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Alzheimer's disease‐associated post‐translational modifications of tau influence tau propagation.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.080107
By:
- Dickson, John R;
- Fernandes, Analiese R;
- Sobolewski, Robert;
- Fan, Zhanyun;
- Hyman, Bradley T.
Publication type:
Article
GFAP Upregulation by Astrocytes May Attenuate Phospho‐Tau Levels in a Tauopathy Mouse Model.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.078310
By:
- Muñoz‐Castro, Clara;
- Healey, Molly A.;
- Jaisa‐Aad, Methasit;
- Jayakumar, Rojashree;
- Alla, Srinija;
- Kashlan, Zane D.;
- Noori, Ayush;
- Fan, Zhanyun;
- Calvo‐Rodriguez, Maria;
- Das, Sudeshna;
- Hudry, Eloise;
- Hyman, Bradley T.;
- Serrano‐Pozo, Alberto
Publication type:
Article
Investigating the binding of high molecular weight tau to LRP1.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 4, p. 1, doi. 10.1002/alz.069020
By:
- Cooper, Joanna M;
- Lathuiliere, Aurelien;
- Dickson, John;
- Glynn, Calina;
- Fan, Zhanyun;
- Donahue, Cameron;
- Migliorini, Mary;
- Hyman, Bradley T.;
- Strickland, Dudley K
Publication type:
Article
Optimization of biosensor cell lines for the detection of tau seeding competency in human CSF.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.052474
By:
- Lathuiliere, Aurelien;
- Jo, Youhwa;
- Fan, Zhanyun;
- Hyman, Bradley T.
Publication type:
Article
A unique high-molecular-weight tau species is involved in propagation and accumulates in the cerebrospinal fluid of Alzheimer’s disease patients.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P644, doi. 10.1016/j.jalz.2015.06.938
By:
- Takeda, Shuko;
- Commins, Caitlin;
- Wegmann, Susanne;
- Roe, Allyson D.;
- Fan, Zhanyun;
- DeVos, Sarah L.;
- Costantino, Isabel;
- Trisini Lipsanopoulos, Ana;
- Frosch, Matthew P.;
- Hyman, Bradley T.
Publication type:
Article
Lack of endogenous tau permits tau spreading and protects against tau toxicity in transgenic mice.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P186, doi. 10.1016/j.jalz.2015.07.159
By:
- Wegmann, Susanne;
- Maury, Eduardo A.;
- Kirk, Molly J.;
- Saqran, Lubna;
- Roe, Allyson D.;
- Fan, Zhanyun;
- Nicholls, Samantha B.;
- DeVos, Sarah L.;
- Takeda, Shuko;
- William, Christopher M.;
- Spires-Jones, Tara L.;
- Pitstick, Rose;
- Carlson, George A.;
- Pooler, Amy;
- Hyman, Bradley T.
Publication type:
Article
Direct Visualization of CHIP-Mediated Degradation of Alpha-Synuclein <i>In Vivo</i>: Implications for PD Therapeutics.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0092098
By:
- Dimant, Hemi;
- Zhu, Liya;
- Kibuuka, Laura N.;
- Fan, Zhanyun;
- Hyman, Bradley T.;
- McLean, Pamela J.
Publication type:
Article
Chronic Treatment with Novel Small Molecule Hsp90 Inhibitors Rescues Striatal Dopamine Levels but Not α-Synuclein-Induced Neuronal Cell Loss.
Published in:
PLoS ONE, 2014, v. 9, n. 1, p. 1, doi. 10.1371/journal.pone.0086048
By:
- McFarland, Nikolaus R.;
- Dimant, Hemi;
- Kibuuka, Laura;
- Ebrahimi-Fakhari, Darius;
- Desjardins, Cody A.;
- Danzer, Karin M.;
- Danzer, Michael;
- Fan, Zhanyun;
- Schwarzschild, Michael A.;
- Hirst, Warren;
- McLean, Pamela J.
Publication type:
Article
Allosteric Modulation of PS1/γ-Secretase Conformation Correlates with Amyloid β<sub>42/40</sub> Ratio.
Published in:
PLoS ONE, 2009, v. 4, n. 11, p. e7893, doi. 10.1371/journal.pone.0007893
By:
- Uemura, Kengo;
- Lill, Christina M.;
- Li, Xuejing;
- Peters, Jessica A.;
- Ivanov, Alexander;
- Fan, Zhanyun;
- DeStrooper, Bart;
- Bacskai, Brian J.;
- Hyman, Bradley T.;
- Berezovska, Oksana
Publication type:
Article
Amyloid β Induces the Morphological Neurodegenerative Triad of Spine Loss, Dendritic Simplification, and Neuritic Dystrophies through Calcineurin Activation.
Published in:
Journal of Neuroscience, 2010, v. 30, n. 7, p. 2636, doi. 10.1523/JNEUROSCI.4456-09.2010
By:
- Hai-Yan Wu;
- Hudry, Eloise;
- Hashimoto, Tadafumi;
- Kuchibhotla, Kishore;
- Rozkalne, Anete;
- Zhanyun Fan;
- Spires-Jones, Tara;
- Hong Xie;
- Arbel-Ornath, Michal;
- Grosskreutz, Cynthia L.;
- Bacskai, Brian J.;
- Hyman, Bradley T.
Publication type:
Article
Tau protein liquid–liquid phase separation can initiate tau aggregation.
Published in:
EMBO Journal, 2018, v. 37, n. 7, p. 1, doi. 10.15252/embj.201798049
By:
- Wegmann, Susanne;
- Eftekharzadeh, Bahareh;
- Tepper, Katharina;
- Zoltowska, Katarzyna M.;
- Bennett, Rachel E.;
- Dujardin, Simon;
- Laskowski, Pawel R.;
- MacKenzie, Danny;
- Kamath, Tarun;
- Commins, Caitlin;
- Vanderburg, Charles;
- Roe, Allyson D.;
- Fan, Zhanyun;
- Molliex, Amandine M.;
- Hernandez‐Vega, Amayra;
- Muller, Daniel;
- Hyman, Anthony A.;
- Mandelkow, Eckhard;
- Taylor, J. Paul;
- Hyman, Bradley T.
Publication type:
Article
Removing endogenous tau does not prevent tau propagation yet reduces its neurotoxicity.
Published in:
EMBO Journal, 2015, v. 34, n. 24, p. 3028, doi. 10.15252/embj.201592748
By:
- Wegmann, Susanne;
- Maury, Eduardo A;
- Kirk, Molly J;
- Saqran, Lubna;
- Roe, Allyson;
- DeVos, Sarah L;
- Nicholls, Samantha;
- Fan, Zhanyun;
- Takeda, Shuko;
- Cagsal‐Getkin, Ozge;
- William, Christopher M;
- Spires‐Jones, Tara L;
- Pitstick, Rose;
- Carlson, George A;
- Pooler, Amy M;
- Hyman, Bradley T
Publication type:
Article
Specific in vitro association between the hepatitis C viral genome and core protein.
Published in:
Journal of Medical Virology, 1999, v. 59, n. 2, p. 131, doi. 10.1002/(SICI)1096-9071(199910)59:2<131::AID-JMV1>3.0.CO;2-C
By:
- Fan, Zhanyun;
- Yang, Qi Rui;
- Twu, Jr-Shin;
- Sherker, Averell H.
Publication type:
Article
Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients.
Published in:
2016
By:
- Takeda, Shuko;
- Commins, Caitlin;
- DeVos, Sarah L.;
- Nobuhara, Chloe K.;
- Wegmann, Susanne;
- Roe, Allyson D.;
- Costantino, Isabel;
- Fan, Zhanyun;
- Nicholls, Samantha B.;
- Sherman, Alexis E.;
- Trisini Lipsanopoulos, Ana T.;
- Scherzer, Clemens R.;
- Carlson, George A.;
- Pitstick, Rose;
- Peskind, Elaine R.;
- Raskind, Murray A.;
- Li, Ge;
- Montine, Thomas J.;
- Frosch, Matthew P.;
- Hyman, Bradley T.
Publication type:
journal article
Formation, release, and internalization of stable tau oligomers in cells.
Published in:
Journal of Neurochemistry, 2016, v. 139, n. 6, p. 1163, doi. 10.1111/jnc.13866
By:
- Wegmann, Susanne;
- Nicholls, Samantha;
- Takeda, Shuko;
- Fan, Zhanyun;
- Hyman, Bradley T.
Publication type:
Article
Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport.
Published in:
Journal of Neurochemistry, 2009, v. 111, n. 2, p. 417, doi. 10.1111/j.1471-4159.2009.06316.x
By:
- Stoothoff, Will;
- Jones, Phillip B.;
- Spires-Jones, Tara L.;
- Joyner, Daniel;
- Chhabra, Ekta;
- Bercury, Kathryn;
- Fan, Zhanyun;
- Xie, Hong;
- Bacskai, Brian;
- Edd, Jon;
- Irimia, Daniel;
- Hyman, Bradley T.
Publication type:
Article
Real-time imaging of mitochondrial redox reveals increased mitochondrial oxidative stress associated with amyloid β aggregates in vivo in a mouse model of Alzheimer's disease.
Published in:
Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-024-00702-2
By:
- Calvo-Rodriguez, Maria;
- Kharitonova, Elizabeth K.;
- Snyder, Austin C.;
- Hou, Steven S.;
- Sanchez-Mico, Maria Virtudes;
- Das, Sudeshna;
- Fan, Zhanyun;
- Shirani, Hamid;
- Nilsson, K. Peter R.;
- Serrano-Pozo, Alberto;
- Bacskai, Brian J.
Publication type:
Article
Specific detection of tau seeding activity in Alzheimer's disease using rationally designed biosensor cells.
Published in:
Molecular Neurodegeneration, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13024-023-00643-2
By:
- Lathuiliere, Aurelien;
- Jo, Youhwa;
- Perbet, Romain;
- Donahue, Cameron;
- Commins, Caitlin;
- Quittot, Noé;
- Fan, Zhanyun;
- Bennett, Rachel E.;
- Hyman, Bradley T.
Publication type:
Article
Increased mitochondrial calcium levels associated with neuronal death in a mouse model of Alzheimer's disease.
Published in:
Nature Communications, 2020, v. 11, n. 1, p. 1, doi. 10.1038/s41467-020-16074-2
By:
- Calvo-Rodriguez, Maria;
- Hou, Steven S.;
- Snyder, Austin C.;
- Kharitonova, Elizabeth K.;
- Russ, Alyssa N.;
- Das, Sudeshna;
- Fan, Zhanyun;
- Muzikansky, Alona;
- Garcia-Alloza, Monica;
- Serrano-Pozo, Alberto;
- Hudry, Eloise;
- Bacskai, Brian J.
Publication type:
Article
Characterization of TauC3 antibody and demonstration of its potential to block tau propagation.
Published in:
PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0177914
By:
- Nicholls, Samantha B.;
- DeVos, Sarah L.;
- Commins, Caitlin;
- Nobuhara, Chloe;
- Bennett, Rachel E.;
- Corjuc, Diana L.;
- Maury, Eduardo;
- Eftekharzadeh, Bahareh;
- Akingbade, Ololade;
- Fan, Zhanyun;
- Roe, Allyson D.;
- Takeda, Shuko;
- Wegmann, Susanne;
- Hyman, Bradley T.
Publication type:
Article
Inhibition of the NFAT Pathway Alleviates Amyloid Beta Neurotoxicity in a Mouse Model of Alzheimer's Disease.
Published in:
Journal of Neuroscience, 2012, v. 32, n. 9, p. 3176, doi. 10.1523/JNEUROSCI.6439-11.2012
By:
- Hudry, Eloise;
- Hai-Yan Wu;
- Arbel-Ornath, Michal;
- Hashimoto, Tadafumi;
- Matsouaka, Roland;
- Fan, Zhanyun;
- Spires-Jones, Tara L.;
- Betensky, Rebecca A.;
- Bacskai, Brian J.;
- Hyman, Bradley T.
Publication type:
Article
Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of α-Synuclein.
Published in:
Journal of Neuroscience, 2011, v. 31, n. 41, p. 14508, doi. 10.1523/JNEUROSCI.1560-11.2011
By:
- Ebrahimi-Fakhari, Darius;
- Cantuti-Castelvetri, Ippolita;
- Fan, Zhanyun;
- Rockenstein, Edward;
- Masliah, Eliezer;
- Hyman, Bradley T.;
- McLean, Pamela J.;
- Unni, Vivek K.
Publication type:
Article

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