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Genetic evidence that high BMI in childhood has a protective effect on intermediate diabetes traits, including measures of insulin sensitivity and secretion, after accounting for BMI in adulthood.
- Published in:
- Diabetologia, 2023, v. 66, n. 8, p. 1472, doi. 10.1007/s00125-023-05923-6
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- Article
Higher maternal adiposity reduces offspring birthweight if associated with a metabolically favourable profile.
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- Diabetologia, 2021, v. 64, n. 12, p. 2790, doi. 10.1007/s00125-021-05570-9
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- Article
Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively.
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- Diabetologia, 2016, v. 59, n. 6, p. 1214, doi. 10.1007/s00125-016-3908-5
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- Article
Confirmation of linkage of Duane's syndrome and refinement of the disease locus to an 8.8-cM interval on chromosome 2q31.
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- Human Genetics, 2000, v. 106, n. 6, p. 636, doi. 10.1007/s004390000311
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- Article
Combining Genome and Mouse Knockout Expression Data to Highlight Binding Sites for the Transcription Factor HNF1α.
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- In Silico Biology, 2003, v. 3, n. 1/2, p. 57
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- Publication type:
- Article
Genetically defined favourable adiposity is not associated with a clinically meaningful difference in clinical course in people with type 2 diabetes but does associate with a favourable metabolic profile.
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- Diabetic Medicine, 2021, v. 38, n. 9, p. 1, doi. 10.1111/dme.14531
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- Article
Recent progress in the use of genetics to understand links between type 2 diabetes and related metabolic traits.
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- Genome Biology, 2013, v. 14, n. 3, p. 203, doi. 10.1186/gb-2013-14-3-203
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- Article
Piecing together the FTO jigsaw.
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- Genome Biology, 2011, v. 12, n. 2, p. 1, doi. 10.1186/gb-2011-12-2-104
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- Article
Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
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- 2004
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- journal article
Common variants of the hepatocyte nuclear factor-4alpha P2 promoter are associated with type 2 diabetes in the U.K. population.
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- 2004
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- journal article
Evidence from a large U.K. family collection that genes influencing age of onset of type 2 diabetes map to chromosome 12p and to the MODY3/NIDDM2 locus on 12q24.
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- 2004
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- Publication type:
- journal article
Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
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- 2003
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- journal article
Association and haplotype analysis of the insulin-degrading enzyme (IDE) gene, a strong positional and biological candidate for type 2 diabetes susceptibility.
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- 2003
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- journal article
Genetic variation in the small heterodimer partner gene and young-onset type 2 diabetes, obesity, and birth weight in U.K. subjects.
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- 2003
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- Publication type:
- journal article
A Genome-Wide Scan in Families With Maturity-Onset Diabetes of the Young.
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- Diabetes, 2003, v. 52, n. 3, p. 872, doi. 10.2337/diabetes.52.3.872
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- Publication type:
- Article
Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes.
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- 2003
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- Publication type:
- journal article
A putative functional polymorphism in the IGF-I gene: association studies with type 2 diabetes, adult height, glucose tolerance, and fetal growth in U.K. populations.
- Published in:
- 2002
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- Publication type:
- journal article
A Putative Functional Polymorphism in the IGF-I Gene.
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- Diabetes, 2002, v. 51, n. 7, p. 2313, doi. 10.2337/diabetes.51.7.2313
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- Article
Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.
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- 2002
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- journal article
Variation in the calpain-10 gene affects blood glucose levels in the British population.
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- 2002
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- journal article
beta-cell genes and diabetes: quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1alpha and glucokinase mutations.
- Published in:
- 2001
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- Publication type:
- journal article
Beta-Cell Genes and Diabetes.
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- Diabetes, 2001, v. 50, p. S94, doi. 10.2337/diabetes.50.2007.S94
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- Article
Analysis of parent-offspring trios provides evidence for linkage and association between the insulin gene and type 2 diabetes mediated exclusively through paternally transmitted class III variable number tandem repeat alleles.
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- 2000
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- Publication type:
- journal article
Parent-Offspring Trios.
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- Diabetes, 1999, v. 48, n. 12, p. 2475, doi. 10.2337/diabetes.48.12.2475
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- Article
Allelic drop-out in exon 2 of the hepatocyte nuclear factor-1alpha gene hinders the identification of mutations in three families with maturity-onset diabetes of the young.
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- 1999
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- Publication type:
- journal article
Mutations in the hepatocyte nuclear factor-1alpha gene are a common cause of maturity-onset diabetes of the young in the U.K.
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- 1997
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- Publication type:
- journal article
Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.
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- 2016
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- Publication type:
- journal article
Genome-wide association studies provide new insights into type 2 diabetes aetiology.
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- 2007
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- Publication type:
- journal article
Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-41712-1
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- Publication type:
- Article
Adult height variants affect birth length and growth rate in children.
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- Human Molecular Genetics, 2011, v. 20, n. 20, p. 4069, doi. 10.1093/hmg/ddr309
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- Publication type:
- Article
Allelic heterogeneity and more detailed analyses of known loci explain additional phenotypic variation and reveal complex patterns of association.
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- Human Molecular Genetics, 2011, v. 20, n. 20, p. 4082, doi. 10.1093/hmg/ddr328
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- Publication type:
- Article
A common genetic variant in the 15q24 nicotinic acetylcholine receptor gene cluster (CHRNA5–CHRNA3–CHRNB4) is associated with a reduced ability of women to quit smoking in pregnancy.
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- Human Molecular Genetics, 2009, v. 18, n. 15, p. 2922, doi. 10.1093/hmg/ddp216
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- Article
Prosaposin is a regulator of progranulin levels and oligomerization.
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- Nature Communications, 2016, v. 7, n. 6, p. 11992, doi. 10.1038/ncomms11992
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- Article
Babies of South Asian and European Ancestry Show Similar Associations With Genetic Risk Score for Birth Weight Despite the Smaller Size of South Asian Newborns.
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- Diabetes, 2022, v. 71, n. 4, p. 821, doi. 10.2337/db21-0479
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- Article
Genetic Evidence for Different Adiposity Phenotypes and Their Opposing Influences on Ectopic Fat and Risk of Cardiometabolic Disease.
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- 2021
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- Publication type:
- journal article
190-LB: Using Genetics to Uncouple Higher Adiposity from Its Adverse Metabolic Effects.
- Published in:
- Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-190-LB
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- Publication type:
- Article
188-LB: Type 2 Diabetes Is Genetically Correlated with Multiple Long-Term Conditions but These Correlations Are Only Partly Explained by BMI.
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- Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-188-LB
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- Article
189-LB: Using Genetics to Separate Childhood from Adult BMI Shows That Higher Childhood BMI Has No Direct Effect on Reduced Insulin Secretion or Sensitivity in Later Life.
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- Diabetes, 2021, v. 70, p. N.PAG, doi. 10.2337/db21-189-LB
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- Publication type:
- Article
A Mendelian Randomization Study Provides Evidence That Adiposity and Dyslipidemia Lead to Lower Urinary Albumin-to-Creatinine Ratio, a Marker of Microvascular Function.
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- Diabetes, 2020, v. 69, n. 5, p. 1072, doi. 10.2337/db19-0862
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- Article
Using Genetic Variants to Assess the Relationship Between Circulating Lipids and Type 2 Diabetes.
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- Diabetes, 2015, v. 64, n. 7, p. 2676, doi. 10.2337/db14-1710
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- Article
Physiology Helps GWAS Take a Step Closer to Mechanism.
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- Diabetes, 2014, v. 63, n. 6, p. 1836, doi. 10.2337/db14-0130
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- Article
Biomarkers for Type 2 Diabetes and Impaired Fasting Glucose Using a Nontargeted Metabolomics Approach.
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- Diabetes, 2013, v. 62, n. 12, p. 4270, doi. 10.2337/db13-0570
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- Article
Deep Resequencing Unveils Genetic Architecture of ADIPOQ and Identifies a Novel Low-Frequency Variant Strongly Associated With Adiponectin Variation.
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- Diabetes, 2012, v. 61, n. 5, p. 1297, doi. 10.2337/db11-0985
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- Article
Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated With Fasting and Postchallenge Glucose Levels in Pregnancy and With the New Consensus Definition of Gestational Diabetes Mellitus From the International Association of Diabetes and Pregnancy Study Groups
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- Diabetes, 2010, v. 59, n. 10, p. 2682, doi. 10.2337/db10-0177
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- Article
Polygenic Risk Variants for Type 2 Diabetes Susceptibility Modify Age at Diagnosis in Monogenic HNF1A Diabetes.
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- Diabetes, 2010, v. 59, n. 1, p. 266, doi. 10.2337/db09-0555
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- Publication type:
- Article
Linkage Disequilibrium Mapping of the Replicated Type 2 Diabetes Linkage Signal on Chromosome 1q.
- Published in:
- Diabetes, 2009, v. 58, n. 7, p. 1704, doi. 10.2337/db09-0081
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- Publication type:
- Article
Interrogating Type 2 Diabetes Genome-Wide Association Data Using a Biological Pathway-Based Approach.
- Published in:
- Diabetes, 2009, v. 58, n. 6, p. 1463, doi. 10.2337/db08-1378
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- Publication type:
- Article
Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data.
- Published in:
- Diabetes, 2009, v. 58, n. 2, p. 505, doi. 10.2337/db08-0906
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- Publication type:
- Article
Population-Specific Risk of Type 2 Diabetes Conferred by HNF4A P2 Promoter Variants.
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- Diabetes, 2008, v. 57, n. 11, p. 3161, doi. 10.2337/db08-0719
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- Publication type:
- Article
Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk.
- Published in:
- Diabetes, 2008, v. 57, n. 11, p. 3129, doi. 10.2337/db08-0504
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- Publication type:
- Article