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Kinetic deuterium isotope effects in cytochrome P450 oxidation reactions.
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- Journal of Labelled Compounds & Radiopharmaceuticals, 2013, v. 56, n. 9/10, p. 428, doi. 10.1002/jlcr.3031
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- Article
Elucidating mechanisms of drug-induced toxicity.
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- Nature Reviews Drug Discovery, 2005, v. 4, n. 5, p. 410, doi. 10.1038/nrd1720
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- Article
CYTOCHROME P450 ENZYMES IN THE GENERATION OF COMMERCIAL PRODUCTS.
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- Nature Reviews Drug Discovery, 2002, v. 1, n. 5, p. 359, doi. 10.1038/nrd792
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- Article
Detection and Characterization of 1,2-Dibromoethane-Derived DNA Crosslinks Formed with O<sup>6</sup>-Alkylguanine-DNA Alkyltransferase.
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- Angewandte Chemie International Edition, 2013, v. 52, n. 49, p. 12879, doi. 10.1002/anie.201307580
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- Article
Minipig cytochrome P450 3A, 2A and 2C enzymes have similar properties to human analogs.
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- BMC Pharmacology, 2001, v. 1, p. 11, doi. 10.1186/1471-2210-1-11
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- Article
Formation of potentially toxic metabolites of drugs in reactions catalyzed by human drug-metabolizing enzymes.
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- Archives of Toxicology, 2024, v. 98, n. 6, p. 1581, doi. 10.1007/s00204-024-03710-9
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- Article
Roles of selected non-P450 human oxidoreductase enzymes in protective and toxic effects of chemicals: review and compilation of reactions.
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- Archives of Toxicology, 2022, v. 96, n. 8, p. 2145, doi. 10.1007/s00204-022-03304-3
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- Article
Next-generation sequencing reveals the biological significance of the N²,3-ethenoguanine lesion in vivo.
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- Nucleic Acids Research, 2015, v. 43, n. 11, p. 5489, doi. 10.1093/nar/gkv243
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- Article
Biosynthesis of New Indigoid Inhibitors of Protein Kinases Using Recombinant Cytochrome P450 2A6.
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- Chemistry & Biodiversity, 2005, v. 2, n. 1, p. 51, doi. 10.1002/cbdv.200490166
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- Article
Mechanistic Studies with DNA Polymerases Reveal Complex Outcomes following Bypass of DNA Damage.
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- Journal of Nucleic Acids, 2010, p. 1, doi. 10.4061/2010/830473
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- Publication type:
- Article
Association of pharmacokinetic profiles of lenalidomide in human plasma simulated using pharmacokinetic data in humanized-liver mice with liver toxicity detected by human serum albumin RNA.
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- Journal of Toxicological Sciences, 2018, v. 43, n. 6, p. 369, doi. 10.2131/jts.43.369
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- Article
Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity.
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- Journal of Toxicological Sciences, 2017, v. 42, n. 3, p. 343, doi. 10.2131/jts.42.343
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- Article
The CYP3A4 intron 6 C>T polymorphism (CYP3A4*22) is associated with reduced CYP3A4 protein level and function in human liver microsomes.
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- Journal of Toxicological Sciences, 2013, v. 38, n. 3, p. 349, doi. 10.2131/jts.38.349
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- Article
Substrate binding to cytochromes P450.
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- Analytical & Bioanalytical Chemistry, 2008, v. 392, n. 6, p. 1019, doi. 10.1007/s00216-008-2244-0
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- Publication type:
- Article
Detection and Characterization of 1,2-Dibromoethane-Derived DNA Crosslinks Formed with O<sup>6</sup>-Alkylguanine-DNA Alkyltransferase.
- Published in:
- Angewandte Chemie, 2013, v. 125, n. 49, p. 13117, doi. 10.1002/ange.201307580
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- Publication type:
- Article
Replication of N<sup>2</sup>,3-Ethenoguanine by DNA Polymerases.
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- Angewandte Chemie, 2012, v. 124, n. 22, p. 5562, doi. 10.1002/ange.201109004
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- Publication type:
- Article
Selective Modulation of DNA Polymerase Activity by Fixed-Conformation Nucleoside Analogues.
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- Angewandte Chemie, 2010, v. 122, n. 41, p. 7643, doi. 10.1002/ange.201003168
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- Article
Mechanisms of cytochrome P450 substrate oxidation: MiniReview.
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- Journal of Biochemical & Molecular Toxicology, 2007, v. 21, n. 4, p. 163, doi. 10.1002/jbt.20174
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- Article
Generation of reactive intermediates.
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- Journal of Biochemical & Molecular Toxicology, 2005, v. 19, n. 3, p. 173, doi. 10.1002/jbt.20072
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- Article
Cytochrome P450 metabolism of the post-lanosterol intermediates explains enigmas of cholesterol synthesis.
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- Scientific Reports, 2016, p. 28462, doi. 10.1038/srep28462
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- Article
Decreased intestinal CYP3A in celiac disease: Reversal after successful gluten-free diet: A potential source of interindividual variability in first-pass drug metabolism<sup>*</sup>.
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- Clinical Pharmacology & Therapeutics, 1996, v. 59, n. 1, p. 41, doi. 10.1016/S0009-9236(96)90022-3
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- Article
Metabolic activation, DNA adducts, and H- ras mutations in human neoplastic and non-neoplastic laryngeal tissue.
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- Journal of Cellular Biochemistry, 1993, v. 53, p. 129, doi. 10.1002/jcb.240531018
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- Article
Corrigendum: Incorporation of Nucleoside Probes Opposite O<sup>6</sup>-Methylguanine by Sulfolobus solfataricus DNA Polymerase Dpo4: Importance of Hydrogen Bonding.
- Published in:
- ChemBioChem, 2013, v. 14, n. 15, p. 1918, doi. 10.1002/cbic.201300564
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- Article
Incorporation of Nucleoside Probes Opposite O<sup>6</sup>-Methylguanine by Sulfolobus solfataricus DNA Polymerase Dpo4: Importance of Hydrogen Bonding.
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- ChemBioChem, 2013, v. 14, n. 13, p. 1634, doi. 10.1002/cbic.201300296
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- Article
Metabolism of chemical carcinogens.
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- Carcinogenesis, 2000, v. 21, n. 3, p. 345, doi. 10.1093/carcin/21.3.345
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- Article
Catalytic properties of polymorphic human cytochrome P450 1B1 variants.
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- Carcinogenesis, 1999, v. 20, n. 8, p. 1607, doi. 10.1093/carcin/20.8.1607
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- Article
Elucidation of kinetic mechanisms of human translesion DNA polymerase κ using tryptophan mutants.
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- FEBS Journal, 2014, v. 281, n. 19, p. 4394, doi. 10.1111/febs.12947
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- Article
Human liver mitochondrial cytochrome P450 2D6 – individual variations and implications in drug metabolism.
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- FEBS Journal, 2009, v. 276, n. 13, p. 3440, doi. 10.1111/j.1742-4658.2009.07067.x
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- Article
Roles of Ferric Peroxide Anion Intermediates (Fe<sup>3+</sup>O<sub>2</sub><sup>−</sup>, Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model.
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- Angewandte Chemie, 2024, v. 136, n. 33, p. 1, doi. 10.1002/ange.202406542
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- Article
Oxygen‐18 Labeling Reveals a Mixed Fe−O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α‐Demethylation.
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- Angewandte Chemie, 2024, v. 136, n. 9, p. 1, doi. 10.1002/ange.202317711
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- Article
Use of genetically engineered Salmonella typhimurium OY1002/1A2 strain coexpressing human cytochrome P450 1A2 and NADPH-cytochrome P450 reductase and bacterial O-acetyltransferase in SOS/ umu assay.
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- Environmental & Molecular Mutagenesis, 2000, v. 36, n. 2, p. 121, doi. 10.1002/1098-2280(2000)36:2<121::AID-EM6>3.0.CO;2-P
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- Article
Functional Genomics and Proteomics Applied to the Study of Nutritional Metabolism.
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- Nutrition Reviews, 2001, v. 59, n. 8, p. 259
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- Article
The safety evaluation of food flavouring substances: the role of metabolic studies.
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- Toxicology Research, 2018, v. 7, n. 4, p. 618, doi. 10.1039/c7tx00254h
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- Publication type:
- Article
Roles of Ferric Peroxide Anion Intermediates (Fe<sup>3+</sup>O<sub>2</sub><sup>−</sup>, Compound 0) in Cytochrome P450 19A1 Steroid Aromatization and a Cytochrome P450 2B4 Secosteroid Oxidation Model.
- Published in:
- Angewandte Chemie International Edition, 2024, v. 63, n. 33, p. 1, doi. 10.1002/anie.202406542
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- Publication type:
- Article
Oxygen‐18 Labeling Reveals a Mixed Fe−O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14α‐Demethylation.
- Published in:
- Angewandte Chemie International Edition, 2024, v. 63, n. 9, p. 1, doi. 10.1002/anie.202317711
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- Publication type:
- Article
Inhibition of Human Cytochrome P450 2D6 by Schering 66712.
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- FASEB Journal, 2007, v. 21, n. 5, p. A670, doi. 10.1096/fasebj.21.5.a670-a
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- Article
The role of Arg332 in Dpo4-catalyzed bypass of 7,8-dihydro-2′- oxodeoxyguanosine.
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- FASEB Journal, 2007, v. 21, n. 5, p. A272, doi. 10.1096/fasebj.21.5.a272-a
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- Article
Forum. Symposium overview: characterization of xenobiotic metabolizing enzyme function using heterologous expression systems.
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- Toxicological Sciences, 1999, v. 48, n. 2, p. 143, doi. 10.1093/toxsci/48.2.143
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- Publication type:
- Article
Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains.
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- Mutagenesis, 2006, v. 21, n. 6, p. 411, doi. 10.1093/mutage/gel047
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- Publication type:
- Article
Etheno adducts: from tRNA modifications to DNA adducts and back to miscoding ribonucleotides.
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- Genes & Environment, 2021, v. 43, n. 1, p. 1, doi. 10.1186/s41021-021-00199-x
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- Article
The P450 Superfamily: Update on New Sequences, Gene Mapping, Accession Numbers, Early Trivial Names of Enzymes, and Nomenclature.
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- DNA & Cell Biology, 1993, v. 12, n. 1, p. 1, doi. 10.1089/dna.1993.12.1
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- Article
CORRIGENDUM.
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- DNA & Cell Biology, 1991, v. 10, n. 5, p. 397, doi. 10.1089/dna.1991.10.397
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- Article
The P450 Superfamily: Update on New Sequences, Gene Mapping, and Recommended Nomenclature.
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- DNA & Cell Biology, 1991, v. 10, n. 1, p. 1, doi. 10.1089/dna.1991.10.1
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- Article
Human Family 1–4 cytochrome P450 enzymes involved in the metabolic activation of xenobiotic and physiological chemicals: an update.
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- Archives of Toxicology, 2021, v. 95, n. 2, p. 395, doi. 10.1007/s00204-020-02971-4
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- Article
Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases.
- Published in:
- Nucleic Acids Research, 2023, v. 51, n. 8, p. 3888, doi. 10.1093/nar/gkad190
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- Article
Mechanisms of Cytochrome P450 Reactions.
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- Acta Chimica Slovenica, 2008, v. 55, n. 1, p. 7
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- Article
Enantioselective hydrolysis of oxazepam 3-acetate by esterases in human and rat liver microsomes and rat brain s9 fraction.
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- Chirality, 1990, v. 2, n. 3, p. 150, doi. 10.1002/chir.530020305
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- Article
Cytochrome P450 Enzymes in Drug Metabolism and Chemical Toxicology.
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- Biochemistry & Molecular Biology Education, 2006, v. 34, n. 2, p. 66, doi. 10.1002/bmb.2006.49403402066
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- Article
Exploiting the Versatility of Human Cytochrome P450 Enzymes: The Promise of Blue Roses From Biotechnology.
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- IUBMB Life, 2001, v. 52, n. 6, p. 271, doi. 10.1080/152165401317291110
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- Article
Modified nicotine metabolism in transgenic tobacco plants expressing the human cytochrome P450 2A6 cDNA
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- FEBS Letters, 2005, v. 579, n. 11, p. 2480, doi. 10.1016/j.febslet.2005.02.082
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- Publication type:
- Article