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Optimizing the use of CROs by academia and small companies.
Published in:
Nature Reviews Drug Discovery, 2013, v. 12, n. 7, p. 487, doi. 10.1038/nrd4057
By:
- Lane, Rachel F.;
- Friedman, Lauren G.;
- Keith, Curtis;
- Braithwaite, Steven P.;
- Frearson, Julie A.;
- Lowe, David A.;
- Longo, Frank M.;
- Refolo, Lorenzo M.;
- Watterson, D. Martin;
- Tsaioun, Katya;
- Shineman, Diana W.;
- Fillit, Howard M.
Publication type:
Article
Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
Published in:
ChemMedChem, 2019, v. 14, n. 14, p. 1329, doi. 10.1002/cmdc.201900329
By:
- Norcross, Neil R.;
- Wilson, Caroline;
- Baragaña, Beatriz;
- Hallyburton, Irene;
- Osuna‐Cabello, Maria;
- Norval, Suzanne;
- Riley, Jennifer;
- Fletcher, Daniel;
- Sinden, Robert;
- Delves, Michael;
- Ruecker, Andrea;
- Duffy, Sandra;
- Meister, Stephan;
- Antonova‐Koch, Yevgeniya;
- Crespo, Benigno;
- de Cózar, Cristina;
- Sanz, Laura M.;
- Gamo, Francisco Javier;
- Avery, Vicky M.;
- Frearson, Julie A.
Publication type:
Article
Assessment of Pseudomonas aeruginosa N<sup>5</sup>,N<sup>10</sup>- Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target.
Published in:
PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035973
By:
- Eadsforth, Thomas C.;
- Gardiner, Mary;
- Maluf, Fernando V.;
- McElroy, Stuart;
- James, Daniel;
- Frearson, Julie;
- Gray, David;
- Hunter, William N.
Publication type:
Article
IspE Inhibitors Identified by a Combination of In Silico and In Vitro High-Throughput Screening.
Published in:
PLoS ONE, 2012, v. 7, n. 4, p. 1, doi. 10.1371/journal.pone.0035792
By:
- Tidten-Luksch, Naomi;
- Grimaldi, Raffaella;
- Torrie, Leah S.;
- Frearson, Julie A.;
- Hunter, William N.;
- Brenk, Ruth
Publication type:
Article
N-myristoyltransferase inhibitors as new leads to treat sleeping sickness.
Published in:
Nature, 2010, v. 464, n. 7289, p. 728, doi. 10.1038/nature08893
By:
- Frearson, Julie A.;
- Brand, Stephen;
- McElroy, Stuart P.;
- Cleghorn, Laura A. T.;
- Smid, Ondrej;
- Stojanovski, Laste;
- Price, Helen P.;
- Guther, M. Lucia S.;
- Torrie, Leah S.;
- Robinson, David A.;
- Hallyburton, Irene;
- Mpamhanga, Chidochangu P.;
- Brannigan, James A.;
- Wilkinson, Anthony J.;
- Hodgkinson, Michael;
- Hui, Raymond;
- Wei Qiu;
- Raimi, Olawale G.;
- van Aalten, Daan M. F.;
- Brenk, Ruth
Publication type:
Article
The role of phosphotyrosine phosphatases in haematopoietic cell signal transduction.
Published in:
BioEssays, 1997, v. 19, n. 5, p. 417, doi. 10.1002/bies.950190509
By:
- Frearson, Julie A.;
- Alexander, Denis R.
Publication type:
Article
Screening a protein kinase inhibitor library against Plasmodium falciparum.
Published in:
Malaria Journal, 2017, v. 16, p. 1, doi. 10.1186/s12936-017-2085-4
By:
- Hallyburton, Irene;
- Grimaldi, Raffaella;
- Woodland, Andrew;
- Baragaña, Beatriz;
- Luksch, Torsten;
- Spinks, Daniel;
- James, Daniel;
- Leroy, Didier;
- Waterson, David;
- Fairlamb, Alan H.;
- Wyatt, Paul G.;
- Gilbert, Ian H.;
- Frearson, Julie A.
Publication type:
Article
Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library.
Published in:
ChemMedChem, 2015, v. 10, n. 11, p. 1809, doi. 10.1002/cmdc.201500300
By:
- Woodland, Andrew;
- Thompson, Stephen;
- Cleghorn, Laura A. T.;
- Norcross, Neil;
- De Rycker, Manu;
- Grimaldi, Raffaella;
- Hallyburton, Irene;
- Rao, Bhavya;
- Norval, Suzanne;
- Stojanovski, Laste;
- Brun, Reto;
- Kaiser, Marcel;
- Frearson, Julie A.;
- Gray, David W.;
- Wyatt, Paul G.;
- Read, Kevin D.;
- Gilbert, Ian H.
Publication type:
Article
Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.
Published in:
ChemMedChem, 2015, v. 10, n. 11, p. 1821, doi. 10.1002/cmdc.201500301
By:
- Spinks, Daniel;
- Smith, Victoria;
- Thompson, Stephen;
- Robinson, David A.;
- Luksch, Torsten;
- Smith, Alasdair;
- Torrie, Leah S.;
- McElroy, Stuart;
- Stojanovski, Laste;
- Norval, Suzanne;
- Collie, Iain T.;
- Hallyburton, Irene;
- Rao, Bhavya;
- Brand, Stephen;
- Brenk, Ruth;
- Frearson, Julie A.;
- Read, Kevin D.;
- Wyatt, Paul G.;
- Gilbert, Ian H.
Publication type:
Article
Cover Picture: Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode (ChemMedChem 11/2015).
Published in:
ChemMedChem, 2015, v. 10, n. 11, p. 1769, doi. 10.1002/cmdc.201500397
By:
- Spinks, Daniel;
- Smith, Victoria;
- Thompson, Stephen;
- Robinson, David A.;
- Luksch, Torsten;
- Smith, Alasdair;
- Torrie, Leah S.;
- McElroy, Stuart;
- Stojanovski, Laste;
- Norval, Suzanne;
- Collie, Iain T.;
- Hallyburton, Irene;
- Rao, Bhavya;
- Brand, Stephen;
- Brenk, Ruth;
- Frearson, Julie A.;
- Read, Kevin D.;
- Wyatt, Paul G.;
- Gilbert, Ian H.
Publication type:
Article
Back Cover: From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti- Trypanosoma brucei Drug Discovery Lead Molecules (ChemMedChem 7/2013).
Published in:
ChemMedChem, 2013, v. 8, n. 7, p. 1228, doi. 10.1002/cmdc.201390029
By:
- Woodland, Andrew;
- Grimaldi, Raffaella;
- Luksch, Torsten;
- Cleghorn, Laura A. T.;
- Ojo, Kayode K.;
- Van Voorhis, Wesley C.;
- Brenk, Ruth;
- Frearson, Julie A.;
- Gilbert, Ian H.;
- Wyatt, Paul G.
Publication type:
Article
From On-Target to Off-Target Activity: Identification and Optimisation of Trypanosoma brucei GSK3 Inhibitors and Their Characterisation as Anti- Trypanosoma brucei Drug Discovery Lead Molecules.
Published in:
ChemMedChem, 2013, v. 8, n. 7, p. 1127, doi. 10.1002/cmdc.201300072
By:
- Woodland, Andrew;
- Grimaldi, Raffaella;
- Luksch, Torsten;
- Cleghorn, Laura A. T.;
- Ojo, Kayode K.;
- Van Voorhis, Wesley C.;
- Brenk, Ruth;
- Frearson, Julie A.;
- Gilbert, Ian H.;
- Wyatt, Paul G.
Publication type:
Article
Design, Synthesis and Biological Evaluation of Trypanosoma brucei Trypanothione Synthetase Inhibitors.
Published in:
ChemMedChem, 2012, v. 7, n. 1, p. 95, doi. 10.1002/cmdc.201100420
By:
- Spinks, Daniel;
- Torrie, Leah S.;
- Thompson, Stephen;
- Harrison, Justin R.;
- Frearson, Julie A.;
- Read, Kevin D.;
- Fairlamb, Alan H.;
- Wyatt, Paul G.;
- Gilbert, Ian H.
Publication type:
Article
Identification of Inhibitors of the Leishmania cdc2-Related Protein Kinase CRK3.
Published in:
ChemMedChem, 2011, v. 6, n. 12, p. 2214, doi. 10.1002/cmdc.201100344
By:
- Cleghorn, Laura A. T.;
- Woodland, Andrew;
- Collie, Iain T.;
- Torrie, Leah S.;
- Norcross, Neil;
- Luksch, Torsten;
- Mpamhanga, Chido;
- Walker, Roderick G.;
- Mottram, Jeremy C.;
- Brenk, Ruth;
- Frearson, Julie A.;
- Gilbert, Ian H.;
- Wyatt, Paul G.
Publication type:
Article
Optimisation of the Anti- Trypanosoma brucei Activity of the Opioid Agonist U50488.
Published in:
ChemMedChem, 2011, v. 6, n. 10, p. 1832, doi. 10.1002/cmdc.201100278
By:
- Smith, Victoria C.;
- Cleghorn, Laura A. T.;
- Woodland, Andrew;
- Spinks, Daniel;
- Hallyburton, Irene;
- Collie, Iain T.;
- Yi Mok, N.;
- Norval, Suzanne;
- Brenk, Ruth;
- Fairlamb, Alan H.;
- Frearson, Julie A.;
- Read, Kevin D.;
- Gilbert, Ian H.;
- Wyatt, Paul G.
Publication type:
Article
Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1.
Published in:
ChemMedChem, 2011, v. 6, n. 2, p. 302, doi. 10.1002/cmdc.201000450
By:
- Spinks, Daniel;
- Ong, Han B.;
- Mpamhanga, Chidochangu P.;
- Shanks, Emma J.;
- Robinson, David A.;
- Collie, Iain T.;
- Read, Kevin D.;
- Frearson, Julie A.;
- Wyatt, Paul G.;
- Brenk, Ruth;
- Fairlamb, Alan H.;
- Gilbert, Ian H.
Publication type:
Article
Cover Picture: Synthesis and Evaluation of Indatraline-Based Inhibitors for Trypanothione Reductase / Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1 / Modified 5′-Trityl Nucleosides as Inhibitors of Plasmodium falciparum dUTPase (ChemMedChem 2/2011)
Published in:
ChemMedChem, 2011, v. 6, n. 2, p. 209, doi. 10.1002/cmdc.201190000
By:
- Walton, Jeffrey G. A.;
- Jones, Deuan C.;
- Kiuru, Paula;
- Durie, Alastair J.;
- Westwood, Nicholas J.;
- Fairlamb, Alan H.;
- Spinks, Daniel;
- Ong, Han B.;
- Mpamhanga, Chidochangu P.;
- Shanks, Emma J.;
- Robinson, David A.;
- Collie, Iain T.;
- Read, Kevin D.;
- Frearson, Julie A.;
- Wyatt, Paul G.;
- Brenk, Ruth;
- Gilbert, Ian H.;
- Ruda, Gian Filippo;
- Nguyen, Corinne;
- Ziemkowski, Przemysław
Publication type:
Article
Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei.
Published in:
ChemMedChem, 2009, v. 4, n. 12, p. 2060, doi. 10.1002/cmdc.200900262
By:
- Spinks, Daniel;
- Shanks, Emma J.;
- Cleghorn, Laura A. T.;
- McElroy, Stuart;
- Jones, Deuan;
- James, Daniel;
- Fairlamb, Alan H.;
- Frearson, Julie A.;
- Wyatt, Paul G.;
- Gilbert, Ian H.
Publication type:
Article
Cover Picture: Improved Tricyclic Inhibitors of Trypanothione Reductase by Screening and Chemical Synthesis / Synthesis and Evaluation of 1-(1-(Benzo[ b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase (ChemMedChem 8/2009)
Published in:
ChemMedChem, 2009, v. 4, n. 8, p. 1209, doi. 10.1002/cmdc.200990035
By:
- Richardson, John L.;
- Nett, Isabelle R. E.;
- Jones, Deuan C.;
- Abdille, Mohamed H.;
- Gilbert, Ian H.;
- Fairlamb, Alan H.;
- Patterson, Stephen;
- Shanks, Emma J.;
- Frearson, Julie A.;
- Wyatt, Paul G.
Publication type:
Article
Synthesis and Evaluation of 1-(1-(Benzo[ b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase.
Published in:
ChemMedChem, 2009, v. 4, n. 8, p. 1341, doi. 10.1002/cmdc.200900098
By:
- Patterson, Stephen;
- Jones, Deuan C.;
- Shanks, Emma J.;
- Frearson, Julie A.;
- Gilbert, Ian H.;
- Wyatt, Paul G.;
- Fairlamb, Alan H.
Publication type:
Article
Lessons Learnt from Assembling Screening Libraries for Drug Discovery for Neglected Diseases.
Published in:
ChemMedChem, 2008, v. 3, n. 3, p. 435, doi. 10.1002/cmdc.200700139
By:
- Brenk, Ruth;
- Schipani, Alessandro;
- James, Daniel;
- Krasowski, Agata;
- Gilbert, Ian Hugh;
- Frearson, Julie;
- Wyatt, Paul Graham
Publication type:
Article
A tyrosine-phosphorylated 110-120-kDa protein associates with the C-terminal SH2 domain of phosphotyrosine phosphatase-1D in T cell receptor-stimulated T cells.
Published in:
European Journal of Immunology, 1996, v. 26, n. 7, p. 1539, doi. 10.1002/eji.1830260720
By:
- Frearson, Julie A.;
- Yi, Taolin;
- Alexander, Denis R.
Publication type:
Article

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