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A Novel Calcium-Dependent Kinase Inhibitor, Bumped Kinase Inhibitor 1517, Cures Cryptosporidiosis in Immunosuppressed Mice.
Published in:
2016
By:
- Castellanos-Gonzalez, Alejandro;
- Sparks, Hayley;
- Nava, Samantha;
- Huang, Wenlin;
- Zhang, Zhongsheng;
- Rivas, Kasey;
- Hulverson, Matthew A.;
- Barrett, Lynn K.;
- Ojo, Kayode K.;
- Erkang Fan;
- Van Voorhis, Wesley C.;
- White Jr, Arthur Clinton;
- Fan, Erkang;
- White, Arthur Clinton Jr
Publication type:
journal article
The crystal structure of the drug target <italic>Mycobacterium tuberculosis</italic> methionyl‐tRNA synthetase in complex with a catalytic intermediate.
Published in:
Acta Crystallographica: Section F, Structural Biology Communications, 2018, v. 74, n. 4, p. 245, doi. 10.1107/S2053230X18003151
By:
- Barros-Álvarez, Ximena;
- Turley, Stewart;
- Ranade, Ranae M.;
- Gillespie, J. Robert;
- Duster, Nicole A.;
- Verlinde, Christophe L. M. J.;
- Fan, Erkang;
- Buckner, Frederick S.;
- Hol, Wim G. J.
Publication type:
Article
Multivalent Drug Design and Inhibition of Cholera Toxin by Specific and Transient Protein–Ligand Interactions.
Published in:
2008
By:
- Jiyun Liu;
- Begley, Darren;
- Mitchell, Daniel D.;
- Verlinde, Christophe L. M. J.;
- Varani, Gabriele;
- Fan, Erkang
Publication type:
Letter
Synthesis of 2-Amino 3-Substituted Quinazolin-4(3H)-one Derivatives via Iodine-Mediated Guanidinylation of Pbf-Activated Thiourea.
Published in:
Journal of Heterocyclic Chemistry, 2013, v. 50, n. 2, p. 304, doi. 10.1002/jhet.1067
By:
- Li, Jizhen;
- Mi, Yuhua;
- He, Jianghua;
- Luo, Xuyang;
- Fan, Erkang
Publication type:
Article
Screening a fragment cocktail library using ultrafiltration.
Published in:
Analytical & Bioanalytical Chemistry, 2011, v. 401, n. 5, p. 1589, doi. 10.1007/s00216-011-5225-7
By:
- Shibata, Sayaka;
- Zhang, Zhongsheng;
- Korotkov, Konstantin;
- Delarosa, Jaclyn;
- Napuli, Alberto;
- Kelley, Angela;
- Mueller, Natasha;
- Ross, Jennifer;
- Zucker, Frank;
- Buckner, Frederick;
- Merritt, Ethan;
- Verlinde, Christophe;
- Voorhis, Wesley;
- Hol, Wim;
- Fan, Erkang
Publication type:
Article
<i>Neospora caninum</i> Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy.
Published in:
PLoS ONE, 2014, v. 9, n. 3, p. 1, doi. 10.1371/journal.pone.0092929
By:
- Ojo, Kayode K.;
- Reid, Molly C.;
- Kallur Siddaramaiah, Latha;
- Müller, Joachim;
- Winzer, Pablo;
- Zhang, Zhongsheng;
- Keyloun, Katelyn R.;
- Vidadala, Rama Subba Rao;
- Merritt, Ethan A.;
- Hol, Wim G. J.;
- Maly, Dustin J.;
- Fan, Erkang;
- Van Voorhis, Wesley C.;
- Hemphill, Andrew
Publication type:
Article
A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation.
Published in:
Journal of Infectious Diseases, 2014, v. 209, n. 2, p. 275, doi. 10.1093/infdis/jit522
By:
- Ojo, Kayode K.;
- Eastman, Richard T.;
- Vidadala, RamaSubbaRao;
- Zhang, Zhongsheng;
- Rivas, Kasey L.;
- Choi, Ryan;
- Lutz, Justin D.;
- Reid, Molly C.;
- Fox, Anna M. W.;
- Hulverson, Matthew A.;
- Kennedy, Mark;
- Isoherranen, Nina;
- Kim, Laura M.;
- Comess, Kenneth M.;
- Kempf, Dale J.;
- Verlinde, Christophe L. M. J.;
- Su, Xin-zhuan;
- Kappe, Stefan H. I.;
- Maly, Dustin J.;
- Fan, Erkang
Publication type:
Article
A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis.
Published in:
Journal of Infectious Diseases, 2013, v. 208, n. 8, p. 1342, doi. 10.1093/infdis/jit327
By:
- Castellanos-Gonzalez, Alejandro;
- White, A. Clinton;
- Ojo, Kayode K.;
- Vidadala, Rama S. R.;
- Zhang, Zhongsheng;
- Reid, Molly C.;
- Fox, Anna M. W.;
- Keyloun, Katelyn R.;
- Rivas, Kasey;
- Irani, Ayesha;
- Dann, Sara M.;
- Fan, Erkang;
- Maly, Dustin J.;
- Van Voorhis, Wesley C.
Publication type:
Article
A Self-Assembling, Hydrogen-Bonded Helix.
Published in:
Angewandte Chemie International Edition, 1993, v. 32, n. 1, p. 119, doi. 10.1002/anie.199301191
By:
- Geib, Steven J.;
- Vicent, Cristina;
- Fan, Erkang;
- Hamilton, Andrew D.
Publication type:
Article
Correction: Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
Published in:
2016
By:
- Ojo, Kayode K.;
- Ranade, Ranae M.;
- Zhang, Zhongsheng;
- Dranow, David M.;
- Myers, Janette B.;
- Choi, Ryan;
- Nakazawa Hewitt, Steve;
- Edwards, Thomas E.;
- Davies, Douglas R.;
- Lorimer, Donald;
- Boyle, Stephen M.;
- Barrett, Lynn K.;
- Buckner, Frederick S.;
- Fan, Erkang;
- Van Voorhis, Wesley C.
Publication type:
Correction Notice
Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis.
Published in:
PLoS ONE, 2016, v. 11, n. 8, p. 1, doi. 10.1371/journal.pone.0160350
By:
- Ojo, Kayode K.;
- Ranade, Ranae M.;
- Zhang, Zhongsheng;
- Dranow, David M.;
- Myers, Janette B.;
- Choi, Ryan;
- Nakazawa Hewitt, Steve;
- Edwards, Thomas E.;
- Davies, Douglas R.;
- Lorimer, Donald;
- Boyle, Stephen M.;
- Barrett, Lynn K.;
- Buckner, Frederick S.;
- Fan, Erkang;
- Van Voorhis, Wesley C.
Publication type:
Article
Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Published in:
PLoS Neglected Tropical Diseases, 2014, v. 8, n. 4, p. 1, doi. 10.1371/journal.pntd.0002775
By:
- Koh, Cho Yeow;
- Kim, Jessica E.;
- Wetzel, Allan B.;
- de van der Schueren, Will J.;
- Shibata, Sayaka;
- Ranade, Ranae M.;
- Liu, Jiyun;
- Zhang, Zhongsheng;
- Gillespie, J. Robert;
- Buckner, Frederick S.;
- Verlinde, Christophe L. M. J.;
- Fan, Erkang;
- Hol, Wim G. J.
Publication type:
Article
Structures of <i>Trypanosoma brucei</i> Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness.
Published in:
PLoS Neglected Tropical Diseases, 2014, v. 8, n. 4, p. 1, doi. 10.1371/journal.pntd.0002775
By:
- Koh, Cho Yeow;
- Kim, Jessica E.;
- Wetzel, Allan B.;
- de van der Schueren, Will J.;
- Shibata, Sayaka;
- Ranade, Ranae M.;
- Liu, Jiyun;
- Zhang, Zhongsheng;
- Gillespie, J. Robert;
- Buckner, Frederick S.;
- Verlinde, Christophe L. M. J.;
- Fan, Erkang;
- Hol, Wim G. J.
Publication type:
Article
Synthesis and Biological Evaluation of 6-Substituted 5-Alkyl-2-(phenylaminocarbonylmethylthio)pyrimidin-4(3 H)-ones as Potent HIV-1 NNRTIs.
Published in:
ChemMedChem, 2011, v. 6, n. 5, p. 826, doi. 10.1002/cmdc.201000555
By:
- Yu, Mingyan;
- Li, Zhenyu;
- Liu, Shuai;
- Fan, Erkang;
- Pannecouque, Christophe;
- De Clercq, Erik;
- Liu, Xinyong
Publication type:
Article
Pharmacokinetics and In Vivo Efficacy of Pyrazolopyrimidine, Pyrrolopyrimidine, and 5-Aminopyrazole-4-Carboxamide Bumped Kinase Inhibitors against Toxoplasmosis.
Published in:
2019
By:
- Hulverson, Matthew A;
- Bruzual, Igor;
- McConnell, Erin V;
- Huang, Wenlin;
- Vidadala, Rama S R;
- Choi, Ryan;
- Arnold, Samuel L M;
- Whitman, Grant R;
- McCloskey, Molly C;
- Barrett, Lynn K;
- Rivas, Kasey L;
- Scheele, Suzanne;
- DeRocher, Amy E;
- Parsons, Marilyn;
- Ojo, Kayode K;
- Maly, Dustin J;
- Fan, Erkang;
- Voorhis, Wesley C Van;
- Doggett, J Stone;
- Van Voorhis, Wesley C
Publication type:
journal article
Necessity of Bumped Kinase Inhibitor Gastrointestinal Exposure in Treating Cryptosporidium Infection.
Published in:
2017
By:
- Arnold, Samuel L. M.;
- Choi, Ryan;
- Hulverson, Matthew A.;
- Schaefer, Deborah A.;
- Vinayak, Sumiti;
- Vidadala, Rama S. R.;
- McCloskey, Molly C.;
- Whitman, Grant R.;
- Huang, Wenlin;
- Barrett, Lynn K.;
- Ojo, Kayode K.;
- Fan, Erkang;
- Maly, Dustin J.;
- Riggs, Michael W.;
- Striepen, Boris;
- Van Voorhis, Wesley C.
Publication type:
journal article
Novel Bumped Kinase Inhibitors Are Safe and Effective Therapeutics in the Calf Clinical Model for Cryptosporidiosis.
Published in:
2016
By:
- Schaefer, Deborah A.;
- Betzer, Dana P.;
- Smith, Kylie D.;
- Millman, Zachary G.;
- Michalski, Hannah C.;
- Menchaca, Sarah E.;
- Zambriski, Jennifer A.;
- Ojo, Kayode K.;
- Hulverson, Matthew A.;
- Arnold, Samuel L. M.;
- Rivas, Kasey L.;
- Vidadala, Rama S. R.;
- Huang, Wenlin;
- Barrett, Lynn K.;
- Maly, Dustin J.;
- Fan, Erkang;
- Van Voorhis, Wesley C.;
- Riggs, Michael W.
Publication type:
journal article
Molecular Targets of the 5-Amido-Carboxamide Bumped Kinase Inhibitor BKI-1748 in Cryptosporidium parvum and HCT-8 Host Cells.
Published in:
International Journal of Molecular Sciences, 2024, v. 25, n. 5, p. 2707, doi. 10.3390/ijms25052707
By:
- Ajiboye, Jubilee;
- Uldry, Anne-Christine;
- Heller, Manfred;
- Naguleswaran, Arunasalam;
- Fan, Erkang;
- Van Voorhis, Wesley C.;
- Hemphill, Andrew;
- Müller, Joachim
Publication type:
Article
Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model.
Published in:
2020
By:
- Michaels, Samantha A;
- Shih, Han-Wei;
- Zhang, Bailin;
- Navaluna, Edelmar D;
- Zhang, Zhongsheng;
- Ranade, Ranae M;
- Gillespie, J Robert;
- Merritt, Ethan A;
- Fan, Erkang;
- Buckner, Frederick S;
- Paredez, Alexander R;
- Ojo, Kayode K
Publication type:
journal article
Structures of glyceraldehyde 3‐phosphate dehydrogenase in Neisseria gonorrhoeae and Chlamydia trachomatis.
Published in:
Protein Science: A Publication of the Protein Society, 2020, v. 29, n. 3, p. 768, doi. 10.1002/pro.3824
By:
- Barrett, Kayleigh F.;
- Dranow, David M.;
- Phan, Isabelle Q.;
- Michaels, Samantha A.;
- Shaheen, Shareef;
- Navaluna, Edelmar D.;
- Craig, Justin K.;
- Tillery, Logan M.;
- Choi, Ryan;
- Edwards, Thomas E.;
- Conrady, Deborah G.;
- Abendroth, Jan;
- Horanyi, Peter S.;
- Lorimer, Donald D.;
- Van Voorhis, Wesley C.;
- Zhang, Zhongsheng;
- Barrett, Lynn K.;
- Subramanian, Sandhya;
- Staker, Bart;
- Fan, Erkang
Publication type:
Article

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