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Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27032-x
By:
- Meng, Yanxiang;
- Davies, Katherine A.;
- Fitzgibbon, Cheree;
- Young, Samuel N.;
- Garnish, Sarah E.;
- Horne, Christopher R.;
- Luo, Cindy;
- Garnier, Jean-Marc;
- Liang, Lung-Yu;
- Cowan, Angus D.;
- Samson, Andre L.;
- Lessene, Guillaume;
- Sandow, Jarrod J.;
- Czabotar, Peter E.;
- Murphy, James M.
Publication type:
Article
Conformational interconversion of MLKL and disengagement from RIPK3 precede cell death by necroptosis.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22400-z
By:
- Garnish, Sarah E.;
- Meng, Yanxiang;
- Koide, Akiko;
- Sandow, Jarrod J.;
- Denbaum, Eric;
- Jacobsen, Annette V.;
- Yeung, Wayland;
- Samson, Andre L.;
- Horne, Christopher R.;
- Fitzgibbon, Cheree;
- Young, Samuel N.;
- Smith, Phoebe P. C.;
- Webb, Andrew I.;
- Petrie, Emma J.;
- Hildebrand, Joanne M.;
- Kannan, Natarajan;
- Czabotar, Peter E.;
- Koide, Shohei;
- Murphy, James M.
Publication type:
Article
Oligomerization‐driven MLKL ubiquitylation antagonizes necroptosis.
Published in:
EMBO Journal, 2021, v. 40, n. 23, p. 1, doi. 10.15252/embj.2019103718
By:
- Liu, Zikou;
- Dagley, Laura F;
- Shield‐Artin, Kristy;
- Young, Samuel N;
- Bankovacki, Aleksandra;
- Wang, Xiangyi;
- Tang, Michelle;
- Howitt, Jason;
- Stafford, Che A;
- Nachbur, Ueli;
- Fitzgibbon, Cheree;
- Garnish, Sarah E;
- Webb, Andrew I;
- Komander, David;
- Murphy, James M;
- Hildebrand, Joanne M;
- Silke, John
Publication type:
Article
Phosphorylation-dependent pseudokinase domain dimerization drives full-length MLKL oligomerization.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42255-w
By:
- Meng, Yanxiang;
- Garnish, Sarah E.;
- Davies, Katherine A.;
- Black, Katrina A.;
- Leis, Andrew P.;
- Horne, Christopher R.;
- Hildebrand, Joanne M.;
- Hoblos, Hanadi;
- Fitzgibbon, Cheree;
- Young, Samuel N.;
- Dite, Toby;
- Dagley, Laura F.;
- Venkat, Aarya;
- Kannan, Natarajan;
- Koide, Akiko;
- Koide, Shohei;
- Glukhova, Alisa;
- Czabotar, Peter E.;
- Murphy, James M.
Publication type:
Article
A common human MLKL polymorphism confers resistance to negative regulation by phosphorylation.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-41724-6
By:
- Garnish, Sarah E.;
- Martin, Katherine R.;
- Kauppi, Maria;
- Jackson, Victoria E.;
- Ambrose, Rebecca;
- Eng, Vik Ven;
- Chiou, Shene;
- Meng, Yanxiang;
- Frank, Daniel;
- Tovey Crutchfield, Emma C.;
- Patel, Komal M.;
- Jacobsen, Annette V.;
- Atkin-Smith, Georgia K.;
- Di Rago, Ladina;
- Doerflinger, Marcel;
- Horne, Christopher R.;
- Hall, Cathrine;
- Young, Samuel N.;
- Cook, Matthew;
- Athanasopoulos, Vicki
Publication type:
Article
The Role of the Key Effector of Necroptotic Cell Death, MLKL, in Mouse Models of Disease.
Published in:
Biomolecules (2218-273X), 2021, v. 11, n. 6, p. 803, doi. 10.3390/biom11060803
By:
- Tovey Crutchfield, Emma C.;
- Garnish, Sarah E.;
- Hildebrand, Joanne M.
Publication type:
Article
Inhibitors identify an auxiliary role for mTOR signalling in necroptosis execution downstream of MLKL activation.
Published in:
Biochemical Journal, 2024, v. 481, n. 17, p. 1125, doi. 10.1042/BCJ20240255
By:
- Garnish, Sarah E.;
- Horne, Christopher R.;
- Yanxiang Meng;
- Young, Samuel N.;
- Jacobsen, Annette V.;
- Hildebrand, Joanne M.;
- Murphy, James M.
Publication type:
Article
Location, location, location: A compartmentalized view of TNF-induced necroptotic signaling.
Published in:
Science Signaling, 2021, v. 14, n. 668, p. 1, doi. 10.1126/scisignal.abc6178
By:
- Samson, André L.;
- Garnish, Sarah E.;
- Hildebrand, Joanne M.;
- Murphy, James M.
Publication type:
Article
Rare catastrophes and evolutionary legacies: human germline gene variants in MLKL and the necroptosis signalling pathway.
Published in:
Biochemical Society Transactions, 2022, v. 50, n. 1, p. 529, doi. 10.1042/BST20210517
By:
- Garnish, Sarah E.;
- Hildebrand, Joanne M.
Publication type:
Article
Add necroptosis to your asthma action plan.
Published in:
Immunology & Cell Biology, 2021, v. 99, n. 8, p. 800, doi. 10.1111/imcb.12489
By:
- Garnish, Sarah E;
- Tovey Crutchfield, Emma C;
- Murphy, James M;
- Hildebrand, Joanne M
Publication type:
Article
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16887-1
By:
- Samson, Andre L.;
- Zhang, Ying;
- Geoghegan, Niall D.;
- Gavin, Xavier J.;
- Davies, Katherine A.;
- Mlodzianoski, Michael J.;
- Whitehead, Lachlan W.;
- Frank, Daniel;
- Garnish, Sarah E.;
- Fitzgibbon, Cheree;
- Hempel, Anne;
- Young, Samuel N.;
- Jacobsen, Annette V.;
- Cawthorne, Wayne;
- Petrie, Emma J.;
- Faux, Maree C.;
- Shield-Artin, Kristy;
- Lalaoui, Najoua;
- Hildebrand, Joanne M.;
- Silke, John
Publication type:
Article
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16823-3
By:
- Davies, Katherine A.;
- Fitzgibbon, Cheree;
- Young, Samuel N.;
- Garnish, Sarah E.;
- Yeung, Wayland;
- Coursier, Diane;
- Birkinshaw, Richard W.;
- Sandow, Jarrod J.;
- Lehmann, Wil I. L.;
- Liang, Lung-Yu;
- Lucet, Isabelle S.;
- Chalmers, James D.;
- Patrick, Wayne M.;
- Kannan, Natarajan;
- Petrie, Emma J.;
- Czabotar, Peter E.;
- Murphy, James M.
Publication type:
Article
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16819-z
By:
- Hildebrand, Joanne M.;
- Kauppi, Maria;
- Majewski, Ian J.;
- Liu, Zikou;
- Cox, Allison J.;
- Miyake, Sanae;
- Petrie, Emma J.;
- Silk, Michael A.;
- Li, Zhixiu;
- Tanzer, Maria C.;
- Brumatti, Gabriela;
- Young, Samuel N.;
- Hall, Cathrine;
- Garnish, Sarah E.;
- Corbin, Jason;
- Stutz, Michael D.;
- Di Rago, Ladina;
- Gangatirkar, Pradnya;
- Josefsson, Emma C.;
- Rigbye, Kristin
Publication type:
Article

Found: 13