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Three-Amino Acid Spacing of Presenilin Endoproteolysis Suggests a General Stepwise Cleavage of γ-Secretase-Mediated Intramembrane Proteolysis.
- Published in:
- Journal of Neuroscience, 2010, v. 30, n. 23, p. 7853, doi. 10.1523/JNEUROSCI.1443-10.2010
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- Publication type:
- Article
Increased levels of Aβ42 decrease the lifespan of ob/ob mice with dysregulation of microglia and astrocytes.
- Published in:
- FASEB Journal, 2020, v. 34, n. 2, p. 2425, doi. 10.1096/fj.201901028RR
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- Publication type:
- Article
Important functional role of residue x of the presenilin Gx GD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.
- Published in:
- Journal of Neurochemistry, 2013, v. 125, n. 1, p. 144, doi. 10.1111/jnc.12124
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- Publication type:
- Article
Requirement for small side chain residues within the GxGD-motif of presenilin for γ-secretase substrate cleavage.
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- Journal of Neurochemistry, 2010, v. 112, n. 4, p. 940, doi. 10.1111/j.1471-4159.2009.06510.x
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- Publication type:
- Article
Rare variants in β-Amyloid precursor protein (APP) and Parkinson's disease.
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- European Journal of Human Genetics, 2015, v. 23, n. 10, p. 1328, doi. 10.1038/ejhg.2014.300
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- Publication type:
- Article
An Alzheimer-associated TREM2 variant occurs at the ADAM cleavage site and affects shedding and phagocytic function.
- Published in:
- EMBO Molecular Medicine, 2017, v. 9, n. 10, p. 1356, doi. 10.15252/emmm.201707672
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- Publication type:
- Article
Generation and deposition of Aβ43 by the virtually inactive presenilin-1 L435F mutant contradicts the presenilin loss-of-function hypothesis of Alzheimer's disease.
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- EMBO Molecular Medicine, 2016, v. 8, n. 5, p. 458, doi. 10.15252/emmm.201505952
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- Publication type:
- Article
Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor.
- Published in:
- Neurodegenerative Diseases, 2010, v. 6, n. 5/6, p. 230, doi. 10.1159/000236902
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- Publication type:
- Article
Processes of β-Amyloid and Intracellular Cytoplasmic Domain Generation by Presenilin/γ-Secretase.
- Published in:
- Neurodegenerative Diseases, 2008, v. 5, n. 3/4, p. 160, doi. 10.1159/000113690
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- Publication type:
- Article
APLP2 is predominantly cleaved by β‐secretase and γ‐secretase in the human brain.
- Published in:
- Psychogeriatrics, 2023, v. 23, n. 2, p. 311, doi. 10.1111/psyg.12933
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- Publication type:
- Article
Aβ induces endoplasmic reticulum stress causing possible proteasome impairment via the endoplasmic reticulum–associated degradation pathway.
- Published in:
- Psychogeriatrics, 2006, v. 6, n. 3, p. 100, doi. 10.1111/j.1479-8301.2006.00141.x
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- Publication type:
- Article
Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells.
- Published in:
- Psychogeriatrics, 2006, v. 6, n. 3, p. 107, doi. 10.1111/j.1479-8301.2006.00142.x
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- Publication type:
- Article
Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74.
- Published in:
- Biochemical Journal, 2016, v. 473, n. 10, p. 1405, doi. 10.1042/BCJ20160156
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- Publication type:
- Article
P3‐068: INCREASED LEVELS OF Aβ42 DECREASE THE LIFE SPAN OF OB/OB MICE WITH DYSREGULATION OF MICROGLIA AND ASTROCYTES.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2019, v. 15, p. P952, doi. 10.1016/j.jalz.2019.06.3095
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- Publication type:
- Article
Gamma-secretase modulator resistance can be overcome for many pathogenic presenilin mutants by second-generation compounds
- Published in:
- 2011
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- Publication type:
- Abstract
Stepwise autoproteolysis of presenilin 1 is affected by familial Alzheimer's disease mutations
- Published in:
- 2010
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- Publication type:
- Abstract
Loose membrane-bound endogenous factors might modulates the intramembrane cleavages of βAPP
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- 2009
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- Publication type:
- Abstract
Substrate requirements and mechanisms of intramembrane proteolysis by gamma-secretase and related proteases
- Published in:
- 2009
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- Publication type:
- Abstract
Structural and functional analysis of γ-secretase and its protease active site domain
- Published in:
- 2009
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- Publication type:
- Abstract
P4-189: Changes in the clevage precision of presenilin/γ-secretase regulate notch signaling intensity
- Published in:
- 2008
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- Publication type:
- Abstract
P4-188: Intramembrane cleavage of TNFalpha by SPPL2b carrying a familial Alzheimer's disease-like mutation
- Published in:
- 2008
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- Publication type:
- Abstract
P3-339: Characteristics of membrane-bound factors affecting presenilin/γ-secretase cleavages
- Published in:
- 2008
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- Publication type:
- Abstract
P1-415: Identification of a candidate gene associated with Aβ transport from brain to blood
- Published in:
- 2008
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- Publication type:
- Abstract
P4-284: Effects of 3,5-bis(4-nitrophenoxy)-benzoic acid on PS/γ-secretase cleavage
- Published in:
- 2006
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- Publication type:
- Abstract
P4-067: Development of in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-051: Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-403: Comparison of S3 cleavage of Notch-1 with ϵ-cleavage of βAPP by presenilin/γ-secretase
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-252: Characterization of the notch-1 Aβ-like peptides
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-251: Inhibition of Aβ production is possible without directly affecting secretases and notch signaling
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-246: Effects of nitration on PS/γ-secretase
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-241: Presenilin-dependent γ-secretases on plasma membrane and endosomes are functionally distinct
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-284: Effects of 3,5-bis(4-nitrophenoxy)-benzoic acid on PS/γ-secretase cleavage
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-067: Development of in vitro Abeta sink assay, to identify the dissociation of soluble Abeta from fibrils
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-051: Inhibition of endocytosis activates alternative degradation pathway of βAPP in cultured cells
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-403: Comparison of S3 cleavage of Notch-1 with ϵ-cleavage of βAPP by presenilin/γ-secretase
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-252: Characterization of the notch-1 Aβ-like peptides
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-251: Inhibition of Aβ production is possible without directly affecting secretases and notch signaling
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-246: Effects of nitration on PS/γ-secretase
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P3-241: Presenilin-dependent γ-secretases on plasma membrane and endosomes are functionally distinct
- Published in:
- 2006
- By:
- Publication type:
- Abstract
Regulated Intramembrane Proteolysis and Degradation of Murine Epithelial Cell Adhesion Molecule mEpCAM.
- Published in:
- PLoS ONE, 2013, v. 8, n. 8, p. 1, doi. 10.1371/journal.pone.0071836
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- Publication type:
- Article
Differential Regulation of Amyloid Precursor Protein/Presenilin 1 Interaction during Ab40/42 Production Detected Using Fusion Constructs.
- Published in:
- PLoS ONE, 2012, v. 7, n. 11, p. 1, doi. 10.1371/journal.pone.0048551
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- Publication type:
- Article
Ribavirin Treatment for Severe Schizophrenia with Anti-Borna Disease Virus 1 Antibodies 30 Years after Onset.
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- 2023
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- Publication type:
- Case Study
Presenilins mediate a dual intramembranous ?-secretase cleavage of Notch-1.
- Published in:
- EMBO Journal, 2002, v. 21, n. 20, p. 5408, doi. 10.1093/emboj/cdf541
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- Publication type:
- Article
Aβ43‐producing PS1 FAD mutants cause altered substrate interactions and respond to γ‐secretase modulation.
- Published in:
- EMBO Reports, 2020, v. 21, n. 1, p. N.PAG, doi. 10.15252/embr.201947996
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- Publication type:
- Article
Active site geometry stabilization of a presenilin homolog by the lipid bilayer promotes intramembrane proteolysis.
- Published in:
- eLife, 2022, p. 1, doi. 10.7554/eLife.76090
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- Publication type:
- Article
Upregulated expression of a subset of genes in APP;ob/ob mice: Evidence of an interaction between diabetes‐linked obesity and Alzheimer's disease.
- Published in:
- FASEB Bioadvances, 2021, v. 3, n. 5, p. 323, doi. 10.1096/fba.2020-00151
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- Publication type:
- Article
Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.
- Published in:
- EMBO Journal, 2016, v. 35, n. 15, p. 1628, doi. 10.15252/embj.201694151
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- Publication type:
- Article
Shedding of glycan-modifying enzymes by signal peptide peptidase-like 3 ( SPPL3) regulates cellular N-glycosylation.
- Published in:
- EMBO Journal, 2014, v. 33, n. 24, p. 2890, doi. 10.15252/embj.201488375
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- Publication type:
- Article
Deletion of B-cell translocation gene 2 (BTG2) alters the responses of glial cells in white matter to chronic cerebral hypoperfusion.
- Published in:
- 2021
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- Publication type:
- journal article