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Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.59067
By:
- Geusz, Ryan J.;
- Wang, Allen;
- Chiou, Joshua;
- Lancman, Joseph J.;
- Wetton, Nichole;
- Kefalopoulou, Samy;
- Jinzhao Wang;
- Yunjiang Qiu;
- Jian Yan;
- Aylward, Anthony;
- Ren, Bing;
- P.-Duc Si Dong;
- Gaulton, Kyle J.;
- Sander, Maike
Publication type:
Article
Integration of human pancreatic islet genomic data refines regulatory mechanisms at Type 2 Diabetes susceptibility loci.
Published in:
eLife, 2018, p. 1, doi. 10.7554/eLife.31977
By:
- Thurner, Matthias;
- van de Bunt, Martijn;
- Torres, Jason M.;
- Mahajan, Anubha;
- Nylander, Vibe;
- Bennett, Amanda J.;
- Gaulton, Kyle J.;
- Barrett, Amy;
- Burrows, Carla;
- Bell, Christopher G.;
- Lowe, Robert;
- Beck, Stephan;
- Rakyan, Vardhman K.;
- Gloyn, Anna L.;
- McCarthy, Mark I.
Publication type:
Article
Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26950-0
By:
- Geusz, Ryan J.;
- Wang, Allen;
- Lam, Dieter K.;
- Vinckier, Nicholas K.;
- Alysandratos, Konstantinos-Dionysios;
- Roberts, David A.;
- Wang, Jinzhao;
- Kefalopoulou, Samy;
- Ramirez, Araceli;
- Qiu, Yunjiang;
- Chiou, Joshua;
- Gaulton, Kyle J.;
- Ren, Bing;
- Kotton, Darrell N.;
- Sander, Maike
Publication type:
Article
The long noncoding RNA ROCKI regulates inflammatory gene expression.
Published in:
EMBO Journal, 2019, v. 38, n. 8, p. N.PAG, doi. 10.15252/embj.2018100041
By:
- Zhang, Qiong;
- Chao, Ti‐Chun;
- Patil, Veena S;
- Qin, Yue;
- Tiwari, Shashi Kant;
- Chiou, Joshua;
- Dobin, Alexander;
- Tsai, Chih‐Ming;
- Li, Zhonghan;
- Dang, Jason;
- Gupta, Shagun;
- Urdahl, Kevin;
- Nizet, Victor;
- Gingeras, Thomas R;
- Gaulton, Kyle J;
- Rana, Tariq M
Publication type:
Article
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants.
Published in:
Nature Genetics, 2014, v. 46, n. 2, p. 136, doi. 10.1038/ng.2870
By:
- Pasquali, Lorenzo;
- Gaulton, Kyle J;
- Rodríguez-Seguí, Santiago A;
- Mularoni, Loris;
- Miguel-Escalada, Irene;
- Akerman, İldem;
- Tena, Juan J;
- Morán, Ignasi;
- Gómez-Marín, Carlos;
- van de Bunt, Martijn;
- Ponsa-Cobas, Joan;
- Castro, Natalia;
- Nammo, Takao;
- Cebola, Inês;
- García-Hurtado, Javier;
- Maestro, Miguel Angel;
- Pattou, François;
- Piemonti, Lorenzo;
- Berney, Thierry;
- Gloyn, Anna L
Publication type:
Article
A map of open chromatin in human pancreatic islets.
Published in:
Nature Genetics, 2010, v. 42, n. 3, p. 255, doi. 10.1038/ng.530
By:
- Gaulton, Kyle J.;
- Nammo, Takao;
- Pasquali, Lorenzo;
- Simon, Jeremy M.;
- Giresi, Paul G.;
- Fogarty, Marie P.;
- Panhuis, Tami M.;
- Mieczkowski, Piotr;
- Secchi, Antonio;
- Bosco, Domenico;
- Berney, Thierry;
- Montanya, Eduard;
- Mohlke, Karen L.;
- Lieb, Jason D.;
- Ferrer, Jorge
Publication type:
Article
Correction: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.
Published in:
2018
By:
- Liang, Jingjing;
- Le, Thu H.;
- Velez Edwards, Digna R.;
- Tayo, Bamidele O.;
- Gaulton, Kyle J.;
- Smith, Jennifer A.;
- Lu, Yingchang;
- Jensen, Richard A.;
- Chen, Guanjie;
- Yanek, Lisa R.;
- Schwander, Karen;
- Tajuddin, Salman M.;
- Sofer, Tamar;
- Kim, Wonji;
- Kayima, James;
- McKenzie, Colin A.;
- Fox, Ervin;
- Nalls, Michael A.;
- Young, J. Hunter;
- Sun, Yan V.
Publication type:
Correction Notice
Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations.
Published in:
PLoS Genetics, 2017, v. 13, n. 5, p. 1, doi. 10.1371/journal.pgen.1006728
By:
- Liang, Jingjing;
- Le, Thu H.;
- Edwards, Digna R. Velez;
- Tayo, Bamidele O.;
- Gaulton, Kyle J.;
- Smith, Jennifer A.;
- Lu, Yingchang;
- Jensen, Richard A.;
- Chen, Guanjie;
- Yanek, Lisa R.;
- Schwander, Karen;
- Tajuddin, Salman M.;
- Sofer, Tamar;
- Kim, Wonji;
- Kayima, James;
- McKenzie, Colin A.;
- Fox, Ervin;
- Nalls, Michael A.;
- Young, J. Hunter;
- Sun, Yan V.
Publication type:
Article
The South Asian Genome.
Published in:
PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0102645
By:
- Chambers, John C.;
- Abbott, James;
- Zhang, Weihua;
- Turro, Ernest;
- Scott, William R.;
- Tan, Sian-Tsung;
- Afzal, Uzma;
- Afaq, Saima;
- Loh, Marie;
- Lehne, Benjamin;
- O'Reilly, Paul;
- Gaulton, Kyle J.;
- Pearson, Richard D.;
- Li, Xinzhong;
- Lavery, Anita;
- Vandrovcova, Jana;
- Wass, Mark N.;
- Miller, Kathryn;
- Sehmi, Joban;
- Oozageer, Laticia
Publication type:
Article
The miRNA Profile of Human Pancreatic Islets and Beta- Cells and Relationship to Type 2 Diabetes Pathogenesis.
Published in:
PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0055272
By:
- de Bunt, Martijn van;
- Gaulton, Kyle J.;
- Parts, Leopold;
- Moran, Ignasi;
- Johnson, Paul R.;
- Lindgren, Cecilia M.;
- Ferrer, Jorge;
- Gloyn, Anna L.;
- McCarthy, Mark I.
Publication type:
Article
Glucocorticoid signaling in pancreatic islets modulates gene regulatory programs and genetic risk of type 2 diabetes.
Published in:
PLoS Genetics, 2021, v. 17, n. 5, p. 1, doi. 10.1371/journal.pgen.1009531
By:
- Aylward, Anthony;
- Okino, Mei-Lin;
- Benaglio, Paola;
- Chiou, Joshua;
- Beebe, Elisha;
- Padilla, Jose Andres;
- Diep, Sharlene;
- Gaulton, Kyle J.
Publication type:
Article
Trans-ethnic kidney function association study reveals putative causal genes and effects on kidney-specific disease aetiologies.
Published in:
Nature Communications, 2019, v. 10, n. 1, p. 1, doi. 10.1038/s41467-018-07867-7
By:
- Morris, Andrew P.;
- Le, Thu H.;
- Wu, Haojia;
- Akbarov, Artur;
- van der Most, Peter J.;
- Hemani, Gibran;
- Smith, George Davey;
- Mahajan, Anubha;
- Gaulton, Kyle J.;
- Nadkarni, Girish N.;
- Valladares-Salgado, Adan;
- Wacher-Rodarte, Niels;
- Mychaleckyj, Josyf C.;
- Dueker, Nicole D.;
- Guo, Xiuqing;
- Hai, Yang;
- Haessler, Jeffrey;
- Kamatani, Yoichiro;
- Stilp, Adrienne M.;
- Zhu, Gu
Publication type:
Article
Mapping genetic effects on cell type-specific chromatin accessibility and annotating complex immune trait variants using single nucleus ATAC-seq in peripheral blood.
Published in:
PLoS Genetics, 2023, v. 19, n. 6, p. 1, doi. 10.1371/journal.pgen.1010759
By:
- Benaglio, Paola;
- Newsome, Jacklyn;
- Han, Jee Yun;
- Chiou, Joshua;
- Aylward, Anthony;
- Corban, Sierra;
- Miller, Michael;
- Okino, Mei-Lin;
- Kaur, Jaspreet;
- Preissl, Sebastian;
- Gorkin, David U.;
- Gaulton, Kyle J.
Publication type:
Article
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness.
Published in:
Nature Communications, 2017, v. 8, n. 7, p. 16015, doi. 10.1038/ncomms16015
By:
- Willems, Sara M.;
- Wright, Daniel J.;
- Day, Felix R.;
- Trajanoska, Katerina;
- Joshi, Peter K.;
- Morris, John A.;
- Matteini, Amy M.;
- Garton, Fleur C.;
- Grarup, Niels;
- Oskolkov, Nikolay;
- Thalamuthu, Anbupalam;
- Mangino, Massimo;
- Liu, Jun;
- Demirkan, Ayse;
- Lek, Monkol;
- Xu, Liwen;
- Wang, Guan;
- Oldmeadow, Christopher;
- Gaulton, Kyle J.;
- Lotta, Luca A.
Publication type:
Article
Leveraging type 1 diabetes human genetic and genomic data in the T1D knowledge portal.
Published in:
PLoS Biology, 2023, v. 21, n. 9, p. 1, doi. 10.1371/journal.pbio.3002233
By:
- Kudtarkar, Parul;
- Costanzo, Maria C.;
- Sun, Ying;
- Jang, Dongkeun;
- Koesterer, Ryan;
- Mychaleckyj, Josyf C.;
- Nayak, Uma;
- Onengut-Gumuscu, Suna;
- Rich, Stephen S.;
- Flannick, Jason A.;
- Gaulton, Kyle J.;
- Burtt, Noël P.
Publication type:
Article
Comprehensive Association Study of Type 2 Diabetes and Related Quantitative Traits With 222 Candidate Genes.
Published in:
Diabetes, 2008, v. 57, n. 11, p. 3136, doi. 10.2337/db07-1731
By:
- Gaulton, Kyle J.;
- Willer, Cristen J.;
- Yun Li;
- Scott, Laura J.;
- Conneely, Karen N.;
- Jackson, Anne U.;
- Duren, William L.;
- Chines, Peter S.;
- Narisu, Narisu;
- Bonnycastle, Lori L.;
- Luo, Jingchun;
- Tong, Maurine;
- Sprau, Andrew G.;
- Pugh, Elizabeth W.;
- Doheny, Kimberly F.;
- Valle, Timo T.;
- Abecasis, Gonçalo R.;
- Tuomilehto, Jaakko;
- Bergman, Richard N.;
- Collins, Francis S.
Publication type:
Article
A computational system to select candidate genes for complex human traits.
Published in:
Bioinformatics, 2007, v. 23, n. 9, p. 1132, doi. 10.1093/bioinformatics/btm001
By:
- Kyle J. Gaulton;
- Karen L. Mohlke;
- Todd J. Vision
Publication type:
Article
Lipid-Induced Epigenomic Changes in Human Macrophages Identify a Coronary Artery Disease-Associated Variant that Regulates PPAP2B Expression through Altered C/EBP-Beta Binding.
Published in:
PLoS Genetics, 2015, v. 11, n. 4, p. 1, doi. 10.1371/journal.pgen.1005061
By:
- Reschen, Michael E.;
- Gaulton, Kyle J.;
- Lin, Da;
- Soilleux, Elizabeth J.;
- Morris, Andrew J.;
- Smyth, Susan S.;
- O'Callaghan, Christopher A.
Publication type:
Article
The Power of Gene-Based Rare Variant Methods to Detect Disease-Associated Variation and Test Hypotheses About Complex Disease.
Published in:
PLoS Genetics, 2015, v. 11, n. 4, p. 1, doi. 10.1371/journal.pgen.1005165
By:
- Moutsianas, Loukas;
- Agarwala, Vineeta;
- Fuchsberger, Christian;
- Flannick, Jason;
- Rivas, Manuel A.;
- Gaulton, Kyle J.;
- Albers, Patrick K.;
- null, null;
- McVean, Gil;
- Boehnke, Michael;
- Altshuler, David;
- McCarthy, Mark I.
Publication type:
Article
Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus.
Published in:
PLoS Genetics, 2015, v. 11, n. 1, p. 1, doi. 10.1371/journal.pgen.1004876
By:
- Mahajan, Anubha;
- Sim, Xueling;
- Ng, Hui Jin;
- Manning, Alisa;
- Rivas, Manuel A.;
- Highland, Heather M.;
- Locke, Adam E.;
- Grarup, Niels;
- Im, Hae Kyung;
- Cingolani, Pablo;
- Flannick, Jason;
- Fontanillas, Pierre;
- Fuchsberger, Christian;
- Gaulton, Kyle J.;
- Teslovich, Tanya M.;
- Rayner, N. William;
- Robertson, Neil R.;
- Beer, Nicola L.;
- Rundle, Jana K.;
- Bork-Jensen, Jette
Publication type:
Article
Identification of a Regulatory Variant That Binds FOXA1 and FOXA2 at the CDC123/CAMK1D Type 2 Diabetes GWAS Locus.
Published in:
PLoS Genetics, 2014, v. 10, n. 9, p. 1, doi. 10.1371/journal.pgen.1004633
By:
- Fogarty, Marie P.;
- Cannon, Maren E.;
- Vadlamudi, Swarooparani;
- Gaulton, Kyle J.;
- Mohlke, Karen L.
Publication type:
Article
Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults.
Published in:
Human Molecular Genetics, 2010, v. 19, n. 10, p. 2050, doi. 10.1093/hmg/ddq062
By:
- Lange, Leslie A.;
- Croteau-Chonka, Damien C.;
- Marvelle, Amanda F.;
- Qin, Li;
- Gaulton, Kyle J.;
- Kuzawa, Christopher W.;
- McDade, Thomas W.;
- Wang, Yunfei;
- Li, Yun;
- Levy, Shawn;
- Borja, Judith B.;
- Lange, Ethan M.;
- Adair, Linda S.;
- Mohlke, Karen L.
Publication type:
Article
Common DNA sequence variation influences 3-dimensional conformation of the human genome.
Published in:
Genome Biology, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s13059-019-1855-4
By:
- Gorkin, David U.;
- Qiu, Yunjiang;
- Hu, Ming;
- Fletez-Brant, Kipper;
- Liu, Tristin;
- Schmitt, Anthony D.;
- Noor, Amina;
- Chiou, Joshua;
- Gaulton, Kyle J.;
- Sebat, Jonathan;
- Li, Yun;
- Hansen, Kasper D.;
- Ren, Bing
Publication type:
Article
Assessing association between protein truncating variants and quantitative traits.
Published in:
Bioinformatics, 2013, v. 29, n. 19, p. 2419
By:
- Rivas, Manuel A.;
- Pirinen, Matti;
- Neville, Matthew J.;
- Gaulton, Kyle J.;
- Moutsianas, Loukas;
- Lindgren, Cecilia M.;
- Karpe, Fredrik;
- McCarthy, Mark I.;
- Donnelly, Peter
Publication type:
Article
Developing a network view of type 2 diabetes risk pathways through integration of genetic, genomic and functional data.
Published in:
Genome Medicine, 2019, v. 11, n. 1, p. N.PAG, doi. 10.1186/s13073-019-0628-8
By:
- Fernández-Tajes, Juan;
- Gaulton, Kyle J.;
- van de Bunt, Martijn;
- Torres, Jason;
- Thurner, Matthias;
- Mahajan, Anubha;
- Gloyn, Anna L.;
- Lage, Kasper;
- McCarthy, Mark I.
Publication type:
Article
Mechanisms of Type 2 Diabetes Risk Loci.
Published in:
2017
By:
- Gaulton, Kyle;
- Gaulton, Kyle J
Publication type:
journal article
An Integrated Map of Cell Type–Specific Gene Expression in Pancreatic Islets.
Published in:
Diabetes, 2023, v. 72, n. 11, p. 1719, doi. 10.2337/db23-0130
By:
- Elgamal, Ruth M.;
- Kudtarkar, Parul;
- Melton, Rebecca L.;
- Mummey, Hannah M.;
- Benaglio, Paola;
- Okino, Mei-Lin;
- Gaulton, Kyle J.
Publication type:
Article
Erratum. Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings. Diabetes 2023;72:433–448.
Published in:
2023
By:
- Mastracci, Teresa L.;
- Apte, Minoti;
- Amundadottir, Laufey T.;
- Alvarsson, Alexandra;
- Artandi, Steven;
- Bellin, Melena D.;
- Bernal-Mizrachi, Ernesto;
- Caicedo, Alejandro;
- Campbell-Thompson, Martha;
- Cruz-Monserrate, Zobeida;
- Ouaamari, Abdelfattah El;
- Gaulton, Kyle J.;
- Geisz, Andrea;
- Goodarzi, Mark O.;
- Hara, Manami;
- Hull-Meichle, Rebecca L.;
- Kleger, Alexander;
- Klein, Alison P.;
- Kopp, Janel L.;
- Kulkarni, Rohit N.
Publication type:
Correction Notice
Integrated Physiology of the Exocrine and Endocrine Compartments in Pancreatic Diseases: Workshop Proceedings.
Published in:
Diabetes, 2023, v. 72, n. 4, p. 433, doi. 10.2337/db22-0942
By:
- Mastracci, Teresa L.;
- Apte, Minoti;
- Amundadottir, Laufey T.;
- Alvarsson, Alexandra;
- Artandi, Steven;
- Bellin, Melena D.;
- Bernal-Mizrachi, Ernesto;
- Caicedo, Alejandro;
- Campbell-Thompson, Martha;
- Cruz-Monserrate, Zobeida;
- El Ouaamari, Abdelfattah;
- Gaulton, Kyle J.;
- Geisz, Andrea;
- Goodarzi, Mark O.;
- Hara, Manami;
- Hull-Meichle, Rebecca L.;
- Kleger, Alexander;
- Klein, Alison P.;
- Kopp, Janel L.;
- Kulkarni, Rohit N.
Publication type:
Article
1644-P: High Throughput Approach Enables Expanded Clustering of Type 2 Diabetes Genetic Loci Informed by Phenotypic Associations.
Published in:
Diabetes, 2020, v. 69, p. N.PAG, doi. 10.2337/db20-1644-P
By:
- KIM, HYUNKYUNG;
- VON GROTTHUSS, MARCIN;
- MERCADER, JOSEP M.;
- CHIOU, JOSHUA;
- GAULTON, KYLE J.;
- MANNING, ALISA;
- FLOREZ, JOSE C.;
- UDLER, MIRIAM
Publication type:
Article
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.
Published in:
2017
By:
- Scott, Robert A.;
- Scott, Laura J.;
- Mägi, Reedik;
- Marullo, Letizia;
- Gaulton, Kyle J.;
- Kaakinen, Marika;
- Pervjakova, Natalia;
- Pers, Tune H.;
- Johnson, Andrew D.;
- Eicher, John D.;
- Jackson, Anne U.;
- Ferreira, Teresa;
- Yeji Lee;
- Ma, Clement;
- Steinthorsdottir, Valgerdur;
- Thorleifsson, Gudmar;
- Lu Qi;
- Van Zuydam, Natalie R.;
- Mahajan, Anubha;
- Chen, Han
Publication type:
journal article
A Low-Frequency Inactivating Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Published in:
2017
By:
- Manning, Alisa;
- Highland, Heather M.;
- Gasser, Jessica;
- Sim, Xueling;
- Tukiainen, Taru;
- Fontanillas, Pierre;
- Grarup, Niels;
- Rivas, Manuel A.;
- Mahajan, Anubha;
- Locke, Adam E.;
- Cingolani, Pablo;
- Pers, Tune H.;
- Viñuela, Ana;
- Brown, Andrew A.;
- Ying Wu;
- Flannick, Jason;
- Fuchsberger, Christian;
- Gamazon, Eric R.;
- Gaulton, Kyle J.;
- Hae Kyung Im
Publication type:
journal article
Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors.
Published in:
PLoS Genetics, 2015, v. 11, n. 12, p. 1, doi. 10.1371/journal.pgen.1005694
By:
- van de Bunt, Martijn;
- Fox, Jocelyn E. Manning;
- Xiaoqing Dai;
- Barrett, Amy;
- Grey, Caleb;
- Lei Li;
- Bennett, Amanda J.;
- Johnson, Paul R.;
- Rajotte, Raymond V.;
- Gaulton, Kyle J.;
- Dermitzakis, Emmanouil T.;
- MacDonald, Patrick E.;
- McCarthy, Mark I.;
- Gloyn, Anna L.
Publication type:
Article

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