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A network pharmacology approach to investigate dehydrocostus lactone inhibits the proliferation and epithelial-mesenchymal transition of human gastric cancer cells via regulating the PI3K/Akt and extracellular signal-regulated kinases/mitogen-activated protein kinase signalling pathways
Published in:
Journal of Pharmacy & Pharmacology, 2023, v. 75, n. 10, p. 1344, doi. 10.1093/jpp/rgad065
By:
- Wan, Meiqi;
- Dai, Jun;
- Gan, Anna;
- Wang, Jinyu;
- Lin, Fei;
- Zhang, Xiaoying;
- Lv, Xinyan;
- Wu, Bo;
- Yan, Tingxu;
- Jia, Ying
Publication type:
Article
Tissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22463-y
By:
- Zhu, Guanhua;
- Guo, Yu A.;
- Ho, Danliang;
- Poon, Polly;
- Poh, Zhong Wee;
- Wong, Pui Mun;
- Gan, Anna;
- Chang, Mei Mei;
- Kleftogiannis, Dimitrios;
- Lau, Yi Ting;
- Tay, Brenda;
- Lim, Wan Jun;
- Chua, Clarinda;
- Tan, Tira J.;
- Koo, Si-Lin;
- Chong, Dawn Q.;
- Yap, Yoon Sim;
- Tan, Iain;
- Ng, Sarah;
- Skanderup, Anders J.
Publication type:
Article
Exome sequencing of liver fluke-associated cholangiocarcinoma.
Published in:
Nature Genetics, 2012, v. 44, n. 6, p. 690, doi. 10.1038/ng.2273
By:
- Ong, Choon Kiat;
- Subimerb, Chutima;
- Pairojkul, Chawalit;
- Wongkham, Sopit;
- Cutcutache, Ioana;
- Yu, Willie;
- McPherson, John R;
- Allen, George E;
- Ng, Cedric Chuan Young;
- Wong, Bernice Huimin;
- Myint, Swe Swe;
- Rajasegaran, Vikneswari;
- Heng, Hong Lee;
- Gan, Anna;
- Zang, Zhi Jiang;
- Wu, Yingting;
- Wu, Jeanie;
- Lee, Ming Hui;
- Huang, DaChuan;
- Ong, Pauline
Publication type:
Article
Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes.
Published in:
Nature Genetics, 2012, v. 44, n. 5, p. 570, doi. 10.1038/ng.2246
By:
- Zang, Zhi Jiang;
- Cutcutache, Ioana;
- Poon, Song Ling;
- Zhang, Shen Li;
- McPherson, John R;
- Tao, Jiong;
- Rajasegaran, Vikneswari;
- Heng, Hong Lee;
- Deng, Niantao;
- Gan, Anna;
- Lim, Kiat Hon;
- Ong, Choon Kiat;
- Huang, DaChuan;
- Chin, Sze Yung;
- Tan, Iain Beehuat;
- Ng, Cedric Chuan Young;
- Yu, Willie;
- Wu, Yingting;
- Lee, Minghui;
- Wu, Jeanie
Publication type:
Article
Whole-exome sequencing studies of parathyroid carcinomas reveal novel PRUNE2 mutations, distinctive mutational spectra related to APOBEC-catalyzed DNA mutagenesis and mutational enrichment in kinases associated with cell migration and invasion.
Published in:
2015
By:
- Yu, Willie;
- McPherson, John R;
- Stevenson, Mark;
- van Eijk, Ronald;
- Heng, Hong Lee;
- Newey, Paul;
- Gan, Anna;
- Ruano, Dina;
- Huang, Dachuan;
- Poon, Song Ling;
- Ong, Choon Kiat;
- van Wezel, Tom;
- Cavaco, Branca;
- Rozen, Steven G;
- Tan, Patrick;
- Teh, Bin T;
- Thakker, Rajesh V;
- Morreau, Hans
Publication type:
journal article
Individualised multiplexed circulating tumour DNA assays for monitoring of tumour presence in patients after colorectal cancer surgery.
Published in:
Scientific Reports, 2017, p. 40737, doi. 10.1038/srep40737
By:
- Ng, Sarah B.;
- Chua, Clarinda;
- Ng, Matthew;
- Gan, Anna;
- Poon, Polly SY;
- Teo, Melissa;
- Fu, Cherylin;
- Leow, Wei Qiang;
- Lim, Kiat Hon;
- Chung, Alexander;
- Koo, Si-Lin;
- Choo, Su Pin;
- Ho, Danliang;
- Rozen, Steve;
- Tan, Patrick;
- Wong, Mark;
- Burkholder, William F.;
- Tan, Iain Beehuat
Publication type:
Article
Detection of genomic alterations in breast cancer with circulating tumour DNA sequencing.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41598-020-72818-6
By:
- Kleftogiannis, Dimitrios;
- Ho, Danliang;
- Liew, Jun Xian;
- Poon, Polly S. Y.;
- Gan, Anna;
- Ng, Raymond Chee-Hui;
- Tan, Benita Kiat-Tee;
- Tay, Kiang Hiong;
- Lim, Swee H.;
- Tan, Gek San;
- Shih, Chih Chuan;
- Lim, Tony Kiat-Hon;
- Lee, Ann Siew-Gek;
- Tan, Iain Beehuat;
- Yap, Yoon-Sim;
- Ng, Sarah B.
Publication type:
Article
Genome-Wide Mutational Signatures of Aristolochic Acid and Its Application as a Screening Tool.
Published in:
Science Translational Medicine, 2013, v. 5, n. 197, p. 1, doi. 10.1126/scitranslmed.3006086
By:
- Song Ling Poon;
- See-Tong Pang;
- McPherson, John R.;
- Willie Yu;
- Kie Kyon Huang;
- Peiyong Guan;
- Wen-Hui Weng;
- Ee Yan Siew;
- Yujing Liu;
- Hong Lee Heng;
- Soo Ching Chong;
- Gan, Anna;
- Su Ting Tay;
- Weng Khong Lim;
- Cutcutache, Ioana;
- Huang, Dachuan;
- Lian Dee Ler;
- Nairismägi, Maarja-Liisa;
- Ming Hui Lee;
- Ying-Hsu Chang
Publication type:
Article
Mutation signatures implicate aristolochic acid in bladder cancer development.
Published in:
Genome Medicine, 2015, v. 7, n. 1, p. 1, doi. 10.1186/s13073-015-0161-3
By:
- Song Ling Poon;
- Mi Ni Huang;
- Yang Choo;
- McPherson, John R.;
- Yu, Willie;
- Hong Lee Heng;
- Gan, Anna;
- Swe Swe Myint;
- Ee Yan Siew;
- Lian Dee Ler;
- Lay Guat Ng;
- Wen-Hui Weng;
- Cheng-Keng Chuang;
- Yuen, John S. P.;
- See-Tong Pang;
- Tan, Patrick;
- Bin Tean Teh;
- Rozen, Steven G.
Publication type:
Article
Multiregion ultra-deep sequencing reveals early intermixing and variable levels of intratumoral heterogeneity in colorectal cancer.
Published in:
Molecular Oncology, 2017, v. 11, n. 2, p. 124, doi. 10.1002/1878-0261.12012
By:
- Suzuki, Yuka;
- Ng, Sarah Boonhsi;
- Chua, Clarinda;
- Leow, Wei Qiang;
- Chng, Jermain;
- Liu, Shi Yang;
- Ramnarayanan, Kalpana;
- Gan, Anna;
- Ho, Dan Liang;
- Ten, Rachel;
- Su, Yan;
- Lezhava, Alexandar;
- Lai, Jiunn Herng;
- Koh, Dennis;
- Lim, Kiat Hon;
- Tan, Patrick;
- Rozen, Steven G.;
- Tan, Iain Beehuat
Publication type:
Article

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