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Current practice and recommendations for advancing how human variability and susceptibility are considered in chemical risk assessment.
- Published in:
- Environmental Health: A Global Access Science Source, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12940-022-00940-1
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- Article
A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement.
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- Environmental Health: A Global Access Science Source, 2023, v. 21, n. 1, p. 1, doi. 10.1186/s12940-022-00930-3
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- Article
Distributions of Individual Susceptibility among Humans for Toxic Effects: How Much Protection Does the Traditional Tenfold Factor Provide for What Fraction of Which Kinds of Chemicals and Effects?
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- Annals of the New York Academy of Sciences, 1999, v. 895, n. 1, p. 286, doi. 10.1111/j.1749-6632.1999.tb08092.x
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- Article
The Next Generation of Risk Assessment Multi-Year Study--Highlights of Findings, Applications to Risk Assessment, and Future Directions.
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- Environmental Health Perspectives, 2016, v. 124, n. 11, p. 1671, doi. 10.1289/EHP233
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- Article
Addressing Human Variability in Next-Generation Human Health Risk Assessments of Environmental Chemicals.
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- Environmental Health Perspectives, 2013, v. 121, n. 1, p. 23, doi. 10.1289/ehp.1205687
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- Article
Evaluation of the Cardiovascular Effects of Methylmercury Exposures: Current Evidence Supports Development of a Dose-Response Function for Regulatory Benefits Analysis.
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- Environmental Health Perspectives, 2011, v. 119, n. 5, p. 607, doi. 10.1289/ehp.1003012
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- Article
Linear Low-Dose Extrapolation for Noncancer Responses Is Not Generally Appropriate.
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- 2009
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- Letter
State-of-the-Science Workshop Report: Issues and Approaches in Low-Dose--Response Extrapolation for Environmental Health Risk Assessment.
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- Environmental Health Perspectives, 2009, v. 117, n. 2, p. 283, doi. 10.1289/ehp.11502
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- Article
Meeting Report: Moving Upstream--Evaluating Adverse Upstream End Points for Improved Risk Assessment and Decision-Making.
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- Environmental Health Perspectives, 2008, v. 116, n. 11, p. 1568, doi. 10.1289/ehp.11516
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- Article
Assessing Cumulative Health Risks from Exposure to Environmental Mixtures--Three Fundamental Questions.
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- Environmental Health Perspectives, 2007, v. 115, n. 5, p. 825, doi. 10.1289/ehp.9333
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- Article
Evaluation of the U.S. EPA/OSWER Preliminary Remediation Goal for Perchlorate in Groundwater: Focus on Exposure to Nursing Infants.
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- Environmental Health Perspectives, 2007, v. 115, n. 3, p. 361, doi. 10.1289/ehp.9533
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- Article
The Economic Impact of Early Life Environmental Tobacco Smoke Exposure: Early Intervention for Developmental Delay.
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- Environmental Health Perspectives, 2006, v. 114, n. 10, p. 1585, doi. 10.1289/ehp.9165
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- Article
Pharmacokinetic and Pharmacodynamic Factors That Can Affect Sensitivity to Neurotoxic Sequelae in Elderly Individuals.
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- Environmental Health Perspectives, 2005, v. 113, n. 9, p. 1243, doi. 10.1289/ehp.7568
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- Article
Age-Related Differences in Susceptibility to Carcinogenesis. II. Approaches for Application and Uncertainty Analyses for Individual Genetically Acting Carcinogens.
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- Environmental Health Perspectives, 2005, v. 113, n. 4, p. 509, doi. 10.1289/ehp.7564
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- Article
Age-Related Differences in Susceptibility to Carcinogenesis: A Quantitative Analysis of Empirical Animal Bioassay Data.
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- Environmental Health Perspectives, 2004, v. 112, n. 11, p. 1152, doi. 10.1289/ehp.6871
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- Article
Evaluation of Child/Adult Pharmacokinetic Differences from a Database Derived from the Therapeutic Drug Literature.
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- Toxicological Sciences, 2002, v. 66, n. 2, p. 185, doi. 10.1093/toxsci/66.2.185
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- Article
Toxicokinetic interaction of 2,5-hexanedione and methyl ethyl ketone.
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- Archives of Toxicology, 2002, v. 75, n. 11/12, p. 643, doi. 10.1007/s00204-001-0298-2
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- Article
Are Conundrums with Uncertainty Factors an Obstacle to Developing Probabilistic Interpretations of Noncancer Risks from Chemicals?
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- Risk Analysis: An International Journal, 2010, v. 30, n. 3, p. 340, doi. 10.1111/j.1539-6924.2010.01364.x
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- Article
High-Throughput Testing—The NRC Vision, The Challenge of Modeling Dynamic Changes in Biological Systems, and the Reality of Low-Throughput Environmental Health Decision Making.
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- Risk Analysis: An International Journal, 2009, v. 29, n. 4, p. 483, doi. 10.1111/j.1539-6924.2008.01167.x
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- Article
Differences in Pharmacokinetics Between Children and Adults--II. Children's Variability in Drug Elimination Half-Lives and in Some Parameters Needed for Physiologically-Based Pharmacokinetic Modeling.
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- Risk Analysis: An International Journal, 2003, v. 23, n. 1, p. 117, doi. 10.1111/1539-6924.00295
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- Article
Human Interindividual Variability in Parameters Related to Health Risks.
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- Risk Analysis: An International Journal, 1999, v. 19, n. 4, p. 711
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- Article
What Should Be the Implications of Uncertainty, Variability, and Inherent "Biases"/"Conservatism" for Risk Management Decision-Making?
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- Risk Analysis: An International Journal, 1999, v. 19, n. 1, p. 95, doi. 10.1023/A:1006910428080
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- Article
Uncertainty and Variability.
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- Risk Analysis: An International Journal, 1999, v. 19, n. 1, p. 47, doi. 10.1023/A:1006954210333
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- Article
Variability in PAH-DNA Adduct Measurements in Peripheral Mononuclear Cells: Implications for Quantitative Cancer Risk Assessment.
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- Risk Analysis: An International Journal, 1997, v. 17, n. 5, p. 649, doi. 10.1111/j.1539-6924.1997.tb00905.x
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- Article
Comparison of Contact Site Cancer Potency Across Dose Routes: Case Study With Epichlorohydrin.
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- Risk Analysis: An International Journal, 1996, v. 16, n. 5, p. 667, doi. 10.1111/j.1539-6924.1996.tb00816.x
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- Article
Assessment of Variability and Uncertainty Distributions for Practical Risk Analyses.
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- Risk Analysis: An International Journal, 1994, v. 14, n. 5, p. 713, doi. 10.1111/j.1539-6924.1994.tb00282.x
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- Article
Human Interindividual Variability--A Major Source of Uncertainty in Assessing Risks for Noncancer Health Effects.
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- Risk Analysis: An International Journal, 1994, v. 14, n. 4, p. 421, doi. 10.1111/j.1539-6924.1994.tb00260.x
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- Article
Uncertainties in Pharmacokinetic Modeling for Perchloroethylene: II. Comparison of Model Predictions with Data for a Variety of Different Parameters.
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- Risk Analysis: An International Journal, 1993, v. 13, n. 6, p. 599, doi. 10.1111/j.1539-6924.1993.tb01322.x
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- Article
Expected Values for Projected Cancer Risks from Putative Genetically Acting Agents.
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- Risk Analysis: An International Journal, 1991, v. 11, n. 3, p. 359, doi. 10.1111/j.1539-6924.1991.tb00614.x
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- Article
Uncertainties in Pharmacokinetic Modeling for Perchloroethylene. I. Comparison of Model Structure, Parameters, and Predictions for Low-Dose Metabolism Rates for Models Derived by Different Authors.
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- Risk Analysis: An International Journal, 1990, v. 10, n. 3, p. 449, doi. 10.1111/j.1539-6924.1990.tb00528.x
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- Article
Pharmacokinetic Principles for Dose-Rate Extrapolation of Carcinogenic Risk from Genetically Active Agents.
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- Risk Analysis: An International Journal, 1990, v. 10, n. 2, p. 303, doi. 10.1111/j.1539-6924.1990.tb01051.x
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- Article
Three Candidate 'Laws' of Uncertainty Analysis.
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- Risk Analysis: An International Journal, 1990, v. 10, n. 1, p. 11, doi. 10.1111/j.1539-6924.1990.tb01013.x
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- Article
Human Variability in Susceptibility to Toxic Chemicals- A Preliminary Analysis of Pharmacokinetic Data from Normal Volunteers.
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- Risk Analysis: An International Journal, 1987, v. 7, n. 4, p. 415, doi. 10.1111/j.1539-6924.1987.tb00479.x
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- Article
The Promise of Molecular Epidemiology for Quantitative Risk Assessment.
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- Risk Analysis: An International Journal, 1986, v. 6, n. 2, p. 181, doi. 10.1111/j.1539-6924.1986.tb00206.x
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- Article