OpenURL Connection Search

Select item for more details and to access through your institution.

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.66277
By:
- Stokes, Barbara H.;
- Dhingra, Satish K.;
- Rubiano, Kelly;
- Mok, Sachel;
- Straimer, Judith;
- Gnädig, Nina F.;
- Deni, Ioanna;
- Schindler, Kyra A.;
- Bath, Jade R.;
- Ward, Kurt E.;
- Striepen, Josefine;
- Yeo, Tomas;
- Ross, Leila S.;
- Legrand, Eric;
- Ariey, Frédéric;
- Cunningham, Clark H.;
- Souleymane, Issa M.;
- Gansané, Adama;
- Nzoumbou-Boko, Romaric;
- Ndayikunda, Claudette
Publication type:
Article
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
Published in:
Nature Communications, 2017, v. 8, n. 5, p. 15159, doi. 10.1038/ncomms15159
By:
- O'Neill, Paul M.;
- Amewu, Richard K.;
- Charman, Susan A.;
- Sabbani, Sunil;
- Gnädig, Nina F.;
- Straimer, Judith;
- Fidock, David A.;
- Shore, Emma R.;
- Roberts, Natalie L.;
- Wong, Michael H.-L.;
- Hong, W. David;
- Pidathala, Chandrakala;
- Riley, Chris;
- Murphy, Ben;
- Aljayyoussi, Ghaith;
- Gamo, Francisco Javier;
- Sanz, Laura;
- Rodrigues, Janneth;
- Cortes, Carolina Gonzalez;
- Herreros, Esperanza
Publication type:
Article
A broad analysis of resistance development in the malaria parasite.
Published in:
Nature Communications, 2016, v. 7, n. 6, p. 11901, doi. 10.1038/ncomms11901
By:
- Corey, Victoria C.;
- Lukens, Amanda K.;
- Istvan, Eva S.;
- Lee, Marcus C. S.;
- Franco, Virginia;
- Magistrado, Pamela;
- Coburn-Flynn, Olivia;
- Sakata-Kato, Tomoyo;
- Fuchs, Olivia;
- Gnädig, Nina F.;
- Goldgof, Greg;
- Linares, Maria;
- Gomez-Lorenzo, Maria G.;
- De Cózar, Cristina;
- Lafuente-Monasterio, Maria Jose;
- Prats, Sara;
- Meister, Stephan;
- Tanaseichuk, Olga;
- Wree, Melanie;
- Zhou, Yingyao
Publication type:
Article
Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype.
Published in:
PLoS Pathogens, 2015, v. 11, n. 5, p. 1, doi. 10.1371/journal.ppat.1004838
By:
- Bordería, Antonio V.;
- Isakov, Ofer;
- Moratorio, Gonzalo;
- Henningsson, Rasmus;
- Agüera-González, Sonia;
- Organtini, Lindsey;
- Gnädig, Nina F.;
- Blanc, Hervé;
- Alcover, Andrés;
- Hafenstein, Susan;
- Fontes, Magnus;
- Shomron, Noam;
- Vignuzzi, Marco
Publication type:
Article
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.
Published in:
PLoS Pathogens, 2016, v. 12, n. 11, p. 1, doi. 10.1371/journal.ppat.1005976
By:
- Gabryszewski, Stanislaw J.;
- Dhingra, Satish K.;
- Combrinck, Jill M.;
- Lewis, Ian A.;
- Callaghan, Paul S.;
- Hassett, Matthew R.;
- Siriwardana, Amila;
- Henrich, Philipp P.;
- Lee, Andrew H.;
- Gnädig, Nina F.;
- Musset, Lise;
- Llinás, Manuel;
- Egan, Timothy J.;
- Roepe, Paul D.;
- Fidock, David A.
Publication type:
Article
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
Published in:
2016
By:
- Le Bihan, Amélie;
- de Kanter, Ruben;
- Angulo-Barturen, Iñigo;
- Binkert, Christoph;
- Boss, Christoph;
- Brun, Reto;
- Brunner, Ralf;
- Buchmann, Stephan;
- Burrows, Jeremy;
- Dechering, Koen J.;
- Delves, Michael;
- Ewerling, Sonja;
- Ferrer, Santiago;
- Fischli, Christoph;
- Gamo–Benito, Francisco Javier;
- Gnädig, Nina F.;
- Heidmann, Bibia;
- Jiménez-Díaz, María Belén;
- Leroy, Didier;
- Martínez, Maria Santos
Publication type:
journal article
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance.
Published in:
Science Translational Medicine, 2021, v. 13, n. 603, p. 1, doi. 10.1126/scitranslmed.abg6013
By:
- Murithi, James M.;
- Pascal, Cécile;
- Bath, Jade;
- Boulenc, Xavier;
- Gnädig, Nina F.;
- Pasaje, Charisse Flerida A.;
- Rubiano, Kelly;
- Yeo, Tomas;
- Mok, Sachel;
- Klieber, Sylvie;
- Desert, Paul;
- Jiménez-Díaz, María Belén;
- Marfurt, Jutta;
- Rouillier, Mélanie;
- Cherkaoui-Rbati, Mohammed H.;
- Gobeau, Nathalie;
- Wittlin, Sergio;
- Uhlemann, Anne-Catrin;
- Price, Ric N.;
- Wirjanata, Grennady
Publication type:
Article
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
Published in:
PLoS Pathogens, 2020, v. 16, n. 4, p. 1, doi. 10.1371/journal.ppat.1008482
By:
- Gnädig, Nina F.;
- Stokes, Barbara H.;
- Edwards, Rachel L.;
- Kalantarov, Gavreel F.;
- Heimsch, Kim C.;
- Kuderjavy, Michal;
- Crane, Audrey;
- Lee, Marcus C. S.;
- Straimer, Judith;
- Becker, Katja;
- Trakht, Ilya N.;
- Odom John, Audrey R.;
- Mok, Sachel;
- Fidock, David A.
Publication type:
Article
Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18624-0
By:
- Harding, Clare R.;
- Sidik, Saima M.;
- Petrova, Boryana;
- Gnädig, Nina F.;
- Okombo, John;
- Herneisen, Alice L.;
- Ward, Kurt E.;
- Markus, Benedikt M.;
- Boydston, Elizabeth A.;
- Fidock, David A.;
- Lourido, Sebastian
Publication type:
Article
Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-15440-4
By:
- LaMonte, Gregory M.;
- Rocamora, Frances;
- Marapana, Danushka S.;
- Gnädig, Nina F.;
- Ottilie, Sabine;
- Luth, Madeline R.;
- Worgall, Tilla S.;
- Goldgof, Gregory M.;
- Mohunlal, Roxanne;
- Santha Kumar, T. R.;
- Thompson, Jennifer K.;
- Vigil, Edgar;
- Yang, Jennifer;
- Hutson, Dylan;
- Johnson, Trevor;
- Huang, Jianbo;
- Williams, Roy M.;
- Zou, Bing Yu;
- Cheung, Andrea L.;
- Kumar, Prianka
Publication type:
Article

Found: 10