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Unveiling (−)-Englerin A as a Modulator of L-Type Calcium Channels.
- Published in:
- Angewandte Chemie, 2016, v. 128, n. 37, p. 11243, doi. 10.1002/ange.201604336
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- Publication type:
- Article
Unveiling (−)-Englerin A as a Modulator of L-Type Calcium Channels.
- Published in:
- Angewandte Chemie International Edition, 2016, v. 55, n. 37, p. 11077, doi. 10.1002/anie.201604336
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- Publication type:
- Article
Transformation of local Ca<sup>2+</sup> spikes to global Ca<sup>2+</sup> transients: the combinatorial roles of multiple Ca<sup>2+</sup> releasing messengers.
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- EMBO Journal, 2002, v. 21, n. 5, p. 909, doi. 10.1093/emboj/21.5.909
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- Publication type:
- Article
NAADP induces Ca<sup>2+</sup> oscillations via a two-pool mechanism by priming IP<sub>3</sub>- and cADPR-sensitive Ca<sup>2+</sup> stores.
- Published in:
- EMBO Journal, 2001, v. 20, n. 11, p. 2666, doi. 10.1093/emboj/20.11.2666
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- Article
A two-pore channel protein required for regulating mTORC1 activity on starvation.
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- BMC Biology, 2020, v. 18, n. 1, p. 1, doi. 10.1186/s12915-019-0735-4
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- Article
Revealing the secrets of secretion.
- Published in:
- eLife, 2018, p. 1, doi. 10.7554/eLife.43512
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- Article
Intracellular sphingosine releases calcium from lysosomes.
- Published in:
- eLife, 2015, p. 1, doi. 10.7554/eLife.10616
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- Publication type:
- Article
Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice.
- Published in:
- Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-22179-z
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- Publication type:
- Article
Physiological roles of NAADP-mediated Ca signaling.
- Published in:
- SCIENCE CHINA Life Sciences, 2011, v. 54, n. 8, p. 725, doi. 10.1007/s11427-011-4207-5
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- Publication type:
- Article
Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca<sup>2+</sup> signaling.
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- Science Signaling, 2018, v. 11, n. 558, p. 1, doi. 10.1126/scisignal.aat9093
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- Publication type:
- Article
Reconstituted Human TPC1 Is a Proton-Permeable Ion Channel and Is Activated by NAADP or Ca<sup>2+</sup>.
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- Science Signaling, 2014, v. 7, n. 326, p. 1, doi. 10.1126/scisignal.2004854
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- Publication type:
- Article
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium.
- Published in:
- Nature Medicine, 2008, v. 14, n. 11, p. 1247, doi. 10.1038/nm.1876
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- Publication type:
- Article
NAADP‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca<sup>2+</sup> nanodomains, calcineurin and dynamin.
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- EMBO Journal, 2020, v. 39, n. 14, p. 1, doi. 10.15252/embj.2019104058
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- Publication type:
- Article
Calcium signalling by nicotinic acid adenine dinucleotide phosphate (NAADP).
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- FEBS Journal, 2005, v. 272, n. 18, p. 4598, doi. 10.1111/j.1742-4658.2005.04860.x
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- Publication type:
- Article
High resolution structural evidence suggests the Sarcoplasmic Reticulum forms microdomains with Acidic Stores (lysosomes) in the heart.
- Published in:
- Scientific Reports, 2017, p. 40620, doi. 10.1038/srep40620
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- Publication type:
- Article
Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt<sup>+</sup> Cells in Murine Heart.
- Published in:
- Scientific Reports, 2017, p. 40687, doi. 10.1038/srep40687
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- Publication type:
- Article
Expression of Ca<sup>2+</sup>-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
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- EMBO Journal, 2015, v. 34, n. 13, p. 1743, doi. 10.15252/embj.201490009
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- Publication type:
- Article
The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca<sup>2+</sup> release channels.
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- Pflügers Archiv: European Journal of Physiology, 2009, v. 458, n. 5, p. 869, doi. 10.1007/s00424-009-0682-y
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- Article
NAADP mobilizes calcium from acidic organelles through two-pore channels.
- Published in:
- Nature, 2009, v. 459, n. 7246, p. 596, doi. 10.1038/nature08030
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- Publication type:
- Article
Defective platelet function in Niemann‐Pick disease type C1.
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- Journal of Inherited Metabolic Disease Reports, 2020, v. 56, n. 1, p. 46, doi. 10.1002/jmd2.12148
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- Publication type:
- Article
Microinjection of cyclic ADP-ribose triggers a regenerative wave of Ca2+ release and exocytosis of cortical alveoli in medaka eggs.
- Published in:
- Zygote, 1999, v. 7, n. 4, p. 285, doi. 10.1017/s0967199499000684
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- Publication type:
- Article
Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance.
- Published in:
- PLoS ONE, 2020, v. 15, n. 2, p. 1, doi. 10.1371/journal.pone.0229585
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- Article
A multiscale analysis in CD38<sup>-/-</sup> mice unveils major prefrontal cortex dysfunctions.
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- FASEB Journal, 2019, v. 33, n. 5, p. 5823, doi. 10.1096/fj.201800489R
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- Article
GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation.
- Published in:
- 2015
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- Publication type:
- journal article
An N-Terminal Dileucine Motif Directs Two-Pore Channels to the Tonoplast of Plant Cells.
- Published in:
- Traffic, 2012, v. 13, n. 7, p. 1012, doi. 10.1111/j.1600-0854.2012.01366.x
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- Publication type:
- Article
The functional roles of Ca<sup>2+</sup> mobilizing pyridine nucleotides cADPR and NAADP in detrusor and taenia caceum.
- Published in:
- FASEB Journal, 2007, v. 21, n. 6, p. A1161
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- Publication type:
- Article
Chemical Synthesis of the Second Messenger Nicotinic Acid Adenine Dinucleotide Phosphate by Total Synthesis of Nicotinamide Adenine Dinucleotide PhosphateThis research was funded by the Biotechnology and Biology Sciences Research Council and an Engineering and Physical Sciences Research Council (EPSRC) studentship. We acknowledge the use of the EPSRC Chemical Database Service at Daresbury.
- Published in:
- Angewandte Chemie, 2004, v. 116, n. 35, p. 4737, doi. 10.1002/ange.200460054
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- Publication type:
- Article
Mechanistic convergence and shared therapeutic targets in Niemann‐Pick disease.
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- Journal of Inherited Metabolic Disease, 2020, v. 43, n. 3, p. 574, doi. 10.1002/jimd.12191
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- Article
Flipping the switch: How a sperm activates the egg at fertilization.
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- Developmental Dynamics, 2007, v. 236, n. 8, p. 2027, doi. 10.1002/dvdy.21255
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- Publication type:
- Article
Loss of activity mutations in phospholipase C zeta (PLCζ) abolishes calcium oscillatory ability of human recombinant protein in mouse oocytes.
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- 2011
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- Publication type:
- journal article
Acetylation turns leucine into a drug by membrane transporter switching.
- Published in:
- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-95255-5
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- Publication type:
- Article
Glucose and NAADP trigger elementary intracellular β-cell Ca2+ signals.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-88906-0
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- Publication type:
- Article
Two-pore channels: going with the flows.
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- Biochemical Society Transactions, 2022, v. 50, n. 4, p. 1143, doi. 10.1042/BST20220229
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- Article
TPC: the NAADP discovery channel?
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- Biochemical Society Transactions, 2015, v. 43, n. 3, p. 384, doi. 10.1042/BST20140300
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- Article
Identification of a Novel Gene for Diabetic Traits in Rats, Mice, and Humans.
- Published in:
- Genetics, 2014, v. 198, n. 1, p. 17, doi. 10.1534/genetics.114.162982
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- Publication type:
- Article
Chemical Synthesis of the Second Messenger Nicotinic Acid Adenine Dinucleotide Phosphate by Total Synthesis of Nicotinamide Adenine Dinucleotide PhosphateThis research was funded by the Biotechnology and Biology Sciences Research Council and an Engineering and Physical Sciences Research Council (EPSRC) studentship. We acknowledge the use of the EPSRC Chemical Database Service at Daresbury.
- Published in:
- Angewandte Chemie International Edition, 2004, v. 43, n. 35, p. 4637, doi. 10.1002/anie.200460054
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- Publication type:
- Article
Hax-1 identified as a two-pore channel (TPC)-binding protein.
- Published in:
- FEBS Letters, 2013, v. 587, n. 23, p. 3782, doi. 10.1016/j.febslet.2013.10.031
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- Publication type:
- Article
TPCs: Endolysosomal channels for Ca<sup>2+</sup> mobilization from acidic organelles triggered by NAADP
- Published in:
- FEBS Letters, 2010, v. 584, n. 10, p. 1966, doi. 10.1016/j.febslet.2010.02.028
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- Article
Two-pore channels ( TPCs): Current controversies.
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- BioEssays, 2014, v. 36, n. 2, p. 173, doi. 10.1002/bies.201300118
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- Article
Identification of a chemical probe for NAADP by virtual screening.
- Published in:
- Nature Chemical Biology, 2009, v. 5, n. 4, p. 220, doi. 10.1038/nchembio.150
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- Publication type:
- Article
Coordination of agonist-induced Ca2+-signalling patterns by NAADP in pancreatic acinar cells.
- Published in:
- Nature, 1999, v. 398, n. 6722, p. 74, doi. 10.1038/18032
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- Publication type:
- Article
Current methods to analyze lysosome morphology, positioning, motility and function.
- Published in:
- Traffic, 2022, v. 23, n. 5, p. 238, doi. 10.1111/tra.12839
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- Publication type:
- Article
Adrenaline Stimulates Glucagon Secretion by Tpc2-Dependent Ca<sup>2+</sup> Mobilization From Acidic Stores in Pancreatic α-Cells.
- Published in:
- 2018
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- Publication type:
- journal article