.
Published in:
Molecular Microbiology, 2014, v. 94, n. 4, p. 828, doi. 10.1111/mmi.12799
By:
- Caballero‐Lima, David;
- Hautbergue, Guillaume M.;
- Wilson, Stuart A.;
- Sudbery, Peter E.
Publication type:
Article
A Y374X TDP43 truncation leads to an altered metabolic profile in amyotrophic lateral sclerosis fibroblasts driven by pyruvate and TCA cycle intermediate alterations.
Published in:
Frontiers in Aging Neuroscience, 2023, p. 1, doi. 10.3389/fnagi.2023.1151848
By:
- Allen, Scott P.;
- Al Sultan, Afnan;
- Kibirige, Elaine Kabucho;
- Tonkiss, Erin;
- Hamer, Keaton J.;
- Castelli, Lydia M.;
- Ya-Hui Lin;
- Roscoe, Sarah;
- Stefanidis, Nikolaos;
- Mead, Richard J.;
- Highley, J. Robin;
- Cooper-Knock, Johnathan;
- Hautbergue, Guillaume M.;
- Heath, Paul R.;
- Kirby, Janine;
- Shaw, Pamela J.
Publication type:
Article
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.
Published in:
EMBO Journal, 2016, v. 35, n. 15, p. 1656, doi. 10.15252/embj.201694401
By:
- Webster, Christopher P;
- Smith, Emma F;
- Bauer, Claudia S;
- Moller, Annekathrin;
- Hautbergue, Guillaume M;
- Ferraiuolo, Laura;
- Myszczynska, Monika A;
- Higginbottom, Adrian;
- Walsh, Matthew J;
- Whitworth, Alexander J;
- Kaspar, Brian K;
- Meyer, Kathrin;
- Shaw, Pamela J;
- Grierson, Andrew J;
- De Vos, Kurt J
Publication type:
Article
Chtop is a component of the dynamic TREX mRNA export complex.
Published in:
EMBO Journal, 2013, v. 32, n. 3, p. 473, doi. 10.1038/emboj.2012.342
By:
- Chang, Chung‐Te;
- Hautbergue, Guillaume M;
- Walsh, Matthew J;
- Viphakone, Nicolas;
- van Dijk, Thamar B;
- Philipsen, Sjaak;
- Wilson, Stuart A
Publication type:
Article
Molecular basis of RNA recognition and TAP binding by the SR proteins SRp20 and 9G8.
Published in:
EMBO Journal, 2006, v. 25, n. 21, p. 5126, doi. 10.1038/sj.emboj.7601385
By:
- Hargous, Yann;
- Hautbergue, Guillaume M.;
- Tintaru, Aura M.;
- Skrisovska, Lenka;
- Golovanov, Alexander P.;
- Stevenin, James;
- Lu-Yun Lian;
- Wilson, Stuart A.;
- Allain, Frédéric H.-T.
Publication type:
Article
C9ORF72-derived poly-GA DPRs undergo endocytic uptake in iAstrocytes and spread to motor neurons.
Published in:
Life Science Alliance, 2022, v. 5, n. 9, p. 1, doi. 10.26508/lsa.202101276
By:
- Marchi, Paolo M.;
- Marrone, Lara;
- Brasseur, Laurent;
- Coens, Audrey;
- Webster, Christopher P.;
- Bousset, Luc;
- Destro, Marco;
- Smith, Emma F.;
- Walther, Christa G.;
- Alfred, Victor;
- Marroccella, Raffaele;
- Graves, Emily J.;
- Robinson, Darren;
- Shaw, Allan C.;
- Lai Mei Wan;
- Grierson, Andrew J.;
- Ebbens, Stephen J.;
- De Vos, Kurt J.;
- Hautbergue, Guillaume M.;
- Ferraiuolo, Laura
Publication type:
Article
SMN-deficient cells exhibit increased ribosomal DNA damage.
Published in:
Life Science Alliance, 2022, v. 5, n. 8, p. 1, doi. 10.26508/lsa.202101145
By:
- Karyka, Evangelia;
- Ramirez, Nelly Berrueta;
- Webster, Christopher P.;
- Marchi, Paolo M.;
- Graves, Emily J.;
- Godena, Vinay K.;
- Marrone, Lara;
- Bhargava, Anushka;
- Ray, Swagat;
- Ke Ning;
- Crane, Hannah;
- Hautbergue, Guillaume M.;
- El-Khamisy, Sherif F.;
- Azzouz, Mimoun
Publication type:
Article
Invited Review: Decoding the pathophysiological mechanisms that underlie RNA dysregulation in neurodegenerative disorders: a review of the current state of the art.
Published in:
Neuropathology & Applied Neurobiology, 2015, v. 41, n. 2, p. 109, doi. 10.1111/nan.12187
By:
- Walsh, Matthew J.;
- Cooper‐Knock, Johnathan;
- Dodd, Jennifer E.;
- Stopford, Matthew J.;
- Mihaylov, Simeon R.;
- Kirby, Janine;
- Shaw, Pamela J.;
- Hautbergue, Guillaume M.
Publication type:
Article
Sequestration of multiple RNA recognition motif-containing proteins by C9orf72 repeat expansions.
Published in:
Brain: A Journal of Neurology, 2014, v. 137, n. 7, p. 2040, doi. 10.1093/brain/awu120
By:
- Cooper-Knock, Johnathan;
- Walsh, Matthew J.;
- Higginbottom, Adrian;
- Robin Highley, J.;
- Dickman, Mark J.;
- Edbauer, Dieter;
- Ince, Paul G.;
- Wharton, Stephen B.;
- Wilson, Stuart A.;
- Kirby, Janine;
- Hautbergue, Guillaume M.;
- Shaw, Pamela J.
Publication type:
Article
SRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.
Published in:
Nature Communications, 2017, v. 8, n. 7, p. 16063, doi. 10.1038/ncomms16063
By:
- Hautbergue, Guillaume M.;
- Castelli, Lydia M.;
- Ferraiuolo, Laura;
- Sanchez-Martinez, Alvaro;
- Cooper-Knock, Johnathan;
- Higginbottom, Adrian;
- Lin, Ya-Hui;
- Bauer, Claudia S.;
- Dodd, Jennifer E.;
- Myszczynska, Monika A.;
- Alam, Sarah M.;
- Garneret, Pierre;
- Chandran, Jayanth S.;
- Karyka, Evangelia;
- Stopford, Matthew J.;
- Smith, Emma F.;
- Kirby, Janine;
- Meyer, Kathrin;
- Kaspar, Brian K.;
- Isaacs, Adrian M.
Publication type:
Article
Erratum: TREX exposes the RNA-binding domain of Nxf1 to enable mRNA export.
Published in:
Nature Communications, 2013, v. 4, n. 10, p. 2377, doi. 10.1038/ncomms3377
By:
- Viphakone, Nicolas;
- Hautbergue, Guillaume M.;
- Walsh, Matthew;
- Chang, Chung-Te;
- Holland, Arthur;
- Folco, Eric G.;
- Reed, Robin;
- Wilson, Stuart A.
Publication type:
Article
Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells.
Published in:
Toxins, 2018, v. 10, n. 7, p. 261, doi. 10.3390/toxins10070261
By:
- Rust, Aleksander;
- Shah, Sajid;
- Hautbergue, Guillaume M.;
- Davletov, Bazbek
Publication type:
Article
Proteomic and cellular localisation studies suggest non‐tight junction cytoplasmic and nuclear roles for occludin in astrocytes.
Published in:
European Journal of Neuroscience, 2018, v. 47, n. 12, p. 1444, doi. 10.1111/ejn.13933
By:
- Morgan, Sarah V.;
- Garwood, Claire J.;
- Jennings, Luke;
- Simpson, Julie E.;
- Castelli, Lydia M.;
- Heath, Paul R.;
- Mihaylov, Simeon R.;
- Vaquéz‐Villaseñor, Irina;
- Minshull, Thomas C.;
- Ince, Paul G.;
- Dickman, Mark J.;
- Hautbergue, Guillaume M.;
- Wharton, Stephen B.
Publication type:
Article
Atypical TDP‐43 protein expression in an ALS pedigree carrying a p.Y374X truncation mutation in TARDBP.
Published in:
Brain Pathology, 2023, v. 33, n. 1, p. 1, doi. 10.1111/bpa.13104
By:
- Cooper‐Knock, Johnathan;
- Julian, Thomas H.;
- Feneberg, Emily;
- Highley, J. Robin;
- Sidra, Maurice;
- Turner, Martin R.;
- Talbot, Kevin;
- Ansorge, Olaf;
- Allen, Scott P.;
- Moll, Tobias;
- Shelkovnikova, Tatyana;
- Castelli, Lydia;
- Hautbergue, Guillaume M.;
- Hewitt, Christopher;
- Kirby, Janine;
- Wharton, Stephen B.;
- Mead, Richard J.;
- Shaw, Pamela J.
Publication type:
Article
Competitive and Cooperative Interactions Mediate RNA Transfer from Herpesvirus Saimiri ORF57 to the Mammalian Export Adaptor ALYREF.
Published in:
PLoS Pathogens, 2014, v. 10, n. 2, p. 1, doi. 10.1371/journal.ppat.1003907
By:
- Tunnicliffe, Richard B.;
- Hautbergue, Guillaume M.;
- Wilson, Stuart A.;
- Kalra, Priti;
- Golovanov, Alexander P.
Publication type:
Article
An Interaction between KSHV ORF57 and UIF Provides mRNA-Adaptor Redundancy in Herpesvirus Intronless mRNA Export.
Published in:
PLoS Pathogens, 2011, v. 7, n. 7, p. 1, doi. 10.1371/journal.ppat.1002138
By:
- Jackson, Brian R.;
- Boyne, James R.;
- Noerenberg, Marko;
- Taylor, Adam;
- Hautbergue, Guillaume M.;
- Walsh, Matthew J.;
- Wheat, Rachel;
- Blackbourn, David J.;
- Wilson, Stuart A.;
- Whitehouse, Adrian
Publication type:
Article
Structural Basis for the Recognition of Cellular mRNA Export Factor REF by Herpes Viral Proteins HSV-1 ICP27 and HVS ORF57.
Published in:
PLoS Pathogens, 2011, v. 7, n. 1, p. 1, doi. 10.1371/journal.ppat.1001244
By:
- Tunnicliffe, Richard B.;
- Hautbergue, Guillaume M.;
- Kalra, Priti;
- Jackson, Brian R.;
- Whitehouse, Adrian;
- Wilson, Stuart A.;
- Golovanov, Alexander P.
Publication type:
Article
C9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten.
Published in:
Human Molecular Genetics, 2017, v. 26, n. 6, p. 1133, doi. 10.1093/hmg/ddx022
By:
- Stopford, Matthew J.;
- Higginbottom, Adrian;
- Hautbergue, Guillaume M.;
- Cooper-Knock, Johnathan;
- Mulcahy, Padraig J.;
- De Vos, Kurt J.;
- Renton, Alan E.;
- Pliner, Hannah;
- Calvo, Andrea;
- Chio, Adriano;
- Traynor, Bryan J.;
- Azzouz, Mimoun;
- Heath, Paul R.;
- Kirby, Janine;
- Shaw, Pamela J.
Publication type:
Article
The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations.
Published in:
Toxins, 2017, v. 9, n. 11, p. 344, doi. 10.3390/toxins9110344
By:
- Rust, Aleksander;
- Partridge, Lynda J.;
- Davletov, Bazbek;
- Hautbergue, Guillaume M.
Publication type:
Article
Mechanisms of repeat-associated non-AUG translation in neurological microsatellite expansion disorders.
Published in:
Biochemical Society Transactions, 2021, v. 49, n. 2, p. 775, doi. 10.1042/BST20200690
By:
- Castelli, Lydia M.;
- Wan-Ping Huang;
- Ya-Hui Lin;
- Kung-Yao Chang;
- Hautbergue, Guillaume M.
Publication type:
Article
BLF1, the first Burkholderia pseudomallei toxin, connects inhibition of host protein synthesis with melioidosis.
Published in:
Biochemical Society Transactions, 2012, v. 40, n. 4, p. 842, doi. 10.1042/BST20120057
By:
- Hautbergue, Guillaume M.;
- Wilson, Stuart A.
Publication type:
Article
RNA Helicases in Microsatellite Repeat Expansion Disorders and Neurodegeneration.
Published in:
Frontiers in Genetics, 2022, v. 13, p. 1, doi. 10.3389/fgene.2022.886563
By:
- Castelli, Lydia M.;
- Benson, Bridget C.;
- Huang, Wan-Ping;
- Lin, Ya-Hui;
- Hautbergue, Guillaume M.
Publication type:
Article
Drosha regulates neurogenesis by controlling Neurogenin 2 expression independent of microRNAs.
Published in:
Nature Neuroscience, 2012, v. 15, n. 7, p. 962, doi. 10.1038/nn.3139
By:
- Knuckles, Philip;
- Vogt, Miriam A;
- Lugert, Sebastian;
- Milo, Marta;
- Chong, Mark M W;
- Hautbergue, Guillaume M;
- Wilson, Stuart A;
- Littman, Dan R;
- Taylor, Verdon
Publication type:
Article
Directly converted astrocytes retain the ageing features of the donor fibroblasts and elucidate the astrocytic contribution to human CNS health and disease.
Published in:
Aging Cell, 2021, v. 20, n. 1, p. 1, doi. 10.1111/acel.13281
By:
- Gatto, Noemi;
- Dos Santos Souza, Cleide;
- Shaw, Allan C.;
- Bell, Simon M.;
- Myszczynska, Monika A.;
- Powers, Samantha;
- Meyer, Kathrin;
- Castelli, Lydia M.;
- Karyka, Evangelia;
- Mortiboys, Heather;
- Azzouz, Mimoun;
- Hautbergue, Guillaume M.;
- Márkus, Nóra M.;
- Shaw, Pamela J.;
- Ferraiuolo, Laura
Publication type:
Article
Proteinopathies as Hallmarks of Impaired Gene Expression, Proteostasis and Mitochondrial Function in Amyotrophic Lateral Sclerosis.
Published in:
Frontiers in Neuroscience, 2021, v. 15, p. 1, doi. 10.3389/fnins.2021.783624
By:
- Benson, Bridget C.;
- Shaw, Pamela J.;
- Azzouz, Mimoun;
- Highley, J. Robin;
- Hautbergue, Guillaume M.
Publication type:
Article
SRSF1-dependent inhibition of C9ORF72-repeat RNA nuclear export: genome-wide mechanisms for neuroprotection in amyotrophic lateral sclerosis.
Published in:
Molecular Neurodegeneration, 2021, v. 16, n. 1, p. 1, doi. 10.1186/s13024-021-00475-y
By:
- Castelli, Lydia M.;
- Cutillo, Luisa;
- Souza, Cleide Dos Santos;
- Sanchez-Martinez, Alvaro;
- Granata, Ilaria;
- Lin, Ya-Hui;
- Myszczynska, Monika A.;
- Heath, Paul R.;
- Livesey, Matthew R.;
- Ning, Ke;
- Azzouz, Mimoun;
- Shaw, Pamela J.;
- Guarracino, Mario R.;
- Whitworth, Alexander J.;
- Ferraiuolo, Laura;
- Milo, Marta;
- Hautbergue, Guillaume M.
Publication type:
Article

Found: 33