Found: 29

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  • Proteasomal down-regulation of the proapoptotic MST2 pathway contributes to BRAF inhibitor resistance in melanoma.

    Published in:
    Life Science Alliance, 2022, v. 5, n. 10, p. 1, doi. 10.26508/lsa.202201445
    By:
    • Romano, David;
    • García-Gutiérrez, Lucía;
    • Aboud, Nourhan;
    • Duffy, David J.;
    • Flaherty, Keith T.;
    • Frederick, Dennie T.;
    • Kolch, Walter;
    • Matallanas, David
    Publication type:
    Article

  • Author Correction: Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.

    Published in:
    2023
    By:
    • Boshuizen, Julia;
    • Vredevoogd, David W.;
    • Krijgsman, Oscar;
    • Ligtenberg, Maarten A.;
    • Blankenstein, Stephanie;
    • de Bruijn, Beaunelle;
    • Frederick, Dennie T.;
    • Kenski, Juliana C. N.;
    • Parren, Mara;
    • Brüggemann, Marieke;
    • Madu, Max F.;
    • Rozeman, Elisa A.;
    • Song, Ji-Ying;
    • Horlings, Hugo M.;
    • Blank, Christian U.;
    • van Akkooi, Alexander C. J.;
    • Flaherty, Keith T.;
    • Boland, Genevieve M.;
    • Peeper, Daniel S.
    Publication type:
    Correction Notice

  • Resistance to checkpoint blockade therapy through inactivation of antigen presentation.

    Published in:
    Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-01062-w
    By:
    • Sade-Feldman, Moshe;
    • Jiao, Yunxin J.;
    • Chen, Jonathan H.;
    • Rooney, Michael S.;
    • Barzily-Rokni, Michal;
    • Eliane, Jean-Pierre;
    • Bjorgaard, Stacey L.;
    • Hammond, Marc R.;
    • Vitzthum, Hans;
    • Blackmon, Shauna M.;
    • Frederick, Dennie T.;
    • Hazar-Rethinam, Mehlika;
    • Nadres, Brandon A.;
    • Van Seventer, Emily E.;
    • Shukla, Sachet A.;
    • Yizhak, Keren;
    • Ray, John P.;
    • Rosebrock, Daniel;
    • Livitz, Dimitri;
    • Adalsteinsson, Viktor
    Publication type:
    Article

  • Melanoma-specific MHC-II expression represents a tumour-autonomous phenotype and predicts response to anti-PD-1/PD-L1 therapy.

    Published in:
    Nature Communications, 2016, v. 7, n. 1, p. 10582, doi. 10.1038/ncomms10582
    By:
    • Johnson, Douglas B.;
    • Estrada, Monica V.;
    • Salgado, Roberto;
    • Sanchez, Violeta;
    • Doxie, Deon B.;
    • Opalenik, Susan R.;
    • Vilgelm, Anna E.;
    • Feld, Emily;
    • Johnson, Adam S.;
    • Greenplate, Allison R.;
    • Sanders, Melinda E.;
    • Lovly, Christine M.;
    • Frederick, Dennie T.;
    • Kelley, Mark C.;
    • Richmond, Ann;
    • Irish, Jonathan M.;
    • Shyr, Yu;
    • Sullivan, Ryan J.;
    • Puzanov, Igor;
    • Sosman, Jeffrey A.
    Publication type:
    Article

  • Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses.

    Published in:
    Science Translational Medicine, 2021, v. 13, n. 581, p. 1, doi. 10.1126/scitranslmed.abd8636
    By:
    • Lo, Jennifer A.;
    • Kawakubo, Masayoshi;
    • Juneja, Vikram R.;
    • Su, Mack Y.;
    • Erlich, Tal H.;
    • LaFleur, Martin W.;
    • Kemeny, Lajos V.;
    • Rashid, Mamunur;
    • Malehmir, Mohsen;
    • Rabi, S. Alireza;
    • Raghavan, Rumya;
    • Allouche, Jennifer;
    • Kasumova, Gyulnara;
    • Frederick, Dennie T.;
    • Pauken, Kristen E.;
    • Weng, Qing Yu;
    • Pereira da Silva, Marcelo;
    • Xu, Yu;
    • van der Sande, Anita A. J.;
    • Silkworth, Whitney
    Publication type:
    Article

  • One Hippo and many masters: differential regulation of the Hippo pathway in cancer.

    Published in:
    Biochemical Society Transactions, 2014, v. 42, n. 4, p. 816, doi. 10.1042/BST20140030
    By:
    • Romano, David;
    • Matallanas, David;
    • Frederick, Dennie T.;
    • Flaherty, Keith T.;
    • Kolch, Walter
    Publication type:
    Article

  • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.

    Published in:
    Nature, 2012, v. 487, n. 7408, p. 500, doi. 10.1038/nature11183
    By:
    • Straussman, Ravid;
    • Morikawa, Teppei;
    • Shee, Kevin;
    • Barzily-Rokni, Michal;
    • Qian, Zhi Rong;
    • Du, Jinyan;
    • Davis, Ashli;
    • Mongare, Margaret M.;
    • Gould, Joshua;
    • Frederick, Dennie T.;
    • Cooper, Zachary A.;
    • Chapman, Paul B.;
    • Solit, David B.;
    • Ribas, Antoni;
    • Lo, Roger S.;
    • Flaherty, Keith T.;
    • Ogino, Shuji;
    • Wargo, Jennifer A.;
    • Golub, Todd R.
    Publication type:
    Article

  • Co‐targeting BET and MEK as salvage therapy for MAPK and checkpoint inhibitor‐resistant melanoma.

    Published in:
    EMBO Molecular Medicine, 2018, v. 10, n. 5, p. 1, doi. 10.15252/emmm.201708446
    By:
    • Echevarría‐Vargas, Ileabett M.;
    • Reyes‐Uribe, Patricia I.;
    • Guterres, Adam N.;
    • Yin, Xiangfan;
    • Kossenkov, Andrew V.;
    • Liu, Qin;
    • Zhang, Gao;
    • Krepler, Clemens;
    • Cheng, Chaoran;
    • Wei, Zhi;
    • Somasundaram, Rajasekharan;
    • Karakousis, Giorgos;
    • Xu, Wei;
    • Morrissette, Jennifer J. D.;
    • Lu, Yiling;
    • Mills, Gordon B.;
    • Sullivan, Ryan J.;
    • Benchun, Miao;
    • Frederick, Dennie T.;
    • Boland, Genevieve
    Publication type:
    Article

  • Targeting endothelin receptor signalling overcomes heterogeneity driven therapy failure.

    Published in:
    EMBO Molecular Medicine, 2017, v. 9, n. 8, p. 1011, doi. 10.15252/emmm.201607156
    By:
    • Smith, Michael P;
    • Rowling, Emily J;
    • Miskolczi, Zsofia;
    • Ferguson, Jennifer;
    • Spoerri, Loredana;
    • Haass, Nikolas K;
    • Sloss, Olivia;
    • McEntegart, Sophie;
    • Arozarena, Imanol;
    • Kriegsheim, Alex;
    • Rodriguez, Javier;
    • Brunton, Holly;
    • Kmarashev, Jivko;
    • Levesque, Mitchell P;
    • Dummer, Reinhard;
    • Frederick, Dennie T;
    • Andrews, Miles C;
    • Cooper, Zachary A;
    • Flaherty, Keith T;
    • Wargo, Jennifer A
    Publication type:
    Article

  • Adjuvant Radiation Therapy for Clinical Stage III Melanoma in the Modern Therapeutic Era.

    Published in:
    Annals of Surgical Oncology: An Oncology Journal for Surgeons, 2021, v. 28, n. 7, p. 3512, doi. 10.1245/s10434-020-09384-8
    By:
    • Straker III, Richard J.;
    • Song, Yun;
    • Sun, James;
    • Shannon, Adrienne B.;
    • Cohen, Leah S.;
    • Muradova, Elnara;
    • Daou, Hala;
    • Krause, Kate;
    • Li, Siming;
    • Frederick, Dennie T.;
    • Rhodin, Kristen E.;
    • Brizel, David M.;
    • Boland, Genevieve M.;
    • Beasley, Georgia M.;
    • Wuthrick, Evan J.;
    • Sondak, Vernon K.;
    • Zager, Jonathan S.;
    • Lin, Alexander;
    • Lukens, John N.;
    • Karakousis, Giorgos C.
    Publication type:
    Article

  • Correction: Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment.

    Published in:
    2024
    By:
    • Friedman, Adam A.;
    • Amzallag, Arnaud;
    • Pruteanu-Malinici, Iulian;
    • Baniya, Subash;
    • Cooper, Zachary A.;
    • Piris, Adriano;
    • Hargreaves, Leeza;
    • Igras, Vivien;
    • Frederick, Dennie T.;
    • Lawrence, Donald P.;
    • Haber, Daniel A.;
    • Flaherty, Keith T.;
    • Wargo, Jennifer A.;
    • Ramaswamy, Sridhar;
    • Benes, Cyril H.;
    • Fisher, David E.
    Publication type:
    Correction Notice

  • The Hippo effector YAP promotes resistance to RAF- and MEK-targeted cancer therapies.

    Published in:
    Nature Genetics, 2015, v. 47, n. 3, p. 250, doi. 10.1038/ng.3218
    By:
    • Lin, Luping;
    • Chan, Elton;
    • Olivas, Victor;
    • Cade, Lindsay;
    • Pazarentzos, Evangelos;
    • Asthana, Saurabh;
    • Neel, Dana;
    • Yan, Jenny Jiacheng;
    • Lu, Xinyuan;
    • Pham, Luu;
    • Wang, Mingxue M;
    • Collisson, Eric A;
    • Algazi, Alain;
    • Bivona, Trever G;
    • Muñoz-Couselo, Eva;
    • Cortes, Javier;
    • Frederick, Dennie T;
    • Flaherty, Keith T;
    • Cooper, Zachary A;
    • Wargo, Jennifer A
    Publication type:
    Article

  • Dramatic Response of BRAF V600E Mutant Papillary Craniopharyngioma to Targeted Therapy.

    Published in:
    2016
    By:
    • Brastianos, Priscilla K.;
    • Shankar, Ganesh M.;
    • Gill, Corey M.;
    • Taylor-Weiner, Amaro;
    • Nayyar, Naema;
    • Panka, David J.;
    • Sullivan, Ryan J.;
    • Frederick, Dennie T.;
    • Abedalthagafi, Malak;
    • Jones, Pamela S.;
    • Dunn, Ian F.;
    • Nahed, Brian V.;
    • Romero, Javier M.;
    • Louis, David N.;
    • Getz, Gad;
    • Cahill, Daniel P.;
    • Santagata, Sandro;
    • Curry Jr, William T.;
    • Barker, Fred G.;
    • Curry, William T Jr
    Publication type:
    journal article

  • Gut microbiota dependent anti-tumor immunity restricts melanoma growth in Rnf5<sup>−/−</sup> mice.

    Published in:
    Nature Communications, 2019, v. 10, n. 1, p. N.PAG, doi. 10.1038/s41467-019-09525-y
    By:
    • Li, Yan;
    • Tinoco, Roberto;
    • Elmén, Lisa;
    • Segota, Igor;
    • Xian, Yibo;
    • Fujita, Yu;
    • Sahu, Avinash;
    • Zarecki, Raphy;
    • Marie, Kerrie;
    • Feng, Yongmei;
    • Khateb, Ali;
    • Frederick, Dennie T.;
    • Ashkenazi, Shiri K.;
    • Kim, Hyungsoo;
    • Perez, Eva Guijarro;
    • Day, Chi-Ping;
    • Segura Muñoz, Rafael S.;
    • Schmaltz, Robert;
    • Yooseph, Shibu;
    • Tam, Miguel A.
    Publication type:
    Article

  • Pathway signatures derived from on-treatment tumor specimens predict response to anti-PD1 blockade in metastatic melanoma.

    Published in:
    Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-26299-4
    By:
    • Du, Kuang;
    • Wei, Shiyou;
    • Wei, Zhi;
    • Frederick, Dennie T.;
    • Miao, Benchun;
    • Moll, Tabea;
    • Tian, Tian;
    • Sugarman, Eric;
    • Gabrilovich, Dmitry I.;
    • Sullivan, Ryan J.;
    • Liu, Lunxu;
    • Flaherty, Keith T.;
    • Boland, Genevieve M.;
    • Herlyn, Meenhard;
    • Zhang, Gao
    Publication type:
    Article

  • Clinical Profiling of BCL-2 Family Members in the Setting of BRAF Inhibition Offers a Rationale for Targeting <i>De Novo</i> Resistance Using BH3 Mimetics.

    Published in:
    PLoS ONE, 2014, v. 9, n. 7, p. 1, doi. 10.1371/journal.pone.0101286
    By:
    • Frederick, Dennie T.;
    • Salas Fragomeni, Roberto A.;
    • Schalck, Aislyn;
    • Ferreiro-Neira, Isabel;
    • Hoff, Taylor;
    • Cooper, Zachary A.;
    • Haq, Rizwan;
    • Panka, David J.;
    • Kwong, Lawrence N.;
    • Davies, Michael A.;
    • Cusack, James C.;
    • Flaherty, Keith T.;
    • Fisher, David E.;
    • Mier, James W.;
    • Wargo, Jennifer A.;
    • Sullivan, Ryan J.
    Publication type:
    Article

  • A melanocyte lineage program confers resistance to MAP kinase pathway inhibition.

    Published in:
    Nature, 2013, v. 504, n. 7478, p. 138, doi. 10.1038/nature12688
    By:
    • Johannessen, Cory M.;
    • Johnson, Laura A.;
    • Piccioni, Federica;
    • Townes, Aisha;
    • Frederick, Dennie T.;
    • Donahue, Melanie K.;
    • Narayan, Rajiv;
    • Flaherty, Keith T.;
    • Wargo, Jennifer A.;
    • Root, David E.;
    • Garraway, Levi A.
    Publication type:
    Article

  • HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8<sup>+</sup> T-cell infiltration into tumors.

    Published in:
    Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-31713-6
    By:
    • Guan, Lei;
    • Wu, Bin;
    • Li, Ting;
    • Beer, Lynn A.;
    • Sharma, Gaurav;
    • Li, Mingyue;
    • Lee, Chin Nien;
    • Liu, Shujing;
    • Yang, Changsong;
    • Huang, Lili;
    • Frederick, Dennie T.;
    • Boland, Genevieve M.;
    • Shao, Guangcan;
    • Svitkina, Tatyana M.;
    • Cai, Kathy Q.;
    • Chen, Fangping;
    • Dong, Meng-Qiu;
    • Mills, Gordon B.;
    • Schuchter, Lynn M.;
    • Karakousis, Giorgos C.
    Publication type:
    Article

  • STAG2 regulates interferon signaling in melanoma via enhancer loop reprogramming.

    Published in:
    Nature Communications, 2022, v. 13, n. 1, p. 1, doi. 10.1038/s41467-022-29541-9
    By:
    • Chu, Zhaowei;
    • Gu, Lei;
    • Hu, Yeguang;
    • Zhang, Xiaoyang;
    • Li, Man;
    • Chen, Jiajia;
    • Teng, Da;
    • Huang, Man;
    • Shen, Che-Hung;
    • Cai, Li;
    • Yoshida, Toshimi;
    • Qi, Yifeng;
    • Niu, Zhixin;
    • Feng, Austin;
    • Geng, Songmei;
    • Frederick, Dennie T.;
    • Specht, Emma;
    • Piris, Adriano;
    • Sullivan, Ryan J.;
    • Flaherty, Keith T.
    Publication type:
    Article

  • Wnt5 A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells.

    Published in:
    Pigment Cell & Melanoma Research, 2015, v. 28, n. 2, p. 184, doi. 10.1111/pcmr.12330
    By:
    • Webster, Marie R.;
    • Xu, Mai;
    • Kinzler, Kathryn A.;
    • Kaur, Amanpreet;
    • Appleton, Jessica;
    • O'Connell, Michael P.;
    • Marchbank, Katie;
    • Valiga, Alexander;
    • Dang, Vanessa M.;
    • Perego, Michela;
    • Zhang, Gao;
    • Slipicevic, Ana;
    • Keeney, Frederick;
    • Lehrmann, Elin;
    • Wood, William;
    • Becker, Kevin G.;
    • Kossenkov, Andrew V.;
    • Frederick, Dennie T.;
    • Flaherty, Keith T.;
    • Xu, Xiaowei
    Publication type:
    Article

  • Targeting mitochondrial biogenesis to overcome drug resistance to MAPK inhibitors.

    Published in:
    Journal of Clinical Investigation, 2016, v. 126, n. 5, p. 1834, doi. 10.1172/JCI82661
    By:
    • Gao Zhang;
    • Frederick, Dennie T.;
    • Wu, Lawrence;
    • Zhi Wei;
    • Krepler, Clemens;
    • Srinivasan, Satish;
    • Young Chan Chae;
    • Xiaowei Xu;
    • Choi, Harry;
    • Dimwamwa, Elaida;
    • Ope, Omotayo;
    • Shannan, Batool;
    • Basu, Devraj;
    • Dongmei Zhang;
    • Guha, Manti;
    • Min Xiao;
    • Randell, Sergio;
    • Sproesser, Katrin;
    • Wei Xu;
    • Liu, Jephrey
    Publication type:
    Article

  • Co-clinical assessment identifies patterns of BRAF inhibitor resistance in melanoma.

    Published in:
    Journal of Clinical Investigation, 2015, v. 125, n. 4, p. 1459, doi. 10.1172/JCI78954
    By:
    • Kwong, Lawrence N.;
    • Boland, Genevieve M.;
    • Frederick, Dennie T.;
    • Helms, Timothy L.;
    • Akid, Ahmad T.;
    • Miller, John P.;
    • Shan Jiang;
    • Cooper, Zachary A.;
    • Xingzhi Song;
    • Seth, Sahil;
    • Kamara, Jennifer;
    • Protopopov, Alexei;
    • Mills, Gordon B.;
    • Flaherty, Keith T.;
    • Wargo, Jennifer A.;
    • Chin, Lynda
    Publication type:
    Article

  • MAESTRO-Pool Enables Highly Parallel and Specific Mutation-Enrichment Sequencing for Minimal Residual Disease Detection in Cohort Studies.

    Published in:
    Clinical Chemistry, 2024, v. 70, n. 2, p. 434, doi. 10.1093/clinchem/hvad203
    By:
    • Blewett, Timothy;
    • Rhoades, Justin;
    • Liu, Ruolin;
    • Xiong, Kan;
    • Sridhar, Sainetra;
    • Crnjac, Andjela;
    • Cheng, Ju;
    • Lawless, Aleigha R;
    • Frederick, Dennie T;
    • Flaherty, Keith T;
    • Makrigiorgos, Gerassimos Mike;
    • Adalsteinsson, Viktor A
    Publication type:
    Article

  • Reversal of pre-existing NGFR-driven tumor and immune therapy resistance.

    Published in:
    Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-17739-8
    By:
    • Boshuizen, Julia;
    • Vredevoogd, David W.;
    • Krijgsman, Oscar;
    • Ligtenberg, Maarten A.;
    • Blankenstein, Stephanie;
    • de Bruijn, Beaunelle;
    • Frederick, Dennie T.;
    • Kenski, Juliana C. N.;
    • Parren, Mara;
    • Brüggemann, Marieke;
    • Madu, Max F.;
    • Rozeman, Elisa A.;
    • Song, Ji-Ying;
    • Horlings, Hugo M.;
    • Blank, Christian U.;
    • van Akkooi, Alexander C. J.;
    • Flaherty, Keith T.;
    • Boland, Genevieve M.;
    • Peeper, Daniel S.
    Publication type:
    Article

  • MITF Modulates Therapeutic Resistance through EGFR Signaling.

    Published in:
    Journal of Investigative Dermatology, 2015, v. 135, n. 7, p. 1863, doi. 10.1038/jid.2015.105
    By:
    • Ji, Zhenyu;
    • Erin Chen, Yiyin;
    • Kumar, Raj;
    • Taylor, Michael;
    • Jenny Njauw, Ching-Ni;
    • Miao, Benchun;
    • Frederick, Dennie T;
    • Wargo, Jennifer A;
    • Flaherty, Keith T;
    • Jönsson, Göran;
    • Tsao, Hensin
    Publication type:
    Article

  • BAP1 Has a Survival Role in Cutaneous Melanoma.

    Published in:
    Journal of Investigative Dermatology, 2015, v. 135, n. 4, p. 1089, doi. 10.1038/jid.2014.528
    By:
    • Kumar, Raj;
    • Taylor, Michael;
    • Miao, Benchun;
    • Ji, Zhenyu;
    • Njauw, Jenny C-N;
    • Jönsson, Göran;
    • Frederick, Dennie T;
    • Tsao, Hensin
    Publication type:
    Article

  • A Potential Role for Immunotherapy in Thyroid Cancer by Enhancing NY-ESO-1 Cancer Antigen Expression.

    Published in:
    Thyroid, 2014, v. 24, n. 8, p. 1241, doi. 10.1089/thy.2013.0680
    By:
    • Gunda, Viswanath;
    • Frederick, Dennie T.;
    • Bernasconi, Maria J.;
    • Wargo, Jennifer A.;
    • Parangi, Sareh
    Publication type:
    Article

  • Landscape of Targeted Anti-Cancer Drug Synergies in Melanoma Identifies a Novel BRAF-VEGFR/PDGFR Combination Treatment.

    Published in:
    PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0140310
    By:
    • Friedman, Adam A.;
    • Amzallag, Arnaud;
    • Pruteanu-Malinici, Iulian;
    • Baniya, Subash;
    • Cooper, Zachary A.;
    • Piris, Adriano;
    • Hargreaves, Leeza;
    • Igras, Vivien;
    • Frederick, Dennie T.;
    • Lawrence, Donald P.;
    • Haber, Daniel A.;
    • Flaherty, Keith T.;
    • Wargo, Jennifer A.;
    • Ramaswamy, Sridhar;
    • Benes, Cyril H.;
    • Fisher, David E.
    Publication type:
    Article

  • Genome‐wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy.

    Published in:
    Molecular Systems Biology, 2019, v. 15, n. 3, p. N.PAG, doi. 10.15252/msb.20188323
    By:
    • Park, Seung Gu;
    • Sahu, Avinash Das;
    • Ponomarova, Olga;
    • Jerby‐Arnon, Livnat;
    • Wagner, Allon;
    • Miao, Benchun;
    • Friedman, Adam A;
    • Amzallag, Arnaud;
    • Moll, Tabea;
    • Kasumova, Gyulnara;
    • Greninger, Patricia;
    • Egan, Regina K;
    • Damon, Leah J;
    • Frederick, Dennie T;
    • Boland, Genevieve;
    • Benes, Cyril;
    • Flaherty, Keith;
    • Cheng, Kuoyuan;
    • Robinson, Welles;
    • Hannenhalli, Sridhar
    Publication type:
    Article