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Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice.
Published in:
EMBO Molecular Medicine, 2013, v. 5, n. 6, p. 949, doi. 10.1002/emmm.201202231
By:
- Albers, Joachim;
- Rajski, Michal;
- Schönenberger, Désirée;
- Harlander, Sabine;
- Schraml, Peter;
- von Teichman, Adriana;
- Georgiev, Strahil;
- Wild, Peter J.;
- Moch, Holger;
- Krek, Wilhelm;
- Frew, Ian J.
Publication type:
Article
p53 suppresses type II endometrial carcinomas in mice and governs endometrial tumour aggressiveness in humans.
Published in:
EMBO Molecular Medicine, 2012, v. 4, n. 8, p. 808, doi. 10.1002/emmm.201101063
By:
- Wild, Peter J.;
- Ikenberg, Kristian;
- Fuchs, Thomas J.;
- Rechsteiner, Markus;
- Georgiev, Strahil;
- Fankhauser, Niklaus;
- Noske, Aurelia;
- Roessle, Matthias;
- Caduff, Rosmarie;
- Dellas, Athanassios;
- Fink, Daniel;
- Moch, Holger;
- Krek, Wilhelm;
- Frew, Ian J.
Publication type:
Article
IL‐8 and CXCR1 expression is associated with cancer stem cell‐like properties of clear cell renal cancer.
Published in:
Journal of Pathology, 2019, v. 248, n. 3, p. 377, doi. 10.1002/path.5267
By:
- Corrò, Claudia;
- Healy, Marc E;
- Engler, Stefanie;
- Bodenmiller, Bernd;
- Li, Zhe;
- Schraml, Peter;
- Weber, Achim;
- Frew, Ian J;
- Rechsteiner, Markus;
- Moch, Holger
Publication type:
Article
Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions.
Published in:
Journal of Pathology, 2016, v. 239, n. 3, p. 365, doi. 10.1002/path.4736
By:
- Guinot, Anna;
- Lehmann, Holger;
- Wild, Peter J;
- Frew, Ian J
Publication type:
Article
Stress-induced decrease in TRAF2 stability is mediated by Siah2.
Published in:
EMBO Journal, 2002, v. 21, n. 21, p. 5756, doi. 10.1093/emboj/cdf576
By:
- Habelhah, Hasem;
- Frew, Ian J.;
- Laine, Aaron;
- Janes, Peter W.;
- Relaix, Frederic;
- Sassoon, David;
- Bowtell, David D. L.;
- Ronai, Ze'ev
Publication type:
Article
KPNA2 is overexpressed in human and mouse endometrial cancers and promotes cellular proliferation.
Published in:
Journal of Pathology, 2014, v. 234, n. 2, p. 239, doi. 10.1002/path.4390
By:
- Ikenberg, Kristian;
- Valtcheva, Nadejda;
- Brandt, Simone;
- Zhong, Qing;
- Wong, Christine E;
- Noske, Aurelia;
- Rechsteiner, Markus;
- Rueschoff, Jan H;
- Caduff, Rosmarie;
- Dellas, Athanassios;
- Obermann, Ellen;
- Fink, Daniel;
- Fuchs, Thomas;
- Krek, Wilhelm;
- Moch, Holger;
- Frew, Ian J;
- Wild, Peter J
Publication type:
Article
COMPETITION BY SECOND MESSENGER SYSTEMS FOR RECEPTOR INTERACTION AND ACTIVATION: IMPLICATIONS FOR TISSUE-SPECIFIC RESPONSES AND DISEASE THERAPY.
Published in:
Clinical & Experimental Pharmacology & Physiology, 1997, v. 24, n. 8, p. 632, doi. 10.1111/j.1440-1681.1997.tb02104.x
By:
- Crouch, Michael F.;
- Frew, Ian J.;
- Simson, Ljubov;
- Davy, Deborah A.
Publication type:
Article
Therapeutic Effects of Inhibition of Sphingosine-1-Phosphate Signaling in HIF-2α Inhibitor-Resistant Clear Cell Renal Cell Carcinoma.
Published in:
Cancers, 2021, v. 13, n. 19, p. 4801, doi. 10.3390/cancers13194801
By:
- Hoefflin, Rouven;
- Harlander, Sabine;
- Abhari, Behnaz A.;
- Peighambari, Asin;
- Adlesic, Mojca;
- Seidel, Philipp;
- Zodel, Kyra;
- Haug, Stefan;
- Göcmen, Burulca;
- Li, Yong;
- Lahrmann, Bernd;
- Grabe, Niels;
- Heide, Danijela;
- Boerries, Melanie;
- Köttgen, Anna;
- Heikenwalder, Mathias;
- Frew, Ian J.
Publication type:
Article
Sensitivity and Resistance of Oncogenic RAS-Driven Tumors to Dual MEK and ERK Inhibition.
Published in:
Cancers, 2021, v. 13, n. 8, p. 1852, doi. 10.3390/cancers13081852
By:
- Catalano, Antonella;
- Adlesic, Mojca;
- Kaltenbacher, Thorsten;
- Klar, Rhena F. U.;
- Albers, Joachim;
- Seidel, Philipp;
- Brandt, Laura P.;
- Hejhal, Tomas;
- Busenhart, Philipp;
- Röhner, Niklas;
- Zodel, Kyra;
- Fritsch, Kornelia;
- Wild, Peter J.;
- Duyster, Justus;
- Fritsch, Ralph;
- Brummer, Tilman;
- Frew, Ian J.;
- Wang, Zhixiang
Publication type:
Article
pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation.
Published in:
EMBO Journal, 2008, v. 27, n. 12, p. 1747, doi. 10.1038/emboj.2008.96
By:
- Frew, Ian J.;
- Thoma, Claudio R.;
- Georgiev, Strahil;
- Minola, Andrea;
- Hitz, Manuela;
- Montani, Matteo;
- Moch, Holger;
- Krek, Wilhelm
Publication type:
Article
VHL loss causes spindle misorientation and chromosome instability.
Published in:
Nature Cell Biology, 2009, v. 11, n. 8, p. 994, doi. 10.1038/ncb1912
By:
- Thoma, Claudio R.;
- Toso, Alberto;
- Gutbrodt, Katrin L.;
- Reggi, Sabina P.;
- Frew, Ian J.;
- Schraml, Peter;
- Hergovich, Alexander;
- Moch, Holger;
- Meraldi, Patrick;
- Krek, Wilhelm
Publication type:
Article
pVHL and GSK3β are components of a primary cilium-maintenance signalling network.
Published in:
Nature Cell Biology, 2007, v. 9, n. 5, p. 588, doi. 10.1038/ncb1579
By:
- Thoma, Claudio R.;
- Frew, Ian J.;
- Hoerner, Christian R.;
- Montani, Matteo;
- Moch, Holger;
- Krek, Wilhelm
Publication type:
Article
A versatile modular vector system for rapid combinatorial mammalian genetics.
Published in:
Journal of Clinical Investigation, 2015, v. 125, n. 4, p. 1603, doi. 10.1172/JCI79743
By:
- Albers, Joachim;
- Danzer, Claudia;
- Rechsteiner, Markus;
- Lehmann, Holger;
- Brandt, Laura P.;
- Hejhal, Tomas;
- Catalano, Antonella;
- Busenhart, Philipp;
- Gonçalves, Ana Filipa;
- Brandt, Simone;
- Bode, Peter K.;
- Bode-Lesniewska, Beata;
- Wild, Peter J.;
- Frew, Ian J.
Publication type:
Article
VHL suppresses RAPTOR and inhibits mTORC1 signaling in clear cell renal cell carcinoma.
Published in:
Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-94132-5
By:
- Ganner, Athina;
- Gehrke, Christina;
- Klein, Marinella;
- Thegtmeier, Lena;
- Matulenski, Tanja;
- Wingendorf, Laura;
- Wang, Lu;
- Pilz, Felicitas;
- Greidl, Lars;
- Meid, Lisa;
- Kotsis, Fruzsina;
- Walz, Gerd;
- Frew, Ian J.;
- Neumann-Haefelin, Elke
Publication type:
Article
Integrated Metabolomic and Transcriptomic Analysis of Modified Nucleosides for Biomarker Discovery in Clear Cell Renal Cell Carcinoma.
Published in:
Cells (2073-4409), 2023, v. 12, n. 8, p. 1102, doi. 10.3390/cells12081102
By:
- Mohl, Daniel A.;
- Lagies, Simon;
- Zodel, Kyra;
- Zumkeller, Matthias;
- Peighambari, Asin;
- Ganner, Athina;
- Plattner, Dietmar A.;
- Neumann-Haefelin, Elke;
- Adlesic, Mojca;
- Frew, Ian J.;
- Kammerer, Bernd
Publication type:
Article
SCD5 Regulation by VHL Affects Cell Proliferation and Lipid Homeostasis in ccRCC.
Published in:
Cells (2073-4409), 2023, v. 12, n. 6, p. 835, doi. 10.3390/cells12060835
By:
- Ganner, Athina;
- Philipp, Antonia;
- Lagies, Simon;
- Wingendorf, Laura;
- Wang, Lu;
- Pilz, Felicitas;
- Welte, Thomas;
- Grand, Kelli;
- Lienkamp, Soeren S.;
- Klein, Marinella;
- Kammerer, Bernd;
- Frew, Ian J.;
- Walz, Gerd;
- Neumann-Haefelin, Elke
Publication type:
Article
Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells.
Published in:
Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01514-3
By:
- Hejhal, Tomas;
- Harlander, Sabine;
- Gonçalves, Ana Filipa;
- Adlesic, Mojca;
- Frew, Ian J.;
- Brandt, Simone;
- Wild, Peter J.;
- Sommer, Lukas;
- Shakhova, Olga
Publication type:
Article
pVHL: A Multipurpose Adaptor Protein.
Published in:
Science Signaling, 2008, v. 1, n. 24, p. 1, doi. 10.1126/scisignal.124pe30
By:
- Frew, Ian J.;
- Krek, Wilhelm
Publication type:
Article
Oncogenic Hras<sup>G12V</sup> expression plus knockdown of Cdkn2a using ecotropic lentiviral vectors induces high-grade endometrial stromal sarcoma.
Published in:
PLoS ONE, 2017, v. 12, n. 10, p. 1, doi. 10.1371/journal.pone.0186102
By:
- Brandt, Laura P.;
- Albers, Joachim;
- Hejhal, Tomas;
- Catalano, Antonella;
- Wild, Peter J.;
- Frew, Ian J.
Publication type:
Article

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