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Vanadium Complexes with Thioanilide Derivatives of Amino Acids: Inhibition of Human Phosphatases and Specificity in Various Cell Models of Metabolic Disturbances.
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- Pharmaceuticals (14248247), 2024, v. 17, n. 2, p. 229, doi. 10.3390/ph17020229
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- Article
Novel Multimodal Salicylamide Derivative with Antidepressant-like, Anxiolytic-like, Antipsychotic-like, and Anti-Amnesic Activity in Mice.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 2, p. 175, doi. 10.3390/ph16020175
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- Article
Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT 1A and D 2 Receptors.
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- Pharmaceuticals (14248247), 2021, v. 14, n. 8, p. 744, doi. 10.3390/ph14080744
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- Article
Characteristics of metabolic stability and the cell permeability of 2‐pyrimidinyl‐piperazinyl‐alkyl derivatives of 1H‐imidazo[2,1‐f]purine‐2,4(3H,8H)‐dione with antidepressant‐ and anxiolytic‐like activities
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- Chemical Biology & Drug Design, 2019, v. 93, n. 4, p. 511, doi. 10.1111/cbdd.13442
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- Article
Antipsychotic- and Anxiolytic-like Properties of a Multimodal Compound JJGW08 in Rodents.
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- International Journal of Molecular Sciences, 2022, v. 23, n. 24, p. 15929, doi. 10.3390/ijms232415929
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- Article
Synthesis, Anticonvulsant and Antinociceptive Activity of New Hybrid Compounds: Derivatives of 3-(3-Methylthiophen-2-yl)-pyrrolidine-2,5-dione.
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- International Journal of Molecular Sciences, 2020, v. 21, n. 16, p. 5750, doi. 10.3390/ijms21165750
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- Article
Synthesis of N‐(phenoxyalkyl)‐, N‐{2‐[2‐(phenoxy)ethoxy]ethyl}‐ or N‐(phenoxyacetyl)piperazine Derivatives and Their Activity Within the Central Nervous System.
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- ChemistrySelect, 2019, v. 4, n. 32, p. 9381, doi. 10.1002/slct.201902648
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- Article
Antidepressant- and Anxiolytic-Like Effects of New Dual 5-HT<sub>1A</sub> and 5-HT<sub>7</sub> Antagonists in Animal Models.
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- PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0142499
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- Article
A Comparison of the Anorectic Effect and Safety of the Alpha<sub>2</sub>-Adrenoceptor Ligands Guanfacine and Yohimbine in Rats with Diet-Induced Obesity.
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- PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0141327
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- Article
The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling.
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- Journal of Psychopharmacology, 2020, v. 34, n. 12, p. 1431, doi. 10.1177/0269881120959605
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- Article
Xanthine–Dopamine Hybrid Molecules as Multitarget Drugs with Potential for the Treatment of Neurodegenerative Diseases.
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- Biomolecules (2218-273X), 2023, v. 13, n. 7, p. 1079, doi. 10.3390/biom13071079
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- Article
Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT<sub>1A</sub>/5-HT<sub>7</sub> Receptor Ligands and PDE Inhibitors with Antidepressant Activity.
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- Archiv der Pharmazie, 2016, v. 349, n. 12, p. 889, doi. 10.1002/ardp.201600260
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- Article
Structure-5-HT/D<sub>2</sub> Receptor Affinity Relationship in a New Group of 1-Arylpiperazynylalkyl Derivatives of 8-Dialkylamino-3,7-dimethyl-1 H-purine-2,6(3 H,7 H)-dione.
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- Archiv der Pharmazie, 2016, v. 349, n. 10, p. 774, doi. 10.1002/ardp.201600162
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- Article
Connecting GSK-3β Inhibitory Activity with IKK-β or ROCK-1 Inhibition to Target Tau Aggregation and Neuroinflammation in Alzheimer's Disease—Discovery, In Vitro and In Cellulo Activity of Thiazole-Based Inhibitors.
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- Molecules, 2024, v. 29, n. 11, p. 2616, doi. 10.3390/molecules29112616
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- Article
Novel 1-(1-Arylimiazolin-2-Yl)-3-Arylalkilurea Derivatives with Modulatory Activity on Opioid MOP Receptors.
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- Molecules, 2024, v. 29, n. 3, p. 571, doi. 10.3390/molecules29030571
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- Article
Milk-Derived Carbon Quantum Dots: Study of Biological and Chemical Properties Provides Evidence of Toxicity.
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- Molecules, 2022, v. 27, n. 24, p. 8728, doi. 10.3390/molecules27248728
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- Article
Modulation of the MOP Receptor (μ Opioid Receptor) by Imidazo[1,2- a ]imidazole-5,6-Diones: In Search of the Elucidation of the Mechanism of Action.
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- Molecules, 2022, v. 27, n. 9, p. 2930, doi. 10.3390/molecules27092930
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- Article
Antidepressant-like activity and safety profile evaluation of 1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione derivatives as 5-HT<sub>1A</sub> receptor partial agonists.
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- PLoS ONE, 2020, v. 15, n. 8, p. 1, doi. 10.1371/journal.pone.0237196
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HBK-17, a 5-HT<sub>1A</sub> Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling.
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- Frontiers in Pharmacology, 2018, p. N.PAG, doi. 10.3389/fphar.2018.01146
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HBK-14 and HBK-15 Do Not Influence Blood Pressure, Lipid Profile, Glucose Level, or Liver Enzymes Activity after Chronic Treatment in Rats.
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- PLoS ONE, 2016, v. 11, n. 10, p. 1, doi. 10.1371/journal.pone.0165495
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- Article
Aryl-1,3,5-triazine ligands of histamine H receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide.
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- Inflammation Research, 2017, v. 66, n. 1, p. 79, doi. 10.1007/s00011-016-0997-z
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- Article
Impact of N-Alkylamino Substituents on Serotonin Receptor (5-HTR) Affinity and Phosphodiesterase 10A (PDE10A) Inhibition of Isoindole-1,3-dione Derivatives.
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- Molecules, 2020, v. 25, n. 17, p. 3868, doi. 10.3390/molecules25173868
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- Article
The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress.
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- Psychopharmacology, 2021, v. 238, n. 8, p. 2249, doi. 10.1007/s00213-021-05849-0
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Single Administration of HBK-15—a Triple 5-HT<sub>1A</sub>, 5-HT<sub>7</sub>, and 5-HT<sub>3</sub> Receptor Antagonist—Reverses Depressive-Like Behaviors in Mouse Model of Depression Induced by Corticosterone.
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- Molecular Neurobiology, 2018, v. 55, n. 5, p. 3931, doi. 10.1007/s12035-017-0605-4
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- Article