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Lysosome-Disrupting Agents in Combination with Venetoclax Increase Apoptotic Response in Primary Chronic Lymphocytic Leukemia (CLL) Cells Mediated by Lysosomal Cathepsin D Release and Inhibition of Autophagy.
- Published in:
- Cells (2073-4409), 2024, v. 13, n. 12, p. 1041, doi. 10.3390/cells13121041
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- Publication type:
- Article
MEKK1-induced apoptosis requires TRAIL death receptor activation and is inhibited by AKT/PKB through inhibition of MEKK1 cleavage.
- Published in:
- Oncogene, 2002, v. 21, n. 43, p. 6649, doi. 10.1038/sj.onc.1205819
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- Publication type:
- Article
The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia.
- Published in:
- International Journal of Cancer, 2006, v. 118, n. 7, p. 1660, doi. 10.1002/ijc.21547
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- Publication type:
- Article
Misoprostol treatment prevents hypoxia-induced cardiac dysfunction through a 14-3-3 and PKA regulatory motif on Bnip3.
- Published in:
- Cell Death & Disease, 2021, v. 12, n. 12, p. 1, doi. 10.1038/s41419-021-04402-3
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- Publication type:
- Article
The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation.
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- PLoS ONE, 2018, v. 13, n. 10, p. 1, doi. 10.1371/journal.pone.0204792
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- Publication type:
- Article
BNIP3 (Bcl-2 19 kDa Interacting Protein) Acts as Transcriptional Repressor of Apoptosis-Inducing Factor Expression Preventing Cell Death in Human Malignant Gliomas.
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- Journal of Neuroscience, 2009, v. 29, n. 13, p. 4189, doi. 10.1523/JNEUROSCI.5747-08.2009
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- Publication type:
- Article
Role of BNIP3 in proliferation and hypoxia-induced autophagy: implications for personalized cancer therapies Azad & Gibson BNIP3 in proliferation and hypoxia-induced autophagy.
- Published in:
- Annals of the New York Academy of Sciences, 2010, v. 1210, n. 1, p. 8, doi. 10.1111/j.1749-6632.2010.05778.x
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- Publication type:
- Article
Altered T Follicular Helper Cell Subsets and Function in Chronic Lymphocytic Leukemia.
- Published in:
- Frontiers in Oncology, 2021, v. 11, p. N.PAG, doi. 10.3389/fonc.2021.674492
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- Publication type:
- Article
Clinical activities of the epidermal growth factor receptor family inhibitors in breast cancer.
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- Biologics: Targets & Therapy, 2007, v. 1, n. 3, p. 229
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- Publication type:
- Article
Role of the TRAIL/APO2-L death receptors in chlorambucil- and fludarabine-induced apoptosis in chronic lymphocytic leukemia.
- Published in:
- Oncogene, 2003, v. 22, n. 51, p. 8356
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- Publication type:
- Article
BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF.
- Published in:
- Oncogene, 2003, v. 22, n. 30, p. 4734, doi. 10.1038/sj.onc.1206666
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- Publication type:
- Article
Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels.
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- Oxidative Medicine & Cellular Longevity, 2019, p. 1, doi. 10.1155/2019/9561281
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- Publication type:
- Article
Lysosomes as Oxidative Targets for Cancer Therapy.
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- Oxidative Medicine & Cellular Longevity, 2017, p. 1, doi. 10.1155/2017/3749157
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- Publication type:
- Article
Clinical Outcomes in a Large Canadian Centralized CLL Clinic Based on Treatment and Molecular Factors over a Decade.
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- Current Oncology, 2023, v. 30, n. 7, p. 6411, doi. 10.3390/curroncol30070472
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- Publication type:
- Article
Hepatitis B and hepatitis C viral infections in patients with chronic lymphocytic leukemia.
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- Canadian Journal of Gastroenterology & Hepatology, 2014, v. 28, n. 3, p. 131, doi. 10.1155/2014/780350
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- Publication type:
- Article
DNA-PK hyperactivation occurs in deletion 11q chronic lymphocytic leukemia and is both a biomarker and therapeutic target for drug-resistant disease.
- Published in:
- Blood Cancer Journal, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41408-022-00781-8
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- Publication type:
- Article
BNIP3 Interacting with LC3 Triggers Excessive Mitophagy in Delayed Neuronal Death in Stroke.
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- CNS Neuroscience & Therapeutics, 2014, v. 20, n. 12, p. 1045, doi. 10.1111/cns.12325
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- Publication type:
- Article
Poly(ADP-Ribose) Polymerase-1 Causes Mitochondrial Damage and Neuron Death Mediated by Bnip3.
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- Journal of Neuroscience, 2014, v. 34, n. 48, p. 15975, doi. 10.1523/JNEUROSCI.2499-14.2014
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- Publication type:
- Article
Primary del 17 chronic lymphocytic leukaemia lymphocytes are hypersensitive to dasatinib in vitro.
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- 2009
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- Publication type:
- Letter
Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabine in vitro.
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- British Journal of Haematology, 2008, v. 143, n. 5, p. 698, doi. 10.1111/j.1365-2141.2008.07418.x
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- Publication type:
- Article
Increased expression of Mcl-1 is responsible for the blockage of TRAIL-induced apoptosis mediated by EGF/ErbB1 signaling pathway.
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- Journal of Cellular Biochemistry, 2003, v. 89, n. 6, p. 1177, doi. 10.1002/jcb.10597
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- Publication type:
- Article
Comparison of outcome of patients with CLL who are referred or nonreferred to a specialized CLL clinic: a Canadian population-based study.
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- Cancer Medicine, 2016, v. 5, n. 6, p. 971, doi. 10.1002/cam4.559
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- Publication type:
- Article
Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy.
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- Oxidative Medicine & Cellular Longevity, 2018, p. 1, doi. 10.1155/2018/6135739
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- Publication type:
- Article
Estrogen Regulation of Anti-Apoptotic Bcl-2 Family Member Mcl-1 Expression in Breast Cancer Cells.
- Published in:
- PLoS ONE, 2014, v. 9, n. 6, p. 1, doi. 10.1371/journal.pone.0100364
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- Publication type:
- Article
Frequent Occurrence of Highly Expanded but Unrelated B-Cell Clones in Patients with Multiple Myeloma
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- PLoS ONE, 2013, v. 8, n. 5, p. 1, doi. 10.1371/journal.pone.0064927
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- Publication type:
- Article
The Effect of Combined Exposure of 900 MHz Radiofrequency Fields and Doxorubicin in HL-60 Cells.
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- PLoS ONE, 2012, v. 7, n. 9, p. 1, doi. 10.1371/journal.pone.0046102
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- Publication type:
- Article
Methods for detecting autophagy and determining autophagy-induced cell death.
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- Canadian Journal of Physiology & Pharmacology, 2010, v. 88, n. 3, p. 285, doi. 10.1139/Y10-010
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- Publication type:
- Article
Autophagy in clear cell ovarian cancer, a potential marker for hypoxia and poor prognosis?<sup>#</sup>.
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- Journal of Pathology, 2012, v. 228, n. 4, p. 434, doi. 10.1002/path.4100
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- Publication type:
- Article
Expression and function of phosphoinositide 3‐kinase delta in mesenchymal stromal cells from normal and leukaemic bone marrow.
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- British Journal of Haematology, 2019, v. 185, n. 5, p. 883, doi. 10.1111/bjh.15865
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- Publication type:
- Article
ZAP70 expression directly promotes chronic lymphocytic leukaemia cell adhesion to bone marrow stromal cells.
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- British Journal of Haematology, 2015, v. 168, n. 1, p. 139, doi. 10.1111/bjh.13063
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- Publication type:
- Article
The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells.
- Published in:
- Apoptosis, 2006, v. 11, n. 7, p. 1175, doi. 10.1007/s10495-006-8048-9
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- Publication type:
- Article
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c‐Kit ligand stimulation of ES cell‐derived mast cells.
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- EMBO Journal, 2000, v. 19, n. 20, p. 5387, doi. 10.1093/emboj/19.20.5387
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- Publication type:
- Article
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells.
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- EMBO Journal, 2000, v. 19, n. 20, p. 5387, doi. 10.1093/emboj/19.20.5387
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- Publication type:
- Article
Real world risk of infusion reactions and effectiveness of front-line obinutuzumab plus chlorambucil compared with other frontline treatments for chronic lymphocytic leukemia.
- Published in:
- BMC Cancer, 2022, v. 22, n. 1, p. 1, doi. 10.1186/s12885-022-09256-2
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- Publication type:
- Article
Real world risk of infusion reactions and effectiveness of front-line obinutuzumab plus chlorambucil compared with other frontline treatments for chronic lymphocytic leukemia.
- Published in:
- 2022
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- Publication type:
- journal article
Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells.
- Published in:
- PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0182921
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- Publication type:
- Article
Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B Leukemic Cells.
- Published in:
- BMC Cancer, 2011, v. 11, n. 1, p. 268, doi. 10.1186/1471-2407-11-268
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- Publication type:
- Article
Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment.
- Published in:
- Cancers, 2024, v. 16, n. 5, p. 911, doi. 10.3390/cancers16050911
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- Publication type:
- Article
Prostate Cancer Cells Are Sensitive to Lysosomotropic Agent Siramesine through Generation Reactive Oxygen Species and in Combination with Tyrosine Kinase Inhibitors.
- Published in:
- Cancers, 2022, v. 14, n. 22, p. 5478, doi. 10.3390/cancers14225478
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- Publication type:
- Article
Erb-b2 Receptor Tyrosine Kinase 2 (ERBB2) Promotes ATG12-Dependent Autophagy Contributing to Treatment Resistance of Breast Cancer Cells.
- Published in:
- Cancers, 2021, v. 13, n. 5, p. 1038, doi. 10.3390/cancers13051038
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- Publication type:
- Article
Ex Vivo Mitochondrial Respiration Parallels Biochemical Response to Ibrutinib in CLL Cells.
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- Cancers, 2021, v. 13, n. 2, p. 354, doi. 10.3390/cancers13020354
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- Publication type:
- Article
Mitochondrial Respiration Correlates with Prognostic Markers in Chronic Lymphocytic Leukemia and Is Normalized by Ibrutinib Treatment.
- Published in:
- Cancers, 2020, v. 12, n. 3, p. 650, doi. 10.3390/cancers12030650
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- Publication type:
- Article
Transcriptional Modulation by Idelalisib Synergizes with Bendamustine in Chronic Lymphocytic Leukemia.
- Published in:
- Cancers, 2019, v. 11, n. 10, p. 1519, doi. 10.3390/cancers11101519
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- Publication type:
- Article
Targeting Metabolism and Autophagy in the Context of Haematologic Malignancies.
- Published in:
- International Journal of Cell Biology, 2012, p. 1, doi. 10.1155/2012/595976
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- Publication type:
- Article
Brevinin-2R<sup>1</sup> semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway.
- Published in:
- Journal of Cellular & Molecular Medicine, 2008, v. 12, n. 3, p. 1005, doi. 10.1111/j.1582-4934.2008.00129.x
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- Publication type:
- Article
Reactive Oxygen Species (ROS) Regulates Different Types of Cell Death by Acting as a Rheostat.
- Published in:
- Oxidative Medicine & Cellular Longevity, 2021, p. 1, doi. 10.1155/2021/9912436
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- Publication type:
- Article
Negative regulators of cell death pathways in cancer: perspective on biomarkers and targeted therapies.
- Published in:
- Apoptosis, 2018, v. 23, n. 2, p. 93, doi. 10.1007/s10495-018-1440-4
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- Publication type:
- Article
Associations between statin use and risk of non‐Hodgkin lymphomas by subtype.
- Published in:
- International Journal of Cancer, 2018, v. 143, n. 4, p. 971, doi. 10.1002/ijc.31373
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- Publication type:
- Article
Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells.
- Published in:
- International Journal of Cancer, 2015, v. 136, n. 5, p. E455, doi. 10.1002/ijc.29220
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- Publication type:
- Article