Works matching AU Edkins, Sarah

Results: 31

Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.

Published in:

Nature, 2007, v. 447, n. 7147, p. 966, doi. 10.1038/nature05886

By:

Maser, Richard S.;
Choudhury, Bhudipa;
Campbell, Peter J.;
Bin Feng;
Kwok-Kin Wong;
Protopopov, Alexei;
O’Neil, Jennifer;
Gutierrez, Alejandro;
Ivanova, Elena;
Perna, Ilana;
Lin, Eric;
Mani, Vidya;
Shan Jiang;
McNamara, Kate;
Zaghlul, Sara;
Edkins, Sarah;
Stevens, Claire;
Brennan, Cameron;
Martin, Eric S.;
Wiedemeyer, Ruprecht

Publication type:

Article

Patterns of somatic mutation in human cancer genomes.

Published in:

Nature, 2007, v. 446, n. 7132, p. 153, doi. 10.1038/nature05610

By:

Greenman, Christopher;
Stephens, Philip;
Smith, Raffaella;
Dalgliesh, Gillian L.;
Hunter, Christopher;
Bignell, Graham;
Davies, Helen;
Teague, Jon;
Butler, Adam;
Stevens, Claire;
Edkins, Sarah;
O’Meara, Sarah;
Vastrik, Imre;
Schmidt, Esther E.;
Avis, Tim;
Barthorpe, Syd;
Bhamra, Gurpreet;
Buck, Gemma;
Choudhury, Bhudipa;
Clements, Jody

Publication type:

Article

Lung cancer: Intragenic ERBB2 kinase mutations in tumours.

Published in:

Nature, 2004, v. 431, n. 7008, p. 525, doi. 10.1038/431525b

By:

Stephens, Philip;
Hunter, Chris;
Bignell, Graham;
Edkins, Sarah;
Davies, Helen;
Teague, Jon;
Stevens, Claire;
O'Meara, Sarah;
Smith, Raffaella;
Parker, Adrian;
Barthorpe, Andy;
Blow, Matthew;
Brackenbury, Lisa;
Butler, Adam;
Clarke, Oliver;
Cole, Jennifer;
Dicks, Ed;
Dike, Angus;
Drozd, Anja;
Edwards, Ken

Publication type:

Article

Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation.

Published in:

European Journal of Human Genetics, 2012, v. 20, n. 9, p. 1010, doi. 10.1038/ejhg.2012.114

By:

Rujirabanjerd, Sinitdhorn;
Nelson, John;
Tarpey, Patrick S;
Hackett, Anna;
Edkins, Sarah;
Raymond, F Lucy;
Schwartz, Charles E;
Turner, Gillian;
Iwase, Shigeki;
Shi, Yang;
Futreal, P Andrew;
Stratton, Michael R;
Gecz, Jozef

Publication type:

Article

Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype–phenotype correlation.

Published in:

European Journal of Human Genetics, 2010, v. 18, n. 3, p. 330, doi. 10.1038/ejhg.2009.175

By:

Rujirabanjerd, Sinitdhorn;
Nelson, John;
Tarpey, Patrick S.;
Hackett, Anna;
Edkins, Sarah;
Raymond, F Lucy;
Schwartz, Charles E.;
Turner, Gillian;
Iwase, Shigeki;
Yang Shi;
Futreal, P. Andrew;
Stratton, Michael R.;
Gecz, Jozef

Publication type:

Article

Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett's esophagus.

Published in:

Nature Genetics, 2012, v. 44, n. 10, p. 1131, doi. 10.1038/ng.2408

By:

Su, Zhan;
Gay, Laura J;
Strange, Amy;
Palles, Claire;
Band, Gavin;
Whiteman, David C;
Lescai, Francesco;
Langford, Cordelia;
Nanji, Manoj;
Edkins, Sarah;
van der Winkel, Anouk;
Levine, David;
Sasieni, Peter;
Bellenguez, Céline;
Howarth, Kimberley;
Freeman, Colin;
Trudgill, Nigel;
Tucker, Art T;
Pirinen, Matti;
Peppelenbosch, Maikel P

Publication type:

Article

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry.

Published in:

2012

By:

Hunt, Karen A;
Smyth, Deborah J;
Balschun, Tobias;
Ban, Maria;
Mistry, Vanisha;
Ahmad, Tariq;
Anand, Vidya;
Barrett, Jeffrey C;
Bhaw-Rosun, Leena;
Bockett, Nicholas A;
Brand, Oliver J;
Brouwer, Elisabeth;
Concannon, Patrick;
Cooper, Jason D;
Dias, Kerith-Rae M;
van Diemen, Cleo C;
Dubois, Patrick C;
Edkins, Sarah;
Fölster-Holst, Regina;
Fransen, Karin

Publication type:

Letter

Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease.

Published in:

Nature Genetics, 2011, v. 43, n. 12, p. 1193, doi. 10.1038/ng.998

By:

Trynka, Gosia;
Hunt, Karen A;
Bockett, Nicholas A;
Romanos, Jihane;
Mistry, Vanisha;
Szperl, Agata;
Bakker, Sjoerd F;
Bardella, Maria Teresa;
Bhaw-Rosun, Leena;
Castillejo, Gemma;
de la Concha, Emilio G;
de Almeida, Rodrigo Coutinho;
Dias, Kerith-Rae M;
van Diemen, Cleo C;
Dubois, Patrick C A;
Duerr, Richard H;
Edkins, Sarah;
Franke, Lude;
Fransen, Karin;
Gutierrez, Javier

Publication type:

Article

A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.

Published in:

Nature Genetics, 2010, v. 42, n. 11, p. 985, doi. 10.1038/ng.694

By:

Strange, Amy;
Capon, Francesca;
Spencer, Chris C. A.;
Knight, Jo;
Weale, Michael E.;
Allen, Michael H.;
Barton, Anne;
Band, Gavin;
Bellenguez, Céline;
Bergboer, Judith G. M.;
Blackwell, Jenefer M.;
Bramon, Elvira;
Bumpstead, Suzannah J.;
Casas, Juan P.;
Cork, Michael J.;
Corvin, Aiden;
Deloukas, Panos;
Dilthey, Alexander;
Duncanson, Audrey;
Edkins, Sarah

Publication type:

Article

Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

Published in:

Nature Genetics, 2009, v. 41, n. 5, p. 521, doi. 10.1038/ng.349

By:

van Haaften, Gijs;
Dalgliesh, Gillian L.;
Davies, Helen;
Chen, Lina;
Bignell, Graham;
Greenman, Chris;
Edkins, Sarah;
Hardy, Claire;
O'Meara, Sarah;
Teague, Jon;
Butler, Adam;
Hinton, Jonathan;
Latimer, Calli;
Andrews, Jenny;
Barthorpe, Syd;
Beare, Dave;
Buck, Gemma;
Campbell, Peter J.;
Cole, Jennifer;
Forbes, Simon

Publication type:

Article

A systematic, large-scale resequencing screen of X-chromosome coding exons in mental retardation.

Published in:

Nature Genetics, 2009, v. 41, n. 5, p. 535, doi. 10.1038/ng.367

By:

Tarpey, Patrick S.;
Smith, Raffaella;
Pleasance, Erin;
Whibley, Annabel;
Edkins, Sarah;
Hardy, Claire;
O'Meara, Sarah;
Latimer, Calli;
Dicks, Ed;
Menzies, Andrew;
Stephens, Phil;
Blow, Matt;
Greenman, Chris;
Yali Xue;
Tyler-Smith, Chris;
Thompson, Deborah;
Gray, Kristian;
Andrews, Jenny;
Barthorpe, Syd;
Buck, Gemma

Publication type:

Article

Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing.

Published in:

Nature Genetics, 2008, v. 40, n. 6, p. 722, doi. 10.1038/ng.128

By:

Campbell, Peter J.;
Stephens, Philip J.;
Pleasance, Erin D.;
O'Meara, Sarah;
Heng Li;
Santarius, Thomas;
Stebbings, Lucy A.;
Leroy, Catherine;
Edkins, Sarah;
Hardy, Claire;
Teague, Jon W.;
Menzies, Andrew;
Goodhead, Ian;
Turner, Daniel J.;
Clee, Christopher M.;
Quail, Michael A.;
Cox, Antony;
Brown, Clive;
Durbin, Richard;
Hurles, Matthew E.

Publication type:

Article

X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment.

Published in:

Nature Genetics, 2008, v. 40, n. 6, p. 776, doi. 10.1038/ng.149

By:

Dibbens, Leanne M.;
Tarpey, Patrick S.;
Hynes, Kim;
Bayly, Marta A.;
Scheffer, Ingrid E.;
Smith, Raffaella;
Bomar, Jamee;
Sutton, Edwina;
Vandeleur, Lucianne;
Shoubridge, Cheryl;
Edkins, Sarah;
Turner, Samantha J.;
Stevens, Claire;
O'Meara, Sarah;
Tofts, Calli;
Barthorpe, Syd;
Buck, Gemma;
Cole, Jennifer;
Halliday, Kelly;
Jones, David

Publication type:

Article

Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation.

Published in:

Nature Genetics, 2007, v. 39, n. 9, p. 1127, doi. 10.1038/ng2100

By:

Tarpey, Patrick S.;
Lucy Raymond, F.;
Nguyen, Lam S.;
Rodriguez, Jayson;
Hackett, Anna;
Vandeleur, Lucianne;
Smith, Raffaella;
Shoubridge, Cheryl;
Edkins, Sarah;
Stevens, Claire;
O'Meara, Sarah;
Tofts, Calli;
Barthorpe, Syd;
Buck, Gemma;
Cole, Jennifer;
Halliday, Kelly;
Hills, Katy;
Jones, David;
Mironenko, Tatiana;
Perry, Janet

Publication type:

Article

A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

Published in:

Nature Genetics, 2005, v. 37, n. 6, p. 590, doi. 10.1038/ng1571

By:

Stephens, Philip;
Edkins, Sarah;
Davies, Helen;
Greenman, Chris;
Cox, Charles;
Hunter, Chris;
Bignell, Graham;
Teague, Jon;
Smith, Raffaella;
Stevens, Claire;
O'Meara, Sarah;
Parker, Adrian;
Tarpey, Patrick;
Avis, Tim;
Barthorpe, Andy;
Brackenbury, Lisa;
Buck, Gemma;
Butler, Adam;
Clements, Jody;
Cole, Jennifer

Publication type:

Article

Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia.

Published in:

2021

By:

Almotiri, Alhomidi;
Alzahrani, Hamed;
Menendez-Gonzalez, Juan Bautista;
Abdelfattah, Ali;
Alotaibi, Badi;
Saleh, Lubaid;
Greene, Adelle;
Georgiou, Mia;
Gibbs, Alex;
Alsayari, Amani;
Taha, Sarab;
Thomas, Leigh-anne;
Shah, Dhruv;
Edkins, Sarah;
Giles, Peter;
Stemmler, Marc P.;
Brabletz, Simone;
Brabletz, Thomas;
Boyd, Ashleigh S.;
Siebzehnrubl, Florian A.

Publication type:

journal article

Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis.

Published in:

Nature Genetics, 2013, v. 45, n. 6, p. 664, doi. 10.1038/ng.2614

By:

Hinks, Anne;
Cobb, Joanna;
Marion, Miranda C;
Prahalad, Sampath;
Sudman, Marc;
Bowes, John;
Martin, Paul;
Comeau, Mary E;
Sajuthi, Satria;
Andrews, Robert;
Brown, Milton;
Chen, Wei-Min;
Concannon, Patrick;
Deloukas, Panos;
Edkins, Sarah;
Eyre, Stephen;
Gaffney, Patrick M;
Guthery, Stephen L;
Guthridge, Joel M;
Hunt, Sarah E

Publication type:

Article

Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.

Published in:

Nature Genetics, 2013, v. 45, n. 2, p. 208, doi. 10.1038/ng.2518

By:

Fakiola, Michaela;
Strange, Amy;
Cordell, Heather J;
Miller, E Nancy;
Pirinen, Matti;
Su, Zhan;
Mishra, Anshuman;
Mehrotra, Sanjana;
Monteiro, Gloria R;
Band, Gavin;
Bellenguez, Céline;
Dronov, Serge;
Edkins, Sarah;
Freeman, Colin;
Giannoulatou, Eleni;
Gray, Emma;
Hunt, Sarah E;
Lacerda, Henio G;
Langford, Cordelia;
Pearson, Richard

Publication type:

Article

Distinctive Features of Orbital Adipose Tissue (OAT) in Graves' Orbitopathy.

Published in:

International Journal of Molecular Sciences, 2020, v. 21, n. 23, p. 9145, doi. 10.3390/ijms21239145

By:

Zhang, Lei;
Evans, Anna;
von Ruhland, Chris;
Draman, Mohd Shazli;
Edkins, Sarah;
Vincent, Amy E.;
Berlinguer-Palmini, Rolando;
Rees, D. Aled;
Haridas, Anjana S;
Morris, Dan;
Tee, Andrew R.;
Ludgate, Marian;
Turnbull, Doug M.;
Karpe, Fredrik;
Dayan, Colin M.

Publication type:

Article

Gene filtering strategies for machine learning guided biomarker discovery using neonatal sepsis RNA-seq data.

Published in:

Frontiers in Genetics, 2023, v. 14, p. 1, doi. 10.3389/fgene.2023.1158352

By:

Parkinson, Edward;
Liberatore, Federico;
Watkins, W. John;
Andrews, Robert;
Edkins, Sarah;
Hibbert, Julie;
Strunk, Tobias;
Currie, Andrew;
Ghazal, Peter

Publication type:

Article

Sequence analysis of the protein kinase gene family in human testicular germ‐cell tumors of adolescents and adults.

Published in:

Genes, Chromosomes & Cancer, 2006, v. 45, n. 1, p. 42, doi. 10.1002/gcc.20265

By:

Graham Bignell;
Raffaella Smith;
Chris Hunter;
Philip Stephens;
Helen Davies;
Chris Greenman;
Jon Teague;
Adam Butler;
Sarah Edkins;
Claire Stevens;
Sarah O'Meara;
Adrian Parker;
Tim Avis;
Syd Barthorpe;
Lisa Brackenbury;
Gemma Buck;
Jody Clements;
Jennifer Cole;
Ed Dicks;
Ken Edwards

Publication type:

Article

PICNIC: an algorithm to predict absolute allelic copy number variation with microarray cancer data.

Published in:

Biostatistics, 2010, v. 11, n. 1, p. 164, doi. 10.1093/biostatistics/kxp045

By:

Greenman, Chris D.;
Bignell, Graham;
Butler, Adam;
Edkins, Sarah;
Hinton, Jon;
Beare, Dave;
Swamy, Sajani;
Santarius, Thomas;
Chen, Lina;
Widaa, Sara;
Futreal, P. Andy;
Stratton, Michael R.

Publication type:

Article

GLO1-A novel amplified gene in human cancer.

Published in:

Genes, Chromosomes & Cancer, 2010, v. 49, n. 8, p. 711, doi. 10.1002/gcc.20784

By:

Santarius, Thomas;
Bignell, Graham R.;
Greenman, Chris D.;
Widaa, Sara;
Chen, Lina;
Mahoney, Claire L.;
Butler, Adam;
Edkins, Sarah;
Waris, Sahar;
Thornalley, Paul J.;
Futreal, P. Andrew;
Stratton, Michael R.

Publication type:

Article

Mutations of the BRAF gene in human cancer.

Published in:

Nature, 2002, v. 417, n. 6892, p. 949, doi. 10.1038/nature00766

By:

Davies, Helen;
Bignell, Graham R.;
Cox, Charles;
Stephens, Philip;
Edkins, Sarah;
Clegg, Sheila;
Teague, Jon;
Woffendin, Hayley;
Garnett, Mathew J.;
Bottomley, William;
Davis, Neil;
Dicks, Ed;
Ewing, Rebecca;
Floyd, Yvonne;
Gray, Kristian;
Hall, Sarah;
Hawes, Rachel;
Hughes, Jaime;
Kosmidou, Vivian

Publication type:

Article

An Evaluation of Different Target Enrichment Methods in Pooled Sequencing Designs for Complex Disease Association Studies.

Published in:

PLoS ONE, 2011, v. 6, n. 11, p. 1, doi. 10.1371/journal.pone.0026279

By:

Day-Williams, Aaron G.;
McLay, Kirsten;
Drury, Eleanor;
Edkins, Sarah;
Coffey, Alison J.;
Palotie, Aarno;
Zeggini, Eleftheria

Publication type:

Article

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.

Published in:

Nature, 2011, v. 476, n. 7359, p. 214, doi. 10.1038/nature10251

By:

Sawcer, Stephen;
Hellenthal, Garrett;
Pirinen, Matti;
Spencer, Chris C. A.;
Patsopoulos, Nikolaos A.;
Moutsianas, Loukas;
Dilthey, Alexander;
Su, Zhan;
Freeman, Colin;
Hunt, Sarah E.;
Edkins, Sarah;
Gray, Emma;
Booth, David R.;
Potter, Simon C.;
Goris, An;
Band, Gavin;
Bang Oturai, Annette;
Strange, Amy;
Saarela, Janna;
Bellenguez, Céline

Publication type:

Article

Signatures of mutation and selection in the cancer genome.

Published in:

Nature, 2010, v. 463, n. 7283, p. 893, doi. 10.1038/nature08768

By:

Bignell, Graham R.;
Greenman, Chris D.;
Davies, Helen;
Butler, Adam P.;
Edkins, Sarah;
Andrews, Jenny M.;
Buck, Gemma;
Chen, Lina;
Beare, David;
Latimer, Calli;
Widaa, Sara;
Hinton, Jonathon;
Fahey, Ciara;
Fu, Beiyuan;
Swamy, Sajani;
Dalgliesh, Gillian L.;
Teh, Bin T.;
Deloukas, Panos;
Yang, Fengtang;
Campbell, Peter J.

Publication type:

Article

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.

Published in:

Nature, 2010, v. 463, n. 7279, p. 360, doi. 10.1038/nature08672

By:

Dalgliesh, Gillian L.;
Furge, Kyle;
Greenman, Chris;
Chen, Lina;
Bignell, Graham;
Butler, Adam;
Davies, Helen;
Edkins, Sarah;
Hardy, Claire;
Latimer, Calli;
Teague, Jon;
Andrews, Jenny;
Barthorpe, Syd;
Beare, Dave;
Buck, Gemma;
Campbell, Peter J.;
Forbes, Simon;
Mingming Jia;
Jones, David;
Knott, Henry

Publication type:

Article

A small-cell lung cancer genome with complex signatures of tobacco exposure.

Published in:

Nature, 2010, v. 463, n. 7278, p. 184, doi. 10.1038/nature08629

By:

Pleasance, Erin D.;
Cheetham, R. Keira;
Stephens, Philip J.;
McBride, David J.;
Humphray, Sean J.;
Greenman, Chris D.;
Varela, Ignacio;
Meng-Lay Lin;
Ordóñez, Gonzalo R.;
Bignell, Graham R.;
Kai Ye;
Alipaz, Julie;
Bauer, Markus J.;
Beare, David;
Butler, Adam;
Carter, Richard J.;
Chen, Lina;
Cox, Anthony J.;
Edkins, Sarah;
Kokko-Gonzales, Paula I.

Publication type:

Article

A comprehensive catalogue of somatic mutations from a human cancer genome.

Published in:

Nature, 2010, v. 463, n. 7278, p. 191, doi. 10.1038/nature08658

By:

Pleasance, Erin D.;
Cheetham, R. Keira;
Stephens, Philip J.;
McBride, David J.;
Humphray, Sean J.;
Greenman, Chris D.;
Varela, Ignacio;
Lin, Meng-Lay;
Ordóñez, Gonzalo R.;
Bignell, Graham R.;
Ye, Kai;
Alipaz, Julie;
Bauer, Markus J.;
Beare, David;
Butler, Adam;
Carter, Richard J.;
Chen, Lina;
Cox, Anthony J.;
Edkins, Sarah;
Kokko-Gonzales, Paula I.

Publication type:

Article

Complex landscapes of somatic rearrangement in human breast cancer genomes.

Published in:

Nature, 2009, v. 462, n. 7276, p. 1005, doi. 10.1038/nature08645

By:

Stephens, Philip J.;
McBride, David J.;
Meng-Lay Lin;
Varela, Ignacio;
Pleasance, Erin D.;
Simpson, Jared T.;
Stebbings, Lucy A.;
Leroy, Catherine;
Edkins, Sarah;
Mudie, Laura J.;
Greenman, Chris D.;
Mingming Jia;
Latimer, Calli;
Teague, Jon W.;
King Wai Lau;
Burton, John;
Quail, Michael A.;
Swerdlow, Harold;
Churcher, Carol;
Natrajan, Rachael

Publication type:

Article