OpenURL Connection Search

Select item for more details and to access through your institution.

Validation of ELISA Methods for Quantification of Total Tau and Phosporylated-Tau<sub>181</sub> in Human Cerebrospinal Fluid with Measurement in Specimens from Two Alzheimer's Disease Studies.
Published in:
Journal of Alzheimer's Disease, 2011, v. 26, n. 3, p. 531, doi. 10.3233/JAD-2011-110296
By:
- Lachno, D. Richard;
- Romeo, Martin J.;
- Siemers, Eric R.;
- Vanderstichele, Hugo;
- Coart, Els;
- Konrad, Robert J.;
- Zajac, Joseph J.;
- Talbot, Jayne A.;
- Jensen, Hans F.;
- Sethuraman, Gopalan;
- DeMattos, Ronald B.;
- May, Patrick C.;
- Dean, Robert A.
Publication type:
Article
Clusterin contributes to caspase-3?independent brain injury following neonatal hypoxia-ischemia.
Published in:
Nature Medicine, 2001, v. 7, n. 3, p. 338, doi. 10.1038/85487
By:
- Han, Byung Hee;
- DeMattos, Ronald B.;
- Dugan, Laura L.;
- Kim-Han, Jeong Sook;
- Brendza, Robert P.;
- Fryer, John D.;
- Kierson, Malca;
- Cirrito, John;
- Quick, Kevin;
- Harmony, Judith A. K.;
- Aronow, Bruce J.;
- Holtzman, David M.
Publication type:
Article
In Vivo Assessment of Brain Interstitial Fluid with Microdialysis Reveals Plaque-Associated Changes in Amyloid-β Metabolism and Half-Life.
Published in:
Journal of Neuroscience, 2003, v. 23, n. 26, p. 8844, doi. 10.1523/JNEUROSCI.23-26-08844.2003
By:
- Cirrito, John R.;
- May, Patrick C.;
- O'Dell, Mark A.;
- Taylor, Jennie W.;
- Parsadanian, Maia;
- Cramer, Jeffrey W.;
- Audia, James E.;
- Nissen, Jeffrey S.;
- Bales, Kelly R.;
- Paul, Steven M.;
- DeMattos, Ronald B.;
- Holtzman, David M.
Publication type:
Article
Apolipoprotein E Markedly Facilitates Age-Dependent Cerebral Amyloid Angiopathy and Spontaneous Hemorrhage in Amyloid Precursor Protein Transgenic Mice.
Published in:
Journal of Neuroscience, 2003, v. 23, n. 21, p. 7889, doi. 10.1523/JNEUROSCI.23-21-07889.2003
By:
- Fryer, John D.;
- Taylor, Jennie W.;
- DeMattos, Ronald B.;
- Bales, Kelly R.;
- Paul, Steven M.;
- Parsadanian, Maia
Publication type:
Article
Amyloid‐β immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer's Disease mice.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2023, v. 19, p. 1, doi. 10.1002/alz.074142
By:
- Taylor, Xavier;
- Clark, Isaiah;
- Oluoch, Herold;
- Fitzgerald, Griffin;
- Hole, Justin T.;
- DeMattos, Ronald B.;
- Wang, Yaming;
- Pan, Feng
Publication type:
Article
P4‐388: TRAILBLAZER‐ALZ (NCT03367403): A PHASE 2 DISEASE‐MODIFICATION COMBINATION THERAPY TRIAL TARGETING MULTIPLE MECHANISMS OF ACTION ALONG THE AMYLOID PATHWAY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P1622, doi. 10.1016/j.jalz.2018.07.212
By:
- Irizarry, Michael C.;
- Fleisher, Adam S.;
- Hake, Ann Marie;
- Liu, Peng;
- Shcherbinin, Sergey;
- DeMattos, Ronald B.;
- Mintun, Mark A.
Publication type:
Article
P1‐114: MEASUREMENT OF ENDOGENOUS MOUSE TAU IN CEREBROSPINAL FLUID FROM AGED PDAPP MICE FOLLOWING TREATMENT WITH AB‐LOWERING COMPOUNDS.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P314, doi. 10.1016/j.jalz.2018.06.117
By:
- Reising, Nicholas C.;
- Day, Theresa A.;
- Hole, Justin T.;
- Tingley, Francis David;
- Gonzalez-DeWhitt, Patricia A.;
- Mergott, Dustin J.;
- McKinzie, David L.;
- Demattos, Ronald B.;
- Hayashi, Mansuo L.;
- Riddell, David R.
Publication type:
Article
O1‐09‐01: SIGNIFICANT AND SUSTAINED FLORBETAPIR F18 UPTAKE REDUCTION IN PATIENTS WITH SYMPTOMATIC ALZHEIMER'S DISEASE WITH LY3002813, A β‐AMYLOID PLAQUE‐SPECIFIC ANTIBODY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2018, v. 14, p. P239, doi. 10.1016/j.jalz.2018.06.2378
By:
- Fleisher, Adam S.;
- Lowe, Stephen L.;
- Liu, Peng;
- Shcherbinin, Sergey;
- Li, Li;
- Chua, Laiyi;
- Nakano, Masako;
- Hawdon, Anne;
- Willis, Brian A.;
- Schwarz, Adam J.;
- Demattos, Ronald B.;
- Mintun, Mark A.;
- Irizarry, Michael C.
Publication type:
Article
A COMPETITIVE EX-VIVO SCREENING ASSAY TO DETERMINE ABETA ANTIBODY MEDIATED PHAGOCYTOSIS AND PLAQUE SPECIFICITY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P623, doi. 10.1016/j.jalz.2017.06.697
By:
- Liu, Feng;
- Oluoch, Herold;
- Tzaferis, John A.;
- Hole, Justin T.;
- Demattos, Ronald B.;
- Racke, Margaret M.
Publication type:
Article
AGGREGATE-SELECTIVE ANTI-TAU ANTIBODY MC-1 DEMONSTRATED ROBUST IN VITRO AND IN VIVO ACTIVITY TO NEUTRALIZE TRANSMISSIBLE TAU AND REDUCE TAU PATHOLOGY.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P592, doi. 10.1016/j.jalz.2017.07.226
By:
- Hayashi, Mansuo L.;
- Lu, Jirong;
- Wu, Su;
- Bose, Suchira;
- Ahmed, Zeshan;
- Cooper, Jane;
- Murray, Tracey K.;
- Jackson, Samuel J.;
- Cavallini, Annalisa;
- Ward, Mark;
- Driver, David;
- Goedert, Michel;
- Demattos, Ronald B.;
- O'Neill, Michael J.;
- Hutton, Michael
Publication type:
Article
SOLANEZUMAB CENTRAL TARGET ENGAGEMENT AND PHARMACODYNAMIC ACTIVITY IN THE EXPEDITION 3 TRIAL OF PATIENTS WITH MILD AD: COMPARISON TO EXPEDITION/EXPEDITION 2.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2017, v. 13, p. P254, doi. 10.1016/j.jalz.2017.06.116
By:
- Dean, Robert A.;
- Sundell, Karen L.;
- Lachno, David Richard;
- Ferguson-Sells, Lisa R.;
- Case, Michael G.;
- Holdridge, Karen C.;
- Demattos, Ronald B.;
- Raskin, Joel;
- Siemers, Eric R.;
- Willis, Brian A.
Publication type:
Article
OPTIMIZATION OF THE PHARMACOKINETIC (PK) AND PHARMACODYNAMIC (PD) PROPERTIES OF AN ANTI-ABETA ANTIBODY M266 FAB FRAGMENT VARIANT BY SITE-SPECIFIC PEGYLATION.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P433, doi. 10.1016/j.jalz.2016.06.829
By:
- Racke, Margaret M.;
- Day, Theresa A.;
- Hole, Justin T.;
- Chow, Chi-Kin;
- Lu, Jirong;
- DeMattos, Ronald B.
Publication type:
Article
DEVELOPMENT OF A HIGHLY SENSITIVE TAU IMMUNOASSAY TO MEASURE ENDOGENOUS MURINE TAU IN MOUSE CEREBROSPINAL FLUID.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P843, doi. 10.1016/j.jalz.2016.06.1725
By:
- Day, Theresa A.;
- Reising, Nicholas C.;
- Hole, Justin T.;
- Tingley, F. David;
- DeMattos, Ronald B.;
- Hayashi, Mansuo L.
Publication type:
Article
TREM2-MEDIATED EARLY RESPONSE BY RESIDENT MICROGLIA LIMITS DIFFUSION AND TOXICITY OF AMYLOID PLAQUES.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P241, doi. 10.1016/j.jalz.2016.06.431
By:
- Wang, Yaming;
- Ulland, Tyler;
- Ulrich, Jason D.;
- Song, Wilbur;
- Yuan, Peng;
- Mahan, Thomas E.;
- Shi, Yang;
- Gilfillan, Susan;
- Cella, Marina;
- DeMattos, Ronald B.;
- Grutzendler, Jaime;
- Cirrito, John R.;
- Holtzman, David M.;
- Colonna, Marco
Publication type:
Article
SAFETY, PHARMACOKINETICS (PK), AND FLORBETAPIR F-18 POSITRON EMISSION TOMOGRAPHY (PET) AFTER MULTIPLE DOSE ADMINISTRATION OF LY3002813, A β-AMYLOID PLAQUE-SPECIFIC ANTIBODY, IN ALZHEIMER’S DISEASE (AD).
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2016, v. 12, p. P352, doi. 10.1016/j.jalz.2016.06.665
By:
- Irizarry, Michael C.;
- Sims, John R.;
- Lowe, Stephen L.;
- Nakano, Masako;
- Hawdon, Anne;
- Willis, Brian A.;
- Gonzales, Celedon;
- Liu, Peng;
- Fujimoto, Shino;
- Dean, Robert A.;
- Konrad, Robert J.;
- Shcherbinin, Sergey;
- Schwarz, Adam J.;
- Mintun, Mark A.;
- Sr.Devous, Michael D.;
- DeMattos, Ronald B.
Publication type:
Article
Investigation of dose-responses and longitudinal effects of combination therapy with a plaque-specific amyloid beta antibody and bace inhibitor in aged transgenic mice.
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2015, v. 11, n. 7, p. P275, doi. 10.1016/j.jalz.2015.07.364
By:
- DeMattos, Ronald B.;
- Racke, Margaret M.;
- Hole, Justin T.;
- Tzaferis, John A.;
- Liu, Feng;
- Ahmed, Zeshan;
- Fisher, Alice;
- Day, Theresa A.;
- Anderson, Wesley;
- Iversent, Philip;
- Gonzales, Celedon;
- Yang, Zhixiang;
- Boggs, Leonard;
- Monk, Scott A.;
- Mergott, Dustin J.;
- Yang, Ying Y.T.;
- Lu, Jirong;
- Irizarry, Michael C.;
- Sims, John R.;
- May, Patrick C.
Publication type:
Article
Safety and biomarker effects of solanezumab in patients with Alzheimer’s disease
Published in:
Alzheimer's & Dementia: The Journal of the Alzheimer's Association, 2012, v. 8, n. 4, p. 261, doi. 10.1016/j.jalz.2011.09.224
By:
- Farlow, Martin;
- Arnold, Steven E.;
- van Dyck, Christopher H.;
- Aisen, Paul S.;
- Snider, B. Joy;
- Porsteinsson, Anton P.;
- Friedrich, Stuart;
- Dean, Robert A.;
- Gonzales, Celedon;
- Sethuraman, Gopalan;
- DeMattos, Ronald B.;
- Mohs, Richard;
- Paul, Steven M.;
- Siemers, Eric R.
Publication type:
Article
Characterization of amino-terminally truncated Abeta-42 peptides in plasma from Alzheimer's patients receiving solanezumab immunotherapy treatment
Published in:
2010
By:
- DeMattos, Ronald B.;
- Racke, Margaret;
- Gelfanova, Valentina;
- Knierman, Michael;
- Hale, John;
- Dean, Robert;
- Paul, Steven;
- Siemers, Eric
Publication type:
Abstract
Characterization of novel apoE isoform-dependent C-terminal specific proteolysis of Aβ1-42 by microglia
Published in:
2010
By:
- Liu, Feng;
- Lin, Suizhen;
- Chai, Xiyun;
- DeMattos, Ronald B.;
- Paul, Steven M.;
- Lilly, Eli
Publication type:
Abstract
Soluble Aβ clearance from the brain interstitial fluid of PDAPP mice is human apoE isoform-dependent
Published in:
2010
By:
- Castellano, Joseph M.;
- Stewart, Floy R.;
- May, Patrick C.;
- DeMattos, Ronald B.;
- Paul, Steven M.;
- Holtzman, David M.
Publication type:
Abstract
Measurement of cerebrospinal fluid total tau and phospho-tau in phase 2 trials of therapies targeting Aβ
Published in:
2009
By:
- Siemers, Eric R.;
- Dean, Robert A.;
- Lachno, D.R.;
- Zajac, Joseph J.;
- Sethuraman, Gopalan;
- DeMattos, Ronald B.;
- May, Patrick C.
Publication type:
Abstract
Identification, characterization, and comparison of amino-terminally truncated Aβ<sub>42</sub> peptides in Alzheimer's disease brain tissue and in plasma from Alzheimer's patients receiving solanezumab immunotherapy treatment
Published in:
2009
By:
- DeMattos, Ronald B.;
- Racke, Margaret M.;
- Gelfanova, Valentina;
- Forster, Beth;
- Knierman, Michael D.;
- Bryan, Matthew T.;
- Hale, John E.;
- Dean, Robert A.;
- Paul, Steven M.;
- Siemers, Eric R.
Publication type:
Abstract
P4-312: A model-based comparison of the nonclinical and clinical effects of anti-Aβ antibodies on plasma Aβ1-40 levels
Published in:
2006
By:
- Siemers, Eric R.;
- Ferguson-Sells, Lisa;
- Waters, David G.;
- DeMattos, Ronald B.;
- Hansen, Ryan J.
Publication type:
Abstract
P4-293: Evidence for an age dependent rate limiting pool of CNS Aβ in PDAPP mouse altered by Aβ antibody administration
Published in:
2006
By:
- Racke, Margaret M.;
- Bryan, Matthew T.;
- DeMattos, Ronald B.
Publication type:
Abstract
P4-246: Passive immunotherapy with M266 results in altered CSF Aβ
Published in:
2006
By:
- DeMattos, Ronald B.;
- Racke, Margaret M.;
- Bryan, Matthew T.;
- Siemers, Eric R.
Publication type:
Abstract
P2-026: The cholesterol transporter ABCG1 modulates the proteolytic processing of amyloid precursor protein
Published in:
2006
By:
- Tansley, Gavin;
- Burgess, Braydon L.;
- Bryan, Matt;
- Su, Yuan;
- Chan, Jeniffer Y.;
- Naus, Kathryn E.;
- McIsaac, Sean;
- Hirsch-Reinshagen, Veronica;
- Yang, Hsui-Chiung;
- DeMattos, Ronald B.;
- Wellington, Cheryl L.
Publication type:
Abstract
P4-312: A model-based comparison of the nonclinical and clinical effects of anti-Aβ antibodies on plasma Aβ1-40 levels
Published in:
2006
By:
- Siemers, Eric R.;
- Ferguson-Sells, Lisa;
- Waters, David G.;
- DeMattos, Ronald B.;
- Hansen, Ryan J.
Publication type:
Abstract
P4-293: Evidence for an age dependent rate limiting pool of CNS Aβ in PDAPP mouse altered by Aβ antibody administration
Published in:
2006
By:
- Racke, Margaret M.;
- Bryan, Matthew T.;
- DeMattos, Ronald B.
Publication type:
Abstract
P4-246: Passive immunotherapy with M266 results in altered CSF Aβ
Published in:
2006
By:
- DeMattos, Ronald B.;
- Racke, Margaret M.;
- Bryan, Matthew T.;
- Siemers, Eric R.
Publication type:
Abstract
P2-026: The cholesterol transporter ABCG1 modulates the proteolytic processing of amyloid precursor protein
Published in:
2006
By:
- Tansley, Gavin;
- Burgess, Braydon L.;
- Bryan, Matt;
- Su, Yuan;
- Chan, Jeniffer Y.;
- Naus, Kathryn E.;
- McIsaac, Sean;
- Hirsch-Reinshagen, Veronica;
- Yang, Hsui-Chiung;
- DeMattos, Ronald B.;
- Wellington, Cheryl L.
Publication type:
Abstract
Exacerbation of Cerebral Amyloid Angiopathy-Associated Microhemorrhage in Amyloid Precursor Protein Transgenic Mice by Immunotherapy Is Dependent on Antibody Recognition of Deposited Forms of Amyloid β.
Published in:
Journal of Neuroscience, 2005, v. 25, n. 3, p. 629, doi. 10.1523/JNEUROSCI.4337-04.2005
By:
- Racke, Margaret M.;
- Boone, Laura I.;
- Hepburn, Deena L.;
- Parsadainian, Maia;
- Bryan, Matthew T.;
- Ness, Daniel K.;
- Piroozi, Kathy;
- Jordan, William H.;
- Brown, Donna D.;
- Hoffman, Wherly P.;
- Holtzman, David M.;
- Bales, Kelly R.;
- Gitter, Bruce D.;
- May, Patrick C.;
- Paul, Steven M.;
- DeMattos, Ronald B.
Publication type:
Article
A γ-secretase inhibitor decreases amyloid-β production in the central nervous system.
Published in:
Annals of Neurology, 2009, v. 66, n. 1, p. 48, doi. 10.1002/ana.21623
By:
- Bateman, Randall J.;
- Siemers, Eric R.;
- Mawuenyega, Kwasi G.;
- Wen, Guolin;
- Browning, Karen R.;
- Sigurdson, Wendy C.;
- Yarasheski, Kevin E.;
- Friedrich, Stuart W.;
- DeMattos, Ronald B.;
- May, Patrick C.;
- Paul, Steven M.;
- Holtzman, David M.
Publication type:
Article
Human apoE Isoforms Differentially Regulate Brain Amyloid-b Peptide Clearance.
Published in:
Science Translational Medicine, 2011, v. 3, n. 89, p. 1, doi. 10.1126/scitranslmed.3002156
By:
- Castellano, Joseph M.;
- Kim, Jungsu;
- Stewart, Floy R.;
- Jiang, Hong;
- DeMattos, Ronald B.;
- Patterson, Bruce W.;
- Fagan, Anne M.;
- Morris, John C.;
- Mawuenyega, Kwasi G.;
- Cruchaga, Carlos;
- Goate, Alison M.;
- Bales, Kelly R.;
- Paul, Steven M.;
- Bateman, Randall J.;
- Holtzman, David M.
Publication type:
Article
Advancing combination therapy for Alzheimer's disease.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2020, v. 6, n. 1, p. 1, doi. 10.1002/trc2.12073
By:
- Salloway, Stephen P.;
- Sevingy, Jeff;
- Budur, Kumar;
- Pederson, Jan Torleif;
- DeMattos, Ronald B.;
- Von Rosenstiel, Philipp;
- Paez, Antonio;
- Evans, Rebecca;
- Weber, Christopher J.;
- Hendrix, James A.;
- Worley, Susan;
- Bain, Lisa J.;
- Carrillo, Maria C.
Publication type:
Article
Central pharmacodynamic activity of solanezumab in mild Alzheimer's disease dementia.
Published in:
Alzheimer's & Dementia: Translational Research & Clinical Interventions, 2018, v. 4, n. 1, p. 652, doi. 10.1016/j.trci.2018.10.001
By:
- Willis, Brian A.;
- Sundell, Karen;
- Lachno, D. Richard;
- Ferguson‐Sells, Lisa R.;
- Case, Michael G.;
- Holdridge, Karen;
- DeMattos, Ronald B.;
- Raskin, Joel;
- Siemers, Eric R.;
- Dean, Robert A.
Publication type:
Article
Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model.
Published in:
Nature Neuroscience, 2002, v. 5, n. 5, p. 452, doi. 10.1038/nn842
By:
- Dodart, Jean-Cosme;
- Bales, Kelly R.;
- Gannon, Kimberley S.;
- Greene, Stephen J.;
- DeMattos, Ronald B.;
- Mathis, Chantal;
- DeLong, Cynthia A.;
- Wu, Su;
- Wu, Xin;
- Holtzman, David M.;
- Paul, Steven M.
Publication type:
Article
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are linked to vascular inflammation and cerebrovascular damage in a mouse model of Alzheimer's disease.
Published in:
Molecular Neurodegeneration, 2024, v. 19, n. 1, p. 1, doi. 10.1186/s13024-024-00758-0
By:
- Taylor, Xavier;
- Noristani, Harun N.;
- Fitzgerald, Griffin J.;
- Oluoch, Herold;
- Babb, Nick;
- McGathey, Tyler;
- Carter, Lindsay;
- Hole, Justin T.;
- Lacor, Pascale N.;
- DeMattos, Ronald B.;
- Wang, Yaming
Publication type:
Article
Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer's disease mice.
Published in:
Molecular Neurodegeneration, 2023, v. 18, n. 1, p. 1, doi. 10.1186/s13024-023-00649-w
By:
- Taylor, Xavier;
- Clark, Isaiah M.;
- Fitzgerald, Griffin J.;
- Oluoch, Herold;
- Hole, Justin T.;
- DeMattos, Ronald B.;
- Wang, Yaming;
- Pan, Feng
Publication type:
Article
Animal Models for Neural Diseases.
Published in:
Toxicologic Pathology, 2011, v. 39, n. 1, p. 167, doi. 10.1177/0192623310389478
By:
- Jay, Gary W.;
- Demattos, Ronald B.;
- Weinstein, Edward J.;
- Philbert, Martin A.;
- Pardo, Ingrid D.;
- Brown, Tom P.
Publication type:
Article
Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model.
Published in:
Molecular Neurodegeneration, 2018, v. 13, n. 1, p. N.PAG, doi. 10.1186/s13024-018-0296-y
By:
- Wang, Hong;
- Li, Yupeng;
- Ryder, John W.;
- Hole, Justin T.;
- Ebert, Philip J.;
- Airey, David C.;
- Qian, Hui-Rong;
- Logsdon, Benjamin;
- Fisher, Alice;
- Ahmed, Zeshan;
- Murray, Tracey K.;
- Cavallini, Annalisa;
- Bose, Suchira;
- Eastwood, Brian J.;
- Collier, David A.;
- Dage, Jeffrey L.;
- Miller, Bradley B.;
- Merchant, Kalpana M.;
- O'Neill, Michael J.;
- Demattos, Ronald B.
Publication type:
Article

Found: 40