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Transposon Mutagenesis of the Mouse Germline.
Published in:
Genetics, 2003, v. 165, n. 1, p. 243, doi. 10.1093/genetics/165.1.243
By:
- Carlson, Corey M.;
- Dupuy, Adam J.;
- Fritz, Sabine;
- Roberg-Perez, Kevin J.;
- Fletcher, Colin F.;
- Largaespada, David A.
Publication type:
Article
Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer.
Published in:
Nature Communications, 2021, v. 12, n. 1, p. 1, doi. 10.1038/s41467-021-25467-w
By:
- Schachter, Nathan F.;
- Adams, Jessica R.;
- Skowron, Patryk;
- Kozma, Katelyn. J.;
- Lee, Christian A.;
- Raghuram, Nandini;
- Yang, Joanna;
- Loch, Amanda J.;
- Wang, Wei;
- Kucharczuk, Aaron;
- Wright, Katherine L.;
- Quintana, Rita M.;
- An, Yeji;
- Dotzko, Daniel;
- Gorman, Jennifer L.;
- Wojtal, Daria;
- Shah, Juhi S.;
- Leon-Gomez, Paul;
- Pellecchia, Giovanna;
- Dupuy, Adam J.
Publication type:
Article
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.
Published in:
Nature Biotechnology, 2009, v. 27, n. 3, p. 264, doi. 10.1038/nbt.1526
By:
- Keng, Vincent W;
- Villanueva, Augusto;
- Chiang, Derek Y;
- Dupuy, Adam J;
- Ryan, Barbara J;
- Matise, Ilze;
- Silverstein, Kevin A T;
- Sarver, Aaron;
- Starr, Timothy K;
- Akagi, Keiko;
- Tessarollo, Lino;
- Collier, Lara S;
- Powers, Scott;
- Lowe, Scott W;
- Jenkins, Nancy A;
- Copeland, Neal G;
- Llovet, Josep M;
- Largaespada, David A
Publication type:
Article
Transposon mutagenesis identifies genetic drivers of BrafV600E melanoma.
Published in:
Nature Genetics, 2015, v. 47, n. 5, p. 486, doi. 10.1038/ng.3275
By:
- Mann, Michael B;
- Copeland, Neal G;
- Jenkins, Nancy A;
- Black, Michael A;
- Jones, Devin J;
- Newberg, Justin Y;
- Ward, Jerrold M;
- Yew, Christopher Chin Kuan;
- Dupuy, Adam J;
- Rust, Alistair G;
- Bosenberg, Marcus W;
- McMahon, Martin;
- Print, Cristin G
Publication type:
Article
Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.
Published in:
Nature Genetics, 2014, v. 46, n. 1, p. 24, doi. 10.1038/ng.2847
By:
- Bard-Chapeau, Emilie A;
- Nguyen, Anh-Tuan;
- Rust, Alistair G;
- Sayadi, Ahmed;
- Lee, Philip;
- Chua, Belinda Q;
- New, Lee-Sun;
- de Jong, Johann;
- Ward, Jerrold M;
- Chin, Christopher K Y;
- Chew, Valerie;
- Toh, Han Chong;
- Abastado, Jean-Pierre;
- Benoukraf, Touati;
- Soong, Richie;
- Bard, Frederic A;
- Dupuy, Adam J;
- Johnson, Randy L;
- Radda, George K;
- Chan, Eric Chun Yong
Publication type:
Article
Leukaemia disease genes: large-scale cloning and pathway predictions.
Published in:
Nature Genetics, 1999, v. 23, n. 3, p. 348, doi. 10.1038/15531
By:
- Li, Jiayin;
- Shen, Haifa;
- Himmel, Karen L.;
- Dupuy, Adam J.;
- Largaespada, David A.;
- Nakamura, Takuro;
- Shaughnessy, John D.;
- Jenkins, Nancy A.;
- Copeland, Neal G.
Publication type:
Article
Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1.
Published in:
Genesis: The Journal of Genetics & Development, 2012, v. 50, n. 2, p. 112, doi. 10.1002/dvg.20798
By:
- Berquam-Vrieze, Katherine E.;
- Swing, Deborah A.;
- Tessarollo, Lino;
- Dupuy, Adam J.
Publication type:
Article
Transposition and gene disruption in the male germline of the mouse.
Published in:
Genesis: The Journal of Genetics & Development, 2001, v. 30, n. 2, p. 82, doi. 10.1002/gene.1037
By:
- Dupuy, Adam J.;
- Fritz, Sabine;
- Largaespada, David A.
Publication type:
Article
Novel Molecular and Computational Methods Improve the Accuracy of Insertion Site Analysis in Sleeping Beauty-Induced Tumors.
Published in:
PLoS ONE, 2011, v. 6, n. 9, p. 1, doi. 10.1371/journal.pone.0024668
By:
- Brett, Benjamin T.;
- Berquam-Vrieze, Katherine E.;
- Nannapaneni, Kishore;
- Jian Huang;
- Scheetz, Todd E.;
- Dupuy, Adam J.
Publication type:
Article
Somatic Mutagenesis with a Sleeping Beauty Transposon System Leads to Solid Tumor Formation in Zebrafish.
Published in:
PLoS ONE, 2011, v. 6, n. 4, p. 1, doi. 10.1371/journal.pone.0018826
By:
- McGrail, Maura;
- Hatler, Julia M.;
- Xianyan Kuang;
- Hsin-Kai Liao;
- Nannapaneni, Kishore;
- Noack Watt, Kristin E.;
- Uhl, Juli D.;
- Largaespada, David A.;
- Vollbrecht, Erik;
- Scheetz, Todd E.;
- Dupuy, Adam J.;
- Hostetter, Jesse M.;
- Essner, Jeffrey J.
Publication type:
Article
Ectopic Expression of Zmiz1 Induces Cutaneous Squamous Cell Malignancies in a Mouse Model of Cancer.
Published in:
Journal of Investigative Dermatology, 2013, v. 133, n. 7, p. 1863, doi. 10.1038/jid.2013.77
By:
- Rogers, Laura M;
- Riordan, Jesse D;
- Swick, Brian L;
- Meyerholz, David K;
- Dupuy, Adam J
Publication type:
Article
A Transposon-Based Analysis of Gene Mutations Related to Skin Cancer Development.
Published in:
Journal of Investigative Dermatology, 2013, v. 133, n. 1, p. 239, doi. 10.1038/jid.2012.245
By:
- Quintana, Rita M;
- Dupuy, Adam J;
- Bravo, Ana;
- Casanova, M Llanos;
- Alameda, Josefa P;
- Page, Angustias;
- Sánchez-Viera, Miguel;
- Ramírez, Angel;
- Navarro, Manuel
Publication type:
Article
Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse.
Published in:
Nature, 2005, v. 436, n. 7048, p. 272, doi. 10.1038/nature03681
By:
- Collier, Lara S.;
- Carlson, Corey M.;
- Ravimohan, Shruthi;
- Dupuy, Adam J.;
- Largaespada, David A.
Publication type:
Article
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.
Published in:
Nature, 2005, v. 436, n. 7048, p. 221, doi. 10.1038/nature03691
By:
- Dupuy, Adam J.;
- Akagi, Keiko;
- Largaespada, David A.;
- Copeland, Neal G.;
- Jenkins, Nancy A.
Publication type:
Article
Single-cell genomics analysis reveals complex genetic interactions in an in vivo model of acquired BRAF inhibitor resistance.
Published in:
NAR Cancer, 2024, v. 6, n. 1, p. 1, doi. 10.1093/narcan/zcad061
By:
- Schillo, Jacob L;
- Feddersen, Charlotte R;
- Peplinski, Rebekah M;
- Powell, Lexy S;
- Varzavand, Afshin;
- Stipp, Christopher S;
- Riordan, Jesse D;
- Dupuy, Adam J
Publication type:
Article
Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics.
Published in:
Frontiers in Oncology, 2019, p. 1, doi. 10.3389/fonc.2019.00611
By:
- Guimaraes-Young, Amy;
- Feddersen, Charlotte R.;
- Dupuy, Adam J.
Publication type:
Article
Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms.
Published in:
International Journal of Cancer, 2017, v. 140, n. 4, p. 853, doi. 10.1002/ijc.30491
By:
- Morris, Shelli M.;
- Davison, Jerry;
- Carter, Kelly T.;
- O'Leary, Rachele M.;
- Trobridge, Patty;
- Knoblaugh, Sue E.;
- Myeroff, Lois L.;
- Markowitz, Sanford D.;
- Brett, Benjamin T.;
- Scheetz, Todd E.;
- Dupuy, Adam J.;
- Starr, Timothy K.;
- Grady, William M.
Publication type:
Article
Clonal selection drives genetic divergence of metastatic medulloblastoma.
Published in:
Nature, 2012, v. 482, n. 7386, p. 529, doi. 10.1038/nature10825
By:
- Wu, Xiaochong;
- Northcott, Paul A.;
- Dubuc, Adrian;
- Dupuy, Adam J.;
- Shih, David J. H.;
- Witt, Hendrik;
- Croul, Sidney;
- Bouffet, Eric;
- Fults, Daniel W.;
- Eberhart, Charles G.;
- Garzia, Livia;
- Van Meter, Timothy;
- Zagzag, David;
- Jabado, Nada;
- Schwartzentruber, Jeremy;
- Majewski, Jacek;
- Scheetz, Todd E.;
- Pfister, Stefan M.;
- Korshunov, Andrey;
- Li, Xiao-Nan
Publication type:
Article
SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas.
Published in:
NPJ Precision Oncology, 2022, v. 6, n. 1, p. 1, doi. 10.1038/s41698-022-00310-7
By:
- Zhu, Eliot Y.;
- Riordan, Jesse D.;
- Vanneste, Marion;
- Henry, Michael D.;
- Stipp, Christopher S.;
- Dupuy, Adam J.
Publication type:
Article
Gene insertion and long-term expression in lung mediated by the sleeping beauty transposon system
Published in:
Molecular Therapy, 2003, v. 8, n. 3, p. 501, doi. 10.1016/S1525-0016(03)00211-9
By:
- Belur, Lalitha R.;
- Frandsen, Joel L.;
- Dupuy, Adam J.;
- Ingbar, David H.;
- Largaespada, David A.;
- Hackett, Perry B.;
- Scott McIvor, R.
Publication type:
Article
Gene transfer into genomes of human cells by the sleeping beauty transposon system
Published in:
Molecular Therapy, 2003, v. 8, n. 1, p. 108, doi. 10.1016/S1525-0016(03)00099-6
By:
- Geurts, Aron M.;
- Yang, Ying;
- Clark, Karl J.;
- Liu, Geyi;
- Cui, Zongbin;
- Dupuy, Adam J.;
- Bell, Jason B.;
- Largaespada, David A.;
- Hackett, Perry B.
Publication type:
Article
A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells.
Published in:
BMC Genomics, 2019, v. 20, n. 1, p. N.PAG, doi. 10.1186/s12864-019-5888-6
By:
- Feddersen, Charlotte R.;
- Wadsworth, Lexy S.;
- Zhu, Eliot Y.;
- Vaughn, Hayley R.;
- Voigt, Andrew P.;
- Riordan, Jesse D.;
- Dupuy, Adam J.
Publication type:
Article
The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis.
Published in:
PLoS Genetics, 2013, v. 9, n. 12, p. 1, doi. 10.1371/journal.pgen.1003937
By:
- DeZwaan-McCabe, Diane;
- Riordan, Jesse D.;
- Arensdorf, Angela M.;
- Icardi, Michael S.;
- Dupuy, Adam J.;
- Rutkowski, D. Thomas
Publication type:
Article
Identification of Rtl1, a Retrotransposon-Derived Imprinted Gene, as a Novel Driver of Hepatocarcinogenesis.
Published in:
PLoS Genetics, 2013, v. 9, n. 4, p. 1, doi. 10.1371/journal.pgen.1003441
By:
- Riordan, Jesse D.;
- Keng, Vincent W.;
- Tschida, Barbara R.;
- Scheetz, Todd E.;
- Bell, Jason B.;
- Podetz-Pedersen, Kelly M.;
- Moser, Catherine D.;
- Copeland, Neal G.;
- Jenkins, Nancy A.;
- Roberts, Lewis R.;
- Largaespada, David A.;
- Dupuy, Adam J.
Publication type:
Article
Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice.
Published in:
Scientific Reports, 2019, v. 9, n. 1, p. N.PAG, doi. 10.1038/s41598-019-41805-x
By:
- Loeb, Keith R.;
- Hughes, Bridget T.;
- Fissel, Brian M.;
- Osteen, Nyka J.;
- Knoblaugh, Sue E.;
- Grim, Jonathan E.;
- Drury, Luke J.;
- Sarver, Aaron;
- Dupuy, Adam J.;
- Clurman, Bruce E.
Publication type:
Article
Sleeping beauty: a novel cancer gene discovery tool.
Published in:
Human Molecular Genetics, 2006, v. 15, n. suppl_1, p. R75, doi. 10.1093/hmg/ddl061
By:
- Dupuy, Adam J.;
- Jenkins, Nancy A.;
- Copeland, Neal G.
Publication type:
Article
Sleeping beauty: a novel cancer gene discovery tool.
Published in:
Human Molecular Genetics, 2006, v. 15, n. 1, p. r75, doi. 10.1093/hmg/ddl061
By:
- Dupuy, Adam J.;
- Jenkins, Nancy A.;
- Copeland, Neal G.
Publication type:
Article
Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens.
Published in:
BMC Genomics, 2014, v. 15, n. 1, p. 660, doi. 10.1186/1471-2164-15-1150
By:
- Riordan, Jesse D.;
- Drury, Luke J.;
- Smith, Ryan P.;
- Brett, Benjamin T.;
- Rogers, Laura M.;
- Scheetz, Todd E.;
- Dupuy, Adam J.
Publication type:
Article
Machine learning approach informs biology of cancer drug response.
Published in:
BMC Bioinformatics, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s12859-022-04720-z
By:
- Zhu, Eliot Y.;
- Dupuy, Adam J.
Publication type:
Article
Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis.
Published in:
Frontiers in Oncology, 2020, p. 1, doi. 10.3389/fonc.2020.00442
By:
- Vanneste, Marion;
- Feddersen, Charlotte R.;
- Varzavand, Afshin;
- Zhu, Elliot Y.;
- Foley, Tyler;
- Zhao, Lei;
- Holt, Kathleen H.;
- Milhem, Mohammed;
- Piper, Robert;
- Stipp, Christopher S.;
- Dupuy, Adam J.;
- Henry, Michael D.
Publication type:
Article
A Trp53fl/flPtenfl/fl mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging.
Published in:
PLoS ONE, 2017, v. 12, n. 8, p. 1, doi. 10.1371/journal.pone.0183469
By:
- Buchakjian, Marisa R.;
- Merritt, Nicole M.;
- Moose, Devon L.;
- Dupuy, Adam J.;
- Tanas, Munir R.;
- Henry, Michael D.
Publication type:
Article

Found: 31

Transposon Mutagenesis of the Mouse Germline.

Single allele loss-of-function mutations select and sculpt conditional cooperative networks in breast cancer.

A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma.

Transposon mutagenesis identifies genetic drivers of Braf<sup>V600E</sup> melanoma.

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model.

Leukaemia disease genes: large-scale cloning and pathway predictions.

Characterization of transgenic mice expressing cancer-associated variants of human NOTCH1.

Transposition and gene disruption in the male germline of the mouse.

Novel Molecular and Computational Methods Improve the Accuracy of Insertion Site Analysis in Sleeping Beauty-Induced Tumors.

Somatic Mutagenesis with a Sleeping Beauty Transposon System Leads to Solid Tumor Formation in Zebrafish.

Ectopic Expression of Zmiz1 Induces Cutaneous Squamous Cell Malignancies in a Mouse Model of Cancer.

A Transposon-Based Analysis of Gene Mutations Related to Skin Cancer Development.

Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse.

Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system.

Single-cell genomics analysis reveals complex genetic interactions in an in vivo model of acquired BRAF inhibitor resistance.

Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics.

Transposon mutagenesis identifies candidate genes that cooperate with loss of transforming growth factor-beta signaling in mouse intestinal neoplasms.

Clonal selection drives genetic divergence of metastatic medulloblastoma.

SRC-RAC1 signaling drives drug resistance to BRAF inhibition in de-differentiated cutaneous melanomas.

Gene insertion and long-term expression in lung mediated by the sleeping beauty transposon system

Gene transfer into genomes of human cells by the sleeping beauty transposon system

A simplified transposon mutagenesis method to perform phenotypic forward genetic screens in cultured cells.

The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis.

Identification of Rtl1, a Retrotransposon-Derived Imprinted Gene, as a Novel Driver of Hepatocarcinogenesis.

Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice.

Sleeping beauty: a novel cancer gene discovery tool.

Sleeping beauty: a novel cancer gene discovery tool.

Sequencing methods and datasets to improve functional interpretation of sleeping beauty mutagenesis screens.

Machine learning approach informs biology of cancer drug response.

Functional Genomic Screening Independently Identifies CUL3 as a Mediator of Vemurafenib Resistance via Src-Rac1 Signaling Axis.

A Trp53<sup>fl/fl</sup>Pten<sup>fl/fl</sup> mouse model of undifferentiated pleomorphic sarcoma mediated by adeno-Cre injection and in vivo bioluminescence imaging.