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Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors.
Published in:
Journal of Clinical Investigation, 2013, v. 123, n. 1, p. 315, doi. 10.1172/JCI64180
By:
- Sukhai, Mahadeo A.;
- Prabha, Swayam;
- Hurren, Rose;
- C. Rutledge, Angela;
- Y. Lee, Anna;
- Sriskanthadevan, Shrivani;
- Sun, Hong;
- Wang, Xiaoming;
- Skrtic, Marko;
- Seneviratne, Ayesh;
- Cusimano, Maria;
- Jhas, Bozhena;
- Gronda, Marcela;
- MacLean, Neil;
- E. Cho, Eunice;
- A., Paul;
- Spagnuolo;
- Sharmeen, Sumaiya;
- Gebbia, Marinella;
- Urbanus, Malene
Publication type:
Article
Macrophage Jak2 deficiency accelerates atherosclerosis through defects in cholesterol efflux.
Published in:
Communications Biology, 2022, v. 5, n. 1, p. 1, doi. 10.1038/s42003-022-03078-5
By:
- Dotan, Idit;
- Yang, Jiaqi;
- Ikeda, Jiro;
- Roth, Ziv;
- Pollock-Tahiri, Evan;
- Desai, Harsh;
- Sivasubramaniyam, Tharini;
- Rehal, Sonia;
- Rapps, Josh;
- Li, Yu Zhe;
- Le, Helen;
- Farber, Gedaliah;
- Alchami, Edouard;
- Xiao, Changting;
- Karim, Saraf;
- Gronda, Marcela;
- Saikali, Michael F.;
- Tirosh, Amit;
- Wagner, Kay-Uwe;
- Genest, Jacques
Publication type:
Article
A Novel Formulation of Tigecycline Has Enhanced Stability and Sustained Antibacterial and Antileukemic Activity.
Published in:
PLoS ONE, 2014, v. 9, n. 5, p. 1, doi. 10.1371/journal.pone.0095281
By:
- Jitkova, Yulia;
- Gronda, Marcela;
- Hurren, Rose;
- Wang, Xiaoming;
- Goard, Carolyn A.;
- Jhas, Bozhena;
- Schimmer, Aaron D.
Publication type:
Article
Metabolic Adaptation to Chronic Inhibition of Mitochondrial Protein Synthesis in Acute Myeloid Leukemia Cells.
Published in:
PLoS ONE, 2013, v. 8, n. 3, p. 1, doi. 10.1371/journal.pone.0058367
By:
- Jhas, Bozhena;
- Sriskanthadevan, Shrivani;
- Skrtic, Marko;
- Sukhai, Mahadeo A.;
- Voisin, Veronique;
- Jitkova, Yulia;
- Gronda, Marcela;
- Hurren, Rose;
- Laister, Rob C.;
- Bader, Gary D.;
- Minden, Mark D.;
- Schimmer, Aaron D.
Publication type:
Article
Suppression of Cancer Progression by MGAT1 shRNA Knockdown.
Published in:
PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0043721
By:
- Zavareh, Reza Beheshti;
- Sukhai, Mahadeo A.;
- Hurren, Rose;
- Gronda, Marcela;
- Xiaoming Wang;
- Simpson, Craig D.;
- Maclean, Neil;
- Zih, Francis;
- Ketela, Troy;
- Swallow, Carol J.;
- Moffat, Jason;
- Rose, David R.;
- Schachter, Harry;
- Schimmer, Aaron D.;
- Dennis, James W.;
- Ming Tat Ling
Publication type:
Article
Critical Role for Fas-Associated Death Domain-Like lnterleukin-1-Converting Enzyme-Like Inhibitory Protein in Anoikis Resistance and Distant Tumor Formation.
Published in:
JNCI: Journal of the National Cancer Institute, 2007, v. 99, n. 10, p. 811, doi. 10.1093/jnci/djk182
By:
- Mawji, Imtiaz A.;
- Simpson, Craig D.;
- Hurren, Rose;
- Gronda, Marcela;
- Williams, Moyo A.;
- Filmus, Jorge;
- Jonkman, James;
- Da Costa, Ralph S.;
- Wilson, Brian C.;
- Thomas, Michael P.;
- Reed, John C.;
- Glinsky, Gennadi V.;
- Schimmer, Aaron D.
Publication type:
Article
A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia.
Published in:
Cancer Medicine, 2016, v. 5, n. 11, p. 3031, doi. 10.1002/cam4.845
By:
- Reed, Gregory A.;
- Schiller, Gary J.;
- Kambhampati, Suman;
- Tallman, Martin S.;
- Douer, Dan;
- Minden, Mark D.;
- Yee, Karen W.;
- Gupta, Vikas;
- Brandwein, Joseph;
- Jitkova, Yulia;
- Gronda, Marcela;
- Hurren, Rose;
- Shamas ‐ Din, Aisha;
- Schuh, Andre C.;
- Schimmer, Aaron D.
Publication type:
Article
A Phase I Study of the Metal Ionophore Clioquinol in Patients With Advanced Hematologic Malignancies.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2012, v. 12, n. 5, p. 330, doi. 10.1016/j.clml.2012.05.005
By:
- Schimmer, Aaron D.;
- Jitkova, Yulia;
- Gronda, Marcela;
- Zezhou Wang;
- Brandwein, Joseph;
- Chen, Christine;
- Gupta, Vikas;
- Schuh, Andre;
- Yee, Karen;
- Chen, Jian;
- Ackloo, Suzanne;
- Booth, Tristan;
- Keays, Sharon;
- Minden, Mark D.
Publication type:
Article
Global Interactome Mapping of Mitochondrial Intermembrane Space Proteases Identifies a Novel Function for HTRA2.
Published in:
Proteomics, 2019, v. 19, n. 24, p. N.PAG, doi. 10.1002/pmic.201900139
By:
- Botham, Aaron;
- Coyaud, Etienne;
- Nirmalanandhan, Victor Sanjit;
- Gronda, Marcela;
- Hurren, Rose;
- Maclean, Neil;
- St‐Germain, Jonathan;
- Mirali, Sara;
- Laurent, Estelle;
- Raught, Brian;
- Schimmer, Aaron
Publication type:
Article
The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability.
Published in:
Science Translational Medicine, 2020, v. 12, n. 538, p. 1, doi. 10.1126/scitranslmed.aaz8264
By:
- Mirali, Sara;
- Botham, Aaron;
- Voisin, Veronique;
- Xu, Changjiang;
- St-Germain, Jonathan;
- Sharon, David;
- Hoff, Fieke W.;
- Qiu, Yihua;
- Hurren, Rose;
- Gronda, Marcela;
- Jitkova, Yulia;
- Nachmias, Boaz;
- MacLean, Neil;
- Wang, Xiaoming;
- Arruda, Andrea;
- Minden, Mark D.;
- Horton, Terzah M.;
- Kornblau, Steven M.;
- Chan, Steven M.;
- Bader, Gary D.
Publication type:
Article
Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies.
Published in:
American Journal of Hematology, 2014, v. 89, n. 4, p. 363, doi. 10.1002/ajh.23640
By:
- Minden, Mark D.;
- Hogge, Donna E.;
- Weir, Scott J.;
- Kasper, Jim;
- Webster, Debra A.;
- Patton, Lavonne;
- Jitkova, Yulia;
- Hurren, Rose;
- Gronda, Marcela;
- Goard, Carolyn A.;
- Rajewski, Lian G.;
- Haslam, John L.;
- Heppert, Kathleen E.;
- Schorno, Kevin;
- Chang, Hong;
- Brandwein, Joseph M.;
- Gupta, Vikas;
- Schuh, Andre C.;
- Trudel, Suzanne;
- Yee, Karen W. L.
Publication type:
Article
Carnitine transporter CT2 (SLC22A16) is over-expressed in acute myeloid leukemia (AML) and target knockdown reduces growth and viability of AML cells.
Published in:
Apoptosis, 2015, v. 20, n. 8, p. 1099, doi. 10.1007/s10495-015-1137-x
By:
- Wu, Yan;
- Hurren, Rose;
- MacLean, Neil;
- Gronda, Marcela;
- Jitkova, Yulia;
- Sukhai, Mahadeo;
- Minden, Mark;
- Schimmer, Aaron
Publication type:
Article
Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells.
Published in:
Apoptosis, 2015, v. 20, n. 7, p. 948, doi. 10.1007/s10495-015-1123-3
By:
- Bernard, Dannie;
- Gebbia, Marinella;
- Prabha, Swayam;
- Gronda, Marcela;
- MacLean, Neil;
- Wang, Xiaoming;
- Hurren, Rose;
- Sukhai, Mahadeo;
- Cho, Eunice;
- Manolson, Morris;
- Datti, Alessandro;
- Wrana, Jeffrey;
- Minden, Mark;
- Al-Awar, Rima;
- Aman, Ahmed;
- Nislow, Corey;
- Giaever, Guri;
- Schimmer, Aaron
Publication type:
Article
Mitochondrial DNA damage by bleomycin induces AML cell death.
Published in:
Apoptosis, 2015, v. 20, n. 6, p. 811, doi. 10.1007/s10495-015-1119-z
By:
- Yeung, ManTek;
- Hurren, Rose;
- Nemr, Carine;
- Wang, Xiaoming;
- Hershenfeld, Samantha;
- Gronda, Marcela;
- Liyanage, Sanduni;
- Wu, Yan;
- Augustine, Jeevan;
- Lee, Eric;
- Spagnuolo, Paul;
- Southall, Noel;
- Chen, Catherine;
- Zheng, Wei;
- Jeyaraju, Danny;
- Minden, Mark;
- Laposa, Rebecca;
- Schimmer, Aaron
Publication type:
Article
Disruption of the endoplasmic reticulum and increases in cytoplasmic calcium are early events in cell death induced by the natural triterpenoid Asiatic acid.
Published in:
Apoptosis, 2006, v. 11, n. 9, p. 1463, doi. 10.1007/s10495-006-9086-z
By:
- Gurfinkel, Debbie M.;
- Chow, Sue;
- Hurren, Rose;
- Gronda, Marcela;
- Henderson, Clare;
- Berube, Christina;
- Hedley, David W.;
- Schimmer, Aaron D.
Publication type:
Article

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