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Drugging the undruggable RAS: Mission Possible?
- Published in:
- Nature Reviews Drug Discovery, 2014, v. 13, n. 11, p. 828, doi. 10.1038/nrd4389
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- Publication type:
- Article
Characterization of TR‐107, a novel chemical activator of the human mitochondrial protease ClpP.
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- Pharmacology Research & Perspectives, 2022, v. 10, n. 4, p. 1, doi. 10.1002/prp2.993
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- Publication type:
- Article
The coupling of α<sub>6</sub>β<sub>4</sub> integrin to Ras–MAP kinase pathways mediated by Shc controls keratinocyte proliferation.
- Published in:
- EMBO Journal, 1997, v. 16, n. 9, p. 2365, doi. 10.1093/emboj/16.9.2365
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- Publication type:
- Article
Guanine nucleotide exchange factors: Activators of Ras superfamily proteins.
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- Molecular Reproduction & Development, 1995, v. 42, n. 4, p. 468, doi. 10.1002/mrd.1080420415
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- Publication type:
- Article
Application of a MYC degradation screen identifies sensitivity to CDK9 inhibitors in KRAS-mutant pancreatic cancer.
- Published in:
- Science Signaling, 2019, v. 12, n. 590, p. 1, doi. 10.1126/scisignal.aav7259
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- Publication type:
- Article
Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies.
- Published in:
- Science Signaling, 2017, v. 10, n. 498, p. 1, doi. 10.1126/scisignal.aao3332
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- Publication type:
- Article
Release of autoinhibition of ASEF by APC leads to CDC42 activation and tumor suppression.
- Published in:
- Nature Structural & Molecular Biology, 2007, v. 14, n. 9, p. 814, doi. 10.1038/nsmb1290
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- Publication type:
- Article
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.
- Published in:
- Nature Reviews Molecular Cell Biology, 2005, v. 6, n. 2, p. 167, doi. 10.1038/nrm1587
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- Publication type:
- Article
ROCK-generated contractility regulates breast epithelial cell differentiation in response to the physical properties of a three-dimensional collagen matrix.
- Published in:
- Journal of Cell Biology, 2003, v. 163, n. 3, p. 583, doi. 10.1083/jcb.200305010
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- Publication type:
- Article
The C. elegans Chp/Wrch Ortholog CHW-1 Contributes to LIN-18/Ryk and LIN-17/Frizzled Signaling in Cell Polarity.
- Published in:
- PLoS ONE, 2015, v. 10, n. 7, p. 1, doi. 10.1371/journal.pone.0133226
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- Publication type:
- Article
The RhoGEF TEM4 Regulates Endothelial Cell Migration by Suppressing Actomyosin Contractility.
- Published in:
- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0066260
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- Publication type:
- Article
Identification of a Novel Actin-Binding Domain within the Rho Guanine Nucleotide Exchange Factor TEM4.
- Published in:
- PLoS ONE, 2012, v. 7, n. 7, p. 1, doi. 10.1371/journal.pone.0041876
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- Publication type:
- Article
Regulator of G-Protein Signaling 14 (RGS14) Is a Selective H-Ras Effector.
- Published in:
- PLoS ONE, 2009, v. 4, n. 3, p. 1, doi. 10.1371/journal.pone.0004884
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- Publication type:
- Article
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation.
- Published in:
- Oncogene, 2004, v. 23, n. 58, p. 9369, doi. 10.1038/sj.onc.1208182
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- Publication type:
- Article
The dark side of Ras: regulation of apoptosis.
- Published in:
- Oncogene, 2003, v. 22, n. 56, p. 8999, doi. 10.1038/sj.onc.1207111
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- Publication type:
- Article
KRASMutant Pancreatic Cancer: No Lone Path to an Effective Treatment.
- Published in:
- Cancers, 2016, v. 8, n. 4, p. 45, doi. 10.3390/cancers8040045
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- Publication type:
- Article
Detection of phenotype‐specific therapeutic vulnerabilities in breast cells using a CRISPR loss‐of‐function screen.
- Published in:
- Molecular Oncology, 2021, v. 15, n. 8, p. 2026, doi. 10.1002/1878-0261.12951
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- Publication type:
- Article
CIB1 depletion impairs cell survival and tumor growth in triple-negative breast cancer.
- Published in:
- Breast Cancer Research & Treatment, 2015, v. 152, n. 2, p. 337, doi. 10.1007/s10549-015-3458-4
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- Publication type:
- Article
Mediator kinase inhibition impedes transcriptional plasticity and prevents resistance to ERK/MAPK-targeted therapy in KRAS-mutant cancers.
- Published in:
- NPJ Precision Oncology, 2024, v. 8, n. 1, p. 1, doi. 10.1038/s41698-024-00615-9
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- Publication type:
- Article
Tiam1 mediates Ras activation of Rac by a PI(3)K-independent mechanism.
- Published in:
- Nature Cell Biology, 2002, v. 4, n. 8, p. 621, doi. 10.1038/ncb833
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- Publication type:
- Article
The thrombin receptor, PAR-1, causes transformation by activation of Rho-mediated signaling pathways.
- Published in:
- Oncogene, 2001, v. 20, n. 16, p. 1953, doi. 10.1038/sj.onc.1204281
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- Publication type:
- Article
Rho GTPase-dependent transformation by G protein-coupled receptors.
- Published in:
- Oncogene, 2001, v. 20, n. 13, p. 1547, doi. 10.1038/sj.onc.1204188
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- Publication type:
- Article
G2A is an oncogenic G protein-coupled receptor.
- Published in:
- Oncogene, 2000, v. 19, n. 34, p. 3866, doi. 10.1038/sj.onc.1203731
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- Publication type:
- Article
Cellular functions of TC10, a Rho family GTPase: regulation of morphology, signal transduction and cell growth.
- Published in:
- Oncogene, 1999, v. 18, n. 26, p. 3831, doi. 10.1038/sj.onc.1202758
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- Publication type:
- Article
TC21 and Ras share indistinguishable transforming and differentiating activities.
- Published in:
- Oncogene, 1999, v. 18, n. 12, p. 2107, doi. 10.1038/sj.onc.1202517
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- Publication type:
- Article
Differential contribution of the ERK and JNK mitogen-activated protein kinase cascades to Ras transformation of HT1080 fibrosarcoma and DLD-1 colon carcinoma cells.
- Published in:
- Oncogene, 1999, v. 18, n. 10, p. 1807, doi. 10.1038/sj.onc.1202482
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- Publication type:
- Article
Increasing complexity of Ras signaling.
- Published in:
- Oncogene, 1998, v. 17, n. 11, p. 1395, doi. 10.1038/sj.onc.1202174
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- Publication type:
- Article
Rho family proteins and Ras transformation: the RHOad less traveled gets congested.
- Published in:
- Oncogene, 1998, v. 17, n. 11, p. 1415, doi. 10.1038/sj.onc.1202181
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- Publication type:
- Article
Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade.
- Published in:
- Oncogene, 1998, v. 16, n. 20, p. 2565, doi. 10.1038/sj.onc.1201784
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- Publication type:
- Article
R-Ras is regulated by activators and effectors distinct from those that control Ras function.
- Published in:
- Oncogene, 1997, v. 14, n. 2, p. 133, doi. 10.1038/sj.onc.1200815
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- Publication type:
- Article
Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins.
- Published in:
- BioEssays, 1995, v. 17, n. 5, p. 395, doi. 10.1002/bies.950170507
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- Publication type:
- Article
Citron Kinase, a RhoA Effector, Enhances HIV-1 Virion Production by Modulating Exocytosis.
- Published in:
- Traffic, 2006, v. 7, n. 12, p. 1643, doi. 10.1111/j.1600-0854.2006.00503.x
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- Publication type:
- Article
Enhanced cathepsin L expression is mediated by different Ras effector pathways in fibroblasts and epithelial cells.
- Published in:
- International Journal of Cancer, 2004, v. 112, n. 2, p. 190, doi. 10.1002/ijc.20398
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- Publication type:
- Article
DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms.
- Published in:
- Molecular Carcinogenesis, 2008, v. 47, n. 5, p. 326, doi. 10.1002/mc.20389
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- Publication type:
- Article
Ras-mediated intestinal epithelial cell transformation requires cyclooxygenase-2-induced prostaglandin E<sub>2</sub> signaling.
- Published in:
- Molecular Carcinogenesis, 2007, v. 46, n. 12, p. 958, doi. 10.1002/mc.20333
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- Publication type:
- Article
Activation of ras oncogenes in chemically transformed BALB/MK-2 mouse keratinocytes.
- Published in:
- Molecular Carcinogenesis, 1989, v. 2, n. 3, p. 150, doi. 10.1002/mc.2940020308
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- Publication type:
- Article
Genome-wide DNA methylation analysis of KRAS mutant cell lines.
- Published in:
- Scientific Reports, 2020, v. 10, n. 1, p. 1, doi. 10.1038/s41598-020-66797-x
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- Publication type:
- Article
RHOA<sup>L57V</sup> drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling.
- Published in:
- Science Signaling, 2023, v. 16, n. 816, p. 1, doi. 10.1126/scisignal.adg5289
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- Publication type:
- Article
RAS, wanted dead or alive: Advances in targeting RAS mutant cancers.
- Published in:
- Science Signaling, 2020, v. 13, n. 624, p. 1, doi. 10.1126/scisignal.aay6013
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- Publication type:
- Article
Differential regulation of SHC proteins by nerve growth factor in sensory neurons and PC12 cells.
- Published in:
- European Journal of Neuroscience, 1998, v. 10, n. 6, doi. 10.1046/j.1460-9568.1998.00209.x
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- Publication type:
- Article
The ERK mitogen-activated protein kinase signaling network: the final frontier in RAS signal transduction.
- Published in:
- Biochemical Society Transactions, 2021, v. 49, n. 1, p. 253, doi. 10.1042/BST20200507
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- Publication type:
- Article
Cancer: Drug for an 'undruggable' protein.
- Published in:
- Nature, 2013, v. 497, n. 7451, p. 577, doi. 10.1038/nature12248
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- Publication type:
- Article
Alterations in the extracellular matrix organization associated with the reexpression of tumorigenicity in human cell hybrids.
- Published in:
- International Journal of Cancer, 1980, v. 26, n. 4, p. 451, doi. 10.1002/ijc.2910260410
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- Publication type:
- Article
Computational design of chemogenetic and optogenetic split proteins.
- Published in:
- Nature Communications, 2018, v. 9, n. 1, p. 1, doi. 10.1038/s41467-018-06531-4
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- Publication type:
- Article
Structural basis for the selective activation of Rho GTPases by Dbl exchange factors.
- Published in:
- Nature Structural Biology, 2002, v. 9, n. 6, p. 468, doi. 10.1038/nsb796
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- Publication type:
- Article
Molecular basis for Rac1 recognition by guanine nucleotide exchange factors.
- Published in:
- Nature Structural Biology, 2001, v. 8, n. 12, p. 1037, doi. 10.1038/nsb719
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- Publication type:
- Article
Phase Ib Study of Ulixertinib Plus Gemcitabine and Nab-Paclitaxel in Patients with Metastatic Pancreatic Adenocarcinoma.
- Published in:
- Oncologist, 2023, v. 28, n. 2, p. e115, doi. 10.1093/oncolo/oyac237
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- Publication type:
- Article
A Six-Gene Signature Predicts Survival of Patients with Localized Pancreatic Ductal Adenocarcinoma.
- Published in:
- PLoS Medicine, 2010, v. 7, n. 7, p. 1, doi. 10.1371/journal.pmed.1000307
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- Publication type:
- Article
GTPase traffic control.
- Published in:
- Nature, 2000, v. 405, n. 6788, p. 749, doi. 10.1038/35015654
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- Publication type:
- Article
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
- Published in:
- 2010
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- Publication type:
- journal article