Found: 11

Select item for more details and to access through your institution.

  • Antibody-Drug Conjugates for the Treatment of Cancer.

    Published in:
    Chemical Biology & Drug Design, 2013, v. 81, n. 1, p. 113, doi. 10.1111/cbdd.12085
    By:
    • Flygare, John A.;
    • Pillow, Thomas H.;
    • Aristoff, Paul
    Publication type:
    Article

  • Mechanistic and Structural Understanding of Uncompetitive Inhibitors of Caspase-6.

    Published in:
    PLoS ONE, 2012, v. 7, n. 12, p. 1, doi. 10.1371/journal.pone.0050864
    By:
    • Heise, Christopher E.;
    • Murray, Jeremy;
    • Augustyn, Katherine E.;
    • Bravo, Brandon;
    • Chugha, Preeti;
    • Cohen, Frederick;
    • Giannetti, Anthony M.;
    • Gibbons, Paul;
    • Hannoush, Rami N.;
    • Hearn, Brian R.;
    • Jaishankar, Priyadarshini;
    • Ly, Cuong Q.;
    • Shah, Kinjalkumar;
    • Stanger, Karen;
    • Steffek, Micah;
    • Yinyan Tang;
    • Xianrui Zhao;
    • Lewcock, Joseph W.;
    • Renslo, Adam R.;
    • Flygare, John
    Publication type:
    Article

  • Activity-based probes for the ubiquitin conjugation-deconjugation machinery: new chemistries, new tools, and new insights.

    Published in:
    FEBS Journal, 2017, v. 284, n. 10, p. 1555, doi. 10.1111/febs.14039
    By:
    • Hewings, David S.;
    • Flygare, John A.;
    • Bogyo, Matthew;
    • Wertz, Ingrid E.
    Publication type:
    Article

  • Activity-based probes for the multicatalytic proteasome.

    Published in:
    FEBS Journal, 2017, v. 284, n. 10, p. 1540, doi. 10.1111/febs.14016
    By:
    • Hewings, David S.;
    • Flygare, John A.;
    • Wertz, Ingrid E.;
    • Bogyo, Matthew
    Publication type:
    Article

  • Targeting LGR5<sup>+</sup> cells with an antibody-drug conjugate for the treatment of colon cancer.

    Published in:
    Science Translational Medicine, 2015, v. 7, n. 314, p. 1, doi. 10.1126/scitranslmed.aac7433
    By:
    • Junttila, Melissa R.;
    • Weiguang Mao;
    • Xi Wang;
    • Bu-Er Wang;
    • Thinh Pham;
    • Flygare, John;
    • Shang-Fan Yu;
    • Sharon Yee;
    • Goldenberg, David;
    • Fields, Carter;
    • Eastham-Anderson, Jeffrey;
    • Singh, Mallika;
    • Vij, Rajesh;
    • Jo-Anne Hongo;
    • Firestein, Ron;
    • Schutten, Melissa;
    • Flagella, Kelly;
    • Polakis, Paul;
    • Polson, Andrew G.
    Publication type:
    Article

  • Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

    Published in:
    Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-03511-6
    By:
    • Hewings, David S.;
    • Heideker, Johanna;
    • Ma, Taylur P.;
    • AhYoung, Andrew P.;
    • Oualid, Farid El;
    • Amore, Alessia;
    • Costakes, Gregory T.;
    • Kirchhofer, Daniel;
    • Brasher, Bradley;
    • Pillow, Thomas;
    • Popovych, Nataliya;
    • Maurer, Till;
    • Schwerdtfeger, Carsten;
    • Forrest, William F.;
    • Yu, Kebing;
    • Flygare, John;
    • Bogyo, Matthew;
    • Wertz, Ingrid E.
    Publication type:
    Article

  • Tailoring Small Molecules for an Allosteric Site on Procaspase-6.

    Published in:
    ChemMedChem, 2014, v. 9, n. 1, p. 73, doi. 10.1002/cmdc.201300424
    By:
    • Murray, Jeremy;
    • Giannetti, Anthony M.;
    • Steffek, Micah;
    • Gibbons, Paul;
    • Hearn, Brian R.;
    • Cohen, Frederick;
    • Tam, Christine;
    • Pozniak, Christine;
    • Bravo, Brandon;
    • Lewcock, Joe;
    • Jaishankar, Priyadarshini;
    • Ly, Cuong Q.;
    • Zhao, Xianrui;
    • Tang, Yinyan;
    • Chugha, Preeti;
    • Arkin, Michelle R.;
    • Flygare, John;
    • Renslo, Adam R.
    Publication type:
    Article

  • Inside Cover: Tailoring Small Molecules for an Allosteric Site on Procaspase-6 (ChemMedChem 1/2014).

    Published in:
    ChemMedChem, 2014, v. 9, n. 1, p. 2, doi. 10.1002/cmdc.201390058
    By:
    • Murray, Jeremy;
    • Giannetti, Anthony M.;
    • Steffek, Micah;
    • Gibbons, Paul;
    • Hearn, Brian R.;
    • Cohen, Frederick;
    • Tam, Christine;
    • Pozniak, Christine;
    • Bravo, Brandon;
    • Lewcock, Joe;
    • Jaishankar, Priyadarshini;
    • Ly, Cuong Q.;
    • Zhao, Xianrui;
    • Tang, Yinyan;
    • Chugha, Preeti;
    • Arkin, Michelle R.;
    • Flygare, John;
    • Renslo, Adam R.
    Publication type:
    Article

  • Structure-guided design of a selective BCL-X<sub>L</sub> inhibitor.

    Published in:
    Nature Chemical Biology, 2013, v. 9, n. 6, p. 390, doi. 10.1038/nchembio.1246
    By:
    • Lessene, Guillaume;
    • Czabotar, Peter E;
    • Sleebs, Brad E;
    • Zobel, Kerry;
    • Lowes, Kym N;
    • Adams, Jerry M;
    • Baell, Jonathan B;
    • Colman, Peter M;
    • Deshayes, Kurt;
    • Fairbrother, Wayne J;
    • Flygare, John A;
    • Gibbons, Paul;
    • Kersten, Wilhelmus J A;
    • Kulasegaram, Sanji;
    • Moss, Rebecca M;
    • Parisot, John P;
    • Smith, Brian J;
    • Street, Ian P;
    • Yang, Hong;
    • Huang, David C S
    Publication type:
    Article

  • Toxicity Profile of Small-Molecule IAP Antagonist GDC-0152 Is Linked to TNF-α Pharmacology.

    Published in:
    Toxicological Sciences, 2013, v. 131, n. 1, p. 247, doi. 10.1093/toxsci/kfs265
    By:
    • Erickson, Rebecca I.;
    • Tarrant, Jacqueline;
    • Cain, Gary;
    • Lewin-Koh, Sock-Cheng;
    • Dybdal, Noel;
    • Wong, Harvey;
    • Blackwood, Elizabeth;
    • West, Kristina;
    • Steigerwalt, Ronald;
    • Mamounas, Michael;
    • Flygare, John A.;
    • Amemiya, Kenjie;
    • Dambach, Donna;
    • Fairbrother, Wayne J.;
    • Diaz, Dolores
    Publication type:
    Article

  • Dogs Are More Sensitive to Antagonists of Inhibitor of Apoptosis Proteins Than Rats and Humans: A Translational Toxicokinetic/Toxicodynamic Analysis.

    Published in:
    Toxicological Sciences, 2012, v. 130, n. 1, p. 205, doi. 10.1093/toxsci/kfs235
    By:
    • Wong, Harvey;
    • Budha, Nageshwar R.;
    • West, Kristina;
    • Blackwood, Elizabeth;
    • Ware, Joseph A.;
    • Yu, Ron;
    • Darbonne, Walter C.;
    • Gould, Stephen E.;
    • Steigerwalt, Ronald;
    • Erickson, Rebecca;
    • Hop, Cornelis E. A. C.;
    • LoRusso, Patricia;
    • Eckhardt, S. Gail;
    • Wagner, Andrew;
    • Chan, Iris T.;
    • Mamounas, Michael;
    • Flygare, John A.;
    • Fairbrother, Wayne J.
    Publication type:
    Article