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P4‐140: CURRENT CLINICAL UNDERSTANDING OF THE TREATMENT OF ALZHEIMER'S DISEASE: PHYSICIANS' PERSPECTIVES.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1492, doi. 10.1016/j.jalz.2018.06.2544
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The National Institute on Aging and the Alzheimer's Association Research Framework for Alzheimer's disease: Perspectives from the Research Roundtable.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, n. 4, p. 563, doi. 10.1016/j.jalz.2018.03.002
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- Article
A Cas9-based toolkit to program gene expression in Saccharomyces cerevisiae.
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- Nucleic Acids Research, 2017, v. 45, n. 1, p. 496, doi. 10.1093/nar/gkw1023
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- Article
Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin.
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- Nature Medicine, 2009, v. 15, n. 12, p. 1407, doi. 10.1038/nm.2056
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- Article
Randomized, double-blind, placebo-controlled study to evaluate the safety, pharmacokinetics and pharmacodynamics of avagacestat (BMS 708163) in healthy Japanese and non-Japanese subjects
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- 2012
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- Abstract
The effect of concomitant administration of multiple doses of avagacestat on the pharmacokinetics of either donepezil or galantamine in healthy subjects
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- 2012
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- Abstract
Randomized, placebo-controlled, double blind, single- and multiple-dose study to evaluate the pharmacokinetics, safety and tolerability of avagacestat (BMS-708163) in healthy young male and elderly male and female Chinese subjects
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- 2012
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- Abstract
Randomized, double-blinded, placebo-controlled study to evaluate the safety, pharmacokinetics, and pharmacodynamics of avagacestat (BMS 708163) in healthy Japanese and non-Japanese subjects
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- 2012
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- Abstract
An assessment of variability in CSF biomarkers in clinical experimental models: a meta-analysis
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- 2011
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- Abstract
The Gamma Secretase Inhibitor, BMS-708163 Increases Alpha Secretase Abeta Peptide Cleavage Fragments and Decreases the Gamma Secretase Abeta Peptide 1-34 Fragment in Cerebrospinal Fluid
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- 2011
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- Abstract
No Clinically Relevant Effect of BMS-708163, a γ-Secretase Inhibitor, on QTc Interval in Healthy Subjects
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- 2011
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The safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple doses of BMS-708163 in young and elderly Japanese subjects
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- 2010
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- Abstract
A placebo-controlled, ascending, multiple-dose study to evaluate the safety, pharmacokinetics (PK) and pharmacodynamics (PD) of BMS-708163 in healthy young and elderly subjects
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- 2010
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- Abstract
The safety, tolerability, pharmacokinetics and pharmacodynamics of single doses of BMS-708163 in young and elderly subjects
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- 2010
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- Abstract
Effect of concomitant administration of multiple doses of BMS-708163 on safety, tolerability, and the pharmacokinetics of midazolam, warfarin, caffeine, omeprazole, and dextromethorphan in healthy male subjects by administration of a modified Cooperstown cocktail
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- 2010
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- Abstract
A study to evaluate the effects of single oral doses of BMS-708163 in the cerebrospinal fluid of healthy young men
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- 2010
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- Abstract
Development of a Microfluidic Device for Detection of Pathogens in Oral Samples Using Upconverting Phosphor Technology (UPT).
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- Annals of the New York Academy of Sciences, 2007, v. 1098, p. 375, doi. 10.1196/annals.1384.020
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- Article
Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease.
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- Scientific Reports, 2016, p. 20750, doi. 10.1038/srep20750
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- Article
A contrast in safety, pharmacokinetics and pharmacodynamics across age groups after a single 50 mg oral dose of the γ-secretase inhibitor avagacestat.
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- British Journal of Clinical Pharmacology, 2013, v. 75, n. 1, p. 136, doi. 10.1111/j.1365-2125.2012.04339.x
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- Article
Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 "NMDA" Receptor Subunits.
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- Journal of Neuroscience, 2010, v. 30, n. 34, p. 11501, doi. 10.1523/JNEUROSCI.1593-10.2010
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- Article
Neuroprotection by the NR3A Subunit of the NMDA Receptor.
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- Journal of Neuroscience, 2009, v. 29, n. 16, p. 5260, doi. 10.1523/JNEUROSCI.1067-09.2009
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- Article
Early immune factors associated with the development of post-acute sequelae of SARS-CoV-2 infection in hospitalized and non-hospitalized individuals.
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- Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1348041
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Psychometric testing of the Fall Risks for Older People in the Community screening tool (FROP-Com screen) for community-dwelling people with stroke.
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- PLoS ONE, 2020, v. 15, n. 5, p. 1, doi. 10.1371/journal.pone.0233045
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Effects of Single Doses of Avagacestat (BMS-708163) on Cerebrospinal Fluid Aβ Levels in Healthy Young Men.
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- Clinical Drug Investigation, 2012, v. 32, n. 11, p. 761, doi. 10.1007/s40261-012-0006-4
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- Article
An integrated multi-study analysis of intra-subject variability in cerebrospinal fluid amyloid-β concentrations collected by lumbar puncture and indwelling lumbar catheter.
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- Alzheimer's Research & Therapy, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13195-015-0136-z
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A Placebo-Controlled, Multiple Ascending Dose Study to Evaluate the Safety, Pharmacokinetics and Pharmacodynamics of Avagacestat (BMS-708163) in Healthy Young and Elderly Subjects.
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- Clinical Pharmacokinetics, 2012, v. 51, n. 10, p. 681, doi. 10.1007/s40262-012-0005-x
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- Article
Current state of Alzheimer's fluid biomarkers.
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- Acta Neuropathologica, 2018, v. 136, n. 6, p. 821, doi. 10.1007/s00401-018-1932-x
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Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau.
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- Molecular Neurodegeneration, 2006, v. 1, p. 7, doi. 10.1186/1750-1326-1-7
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Calnuc binds to Alzheimer’s β-amyloid precursor protein and affects its biogenesis.
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- Journal of Neurochemistry, 2007, v. 100, n. 6, p. 1505, doi. 10.1111/j.1471-4159.2006.04336.x
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- Article