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Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.
- Published in:
- Scientific Reports, 2015, p. 14552, doi. 10.1038/srep14552
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- Article
Author Correction: Propensity of selecting mutant parasites for the antimalarial drug cabamiquine.
- Published in:
- 2023
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- Correction Notice
Propensity of selecting mutant parasites for the antimalarial drug cabamiquine.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40974-8
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- Article
Propensity of selecting mutant parasites for the antimalarial drug cabamiquine.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-40974-8
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- Article
A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048.
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- Clinical Infectious Diseases, 2020, v. 71, n. 10, p. e657, doi. 10.1093/cid/ciaa368
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- Article
Pyronaridine-artesunate Shows Promise as an Effective and Well-tolerated Treatment for Artemisinin-resistant Plasmodium falciparum Malaria.
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- Clinical Infectious Diseases, 2020, v. 79, n. 10, p. 2196, doi. 10.1093/cid/ciz583
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- Article
Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine.
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- Journal of Infectious Diseases, 2023, v. 227, n. 10, p. 1121, doi. 10.1093/infdis/jiac469
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- Article
Mutant PfCRT Can Mediate Piperaquine Resistance in African Plasmodium falciparum With Reduced Fitness and Increased Susceptibility to Other Antimalarials.
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- 2022
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- Publication type:
- journal article
Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches.
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- FASEB Journal, 2011, v. 25, n. 10, p. 3583, doi. 10.1096/fj.11-187401
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- Article
Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology.
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- PLoS Pathogens, 2016, v. 12, n. 11, p. 1, doi. 10.1371/journal.ppat.1005976
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- Article
Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum.
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- Molecular Biology & Evolution, 2016, v. 33, n. 6, p. 1554, doi. 10.1093/molbev/msw037
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- Article
Origin of Robustness in Generating Drug-Resistant Malaria Parasites.
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- Molecular Biology & Evolution, 2014, v. 31, n. 7, p. 1649
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- Article
A key role for lipoic acid synthesis during Plasmodium liver stage development.
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- Cellular Microbiology, 2013, v. 15, n. 9, p. 1585, doi. 10.1111/cmi.12137
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- Article
Spatial and temporal mapping of the PfEMP1 export pathway in Plasmodium falciparum.
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- Cellular Microbiology, 2013, v. 15, n. 8, p. 1401, doi. 10.1111/cmi.12125
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- Article
Identification of a role for the PfEMP1 semi-conserved head structure in protein trafficking to the surface of Plasmodium falciparum infected red blood cells.
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- Cellular Microbiology, 2010, v. 12, n. 10, p. 1446, doi. 10.1111/j.1462-5822.2010.01481.x
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- Article
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
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- Nature Communications, 2017, v. 8, n. 5, p. 15159, doi. 10.1038/ncomms15159
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- Article
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
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- Nature Communications, 2017, v. 8, n. 2, p. 14574, doi. 10.1038/ncomms14574
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- Article
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies.
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- Nature Communications, 2016, v. 7, n. 5, p. 11553, doi. 10.1038/ncomms11553
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- Article
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2.
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- ChemMedChem, 2022, v. 17, n. 22, p. 1, doi. 10.1002/cmdc.202200393
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- Article
Perspectives: The missing pieces.
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- Nature, 2012, v. 484, n. 7395, p. S22, doi. 10.1038/484S22a
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- Article
Drug discovery: Priming the antimalarial pipeline.
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- Nature, 2010, v. 465, n. 7296, p. 297, doi. 10.1038/465297a
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- Article
Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone.
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- Communications Biology, 2019, v. 2, n. 1, p. N.PAG, doi. 10.1038/s42003-019-0397-3
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- Article
A high susceptibility to redox imbalance of the transmissible stages of P lasmodium falciparum revealed with a luciferase-based mature gametocyte assay.
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- Molecular Microbiology, 2017, v. 104, n. 2, p. 306, doi. 10.1111/mmi.13626
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- Article
CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs.
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- Molecular Microbiology, 2016, v. 101, n. 3, p. 381, doi. 10.1111/mmi.13397
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- Article
Balancing drug resistance and growth rates via compensatory mutations in the P lasmodium falciparum chloroquine resistance transporter.
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- Molecular Microbiology, 2015, v. 97, n. 2, p. 381, doi. 10.1111/mmi.13035
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- Article
Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif.
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- Molecular Microbiology, 2008, v. 68, n. 6, p. 1535, doi. 10.1111/j.1365-2958.2008.06250.x
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- Article
Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.
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- Molecular Microbiology, 2007, v. 65, n. 1, p. 27, doi. 10.1111/j.1365-2958.2007.05753.x
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- Article
Differences in trans-stimulated chloroquine efflux kinetics are linked to PfCRT in Plasmodium falciparum.
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- Molecular Microbiology, 2007, v. 64, n. 2, p. 407, doi. 10.1111/j.1365-2958.2007.05664.x
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- Publication type:
- Article
PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.
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- Molecular Microbiology, 2006, v. 62, n. 1, p. 238, doi. 10.1111/j.1365-2958.2006.05368.x
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- Article
Transfusion of stored blood impairs host defenses against Gram-negative pathogens in mice.
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- Transfusion, 2014, v. 54, n. 11, p. 2842, doi. 10.1111/trf.12712
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- Article
Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1.
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- BMC Genomics, 2015, v. 16, p. 1, doi. 10.1186/s12864-015-2320-8
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- Article
Mitotic Evolution of Plasmodium falciparum Shows a Stable Core Genome but Recombination in Antigen Families.
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- PLoS Genetics, 2013, v. 9, n. 2, p. 1, doi. 10.1371/journal.pgen.1003293
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- Article
Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound.
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- Frontiers in Pharmacology, 2020, v. 11, p. 1, doi. 10.3389/fphar.2020.00246
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- Article
Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine.
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- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-05652-0
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- Article
Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.
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- PLoS Pathogens, 2020, v. 16, n. 4, p. 1, doi. 10.1371/journal.ppat.1008482
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- Article
Modeling Within-Host Effects of Drugs on <i>Plasmodium falciparum</i> Transmission and Prospects for Malaria Elimination.
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- PLoS Computational Biology, 2014, v. 10, n. 1, p. 1, doi. 10.1371/journal.pcbi.1003434
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- Article
Malaria's Missing Number: Calculating the Human Component of R0 by a Within-Host Mechanistic Model of Plasmodium falciparum Infection and Transmission.
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- PLoS Computational Biology, 2013, v. 9, n. 4, p. 1, doi. 10.1371/journal.pcbi.1003025
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- Article
Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters.
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- Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-49348-x
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- Article
Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility.
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- Nature Communications, 2020, v. 11, n. 1, p. N.PAG, doi. 10.1038/s41467-020-18624-0
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- Article
Oleic Acid Biosynthesis in Plasmodium falciparum: Characterization of the Stearoyl-CoA Desaturase and Investigation as a Potential Therapeutic Target.
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- PLoS ONE, 2009, v. 4, n. 9, p. 1, doi. 10.1371/journal.pone.0006889
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- Article
Piperaquine-resistant PfCRT mutations differentially impact drug transport, hemoglobin catabolism and parasite physiology in Plasmodium falciparum asexual blood stages.
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- PLoS Pathogens, 2022, v. 18, n. 10, p. 1, doi. 10.1371/journal.ppat.1010926
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- Publication type:
- Article
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
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- Science Translational Medicine, 2015, v. 7, n. 296, p. 1, doi. 10.1126/scitranslmed.aaa6645
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- Article
Genetic linkage of pfmdr1 with food vacuolar solute import in Plasmodium falciparum.
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- EMBO Journal, 2006, v. 25, n. 13, p. 3000, doi. 10.1038/sj.emboj.7601203
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- Article
A critical role for PfCRT K76T in Plasmodium falciparum verapamil-reversible chloroquine resistance.
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- EMBO Journal, 2005, v. 24, n. 13, p. 2294, doi. 10.1038/sj.emboj.7600681
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- Publication type:
- Article
Site-specific genome editing in Plasmodium falciparum using engineered zinc-finger nucleases.
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- Nature Methods, 2012, v. 9, n. 10, p. 993, doi. 10.1038/nmeth.2143
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- Article
Malaria: progress, perils, and prospects for eradication.
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- 2008
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- Publication type:
- journal article
Parasite-induced ER stress response in hepatocytes facilitates Plasmodium liver stage infection.
- Published in:
- EMBO Reports, 2015, v. 16, n. 8, p. 955, doi. 10.15252/embr.201439979
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- Article
The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-81343-z
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- Article
Blocking Plasmodium Development in Mosquitoes: A Powerful New Approach for Expanding Malaria Control Efforts.
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- American Journal of Tropical Medicine & Hygiene, 2019, v. 101, n. 4, p. 734, doi. 10.4269/ajtmh.19-0318
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- Article
In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei.
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- Journal of Antibiotics, 2011, v. 64, n. 12, p. 799, doi. 10.1038/ja.2011.94
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- Article