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SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.
Published in:
2011
By:
- Pearson, Helen B.;
- Perez-Mancera, Pedro A.;
- Dow, Lukas E.;
- Ryan, Andrew;
- Tennstedt, Pierre;
- Bogani, Debora;
- Elsum, Imogen;
- Greenfield, Andy;
- Tuveson, David A.;
- Simon, Ronald;
- Humbert, Patrick O.
Publication type:
journal article
Novel genetically engineered mouse models for clear cell renal cell carcinoma.
Published in:
Scientific Reports, 2023, v. 13, n. 1, p. 1, doi. 10.1038/s41598-023-35106-7
By:
- van der Mijn, Johannes C.;
- Laursen, Kristian B.;
- Fu, Leiping;
- Khani, Francesca;
- Dow, Lukas E.;
- Nowak, Dawid G.;
- Chen, Qiuying;
- Gross, Steven S.;
- Nanus, David M.;
- Gudas, Lorraine J.
Publication type:
Article
Optimized base editors enable efficient editing in cells, organoids and mice.
Published in:
Nature Biotechnology, 2018, v. 36, n. 10, p. 888, doi. 10.1038/nbt.4194
By:
- Zafra, Maria Paz;
- Schatoff, Emma M;
- Katti, Alyna;
- Foronda, Miguel;
- Breinig, Marco;
- Schweitzer, Anabel Y;
- Simon, Amber;
- Han, Teng;
- Goswami, Sukanya;
- Montgomery, Emma;
- Thibado, Jordana;
- Kastenhuber, Edward R;
- Sánchez-Rivera, Francisco J;
- Shi, Junwei;
- Vakoc, Christopher R;
- Lowe, Scott W;
- Tschaharganeh, Darjus F;
- Dow, Lukas E
Publication type:
Article
Optimized base editors enable efficient editing in cells, organoids and mice.
Published in:
Nature Biotechnology, 2018, v. 36, n. 9, p. 888, doi. 10.1038/nbt.4194
By:
- Zafra, Maria Paz;
- Schatoff, Emma M;
- Katti, Alyna;
- Foronda, Miguel;
- Breinig, Marco;
- Schweitzer, Anabel Y;
- Simon, Amber;
- Han, Teng;
- Goswami, Sukanya;
- Montgomery, Emma;
- Thibado, Jordana;
- Kastenhuber, Edward R;
- Sánchez-Rivera, Francisco J;
- Shi, Junwei;
- Vakoc, Christopher R;
- Lowe, Scott W;
- Tschaharganeh, Darjus F;
- Dow, Lukas E
Publication type:
Article
Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer.
Published in:
Nature Biotechnology, 2017, v. 35, n. 6, p. 577, doi. 10.1038/nbt.3837
By:
- O'Rourke, Kevin P;
- Loizou, Evangelia;
- Livshits, Geulah;
- Schatoff, Emma M;
- Baslan, Timour;
- Manchado, Eusebio;
- Simon, Janelle;
- Romesser, Paul B;
- Leach, Benjamin;
- Han, Teng;
- Pauli, Chantal;
- Beltran, Himisha;
- Rubin, Mark A;
- Dow, Lukas E;
- Lowe, Scott W
Publication type:
Article
Inducible in vivo genome editing with CRISPR-Cas9.
Published in:
Nature Biotechnology, 2015, v. 33, n. 4, p. 390, doi. 10.1038/nbt.3155
By:
- Dow, Lukas E;
- Fisher, Jonathan;
- O'Rourke, Kevin P;
- Muley, Ashlesha;
- Kastenhuber, Edward R;
- Livshits, Geulah;
- Tschaharganeh, Darjus F;
- Socci, Nicholas D;
- Lowe, Scott W
Publication type:
Article
Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi.
Published in:
Nature Biotechnology, 2011, v. 29, n. 1, p. 79, doi. 10.1038/nbt.1720
By:
- Zuber, Johannes;
- McJunkin, Katherine;
- Fellmann, Christof;
- Dow, Lukas E.;
- Taylor, Meredith J.;
- Hannon, Gregory J.;
- Lowe, Scott W.
Publication type:
Article
In situ CRISPR‐Cas9 base editing for the development of genetically engineered mouse models of breast cancer.
Published in:
EMBO Journal, 2020, v. 39, n. 5, p. 1, doi. 10.15252/embj.2019102169
By:
- Annunziato, Stefano;
- Lutz, Catrin;
- Henneman, Linda;
- Bhin, Jinhyuk;
- Wong, Kim;
- Siteur, Bjørn;
- Gerwen, Bas;
- Korte‐Grimmerink, Renske;
- Zafra, Maria Paz;
- Schatoff, Emma M;
- Drenth, Anne Paulien;
- der Burg, Eline;
- Eijkman, Timo;
- Mukherjee, Siddhartha;
- Boroviak, Katharina;
- Wessels, Lodewyk FA;
- de Ven, Marieke;
- Huijbers, Ivo J;
- Adams, David J;
- Dow, Lukas E
Publication type:
Article
Oncogenic context shapes the fitness landscape of tumor suppression.
Published in:
Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-42156-y
By:
- Blair, Lily M.;
- Juan, Joseph M.;
- Sebastian, Lafia;
- Tran, Vy B.;
- Nie, Wensheng;
- Wall, Gregory D.;
- Gerceker, Mehmet;
- Lai, Ian K.;
- Apilado, Edwin A.;
- Grenot, Gabriel;
- Amar, David;
- Foggetti, Giorgia;
- Do Carmo, Mariana;
- Ugur, Zeynep;
- Deng, Debbie;
- Chenchik, Alex;
- Paz Zafra, Maria;
- Dow, Lukas E.;
- Politi, Katerina;
- MacQuitty, Jonathan J.
Publication type:
Article
Conditional Reverse Tet-Transactivator Mouse Strains for the Efficient Induction of TRE-Regulated Transgenes in Mice.
Published in:
PLoS ONE, 2014, v. 9, n. 4, p. 1, doi. 10.1371/journal.pone.0095236
By:
- Dow, Lukas E.;
- Nasr, Zeina;
- Saborowski, Michael;
- Ebbesen, Saya H.;
- Manchado, Eusebio;
- Tasdemir, Nilgun;
- Lee, Teresa;
- Pelletier, Jerry;
- Lowe, Scott W.
Publication type:
Article
Variability of Inducible Expression across the Hematopoietic System of Tetracycline Transactivator Transgenic Mice.
Published in:
PLoS ONE, 2013, v. 8, n. 1, p. 1, doi. 10.1371/journal.pone.0054009
By:
- Takiguchi, Megumi;
- Dow, Lukas E.;
- Prier, Julia E.;
- Carmichael, Catherine L.;
- Kile, Benjamin T.;
- Turner, Stephen J.;
- Lowe, Scott W.;
- Huang, David C. S.;
- Dickins, Ross A.
Publication type:
Article
hScrib is a functional homologue of the Drosophila tumour suppressor Scribble.
Published in:
Oncogene, 2003, v. 22, n. 58, p. 9225, doi. 10.1038/sj.onc.1207154
By:
- Dow, Lukas E.;
- Brumby, Anthony M.;
- Muratore, Rosa;
- Coombe, Michelle L.;
- Sedelies, Karin A.;
- Trapani, Joseph A.;
- Russell, Sarah M.;
- Richardson, Helena E.;
- Humbert, Patrick O.
Publication type:
Article
KRAS mutant rectal cancer cells interact with surrounding fibroblasts to deplete the extracellular matrix.
Published in:
Molecular Oncology, 2021, v. 15, n. 10, p. 2766, doi. 10.1002/1878-0261.12960
By:
- Kim, Jin K.;
- Marco, Michael R.;
- Seo-Hyun Choi;
- Xuan Qu;
- Chin-Tung Chen;
- Elkabets, Moshe;
- Fairchild, Lauren;
- Chow, Oliver;
- Barriga, Francisco M.;
- Dow, Lukas E.;
- O'Rourke, Kevin;
- Szeglin, Bryan;
- Yarilin, Dmitry;
- Sho Fujisawa;
- Manova-Todorova, Katia;
- Paty, Philip B.;
- Shia, Jinru;
- Leslie, Christina;
- Smith, J. Joshua;
- Lowe, Scott
Publication type:
Article
Suppression of eukaryotic initiation factor 4E prevents chemotherapy-induced alopecia.
Published in:
BMC Pharmacology & Toxicology, 2013, v. 14, n. 1, p. 1, doi. 10.1186/2050-6511-14-58
By:
- Nasr, Zeina;
- Dow, Lukas E.;
- Paquet, Marilene;
- Chu, Jennifer;
- Ravindar, Kontham;
- Somaiah, Ragam;
- Deslongchamps, Pierre;
- Porco Jr, John A.;
- Lowe, Scott W.;
- Pelletier, Jerry
Publication type:
Article
Tankyrase inhibition sensitizes cells to CDK4 blockade.
Published in:
PLoS ONE, 2019, v. 14, n. 12, p. N.PAG, doi. 10.1371/journal.pone.0226645
By:
- Foronda, Miguel;
- Tarumoto, Yusuke;
- Schatoff, Emma M.;
- Leach, Benjamin I.;
- Diaz, Bianca J.;
- Zimmerman, Jill;
- Goswami, Sukanya;
- Shusterman, Michael;
- Vakoc, Christopher R.;
- Dow, Lukas E.
Publication type:
Article
Systemic silencing of PHD2 causes reversible immune regulatory dysfunction.
Published in:
2019
By:
- Atsushi Yamamoto;
- Hester, Joanna;
- Macklin, Philip S.;
- Kawai, Kento;
- Masateru Uchiyama;
- Biggs, Daniel;
- Bishop, Tammie;
- Bull, Katherine;
- Xiaotong Cheng;
- Cawthorne, Eleanor;
- Coleman, Mathew L.;
- Crockford, Tanya L.;
- Davies, Ben;
- Dow, Lukas E.;
- Goldin, Rob;
- Kranc, Kamil;
- Hiromi Kudo;
- Lawson, Hannah;
- McAuliffe, James;
- Milward, Kate
Publication type:
journal article
Generation of focal mutations and large genomic deletions in the pancreas using inducible in vivo genome editing.
Published in:
Carcinogenesis, 2020, v. 41, n. 3, p. 334, doi. 10.1093/carcin/bgz108
By:
- Mishra, Amrendra;
- Emamgholi, Fatemeh;
- Erlangga, Zulrahman;
- Hartleben, Björn;
- Unger, Kristian;
- Wolff, Katharina;
- Teichmann, Ulrike;
- Kessel, Michael;
- Woller, Norman;
- Kühnel, Florian;
- Dow, Lukas E;
- Manns, Michael P;
- Vogel, Arndt;
- Lowe, Scott W;
- Saborowski, Anna;
- Saborowski, Michael
Publication type:
Article
R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine.
Published in:
Nature Communications, 2017, v. 8, n. 7, p. 15945, doi. 10.1038/ncomms15945
By:
- Han, Teng;
- Schatoff, Emma M.;
- Murphy, Charles;
- Zafra, Maria Paz;
- Wilkinson, John E.;
- Elemento, Olivier;
- Dow, Lukas E.
Publication type:
Article
Generation of precision preclinical cancer models using regulated in vivo base editing.
Published in:
Nature Biotechnology, 2024, v. 42, n. 3, p. 437, doi. 10.1038/s41587-023-01900-x
By:
- Katti, Alyna;
- Vega-Pérez, Adrián;
- Foronda, Miguel;
- Zimmerman, Jill;
- Zafra, Maria Paz;
- Granowsky, Elizabeth;
- Goswami, Sukanya;
- Gardner, Eric E.;
- Diaz, Bianca J.;
- Simon, Janelle M.;
- Wuest, Alexandra;
- Luan, Wei;
- Fernandez, Maria Teresa Calvo;
- Kadina, Anastasia P.;
- Walker II, John A.;
- Holden, Kevin;
- Lowe, Scott W.;
- Sánchez Rivera, Francisco J.;
- Dow, Lukas E.
Publication type:
Article
The Polarity Protein Scribble Regulates Myelination and Remyelination in the Central Nervous System.
Published in:
PLoS Biology, 2015, v. 13, n. 3, p. 1, doi. 10.1371/journal.pbio.1002107
By:
- Jarjour, Andrew A.;
- Boyd, Amanda;
- Dow, Lukas E.;
- Holloway, Rebecca K.;
- Goebbels, Sandra;
- Humbert, Patrick O.;
- Williams, Anna;
- ffrench-Constant, Charles
Publication type:
Article
Transcriptional plasticity promotes primary and acquired resistance to BET inhibition.
Published in:
Nature, 2015, v. 525, n. 7570, p. 543, doi. 10.1038/nature14898
By:
- Rathert, Philipp;
- Roth, Mareike;
- Neumann, Tobias;
- Muerdter, Felix;
- Roe, Jae-Seok;
- Muhar, Matthias;
- Deswal, Sumit;
- Cerny-Reiterer, Sabine;
- Peter, Barbara;
- Jude, Julian;
- Hoffmann, Thomas;
- Boryń, Łukasz M.;
- Axelsson, Elin;
- Schweifer, Norbert;
- Tontsch-Grunt, Ulrike;
- Dow, Lukas E.;
- Gianni, Davide;
- Pearson, Mark;
- Valent, Peter;
- Stark, Alexander
Publication type:
Article
EpCAM (CD326) Regulates Intestinal Epithelial Integrity and Stem Cells via Rho-Associated Kinase.
Published in:
Cells (2073-4409), 2021, v. 10, n. 2, p. 256, doi. 10.3390/cells10020256
By:
- Ouchi, Takeshi;
- Morimura, Sohshi;
- Dow, Lukas E.;
- Miyoshi, Hiroyuki;
- Udey, Mark C.;
- Yagi, Hiroshi
Publication type:
Article
GO: a functional reporter system to identify and enrich base editing activity.
Published in:
Nucleic Acids Research, 2020, v. 48, n. 6, p. 2841, doi. 10.1093/nar/gkaa124
By:
- Katti, Alyna;
- Foronda, Miguel;
- Zimmerman, Jill;
- Diaz, Bianca;
- Zafra, Maria Paz;
- Goswami, Sukanya;
- Dow, Lukas E
Publication type:
Article
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2.
Published in:
Science Translational Medicine, 2023, v. 15, n. 684, p. 1, doi. 10.1126/scitranslmed.ade1857
By:
- Bhardwaj, Priya;
- Iyengar, Neil M.;
- Zahid, Heba;
- Carter, Katharine M.;
- Byun, Dong Jun;
- Choi, Man Ho;
- Sun, Qi;
- Savenkov, Oleksandr;
- Louka, Charalambia;
- Liu, Catherine;
- Piloco, Phoebe;
- Acosta, Monica;
- Bareja, Rohan;
- Elemento, Olivier;
- Foronda, Miguel;
- Dow, Lukas E.;
- Oshchepkova, Sofya;
- Giri, Dilip D.;
- Pollak, Michael;
- Zhou, Xi Kathy
Publication type:
Article
RB depletion is required for the continuous growth of tumors initiated by loss of RB.
Published in:
PLoS Genetics, 2021, v. 17, n. 12, p. 1, doi. 10.1371/journal.pgen.1009941
By:
- Doan, Alex;
- Arand, Julia;
- Gong, Diana;
- Drainas, Alexandros P.;
- Shue, Yan Ting;
- Lee, Myung Chang;
- Zhang, Shuyuan;
- Walter, David M.;
- Chaikovsky, Andrea C.;
- Feldser, David M.;
- Vogel, Hannes;
- Dow, Lukas E.;
- Skotheim, Jan M.;
- Sage, Julien
Publication type:
Article
Comprehensive microRNA analysis across genome-edited colorectal cancer organoid models reveals miR-24 as a candidate regulator of cell survival.
Published in:
BMC Genomics, 2022, v. 23, n. 1, p. 1, doi. 10.1186/s12864-022-09018-1
By:
- Villanueva, Jonathan W.;
- Kwong, Lawrence;
- Han, Teng;
- Martinez, Salvador Alonso;
- Shanahan, Michael T.;
- Kanke, Matt;
- Dow, Lukas E.;
- Danko, Charles G.;
- Sethupathy, Praveen
Publication type:
Article

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