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Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.
- Published in:
- 2005
- By:
- Publication type:
- journal article
Targeting protein kinases in central nervous system disorders.
- Published in:
- 2009
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- Publication type:
- journal article
Prediction of Preclinical Alzheimer's Disease: Longitudinal Rates of Change in Cognition.
- Published in:
- Journal of Alzheimer's Disease, 2011, v. 25, n. 4, p. 707, doi. 10.3233/JAD-2011-102133
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- Publication type:
- Article
'End-Stage' Neurofibrillary Tangle Pathology in Preclinical Alzheimer's Disease: Fact or Fiction?
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- Journal of Alzheimer's Disease, 2011, v. 25, n. 3, p. 445, doi. 10.3233/JAD-2011-101980
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- Publication type:
- Article
"End-stage" neurofibrillary tangle pathology in preclinical Alzheimer's disease: fact or fiction?
- Published in:
- 2011
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- Publication type:
- journal article
First‐in‐Human Studies of MW01‐6‐189WH, a Brain‐Penetrant, Antineuroinflammatory Small‐Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.
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- Clinical Pharmacology in Drug Development, 2021, v. 10, n. 2, p. 131, doi. 10.1002/cpdd.795
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- Publication type:
- Article
Calmodulin and calbindin localization in retina from six vertebrate species.
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- Journal of Comparative Neurology, 1991, v. 314, n. 4, p. 750, doi. 10.1002/cne.903140408
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- Publication type:
- Article
Early loss of astrocyte p38alpha MAPK has sexually dimorphic impacts on measures of neuronal excitability and cytokines in aged mice.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.083104
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- Publication type:
- Article
Plasma TDP‐43 Levels are Associated with Neuroimaging Measures of Temporal Lobe Structure.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074948
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- Publication type:
- Article
Behavioral symptoms of Alzheimer's disease and autism spectrum disorder: Insights to guide future non‐pharmacological interventions.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.077069
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- Publication type:
- Article
Early loss of microglial p38α MAPK in the APPswe/PS1dE9 mouse model of Alzheimer's disease alters soluble amyloid beta and reduces microglia co‐localization with amyloid plaques without affecting amyloid‐associated pathology.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.073093
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- Publication type:
- Article
Plasma TDP‐43 Levels are Associated with Neuroimaging Measures of Temporal Lobe Structure.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, n. 10, p. 1, doi. 10.1002/alz.081665
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- Publication type:
- Article
Comorbid Pathology in Clinical Trial Participants: Autopsy Findings and Clinical Features.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 10, p. 1, doi. 10.1002/alz.066347
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- Publication type:
- Article
Discrete white matter hyperintensity (WMH) growth quantification is superior to measurements of total longitudinal WMH volume change: implications for clinical trials in VCID.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2022, v. 18, n. 5, p. 1, doi. 10.1002/alz.064505
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- Publication type:
- Article
Delivering probes and clinical candidates to test precision medicine therapeutic hypotheses.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.055264
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- Publication type:
- Article
Preclinical amyloid‐PET SUVr in the precuneus and posterior cingulate associations with MoCA scores are driven by language domain subscores.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.053223
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- Publication type:
- Article
Executive dysfunction is the earliest sign of preclinical Alzheimer's disease detected by regional Ab‐PET SUVr in the precuneus and posterior cingulate cortex.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2021, v. 17, p. 1, doi. 10.1002/alz.052713
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- Publication type:
- Article
Knockout of microglial P38A mapk in a mouse model of Alzheimer's disease: Molecular and cell biology/neuroinflammation.
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.044932
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- Publication type:
- Article
First‐in‐human studies of MW01‐6‐189WH, a brain‐penetrant, anti‐neuroinflammatory, small molecule drug candidate: Phase 1 safety, tolerability, pharmacokinetic, and pharmacodynamic studies in healthy adult volunteers: Human/Human trials: Inflammation
- Published in:
- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2020, v. 16, n. 11, p. 1, doi. 10.1002/alz.041208
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- Publication type:
- Article
P2‐175: TARGETING NEUROINFLAMMATION IN THE CONTEXT OF ALZHEIMER'S DISEASE WITH COMORBID VASCULAR PATHOLOGY.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P735, doi. 10.1016/j.jalz.2018.06.862
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- Publication type:
- Article
Glial Activation Links Early-Life Seizures and Long-Term Neurologic Dysfunction: Evidence Using a Small Molecule Inhibitor of Proinflammatory Cytokine Upregulation.
- Published in:
- Epilepsia (Series 4), 2007, v. 48, n. 9, p. 1785, doi. 10.1111/j.1528-1167.2007.01135.x
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- Publication type:
- Article
Antisense Approaches to the Function of Glial Cell Proteins.
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- Annals of the New York Academy of Sciences, 1992, v. 660, n. 1, p. 219, doi. 10.1111/j.1749-6632.1992.tb21074.x
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- Publication type:
- Article
Human amyloid β‐induced neuroinflammation is an early event in neurodegeneration.
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- Glia, 2006, v. 53, n. 5, p. 484, doi. 10.1002/glia.20306
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- Publication type:
- Article
Enhanced susceptibility of S-100B transgenic mice to neuroinflammation and neuronal dysfunction induced by intracerebroventricular infusion of human -amyloid.
- Published in:
- Glia, 2005, v. 51, n. 3, p. 209, doi. 10.1002/glia.20194
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- Publication type:
- Article
Activated glia induce neuron death via MAP kinase signaling pathways involving JNK and p38.
- Published in:
- Glia, 2004, v. 45, n. 2, p. 170, doi. 10.1002/glia.10314
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- Publication type:
- Article
The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS.
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- Aging & Disease, 2010, v. 1, n. 3, p. 199
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- Publication type:
- Article
Early chronic suppression of microglial p38α in a model of Alzheimer's disease does not significantly alter amyloid-associated neuropathology.
- Published in:
- PLoS ONE, 2023, v. 17, n. 5, p. 1, doi. 10.1371/journal.pone.0286495
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- Publication type:
- Article
A PLATFORM FOR NOVEL IN VIVO MOLECULAR PROBES FOR ATTENUATION OF SYNAPTIC DYSFUNCTION AND PROINFLAMMATORY CYTOKINE OVERPRODUCTION.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P951, doi. 10.1016/j.jalz.2017.06.1265
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- Publication type:
- Article
A SMALL MOLECULE ANTI-NEUROINFLAMMATORY EXPERIMENTAL THERAPEUTIC INHIBITED IL-1BETA LEVELS AFTER TRAUMATIC BRAIN INJURY WITH NO EFFECT ON MICROGLIA PHYSIOLOGICAL RESPONSES.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P661, doi. 10.1016/j.jalz.2016.06.1499
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- Publication type:
- Article
Diabetes, aging, and the brain: A comparative test of brain amylin in diabetics with late-onset Alzheimer's disease versus non-diabetics with late-onset Alzheimer's disease or early-onset Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P511, doi. 10.1016/j.jalz.2015.06.610
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- Publication type:
- Article
An optimized and isoform-selective p38aMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P473, doi. 10.1016/j.jalz.2015.06.519
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- Publication type:
- Article
Self-reported memory complaints: A comparison of demented and unimpaired outcomes.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P383, doi. 10.1016/j.jalz.2015.06.312
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- Publication type:
- Article
Beyond amyloid: Getting real about nonamyloid targets in Alzheimer's disease.
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- Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2013, v. 9, n. 4, p. 452, doi. 10.1016/j.jalz.2013.01.017
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- Publication type:
- Article
Targeting proinflammatory cytokine up-regulation with a novel anti-cytokine therapeutic, MW-151, attenuates pathology in an APP/PS1 knock-in mouse model
- Published in:
- 2012
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- Publication type:
- Abstract
Cytokine Up-Regulation as a Contributor to CNS Pathophysiology
- Published in:
- 2011
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- Publication type:
- Abstract
P3-374: The role of the chemokine MCP-1 in brain inflammation during endotoxemia
- Published in:
- 2008
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- Publication type:
- Abstract
P2-419: Development of novel protein kinase inhibitors as experimental therapeutics for neurodegenerative disorders
- Published in:
- 2008
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- Publication type:
- Abstract
S4-02-06: Integrative approach targeting neuroinflammation
- Published in:
- 2008
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- Publication type:
- Abstract
P-014: Improving the CNS drug discovery process: Case study with an integrative approach yielding novel potential disease-modifying therapies
- Published in:
- 2007
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- Publication type:
- Abstract
P4-428: Glia as a therapeutic target: Selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration
- Published in:
- 2006
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- Publication type:
- Abstract
O4-06-04: Intraneuronal Abeta42 aggregates seed amyloid plaques and cause neuronal loss in transgenic mice with five familial Alzheimer’s disease mutations
- Published in:
- 2006
- By:
- Publication type:
- Abstract
P4-428: Glia as a therapeutic target: Selective suppression of human amyloid-beta-induced upregulation of brain proinflammatory cytokine production attenuates neurodegeneration
- Published in:
- 2006
- By:
- Publication type:
- Abstract
O4-06-04: Intraneuronal Abeta42 aggregates seed amyloid plaques and cause neuronal loss in transgenic mice with five familial Alzheimer’s disease mutations
- Published in:
- 2006
- By:
- Publication type:
- Abstract
Development of a new class of orally bioavailable and safe experimental therapeutics that attenuate disease progression in an Alzheimer’s disease-related mouse model
- Published in:
- 2005
- By:
- Publication type:
- Abstract
Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer's disease.
- Published in:
- 2020
- By:
- Publication type:
- journal article
Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice.
- Published in:
- 2020
- By:
- Publication type:
- journal article
Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice.
- Published in:
- 2019
- By:
- Publication type:
- journal article
Inhibition of Neuronal p38α, but not p38β MAPK, Provides Neuroprotection Against Three Different Neurotoxic Insults.
- Published in:
- Journal of Molecular Neuroscience, 2015, v. 55, n. 2, p. 509, doi. 10.1007/s12031-014-0372-x
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- Publication type:
- Article
Aminopyridazines attenuate hippocampus-dependent behavioral deficits induced by human β-amyloid in a murine model of neuroinflammation.
- Published in:
- Journal of Molecular Neuroscience, 2004, v. 24, n. 1, p. 115, doi. 10.1385/JMN:24:1:115
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- Publication type:
- Article
A dual role for apolipoprotein E in neuroinflammation.
- Published in:
- Journal of Molecular Neuroscience, 2004, v. 23, n. 3, p. 205, doi. 10.1385/JMN:23:3:205
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- Publication type:
- Article