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Activating STAT3 mutations in CD8+ T-cells correlate to serological positivity in rheumatoid arthritis.
Published in:
Frontiers in Immunology, 2024, p. 1, doi. 10.3389/fimmu.2024.1466276
By:
- Moosic, Katharine B.;
- Olson, Thomas L.;
- Freijat, Mark;
- Khalique, Samara;
- Hamele, Cait E.;
- Shemo, Bryna;
- Boodoo, Jesse;
- Baker, William;
- Khurana, Gitanjali;
- Schmachtenberg, Matthew;
- Duffy, Tristin;
- Ratan, Aakrosh;
- Darrah, Erika;
- Andrade, Felipe;
- Jones, Marieke;
- Olson, Kristine C.;
- Feith, David J.;
- Kimpel, Donald L.;
- Loughran Jr, Thomas P.
Publication type:
Article
Sphingosine kinase‐2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl‐1.
Published in:
British Journal of Haematology, 2020, v. 190, n. 3, p. 405, doi. 10.1111/bjh.16530
By:
- LeBlanc, Francis R.;
- Pearson, Jennifer M.;
- Tan, Su‐Fern;
- Cheon, HeeJin;
- Xing, Jeffrey C.;
- Dunton, Wendy;
- Feith, David J.;
- Loughran, Thomas P.
Publication type:
Article
Retroviral sero‐reactivity in LGL leukaemia patients and family members.
Published in:
British Journal of Haematology, 2020, v. 188, n. 4, p. 522, doi. 10.1111/bjh.16223
By:
- Nyland, Susan B.;
- Feith, David J.;
- Poss, Mary;
- Olson, Thomas L.;
- Krissinger, Daniel J.;
- Poiesz, Bernard J.;
- Ruscetti, Francis W.;
- Loughran, Thomas P.
Publication type:
Article
Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK- LGL leukaemia.
Published in:
British Journal of Haematology, 2015, v. 168, n. 3, p. 371, doi. 10.1111/bjh.13143
By:
- Sun, Xiaoshen;
- Hasanali, Zainul S.;
- Chen, Allshine;
- Zhang, Dianzheng;
- Liu, Xin;
- Wang, Hong‐Gang;
- Feith, David J.;
- Loughran, Thomas P.;
- Xu, Kailin
Publication type:
Article
C6-Ceramide Nanoliposomes Target the Warburg Effect in Chronic Lymphocytic Leukemia.
Published in:
PLoS ONE, 2013, v. 8, n. 12, p. 1, doi. 10.1371/journal.pone.0084648
By:
- Ryland, Lindsay K.;
- Doshi, Ushma A.;
- Shanmugavelandy, Sriram S.;
- Fox, Todd E.;
- Aliaga, Cesar;
- Broeg, Kathleen;
- Baab, Kendall Thomas;
- Young, Megan;
- Khan, Osman;
- Haakenson, Jeremy K.;
- Jarbadan, Nancy Ruth;
- Liao, Jason;
- Wang, Hong-Gang;
- Feith, David J.;
- Loughran Jr, Thomas P.;
- Liu, Xin;
- Kester, Mark
Publication type:
Article
Key role for p27<sup>Kip1</sup>, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G<sub>1</sub> cell cycle arrest in MYCN-amplified human neuroblastoma cells.
Published in:
Oncogene, 2005, v. 24, n. 36, p. 5606, doi. 10.1038/sj.onc.1208808
By:
- Wallick, Christopher J.;
- Gamper, Ivonne;
- Thorne, Mike;
- Feith, David J;
- Takasaki, Kelsie Y;
- Wilson, Shannon M.;
- Seki, Jennifer A.;
- Pegg, Anthony E.;
- Byus, Craig V.;
- Bachmann, André S.
Publication type:
Article
Acid Ceramidase Inhibitor LCL-805 Antagonizes Akt Signaling and Promotes Iron-Dependent Cell Death in Acute Myeloid Leukemia.
Published in:
Cancers, 2023, v. 15, n. 24, p. 5866, doi. 10.3390/cancers15245866
By:
- Ung, Johnson;
- Tan, Su-Fern;
- Fox, Todd E.;
- Shaw, Jeremy J. P.;
- Taori, Maansi;
- Horton, Bethany J.;
- Golla, Upendarrao;
- Sharma, Arati;
- Szulc, Zdzislaw M.;
- Wang, Hong-Gang;
- Chalfant, Charles E.;
- Cabot, Myles C.;
- Claxton, David F.;
- Loughran Jr., Thomas P.;
- Feith, David J.
Publication type:
Article
Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia.
Published in:
Cancers, 2023, v. 15, n. 6, p. 1883, doi. 10.3390/cancers15061883
By:
- Fisher-Wellman, Kelsey H.;
- Kassai, Miki;
- Hagen, James T.;
- Neufer, P. Darrell;
- Kester, Mark;
- Loughran Jr., Thomas P.;
- Chalfant, Charles E.;
- Feith, David J.;
- Tan, Su-Fern;
- Fox, Todd E.;
- Ung, Johnson;
- Fabrias, Gemma;
- Abad, Jose' Luis;
- Sharma, Arati;
- Golla, Upendarrao;
- Claxton, David F.;
- Shaw, Jeremy J. P.;
- Bhowmick, Debajit;
- Cabot, Myles C.
Publication type:
Article
Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation.
Published in:
Cancers, 2020, v. 12, n. 1, p. 126, doi. 10.3390/cancers12010126
By:
- Wang, T. Tiffany;
- Yang, Jun;
- Dighe, Shubha;
- Schmachtenberg, Matthew W.;
- Leigh, Nathan T.;
- Farber, Emily;
- Onengut-Gumuscu, Suna;
- Feith, David J.;
- Ratan, Aakrosh;
- Loughran, Thomas P.;
- Olson, Thomas L.
Publication type:
Article
Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations.
Published in:
Cancer Medicine, 2020, v. 9, n. 18, p. 6533, doi. 10.1002/cam4.3246
By:
- Olson, Kristine C.;
- Moosic, Katharine B.;
- Jones, Marieke K.;
- Larkin, Paige M. K.;
- Olson, Thomas L.;
- Toro, Mariella F.;
- Fox, Todd E.;
- Feith, David J.;
- Loughran, Thomas P.
Publication type:
Article
Vitamin D in hematological disorders and malignancies.
Published in:
European Journal of Haematology, 2017, v. 98, n. 3, p. 187, doi. 10.1111/ejh.12818
By:
- Kulling, Paige M.;
- Olson, Kristine C.;
- Olson, Thomas L.;
- Feith, David J.;
- Loughran, Thomas P.
Publication type:
Article
Ceramide nanoliposomes augment the efficacy of venetoclax and cytarabine in models of acute myeloid leukemia.
Published in:
FASEB Journal, 2022, v. 36, n. 10, p. 1, doi. 10.1096/fj.202200765R
By:
- Khokhlatchev, Andrei V.;
- Sharma, Arati;
- Deering, Tye G.;
- Shaw, Jeremy J. P.;
- Costa‐Pinheiro, Pedro;
- Golla, Upendarrao;
- Annageldiyev, Charyguly;
- Cabot, Myles C.;
- Conaway, Mark R.;
- Tan, Su‐Fern;
- Ung, Johnson;
- Feith, David J.;
- Loughran, Thomas P.;
- Claxton, David F.;
- Fox, Todd E.;
- Kester, Mark
Publication type:
Article
Alterations in sphingolipid composition and mitochondrial bioenergetics represent synergistic therapeutic vulnerabilities linked to multidrug resistance in leukemia.
Published in:
FASEB Journal, 2022, v. 36, n. 1, p. 1, doi. 10.1096/fj.202101194RRR
By:
- Fisher-Wellman, Kelsey H.;
- Hagen, James T.;
- Kassai, Miki;
- Li-Pin Kao;
- Nelson, Margaret A. M.;
- McLaughlin, Kelsey L.;
- Coalson, Hannah S.;
- Fox, Todd E.;
- Su-Fern Tan;
- Feith, David J.;
- Kester, Mark;
- Loughran Jr, Thomas P.;
- Claxton, David F.;
- Cabot, Myles C.
Publication type:
Article
Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias.
Published in:
Carcinogenesis, 2016, v. 37, n. 8, p. 810, doi. 10.1093/carcin/bgw061
By:
- Keller, Ross R.;
- Gestl, Shelley A.;
- Lu, Amy Q.;
- Hoke, Alicia;
- Feith, David J.;
- Gunther, Edward J.
Publication type:
Article
Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice.
Published in:
Carcinogenesis, 2013, v. 34, n. 3, p. 570, doi. 10.1093/carcin/bgs377
By:
- Feith, David J.;
- Pegg, Anthony E.;
- Fong, Louise Y.Y.
Publication type:
Article
S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion.
Published in:
Carcinogenesis, 2012, v. 33, n. 7, p. 1310, doi. 10.1093/carcin/bgs184
By:
- Shi, Chenxu;
- Cooper, Timothy K.;
- McCloskey, Diane E.;
- Glick, Adam B.;
- Shantz, Lisa M.;
- Feith, David J.
Publication type:
Article
Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis.
Published in:
Carcinogenesis, 2007, v. 28, n. 11, p. 2404, doi. 10.1093/carcin/bgm162
By:
- Xiaojing Wang;
- David J. Feith;
- Pat Welsh;
- Catherine S. Coleman;
- Christina Lopez;
- Patrick M. Woster;
- Thomas G. OBrien;
- Anthony E. Pegg
Publication type:
Article
CLL-156: Novel CCL22 Mutations Drive Chronic Lymphoproliferative Disorder of NK Cells Through Biased GPCR Signaling.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S320, doi. 10.1016/S2152-2650(21)01754-7
By:
- Kimura, Shunsuke;
- Baer, Constance;
- Rana, Mitra S;
- Kleist, Andrew;
- Feith, David J.;
- Walter, Wencke;
- Meggendorfer, Manja;
- Olson, Thomas L.;
- Cheon, HeeJin;
- Olson, Kristine C.;
- Ratan, Aakrosh;
- Mueller, Martha-Lena;
- Foran, James M.;
- Janke, Laura;
- Qu, Chunxu;
- Kalathur, Ravi;
- Haferlach, Claudia;
- Kern, Wolfgang;
- Paietta, Elisabeth;
- Babu, M. Madan
Publication type:
Article
Poster: CLL-156: Novel CCL22 Mutations Drive Chronic Lymphoproliferative Disorder of NK Cells Through Biased GPCR Signaling.
Published in:
Clinical Lymphoma, Myeloma & Leukemia, 2021, v. 21, p. S222, doi. 10.1016/S2152-2650(21)01397-5
By:
- Kimura, Shunsuke;
- Baer, Constance;
- Rana, Mitra S.;
- Kleist, Andrew;
- Feith, David J.;
- Walter, Wencke;
- Meggendorfer, Manja;
- Olson, Thomas L.;
- HeeJin Cheon;
- Olson, Kristine C.;
- Ratan, Aakrosh;
- Mueller, Martha-Lena;
- Foran, James M.;
- Janke, Laura;
- Chunxu Qu;
- Kalathur, Ravi;
- Haferlach, Claudia;
- Kern, Wolfgang;
- Paietta, Elisabeth;
- Babu, M. Madan
Publication type:
Article
Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds.
Published in:
Molecular Carcinogenesis, 2007, v. 46, n. 6, p. 453, doi. 10.1002/mc.20294
By:
- Feith, David J.;
- Shantz, Lisa M.;
- Shoop, Paula L.;
- Keefer, Kerry A.;
- Prakashagowda, Chethana;
- Pegg, Anthony E.
Publication type:
Article
The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification.
Published in:
International Journal of Cancer, 2010, v. 126, n. 9, p. 2012, doi. 10.1002/ijc.25074
By:
- Geerts, Dirk;
- Koster, Jan;
- Albert, David;
- Koomoa, Dana-Lynn T.;
- Feith, David J.;
- Pegg, Anthony E.;
- Volckmann, Richard;
- Caron, Huib;
- Versteeg, Rogier;
- Bachmann, André S.
Publication type:
Article
Retrovirus insertion site analysis of LGL leukemia patient genomes.
Published in:
BMC Medical Genomics, 2019, v. 12, n. 1, p. N.PAG, doi. 10.1186/s12920-019-0549-9
By:
- Li, Weiling;
- Yang, Lei;
- Harris, Robert S.;
- Lin, Lin;
- Olson, Thomas L.;
- Hamele, Cait E.;
- Feith, David J.;
- Loughran, Thomas P.;
- Poss, Mary
Publication type:
Article
Advances in the Diagnosis and Treatment of Large Granular Lymphocytic Leukemia.
Published in:
Current Hematologic Malignancy Reports, 2020, v. 15, n. 2, p. 103, doi. 10.1007/s11899-020-00565-6
By:
- Cheon, HeeJin;
- Dziewulska, Karolina H.;
- Moosic, Katharine B.;
- Olson, Kristine C.;
- Gru, Alejandro A.;
- Feith, David J.;
- Loughran, Thomas P.
Publication type:
Article
Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid Arthritis.
Published in:
Frontiers in Oncology, 2022, v. 12, p. 1, doi. 10.3389/fonc.2022.869205
By:
- Moosic, Katharine B.;
- Ananth, Kusuma;
- Andrade, Felipe;
- Feith, David J.;
- Darrah, Erika;
- Loughran Jr, Thomas P.
Publication type:
Article
The Drug Transporter P-Glycoprotein and Its Impact on Ceramide Metabolism—An Unconventional Ally in Cancer Treatment.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 18, p. 9825, doi. 10.3390/ijms25189825
By:
- Ung, Johnson;
- Kassai, Miki;
- Tan, Su-Fern;
- Loughran Jr., Thomas P.;
- Feith, David J.;
- Cabot, Myles C.
Publication type:
Article
LGL leukemia patients exhibit substantial protective humoral responses following SARS‐CoV‐2 vaccination.
Published in:
EJHaem, 2022, v. 3, n. 3, p. 919, doi. 10.1002/jha2.472
By:
- Cheon, Heejin;
- Elghawy, Omar;
- Shemo, Bryna C.;
- Feith, David J.;
- Loughran, Thomas P.
Publication type:
Article
The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia.
Published in:
Frontiers in Oncology, 2020, p. 1, doi. 10.3389/fonc.2020.00393
By:
- Annageldiyev, Charyguly;
- Tan, Su-Fern;
- Thakur, Shreya;
- Dhanyamraju, Pavan Kumar;
- Ramisetti, Srinivasa R.;
- Bhadauria, Preeti;
- Schick, Jacob;
- Zeng, Zheng;
- Sharma, Varun;
- Dunton, Wendy;
- Dovat, Sinisa;
- Desai, Dhimant;
- Zheng, Hong;
- Feith, David J.;
- Loughran, Thomas P.;
- Amin, Shantu;
- Sharma, Arun K.;
- Claxton, David;
- Sharma, Arati
Publication type:
Article
Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia.
Published in:
PLoS ONE, 2018, v. 13, n. 2, p. 1, doi. 10.1371/journal.pone.0193429
By:
- Kulling, Paige M.;
- Olson, Kristine C.;
- Hamele, Cait E.;
- Toro, Mariella F.;
- Tan, Su-Fern;
- Feith, David J.;
- Jr.Loughran, Thomas P.
Publication type:
Article

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