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First-in-human phase I study of JPH203, an L-type amino acid transporter 1 inhibitor, in patients with advanced solid tumors.
- Published in:
- Investigational New Drugs, 2020, v. 38, n. 5, p. 1495, doi. 10.1007/s10637-020-00924-3
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- Publication type:
- Article
Amino acid transporters: molecular structure and physiological roles.
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- Nephrology Dialysis Transplantation, 2000, v. 15, p. 9, doi. 10.1093/ndt/15.suppl_6.9
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- Publication type:
- Article
Interactions of urate transporter URAT1 in human kidney with uricosuric drugs.
- Published in:
- Nephrology, 2011, v. 16, n. 2, p. 156, doi. 10.1111/j.1440-1797.2010.01368.x
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- Publication type:
- Article
L-type amino acid transporter 1 as a potential molecular target in human astrocytic tumors.
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- International Journal of Cancer, 2006, v. 119, n. 3, p. 484, doi. 10.1002/ijc.21866
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- Publication type:
- Article
JPH203, a LAT1 inhibitor, alleviates steroid‐resistant murine airway inflammation mediated by Th17 cells.
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- Allergy, 2023, v. 78, n. 10, p. 2780, doi. 10.1111/all.15798
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- Publication type:
- Article
T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetes.
- Published in:
- 1999
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- Publication type:
- journal article
Mutational and functional analysis of SLC4A4 in a patient with proximal renal tubular acidosis.
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- Pflügers Archiv: European Journal of Physiology, 2004, v. 448, n. 4, p. 438, doi. 10.1007/s00424-004-1278-1
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- Publication type:
- Article
The SLC22 drug transporter family.
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- Pflügers Archiv: European Journal of Physiology, 2004, v. 447, n. 5, p. 666, doi. 10.1007/s00424-003-1089-9
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- Publication type:
- Article
CATs and HATs: the SLC7 family of amino acid transporters.
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- Pflügers Archiv: European Journal of Physiology, 2004, v. 447, n. 5, p. 532, doi. 10.1007/s00424-003-1086-z
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- Publication type:
- Article
Intracellular pH regulatory mechanism in a human renal proximal cell line (HKC-8): evidence for Na<sup>+</sup>/H<sup>+</sup> exchanger, Cl<sup>–</sup>/HCO<sub>3</sub><sup>–</sup> exchanger and Na<sup>+</sup>-HCO<sub>3</sub><sup>–</sup> cotransporter
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- Pflügers Archiv: European Journal of Physiology, 2000, v. 440, n. 5, p. 713, doi. 10.1007/s004240000356
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- Publication type:
- Article
The multispecific organic anion transporter (OAT) family.
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- Pflügers Archiv: European Journal of Physiology, 2000, v. 440, n. 3, p. 337, doi. 10.1007/s004240000297
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- Publication type:
- Article
Molecular identification of a renal urate-anion exchanger that regulates blood urate levels.
- Published in:
- Nature, 2002, v. 417, n. 6887, p. 447, doi. 10.1038/nature742
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- Publication type:
- Article
Roles of Organic Anion Transporters in the Renal Excretion of Perfluorooctanoic Acid.
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- Basic & Clinical Pharmacology & Toxicology, 2008, v. 103, n. 1, p. 1, doi. 10.1111/j.1742-7843.2007.00155.x
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- Publication type:
- Article
Effects of in Utero Exposure to Di(n-butyl) Phthalate for Estrogen Receptors α, β, and Androgen Receptor of Leydig Cell on Rats.
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- Toxicologic Pathology, 2014, v. 42, n. 5, p. 877, doi. 10.1177/0192623313502879
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- Publication type:
- Article
Male Sprague-Dawley Rats Exposed to In Utero Di(n-butyl) Phthalate: Dose Dependent and Age-related Morphological Changes in Leydig Cell Smooth Endoplasmic Reticulum.
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- Toxicologic Pathology, 2013, v. 41, n. 7, p. 984, doi. 10.1177/0192623312474725
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- Publication type:
- Article
Atypical Leydig Cell Hyperplasia in Adult Rats with Low T and High LH Induced by Prenatal Di(n-butyl) Phthalate Exposure.
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- Toxicologic Pathology, 2013, v. 41, n. 3, p. 480, doi. 10.1177/0192623312457272
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- Publication type:
- Article
Transport of <sup>99m</sup>Tc-MAG3 via Rat Renal Organic Anion Transporter 1.
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- Journal of Nuclear Medicine, 2004, v. 45, n. 1, p. 80
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- Publication type:
- Article
Isoform Selectivity of 3-<sup>125</sup>I-Iodo-α-Methyl-LTyrosine Membrane Transport in Human L-Type Amino Acid Transporters.
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- Journal of Nuclear Medicine, 2003, v. 44, n. 2, p. 244
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- Publication type:
- Article
Combination effects of amino acid transporter LAT1 inhibitor nanvuranlat and cytotoxic anticancer drug gemcitabine on pancreatic and biliary tract cancer cells.
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- Cancer Cell International, 2023, v. 23, n. 1, p. 1, doi. 10.1186/s12935-023-02957-z
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- Publication type:
- Article
L-type amino acid transporter 1 (LAT1) is frequently expressed in thymic carcinomas but is absent in thymomas.
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- Journal of Surgical Oncology, 2009, v. 99, n. 7, p. 433, doi. 10.1002/jso.21277
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- Publication type:
- Article
Ultrastructural immunohistochemical study of L-type amino acid transporter 1-4F2 heavy chain in tumor microvasculatures of N-butyl-N- (4-hydroxybutyl) nitrosamine (BBN) induced rat bladder carcinoma.
- Published in:
- Microscopy, 2017, v. 66, n. 3, p. 198, doi. 10.1093/jmicro/dfx008
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- Publication type:
- Article
EFFECT OF CHRONIC K[sup +] DEFICIENCY ON CONTRACTILE PROPERTIES OF SOLEUS MUSCLE IN RATS: EVIDENCE OF SEX DIFFERENCES.
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- Clinical & Experimental Pharmacology & Physiology, 1999, v. 26, n. 4, p. 323, doi. 10.1046/j.1440-1681.1999.03036.x
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- Publication type:
- Article
Human urate transporter 1 (hURAT1) mediates the transport of orotate.
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- Journal of Physiological Sciences, 2011, v. 61, n. 3, p. 253, doi. 10.1007/s12576-011-0136-0
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- Publication type:
- Article
Expression of LAT1 predicts risk of progression of transitional cell carcinoma of the upper urinary tract.
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- Virchows Archiv: European Journal of Pathology, 2007, v. 451, n. 3, p. 681, doi. 10.1007/s00428-007-0457-9
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- Publication type:
- Article
The W258X mutation in SLC22A12 is the predominant cause of Japanese renal hypouricemia.
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- Pediatric Nephrology, 2004, v. 19, n. 7, p. 728, doi. 10.1007/s00467-004-1424-1
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- Publication type:
- Article
Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation.
- Published in:
- Journal of Experimental & Clinical Cancer Research (17569966), 2020, v. 39, n. 1, p. 1, doi. 10.1186/s13046-020-01762-0
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- Publication type:
- Article
Transport of 3-Fluoro-L-α-Methyl-Tyrosine by Tumor-Upregulated L-Type Amino Acid Transporter 1: A Cause of the Tumor Uptake in PET.
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- Journal of Nuclear Medicine, 2012, v. 53, n. 8, p. 1253, doi. 10.2967/jnumed.112.103069
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- Publication type:
- Article
High expression of L-type amino acid transporter 1 as a prognostic marker in bile duct adenocarcinomas.
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- Cancer Medicine, 2014, v. 3, n. 5, p. 1246, doi. 10.1002/cam4.272
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- Publication type:
- Article
High expression of L-type amino-acid transporter 1 (LAT1) in gastric carcinomas: Comparison with non-cancerous lesions.
- Published in:
- Pathology International, 2011, v. 61, n. 5, p. 281, doi. 10.1111/j.1440-1827.2011.02650.x
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- Publication type:
- Article
L-type amino-acid transporter 1 as a novel biomarker for high-grade malignancy in prostate cancer.
- Published in:
- Pathology International, 2009, v. 59, n. 1, p. 7, doi. 10.1111/j.1440-1827.2008.02319.x
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- Publication type:
- Article
Potent human uric acid transporter 1 inhibitors: in vitro and in vivo metabolism and pharmacokinetic studies.
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- Drug Design, Development & Therapy, 2012, v. 6, p. 323, doi. 10.2147/DDDT.S35805
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- Publication type:
- Article
Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities.
- Published in:
- Nature Genetics, 1999, v. 23, n. 3, p. 264, doi. 10.1038/15440
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- Publication type:
- Article
Mutations in Human Urate Transporter 1 Gene in Presecretory Reabsorption Defect Type of Familial Renal Hypouricemia.
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- Journal of Clinical Endocrinology & Metabolism, 2005, v. 90, n. 4, p. 2169, doi. 10.1210/jc.2004-1111
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- Publication type:
- Article
Nuclear Morphometric Analysis of Leydig Cells of Male Pubertal Rats Exposed In Utero to Di(n-butyl) Phthalate.
- Published in:
- Journal of Toxicologic Pathology, 2013, v. 26, n. 4, p. 439, doi. 10.1293/tox.2013-0031
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- Publication type:
- Article
Expression and function of Oat1 and Oat3 in rat kidney exposed to mercuric chloride.
- Published in:
- Archives of Toxicology, 2009, v. 83, n. 10, p. 887, doi. 10.1007/s00204-009-0445-8
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- Publication type:
- Article
Elimination of Organic Anions in Response to an Early Stage of Renal Ischemia-Reperfusion in the Rat: Role of Basolateral Plasma Membrane Transporters and Cortical Renal Blood Flow.
- Published in:
- Pharmacology, 2007, v. 81, n. 2, p. 127, doi. 10.1159/000110555
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- Publication type:
- Article
Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1.
- Published in:
- Cancer & Metabolism, 2022, v. 10, n. 1, p. 1, doi. 10.1186/s40170-022-00295-8
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- Publication type:
- Article
V1a receptor mRNA expression in mouse early proximal tubule (S1) cell line is regulated by protein kinase A.
- Published in:
- IUBMB Life, 1998, v. 44, n. 5, p. 961, doi. 10.1080/15216549800202022
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- Publication type:
- Article
Establishment of a mouse clonal early proximal tubule cell line and outer medullary collecting duct cells expressing P2 purinoceptors.
- Published in:
- IUBMB Life, 1998, v. 44, n. 4, p. 657, doi. 10.1080/15216549800201702
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- Publication type:
- Article
Attenuation of renomedullary phospholipase C isozyme, PLC-δ1, in spontaneously hypertensive rats.
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- IUBMB Life, 1997, v. 43, n. 4, p. 741, doi. 10.1080/15216549700204551
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- Publication type:
- Article
Staurosporine-induced apoptosis of immortalized mouse proximal tubule cells is modulated by bcl-2 expression level.
- Published in:
- IUBMB Life, 1997, v. 42, n. 4, p. 649, doi. 10.1080/15216549700203061
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- Publication type:
- Article
Thromboxane A2 mediates cisplatin-induced apoptosis of renal tubule cells.
- Published in:
- IUBMB Life, 1997, v. 42, n. 1, p. 113, doi. 10.1080/15216549700202491
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- Publication type:
- Article
ATP-induced calcium mobilization in glomerular mesangial cells is mediated by P2U purinoceptor.
- Published in:
- IUBMB Life, 1996, v. 39, n. 6, p. 1193, doi. 10.1080/15216549600201382
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- Publication type:
- Article
Renal urate handling: Clinical relevance of recent advances.
- Published in:
- Current Rheumatology Reports, 2005, v. 7, n. 3, p. 227, doi. 10.1007/s11926-996-0044-0
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- Publication type:
- Article
HOXB9 acts as a negative regulator of activated human T cells in response to amino acid deficiency.
- Published in:
- Immunology & Cell Biology, 2016, v. 94, n. 6, p. 612, doi. 10.1038/icb.2016.13
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- Publication type:
- Article
Treatment effects and predictors of a 24-week course of interferon α-2b plus ribavirin combination therapy for patients with chronic hepatitis C.
- Published in:
- Journal of Gastroenterology & Hepatology, 2006, v. 21, n. 7, p. 1177, doi. 10.1111/j.1440-1746.2006.04311.x
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- Publication type:
- Article
Gene expression profiles in t24 human bladder carcinoma cells by inhibiting an l-type amino acid transporter, lat1.
- Published in:
- Archives of Pharmacal Research, 2007, v. 30, n. 4, p. 444, doi. 10.1007/BF02980218
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- Publication type:
- Article
Reabsorption of neutral amino acids mediated by amino acid transporter LAT2 and TAT1 in the basolateral membrane of proximal tubule.
- Published in:
- Archives of Pharmacal Research, 2005, v. 28, n. 4, p. 421, doi. 10.1007/BF02977671
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- Publication type:
- Article
Altered expression of rat renal cortical OAT1 and OAT3 in response to bilateral ureteral obstruction.
- Published in:
- Kidney International, 2005, v. 68, n. 6, p. 2704, doi. 10.1111/j.1523-1755.2005.00741.x
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- Publication type:
- Article
Disease-causing missense mutations inNPHS2gene alter normal nephrin trafficking to the plasma membrane.
- Published in:
- Kidney International, 2004, v. 66, n. 5, p. 1755, doi. 10.1111/j.1523-1755.2004.00898.x
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- Publication type:
- Article