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Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature.
Published in:
2019
By:
- Bacalini, Maria Giulia;
- Franceschi, Claudio;
- Gentilini, Davide;
- Ravaioli, Francesco;
- Zhou, Xiaoyuan;
- Remondini, Daniel;
- Pirazzini, Chiara;
- Giuliani, Cristina;
- Marasco, Elena;
- Gensous, Noémie;
- Blasio, Anna Maria Di;
- Ellis, Ewa;
- Gramignoli, Roberto;
- Castellani, Gastone;
- Capri, Miriam;
- Strom, Stephen;
- Nardini, Christine;
- Cescon, Matteo;
- Grazi, Gian Luca;
- Garagnani, Paolo
Publication type:
journal article
Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers.
Published in:
European Journal of Immunology, 2017, v. 47, n. 8, p. 1280, doi. 10.1002/eji.201646890
By:
- Forkel, Marianne;
- Berglin, Lena;
- Kekäläinen, Eliisa;
- Carlsson, Adrian;
- Svedin, Emma;
- Michaëlsson, Jakob;
- Nagasawa, Maho;
- Erjefält, Jonas S;
- Mori, Michiko;
- Flodström‐Tullberg, Malin;
- Bergquist, Annika;
- Ljunggren, Hans‐Gustaf;
- Westgren, Magnus;
- Lindforss, Ulrik;
- Friberg, Danielle;
- Jorns, Carl;
- Ellis, Ewa;
- Björkström, Niklas K;
- Mjösberg, Jenny
Publication type:
Article
APOE genotype‐specific lipidomic signatures in primary human hepatocytes.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.076471
By:
- Patra, Kalicharan;
- Almeida, Francisco;
- Giannisis, Andreas;
- Niesnerova, Anezka;
- Nandakumar, Renu;
- Ellis, Ewa;
- Oliveira, Tiago Gil;
- Nielsen, Henrietta M.
Publication type:
Article
Effects of a liver APOEε4‐genotype on synaptic integrity, gliosis and insulin signaling in the brain: Molecular and cell biology/synaptic disruption.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.042463
By:
- Giannisis, Andreas;
- Patra, Kalicharan;
- Edlund, Anna K.;
- Rosa, Andrés De La;
- Nieto, Lur Agirrezabala;
- Gras, Joan Benedicto;
- Moussaud, Simon;
- Bengtsson, Tore;
- Fu, Yuan;
- Bu, Guojun;
- Bial, Greg;
- Foquet, Lander;
- Hammarstedt, Christina;
- Strom, Stephen;
- Kannisto, Kristina;
- Ellis, Ewa;
- Nielsen, Henrietta M.
Publication type:
Article
Gene Editing Correction of a Urea Cycle Defect in Organoid Stem Cell Derived Hepatocyte-like Cells.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 3, p. 1217, doi. 10.3390/ijms22031217
By:
- Zabulica, Mihaela;
- Jakobsson, Tomas;
- Ravaioli, Francesco;
- Vosough, Massoud;
- Gramignoli, Roberto;
- Ellis, Ewa;
- Rooyackers, Olav;
- Strom, Stephen C.;
- Ofir, Rivka
Publication type:
Article
DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome.
Published in:
eLife, 2021, p. 1, doi. 10.7554/eLife.60916
By:
- Hankeova, Simona;
- Salplachta, Jakub;
- Zikmund, Tomas;
- Kavkova, Michaela;
- Van Hul, Noémi;
- Brinek, Adam;
- Smekalova, Veronika;
- Laznovsky, Jakub;
- Dawit, Feven;
- Jaros, Josef;
- Bryja, Vítězslav;
- Lendahl, Urban;
- Ellis, Ewa;
- Nemeth, Antal;
- Fischler, Björn;
- Hannezo, Edouard;
- Kaiser, Jozef;
- Andersson, Emma Rachel
Publication type:
Article
Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-27354-w
By:
- Hildebrandt, Franziska;
- Andersson, Alma;
- Saarenpää, Sami;
- Larsson, Ludvig;
- Van Hul, Noémi;
- Kanatani, Sachie;
- Masek, Jan;
- Ellis, Ewa;
- Barragan, Antonio;
- Mollbrink, Annelie;
- Andersson, Emma R.;
- Lundeberg, Joakim;
- Ankarklev, Johan
Publication type:
Article
Robust expansion of human hepatocytes in Fah−/−/Rag2−/−/Il2rg−/− mice.
Published in:
Nature Biotechnology, 2007, v. 25, n. 8, p. 903, doi. 10.1038/nbt1326
By:
- Azuma, Hisaya;
- Paulk, Nicole;
- Ranade, Aarati;
- Dorrell, Craig;
- Al-Dhalimy, Muhsen;
- Ellis, Ewa;
- Strom, Stephen;
- Kay, Mark A;
- Finegold, Milton;
- Grompe, Markus
Publication type:
Article
CHASING THE CAUSE OF PLASMA APOE DEFICIENCY IN THE LIVERS OF APOEε4 CARRIERS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P975, doi. 10.1016/j.jalz.2017.06.1317
By:
- Moussaud, Simon;
- Brookes, Keeley J.;
- Ellis, Ewa;
- Morgan, Kevin;
- Nielsen, Henrietta M.
Publication type:
Article
Procurement and Evaluation of Hepatocytes for Transplantation From Neonatal Donors After Circulatory Death.
Published in:
Cell Transplantation, 2022, v. 31, p. 1, doi. 10.1177/09636897211069900
By:
- Bluhme, Emil;
- Henckel, Ewa;
- Gramignoli, Roberto;
- Kjellin, Therese;
- Hammarstedt, Christina;
- Nowak, Greg;
- Karadagi, Ahmad;
- Johansson, Helene;
- Jynge, Öystein;
- Söderström, Maria;
- Fischler, Björn;
- Strom, Stephen;
- Ellis, Ewa;
- Hallberg, Boubou;
- Jorns, Carl
Publication type:
Article
Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.
Published in:
Scientific Reports, 2016, p. 25187, doi. 10.1038/srep25187
By:
- Bell, Catherine C.;
- Hendriks, Delilah F. G.;
- Moro, Sabrina M. L.;
- Ellis, Ewa;
- Walsh, Joanne;
- Renblom, Anna;
- Fredriksson Puigvert, Lisa;
- Dankers, Anita C. A.;
- Jacobs, Frank;
- Snoeys, Jan;
- Sison-Young, Rowena L.;
- Jenkins, Rosalind E.;
- Nordling, Åsa;
- Mkrtchian, Souren;
- Park, B. Kevin;
- Kitteringham, Neil R.;
- Goldring, Christopher E. P.;
- Lauschke, Volker M.;
- Ingelman-Sundberg, Magnus
Publication type:
Article
In Situ Characterization of Intrahepatic Non-Parenchymal Cells in PSC Reveals Phenotypic Patterns Associated with Disease Severity.
Published in:
PLoS ONE, 2014, v. 9, n. 8, p. 1, doi. 10.1371/journal.pone.0105375
By:
- Berglin, Lena;
- Bergquist, Annika;
- Johansson, Helene;
- Glaumann, Hans;
- Jorns, Carl;
- Lunemann, Sebastian;
- Wedemeyer, Heiner;
- Ellis, Ewa C.;
- Björkström, Niklas K.
Publication type:
Article
Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism.
Published in:
PLoS ONE, 2013, v. 8, n. 11, p. 1, doi. 10.1371/journal.pone.0078550
By:
- Ellis, Ewa C. S.;
- Nauglers, Scott;
- Parini, Paolo;
- Mörk, Lisa-Mari;
- Jorns, Carl;
- Zemack, Helen;
- Sandblom, Anita Lövgren;
- Björkhem, Ingemar;
- Ericzon, Bo-Göran;
- Wilson, Elizabeth M.;
- Strom, Stephen C.;
- Grompe, Markus
Publication type:
Article
Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency.
Published in:
Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-64017-0
By:
- Karadagi, Ahmad;
- Cavedon, Alex G.;
- Zemack, Helen;
- Nowak, Greg;
- Eybye, Marianne E.;
- Zhu, Xuling;
- Guadagnin, Eleonora;
- White, Rebecca A.;
- Rice, Lisa M.;
- Frassetto, Andrea L.;
- Strom, Stephen;
- Jorns, Carl;
- Martini, Paolo G. V.;
- Ellis, Ewa
Publication type:
Article
Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes.
Published in:
Frontiers in Endocrinology, 2021, v. 11, p. N.PAG, doi. 10.3389/fendo.2020.554922
By:
- Johansson, Helene;
- Søndergaard, Jonas Nørskov;
- Jorns, Carl;
- Kutter, Claudia;
- Ellis, Ewa C. S.
Publication type:
Article
Liver X receptor agonist downregulates growth hormone signaling in the liver.
Published in:
Hormone Molecular Biology & Clinical Investigation, 2011, v. 8, n. 2, p. 471, doi. 10.1515/HMBCI.2011.125
By:
- Zadjali, Fahad;
- Santana-Farre, Ruyman;
- Mirecki-Garrido, Mercedes;
- Ellis, Ewa;
- Norstedt, Gunnar;
- Fernandez-Perez, Leandro;
- Flores-Morales, Amilcar
Publication type:
Article
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance.
Published in:
Science Translational Medicine, 2020, v. 12, n. 532, p. 1, doi. 10.1126/scitranslmed.aaw9709
By:
- Azzimato, Valerio;
- Jager, Jennifer;
- Chen, Ping;
- Morgantini, Cecilia;
- Levi, Laura;
- Barreby, Emelie;
- Sulen, André;
- Oses, Carolina;
- Willerbrords, Joost;
- Xu, Connie;
- Li, Xidan;
- Shen, Joanne X.;
- Akbar, Naveed;
- Haag, Lars;
- Ellis, Ewa;
- Wålhen, Kerstin;
- Näslund, Erik;
- Thorell, Anders;
- Choudhury, Robin P.;
- Lauschke, Volker M.
Publication type:
Article
Acetaminophen induces a reversible switch from rough to smooth endoplasmatic reticulum and leads to glycogen degradation in human hepatocytes.
Published in:
FASEB Journal, 2007, v. 21, n. 5, p. A189, doi. 10.1096/fasebj.21.5.a189
By:
- Ullrich, Anett;
- Stolz, Donna Beer;
- Ellis, Ewa C.;
- Strom, Stephen C.;
- Michalopoulos, George K.;
- Berg, Christine;
- Hengstler, Jan G.;
- Runge, Dieter
Publication type:
Article
A liver‐humanized mouse model of carbamoyl phosphate synthetase 1‐deficiency.
Published in:
Journal of Inherited Metabolic Disease, 2019, v. 42, n. 6, p. 1054, doi. 10.1002/jimd.12067
By:
- Srinivasan, Raghuraman C.;
- Zabulica, Mihaela;
- Hammarstedt, Christina;
- Wu, Tingting;
- Gramignoli, Roberto;
- Kannisto, Kristina;
- Ellis, Ewa;
- Karadagi, Ahmad;
- Fingerhut, Ralph;
- Allegri, Gabriella;
- Rüfenacht, Véronique;
- Thöny, Beat;
- Häberle, Johannes;
- Nuoffer, Jean‐Marc;
- Strom, Stephen C.
Publication type:
Article
Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins.
Published in:
PLoS ONE, 2016, v. 11, n. 9, p. 1, doi. 10.1371/journal.pone.0161383
By:
- Watanabe, Masaaki;
- Zemack, Helen;
- Johansson, Helene;
- Hagbard, Louise;
- Jorns, Carl;
- Li, Meng;
- Ellis, Ewa
Publication type:
Article
Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.
Published in:
Archives of Toxicology, 2019, v. 93, n. 2, p. 385, doi. 10.1007/s00204-018-2354-1
By:
- Copple, Ian M.;
- den Hollander, Wouter;
- Callegaro, Giulia;
- Mutter, Fiona E.;
- Maggs, James L.;
- Schofield, Amy L.;
- Rainbow, Lucille;
- Fang, Yongxiang;
- Sutherland, Jeffrey J.;
- Ellis, Ewa C.;
- Ingelman-Sundberg, Magnus;
- Fenwick, Stephen W.;
- Goldring, Christopher E.;
- van de Water, Bob;
- Stevens, James L.;
- Park, B. Kevin
Publication type:
Article
Hepatocyte Transplantation Improves Phenotype and Extends Survival in a Murine Model of Intermediate Maple Syrup Urine Disease.
Published in:
Molecular Therapy, 2009, v. 17, n. 7, p. 1266, doi. 10.1038/mt.2009.99
By:
- Skvorak, Kristen J.;
- Paul, Harbhajan S.;
- Dorko, Kenneth;
- Marongiu, Fabio;
- Ellis, Ewa;
- Chace, Donald;
- Ferguson, Carolyn;
- Gibson, K. Michael;
- Homanics, Gregg E.;
- Strom, Stephen C.
Publication type:
Article
Increased Prevalence of Alpha-1-Antitrypsin Deficiency in Patients with Biliary Tract Cancer and Its Associated Clinicopathological Features.
Published in:
Cells (2073-4409), 2023, v. 12, n. 12, p. 1663, doi. 10.3390/cells12121663
By:
- Cornillet, Martin;
- Zemack, Helen;
- Jansson, Hannes;
- Sparrelid, Ernesto;
- Ellis, Ewa;
- Björkström, Niklas K.
Publication type:
Article
Serial Assessment of Growth Factors Associated with Liver Regeneration in Patients Operated with Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy.
Published in:
European Surgical Research, 2018, v. 59, n. 1/2, p. 72, doi. 10.1159/000488078
By:
- Sparrelid, Ernesto;
- Johansson, Helene;
- Gilg, Stefan;
- Nowak, Greg;
- Ellis, Ewa;
- Isaksson, Bengt
Publication type:
Article
Impaired postprandial fibroblast growth factor (FGF)-19 response in patients with stage 5 chronic kidney diseases is ameliorated following antioxidative therapy.
Published in:
Nephrology Dialysis Transplantation, 2013, v. 28, n. suppl_4, p. iv212
By:
- Li, Meng;
- Qureshi, Abdul Rashid;
- Ellis, Ewa;
- Axelsson, Jonas
Publication type:
Article
A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells.
Published in:
Science Translational Medicine, 2021, v. 13, n. 599, p. 1, doi. 10.1126/scitranslmed.abb3107
By:
- Zimmer, Christine L.;
- von Seth, Erik;
- Buggert, Marcus;
- Strauss, Otto;
- Hertwig, Laura;
- Nguyen, Son;
- Wong, Alicia Y. W.;
- Zotter, Chiara;
- Berglin, Lena;
- Michaëlsson, Jakob;
- Hansson, Marcus Reuterwall;
- Arnelo, Urban;
- Sparrelid, Ernesto;
- Ellis, Ewa C. S.;
- Söderholm, Johan D.;
- Keita, Åsa V.;
- Holm, Kristian;
- Özenci, Volkan;
- Hov, Johannes R.;
- Mold, Jeff E.
Publication type:
Article
Potency of Individual Bile Acids to Regulate Bile Acid Synthesis and Transport Genes in Primary Human Hepatocyte Cultures.
Published in:
Toxicological Sciences, 2014, v. 141, n. 2, p. 538, doi. 10.1093/toxsci/kfu151
By:
- Liu, Jie;
- Lu, Hong;
- Lu, Yuan-Fu;
- Lei, Xiaohong;
- Cui, Julia Yue;
- Ellis, Ewa;
- Strom, Stephen C.;
- Klaassen, Curtis D.
Publication type:
Article
Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver.
Published in:
Nutrients, 2020, v. 12, n. 2, p. 277, doi. 10.3390/nu12020277
By:
- Gensous, Noémie;
- Ravaioli, Francesco;
- Pirazzini, Chiara;
- Gramignoli, Roberto;
- Ellis, Ewa;
- Storci, Gianluca;
- Capri, Miriam;
- Strom, Stephen;
- Laconi, Ezio;
- Franceschi, Claudio;
- Garagnani, Paolo;
- Marongiu, Fabio;
- Bacalini, Maria Giulia
Publication type:
Article
Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression.
Published in:
PLoS ONE, 2017, v. 12, n. 5, p. 1, doi. 10.1371/journal.pone.0177279
By:
- Karadagi, Ahmad;
- Johansson, Helene;
- Zemack, Helen;
- Salipalli, Sandeep;
- Mörk, Lisa-Mari;
- Kannisto, Kristina;
- Jorns, Carl;
- Gramignoli, Roberto;
- Strom, Stephen;
- Stokkeland, Knut;
- Ericzon, Bo-Göran;
- Jonigk, Danny;
- Janciauskiene, Sabina;
- Nowak, Greg;
- Ellis, Ewa C. S.
Publication type:
Article

Found: 29

Molecular Aging of Human Liver: An Epigenetic/Transcriptomic Signature.

Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers.

APOE genotype‐specific lipidomic signatures in primary human hepatocytes.

Effects of a liver APOEε4‐genotype on synaptic integrity, gliosis and insulin signaling in the brain: Molecular and cell biology/synaptic disruption.

Gene Editing Correction of a Urea Cycle Defect in Organoid Stem Cell Derived Hepatocyte-like Cells.

DUCT reveals architectural mechanisms contributing to bile duct recovery in a mouse model for Alagille syndrome.

Spatial Transcriptomics to define transcriptional patterns of zonation and structural components in the mouse liver.

Robust expansion of human hepatocytes in Fah<sup>−/−</sup>/Rag2<sup>−/−</sup>/Il2rg<sup>−/−</sup> mice.

CHASING THE CAUSE OF PLASMA APOE DEFICIENCY IN THE LIVERS OF APOEε4 CARRIERS.

Procurement and Evaluation of Hepatocytes for Transplantation From Neonatal Donors After Circulatory Death.

Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease.

<i>In Situ</i> Characterization of Intrahepatic Non-Parenchymal Cells in PSC Reveals Phenotypic Patterns Associated with Disease Severity.

Mice with Chimeric Livers Are an Improved Model for Human Lipoprotein Metabolism.

Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiency.

Chenodeoxycholic Acid Modulates Bile Acid Synthesis Independent of Fibroblast Growth Factor 19 in Primary Human Hepatocytes.

Liver X receptor agonist downregulates growth hormone signaling in the liver.

Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance.

Acetaminophen induces a reversible switch from rough to smooth endoplasmatic reticulum and leads to glycogen degradation in human hepatocytes.

A liver‐humanized mouse model of carbamoyl phosphate synthetase 1‐deficiency.

Maintenance of Hepatic Functions in Primary Human Hepatocytes Cultured on Xeno-Free and Chemical Defined Human Recombinant Laminins.

Characterisation of the NRF2 transcriptional network and its response to chemical insult in primary human hepatocytes: implications for prediction of drug-induced liver injury.

Hepatocyte Transplantation Improves Phenotype and Extends Survival in a Murine Model of Intermediate Maple Syrup Urine Disease.

Increased Prevalence of Alpha-1-Antitrypsin Deficiency in Patients with Biliary Tract Cancer and Its Associated Clinicopathological Features.

Serial Assessment of Growth Factors Associated with Liver Regeneration in Patients Operated with Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy.

Impaired postprandial fibroblast growth factor (FGF)-19 response in patients with stage 5 chronic kidney diseases is ameliorated following antioxidative therapy.

A biliary immune landscape map of primary sclerosing cholangitis reveals a dominant network of neutrophils and tissue-resident T cells.

Potency of Individual Bile Acids to Regulate Bile Acid Synthesis and Transport Genes in Primary Human Hepatocyte Cultures.

Aging and Caloric Restriction Modulate the DNA Methylation Profile of the Ribosomal RNA Locus in Human and Rat Liver.

Exogenous alpha 1-antitrypsin down-regulates SERPINA1 expression.